Twisted Fate - League of Legends Champion
Win Rate
47.8%
Pick Rate
1.9%

Twisted FateRunes

FMageMarksman
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 20, 2026
MethodologyData Methodology

Best Twisted Fate runes for LoL Patch 26.7 - Unsealed Spellbook from the Inspiration tree with Resolve secondary (66.7% WR, 0.7% pick rate). Twisted Fate's optimal primary runes are Unsealed Spellbook, Cash Back, Triple Tonic, Jack Of All Trades. Secondary tree: Bone Plating, Overgrowth.

Twisted Fate performs best with Unsealed Spellbook as the keystone rune from the Inspiration tree. Twisted Fate's optimal primary runes are Unsealed Spellbook, Cash Back, Triple Tonic, Jack Of All Trades. Twisted Fate's secondary rune tree is Resolve with Bone Plating, Overgrowth. This rune setup achieves a 66.67% win rate (+18.8% win rate difference) with a 0.7% pick rate across 24 Twisted Fate games.
66.7%Win Rate
+18.8%WR Diff
0.7%Pick Rate
Unsealed SpellbookUnsealed Spellbook

Swap one of your equipped Summoner Spells to a new, single use Summoner Spell. Each unique Summoner Spell you swap to permanently decreases your swap cooldown by 25s (initial swap cooldown is @f3@ seconds).

Your first swap becomes available at 6 mins.

Summoner Spells can only be swapped while out of combat.
After using a swapped Summoner Spell you must swap 3 more times before the first can be selected again.
Smite damage increases after two Summoner Spell swaps.

Cash BackCash Back

Get 7.5% Gold back when you purchase Legendary Items.

Triple TonicTriple Tonic

Upon reaching level 3, gain an Elixir of Avarice.
Upon reaching level 6, gain an Elixir of Force.
Upon reaching level 9, gain an Elixir of Skill.

Jack Of All TradesJack Of All Trades

For each different stat gained from items, gain one Jack stack. Each stack grants you 1 Ability Haste.

Gain 10 or 25 bonus Adaptive Force at 5 and 10 stacks, respectively.

Bone PlatingBone Plating

After taking damage from an enemy champion, the next 3 spells or attacks you receive from them deal 30-60 (based on level) less damage.

Duration: 1.5s
Cooldown: 55s

OvergrowthOvergrowth

Absorb life essence from monsters or enemy minions that die near you, permanently gaining 3 maximum health for every 8.

When you've absorbed 120 monsters or enemy minions, gain an additional 3.5% maximum health.

This alternative Twisted Fate rune build uses Unsealed Spellbook as the keystone from the Inspiration tree. The primary runes are Unsealed Spellbook, Cash Back, Triple Tonic, Jack Of All Trades. Twisted Fate's secondary rune tree is Resolve with Bone Plating, Overgrowth. This setup achieves a 57.89% win rate (+10.1% win rate difference) with a 0.5% pick rate across 19 games.
57.9%Win Rate
+10.1%WR Diff
0.5%Pick Rate
Unsealed SpellbookUnsealed Spellbook

Swap one of your equipped Summoner Spells to a new, single use Summoner Spell. Each unique Summoner Spell you swap to permanently decreases your swap cooldown by 25s (initial swap cooldown is @f3@ seconds).

Your first swap becomes available at 6 mins.

Summoner Spells can only be swapped while out of combat.
After using a swapped Summoner Spell you must swap 3 more times before the first can be selected again.
Smite damage increases after two Summoner Spell swaps.

Cash BackCash Back

Get 7.5% Gold back when you purchase Legendary Items.

Triple TonicTriple Tonic

Upon reaching level 3, gain an Elixir of Avarice.
Upon reaching level 6, gain an Elixir of Force.
Upon reaching level 9, gain an Elixir of Skill.

Jack Of All TradesJack Of All Trades

For each different stat gained from items, gain one Jack stack. Each stack grants you 1 Ability Haste.

Gain 10 or 25 bonus Adaptive Force at 5 and 10 stacks, respectively.

Bone PlatingBone Plating

After taking damage from an enemy champion, the next 3 spells or attacks you receive from them deal 30-60 (based on level) less damage.

Duration: 1.5s
Cooldown: 55s

OvergrowthOvergrowth

Absorb life essence from monsters or enemy minions that die near you, permanently gaining 3 maximum health for every 8.

When you've absorbed 120 monsters or enemy minions, gain an additional 3.5% maximum health.

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Twisted Fate Runes - Frequently Asked Questions

What are the best Twisted Fate runes in patch 26.7?

The best Twisted Fate runes in patch 26.7 use the Inspiration tree with Unsealed Spellbook, Cash Back, Triple Tonic, and Jack Of All Trades, and the Resolve tree with Bone Plating and Overgrowth. This rune setup achieves a 66.7% win rate with a 0.7% pick rate.

What is the win rate for Twisted Fate's best rune page?

Twisted Fate's best rune page has a 66.7% win rate in patch 26.7, which is +18.8% compared to Twisted Fate's average win rate. This rune setup has a 0.7% pick rate among Twisted Fate players.

What keystone should I use on Twisted Fate?

Unsealed Spellbook from the Inspiration tree is the best keystone rune for Twisted Fate in patch 26.7. This keystone synergizes well with Twisted Fate's kit and provides a 66.7% win rate.

What is Twisted Fate's primary rune tree?

Twisted Fate's primary rune tree is Inspiration. The optimal Inspiration runes for Twisted Fate are Unsealed Spellbook, Cash Back, Triple Tonic, and Jack Of All Trades, with Unsealed Spellbook being the keystone of choice.

What is Twisted Fate's secondary rune tree?

Twisted Fate's best secondary rune tree is Resolve. The recommended Resolve runes are Bone Plating and Overgrowth, which complement Twisted Fate's Inspiration primary tree.

What are alternative rune setups for Twisted Fate?

An alternative Twisted Fate rune setup uses Unsealed Spellbook from the Inspiration tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.

How popular are Twisted Fate's runes?

Twisted Fate's top rune page has a 0.7% pick rate in patch 26.7. This indicates that 0.7% of Twisted Fate players use the Unsealed Spellbook setup with Inspiration and Resolve trees.