Elise Runes

The top Elise runes in LoL patch 25.21 are Electrocute, Cheap Shot, Grisly Mementos, Treasure Hunter for Elise's primary runes. Elise's runes in his secondary tree best utilizes Scorch and Manaflow Band. These Elise rune choices provide the best Elise rune build for ranked.

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  Spider Queen

  Human Form: When Elise's abilities hit an enemy, she gains a dormant Spiderling.
  
  Spider Form: Basic attacks deal bonus magic damage and restore health to Elise.

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  Neurotoxin / Venomous Bite

  Human Form: Deals damage based upon how high the target's Health is.
  
  Spider Form: Lunges at an enemy and deals damage based upon how low their Health is.

  Cost:

  • 80/
  • 85/
  • 90/
  • 95/
  • 100

  Cooldown:

  • 6

  Range:

  • 615
• 

  

  Volatile Spiderling / Skittering Frenzy

  Human Form: Releases a venom-gorged Spiderling that explodes when it nears a target.
  
  Spider Form: Elise and her Spiderlings gain Attack Speed.

  Cost:

  • 60/
  • 70/
  • 80/
  • 90/
  • 100

  Cooldown:

  • 12

  Range:

  • 950
• 

  

  Cocoon / Rappel

  Human Form: Stuns the first enemy unit hit and reveals them if they are not stealthed.
  
  Spider Form: Elise and her Spiderlings ascend into the air and then descend upon target enemy. After descending on an enemy target, Elise's bonus damage and healing from Spider Queen is increased.

  Cost:

  • 50

  Cooldown:

  • 12/
  • 12/
  • 11/
  • 11/
  • 10

  Range:

  • 1075
• 

  

  Spider Form

  Transforms into a menacing spider, reducing her attack range in exchange for Move Speed, new abilities, and a Spiderling swarm that will attack her foes.

  Cost:

  • 0

  Cooldown:

  • 3

  Range:

  • 20