Cassiopeia Runes

The top Cassiopeia runes in LoL patch 25.21 are Conqueror, Presence of Mind, Legend: Haste, Cut Down for Cassiopeia's primary runes. Cassiopeia's runes in his secondary tree best utilizes Celerity and Waterwalking. These Cassiopeia rune choices provide the best Cassiopeia rune build for ranked.

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  Serpentine Grace

  Cassiopeia gains Move Speed per level, but she cannot purchase Boots items.

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  Noxious Blast

  Cassiopeia blasts an area with Poison after a brief delay, granting her increased Move Speed if she hits an enemy champion.

  Cost:

  • 50/
  • 55/
  • 60/
  • 65/
  • 70

  Cooldown:

  • 4

  Range:

  • 850
• 

  

  Miasma

  Cassiopeia releases several clouds of poison, slowing, grounding, and lightly damaging enemies that pass through them. Grounded enemies cannot use Movement abilities.

  Cost:

  • 70/
  • 75/
  • 80/
  • 85/
  • 90

  Cooldown:

  • 24/
  • 22/
  • 20/
  • 18/
  • 16

  Range:

  • 700
• 

  

  Twin Fang

  Cassiopeia lets loose an attack that deals increased damage to Poisoned targets and heals her for a percentage of the damage dealt. If the target dies from this attack, Cassiopeia regains Mana.

  Cost:

  • 40

  Cooldown:

  • 1

  Range:

  • 700
• 

  

  Petrifying Gaze

  Cassiopeia releases a swirl of magical energy from her eyes, stunning any enemies in front of her that are facing her and slowing any others with their back turned.

  Cost:

  • 100

  Cooldown:

  • 120/
  • 100/
  • 80

  Range:

  • 825