Vayne Runes

The top Vayne runes in LoL patch 25.21 are Lethal Tempo, Triumph, Legend: Alacrity, Last Stand for Vayne's primary runes. Vayne's runes in his secondary tree best utilizes Nimbus Cloak and Celerity. These Vayne rune choices provide the best Vayne rune build for ranked.

• 

  

  Night Hunter

  Vayne ruthlessly hunts evil-doers, gaining Move Speed when moving toward nearby enemy champions.

• 

  

  Tumble

  Vayne tumbles, maneuvering to carefully place her next shot. Her next attack deals bonus damage.

  Cost:

  • 30

  Cooldown:

  • 6/
  • 5/
  • 4/
  • 3/
  • 2

  Range:

  • 300
• 

  

  Silver Bolts

  Vayne tips her bolts with a rare metal, toxic to evil things. The third consecutive attack or ability against the same target deals a percentage of the target's max health as bonus true damage.

  Cost:

  • 0

  Cooldown:

  • 0

  Range:

  • 750
• 

  

  Condemn

  Vayne draws a heavy crossbow from her back, and fires a huge bolt at her target, knocking them back and dealing damage. If they collide with terrain, they are impaled, dealing bonus damage and stunning them.

  Cost:

  • 90

  Cooldown:

  • 20/
  • 18/
  • 16/
  • 14/
  • 12

  Range:

  • 550
• 

  

  Final Hour

  Readying herself for an epic confrontation, Vayne gains increased Attack Damage, Invisibility during Tumble, reduced Tumble cooldown, and more bonus Move Speed from Night Hunter

  Cost:

  • 80

  Cooldown:

  • 100/
  • 85/
  • 70

  Range:

  • 1