Karthusvs Seraphine
Karthus vs Seraphine is a decisive matchup in LoL patch 26.5. Seraphine wins with a 57.1% win rate (+14.3%) over Karthus based on 7 games. Seraphine wins the early laning phase while Karthus scales better into the late game. Below you'll find the best Karthus build, runes, laning stats, and strategies for the Karthus vs Seraphine matchup.
Karthus Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Karthus performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Seraphine(42.9%)Who Wins the Karthus vs Seraphine Matchup?
Karthus vs Seraphine Matchup Summary
The Karthus vs Seraphine matchup is a decisive matchup in League of Legends ranked play. Based on 7 recent matches analyzed, Seraphine wins with a 57.1% win rate compared to Karthus's 42.9%, giving Seraphine a 14.3 percentage point advantage. Game phase dynamics play a critical role here: Seraphine controls the early laning stage, but Karthus outscales as the game goes longer. The matchup shifts dramatically depending on game length — Seraphine needs to press advantages before Karthus reaches their power spikes, while Karthus should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in damage output, where Karthus leads by 552 DMG/min — a difference that heavily influences the outcome of trades and skirmishes. Seraphine has a strong advantage in this matchup. Karthus players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Seraphine overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Karthus vs Seraphine Laning Phase Breakdown
Karthus is favored during the laning phase against Seraphine, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.
Early Game vs Late Game
Karthus25.0%Seraphine75.0%Karthus66.7%Seraphine33.3%Seraphine dominates the early game (first 15 minutes) with a commanding 75.0% win rate — a 50.0 percentage point lead over Karthus. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Karthus is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Seraphine. Extended games heavily favor Karthus, whose kit and scaling make them a dominant force in team fights and objective control.
This matchup features a dramatic power shift: Seraphine must aggressively press their early advantage and close out the game before Karthus reaches their scaling breakpoints. If Karthus survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.
Best Karthus Runes Against Seraphine
Sorcery
Precision
The Sorcery and Precision rune setup gives Karthus the best tools to compete against Seraphine in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.
Karthus matchup data for League of Legends patch 26.5. The table below shows Karthus's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Karthus build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 50.00% | 34 | 1.2 | 1,172 | 13,925 | 53.3% | 47.4% | |
| 50.00% | 26 | 1.4 | 1,147 | 13,324 | 57.1% | 41.7% | |
| 56.00% | 25 | 1.6 | 1,296 | 17,070 | 50.0% | 57.1% | |
