Kai'Sa Runes

The top Kai'Sa runes in LoL patch 25.21 are Lethal Tempo, Triumph, Legend: Alacrity, Last Stand for Kai'Sa's primary runes. Kai'Sa's runes in his secondary tree best utilizes Biscuit Delivery and Magical Footwear. These Kai'Sa rune choices provide the best Kai'Sa rune build for ranked.

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  Second Skin

  Kai'Sa's basic attacks stack Plasma, dealing increasing bonus magic damage. Allies' immobilizing effects help stack Plasma. Additionally, Kai'Sa's item purchases upgrade her basic spells to have more powerful properties.

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  Icathian Rain

  Kai'Sa shoots a swarm of missiles that seek out nearby targets.
  
  Living Weapon: Icathian Rain is upgraded to shoot more missiles.

  Cost:

  • 55

  Cooldown:

  • 10/
  • 9/
  • 8/
  • 7/
  • 6

  Range:

  • 600
• 

  

  Void Seeker

  Kai'Sa shoots a long range missile, marking enemies with her passive.
  
  Living Weapon: Void Seeker is upgraded to apply more passive marks and reduce cooldown on champion hit.

  Cost:

  • 55/
  • 60/
  • 65/
  • 70/
  • 75

  Cooldown:

  • 22/
  • 20/
  • 18/
  • 16/
  • 14

  Range:

  • 3000
• 

  

  Supercharge

  Kai'Sa briefly increases her Move Speed, then increases her Attack Speed.
  
  Living Weapon: Supercharge is upgraded to briefly grant Invisibility.

  Cost:

  • 30

  Cooldown:

  • 16/
  • 15/
  • 13/
  • 12/
  • 10

  Range:

  • 1
• 

  

  Killer Instinct

  Kai'Sa dashes near an enemy champion.

  Cost:

  • 100

  Cooldown:

  • 120/
  • 90/
  • 60

  Range:

  • 2000/
  • 2500/
  • 3000