Twitch Runes

The top Twitch runes in LoL patch 25.21 are Lethal Tempo, Triumph, Legend: Alacrity, Cut Down for Twitch's primary runes. Twitch's runes in his secondary tree best utilizes Biscuit Delivery and Magical Footwear. These Twitch rune choices provide the best Twitch rune build for ranked.

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  Deadly Venom

  Twitch's basic attacks infect the target, dealing true damage each second.

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  Ambush

  Twitch becomes Camouflaged for a short duration and gains Move Speed. When leaving Camouflage, Twitch gains Attack Speed for a short duration.
  
  When an enemy champion with Deadly Venom dies, Ambush's cooldown is reset.

  Cost:

  • 40

  Cooldown:

  • 16

  Range:

  • 20
• 

  

  Venom Cask

  Twitch hurls a cask of venom that explodes in an area, slowing targets and applying deadly venom to the target.

  Cost:

  • 70

  Cooldown:

  • 13/
  • 12/
  • 11/
  • 10/
  • 9

  Range:

  • 950
• 

  

  Contaminate

  Twitch wreaks further havoc on poisoned enemies with a blast of his vile diseases.

  Cost:

  • 50/
  • 60/
  • 70/
  • 80/
  • 90

  Cooldown:

  • 12/
  • 11/
  • 10/
  • 9/
  • 8

  Range:

  • 1200
• 

  

  Spray and Pray

  Twitch unleashes the full power of his crossbow, shooting bolts over a great distance that pierce all enemies caught in their path.

  Cost:

  • 100

  Cooldown:

  • 90

  Range:

  • 1200