| 39.13% | 23 | 1.4 | 1,055 | 13,963 | 70.0% | 15.4% | |
| 43.48% | 23 | 1.5 | 1,277 | 15,373 | 42.9% | 43.8% | |
| 38.10% | 21 | 1.5 | 941 | 11,081 | 46.1% | 25.0% | |
| 52.38% | 21 | 1.5 | 1,404 | 17,686 | 0.0% | 57.9% | |
| 21.05% | 19 | 1.8 | 1,336 | 14,184 | 25.0% | 18.2% | |
| 72.22% | 18 | 1.8 | 1,288 | 17,430 | 80.0% | 69.2% | |
| 33.33% | 18 | 6.5 | 1,105 | 12,132 | 42.9% | 27.3% | |
| 66.67% | 18 | 1.7 | 1,243 | 14,430 | 71.4% | 63.6% | |
| 41.18% | 17 | 1.6 | 1,115 | 12,589 | 33.3% | 50.0% | |
| 23.53% | 17 | 1.3 | 1,073 | 14,521 | 50.0% | 15.4% | |
| 37.50% | 16 | 1.8 | 1,411 | 14,480 | 25.0% | 41.7% | |
| 37.50% | 16 | 6.0 | 1,410 | 16,269 | 50.0% | 35.7% | |
| 33.33% | 15 | 1.0 | 1,244 | 14,352 | 28.6% | 37.5% | |
| 33.33% | 15 | 1.5 | 1,034 | 12,866 | 50.0% | 22.2% | |
| 53.33% | 15 | 1.2 | 1,193 | 15,043 | 33.3% | 66.7% | |
| 57.14% | 14 | 1.8 | 902 | 12,467 | 50.0% | 66.7% | |
| 28.57% | 14 | 1.5 | 1,243 | 14,769 | 25.0% | 30.0% | |
| 46.15% | 13 | 6.5 | 1,190 | 15,205 | 60.0% | 37.5% | |
| 53.85% | 13 | 2.0 | 1,112 | 13,096 | 42.9% | 66.7% | |
| 50.00% | 12 | 1.2 | 1,070 | 11,808 | 50.0% | 50.0% | |
| 63.64% | 12 | 1.6 | 1,088 | 12,398 | 80.0% | 50.0% | |
| 50.00% | 12 | 6.3 | 1,323 | 15,508 | 33.3% | 55.6% | |
| 9.09% | 11 | 1.3 | 1,251 | 14,283 | 25.0% | 0.0% | |
| 36.36% | 11 | 2.0 | 1,088 | 12,666 | 33.3% | 40.0% | |
| 54.55% | 11 | 6.8 | 1,200 | 12,462 | 40.0% | 66.7% | |
| 50.00% | 10 | 5.8 | 1,229 | 13,974 | 33.3% | 57.1% | |
| 40.00% | 10 | 1.2 | 1,024 | 15,090 | 25.0% | 50.0% | |
| 60.00% | 10 | 1.7 | 1,093 | 15,285 | 50.0% | 62.5% | |
| 30.00% | 10 | 1.5 | 1,242 | 16,377 | 0.0% | 37.5% | |
| 50.00% | 10 | 5.8 | 1,463 | 15,926 | 100.0% | 37.5% | |
| 50.00% | 10 | 5.0 | 973 | 13,157 | 25.0% | 66.7% | |
| 55.56% | 9 | 4.3 | 1,246 | 13,490 | 40.0% | 75.0% | |
| 66.67% | 9 | 1.5 | 1,277 | 16,441 | 33.3% | 83.3% | |
| 33.33% | 9 | 3.1 | 1,319 | 15,130 | 0.0% | 50.0% | |
| 44.44% | 9 | 4.1 | 1,202 | 14,689 | 50.0% | 42.9% | |
| 66.67% | 9 | 1.4 | 1,043 | 12,092 | 100.0% | 40.0% | |
| 55.56% | 9 | 6.3 | 1,094 | 14,259 | 100.0% | 42.9% | |
| 75.00% | 8 | 6.3 | 1,424 | 17,452 | 66.7% | 80.0% | |
| 62.50% | 8 | 6.5 | 1,318 | 15,127 | 66.7% | 60.0% | |
| 50.00% | 8 | 2.0 | 827 | 12,737 | 42.9% | 100.0% | |
| 12.50% | 8 | 1.4 | 988 | 12,715 | 0.0% | 25.0% | |
| 37.50% | 8 | 1.3 | 1,230 | 15,899 | 0.0% | 42.9% | |
| 37.50% | 8 | 6.5 | 1,133 | 12,330 | 40.0% | 33.3% | |
| 50.00% | 8 | 1.6 | 1,588 | 17,226 | 50.0% | 50.0% | |
| 37.50% | 8 | 3.7 | 1,410 | 15,914 | 100.0% | 28.6% | |
| 37.50% | 8 | 1.4 | 914 | 11,729 | 40.0% | 33.3% | |
| 57.14% | 7 | 2.9 | 924 | 11,971 | 75.0% | 33.3% | |
| 42.86% | 7 | 3.3 | 1,176 | 12,850 | 50.0% | 40.0% | |
| 42.86% | 7 | 5.1 | 1,236 | 14,480 | 25.0% | 66.7% | |
| 33.33% | 6 | 3.1 | 1,158 | 11,038 | 25.0% | 50.0% | |
| 66.67% | 6 | 4.7 | 1,162 | 13,684 | 66.7% | 66.7% | |
| 33.33% | 6 | 1.4 | 902 | 10,546 | 20.0% | 100.0% | |
| 33.33% | 6 | 5.4 | 1,445 | 14,906 | 33.3% | 33.3% | |
| 33.33% | 6 | 6.2 | 984 | 11,409 | 50.0% | 25.0% | |
| 16.67% | 6 | 1.2 | 1,062 | 13,805 | 0.0% | 25.0% | |
| 40.00% | 5 | 6.2 | 1,483 | 17,929 | 0.0% | 40.0% | |
| 60.00% | 5 | 5.5 | 1,043 | 12,857 | 100.0% | 50.0% | |
| 60.00% | 5 | 5.9 | 1,412 | 16,170 | 100.0% | 50.0% | |
| 40.00% | 5 | 1.9 | 1,405 | 15,574 | 0.0% | 66.7% | |
| 60.00% | 5 | 2.4 | 912 | 12,688 | 33.3% | 100.0% | |
| 80.00% | 5 | 7.4 | 1,360 | 11,324 | 66.7% | 100.0% | |
| 40.00% | 5 | 6.8 | 922 | 9,674 | 33.3% | 50.0% | |
| 40.00% | 5 | 6.8 | 1,701 | 17,734 | 50.0% | 33.3% | |
| 40.00% | 5 | 6.4 | 1,033 | 12,247 | 0.0% | 50.0% | |
| 80.00% | 5 | 1.2 | 1,144 | 12,971 | 100.0% | 50.0% | |
| 60.00% | 5 | 1.4 | 927 | 13,300 | 50.0% | 66.7% | |
| 40.00% | 5 | 6.6 | 1,577 | 18,837 | 100.0% | 0.0% | |
| 60.00% | 5 | 6.3 | 1,315 | 13,611 | 50.0% | 100.0% | |
| 40.00% | 5 | 1.7 | 1,164 | 16,209 | 50.0% | 33.3% | |
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Karthus vs Seraphine - Frequently Asked Questions
How does Karthus do against Seraphine in League of Legends?
Seraphine wins the Karthus vs Seraphine matchup with a 57.1% win rate compared to Karthus's 42.9%, a 14.3 percentage point difference. This data is based on 7 recent ranked games in patch 26.5.
How does Karthus do against Seraphine in the early game?
In the early game, Seraphine has the advantage against Karthus with a 75.0% win rate versus 25.0%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Karthus do against Seraphine in the late game?
In the late game, Karthus takes over the Karthus vs Seraphine matchup with a 66.7% win rate compared to 33.3%. Karthus scales better into team fights and objective contests after 25 minutes.
Who wins the Karthus vs Seraphine matchup?
Seraphine wins the matchup against Karthus with a 57.1% win rate in League of Legends patch 26.5. The 14.3 percentage point advantage means Seraphine is significantly favored in this lane matchup based on 7 games analyzed.
What is the best Karthus build against Seraphine?
The best Karthus build against Seraphine includes optimized core items. Check the matchup breakdown above for the full item path and build order.
What are the best Karthus runes against Seraphine?
The best Karthus runes against Seraphine use the Sorcery primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Karthus vs Seraphine matchup. See the full rune breakdown in the matchup comparison above.
Does Karthus counter Seraphine?
No, Karthus struggles against Seraphine with only a 42.9% win rate. Seraphine has the advantage in this matchup. Karthus players should focus on safe farming and avoiding extended trades to minimize Seraphine's lead.
How do I play Karthus against Seraphine?
When playing Karthus against Seraphine, play cautiously and avoid Seraphine's power spikes. Focus on safe farming — you outscale Seraphine in the late game. Use the matchup-specific build and runes above to optimize your chances.