Karthusvs Seraphine
Karthus vs Seraphine is a very close matchup in LoL patch 26.9. Karthus wins with a 50.0% win rate (+0.0%) over Seraphine based on 8 games. Seraphine wins the early laning phase while Karthus scales better into the late game. Below you'll find the best Karthus build, runes, laning stats, and strategies for the Karthus vs Seraphine matchup.
Karthus Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Karthus performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Seraphine(50.0%)Who Wins the Karthus vs Seraphine Matchup?
Karthus vs Seraphine Matchup Summary
The Karthus vs Seraphine matchup is essentially a coin-flip matchup in League of Legends ranked play. Based on 8 recent matches analyzed, Karthus wins with a 50.0% win rate compared to Seraphine's 50.0%, giving Karthus a 0.0 percentage point advantage. Game phase dynamics play a critical role here: Seraphine controls the early laning stage, but Karthus outscales as the game goes longer. The matchup shifts dramatically depending on game length — Seraphine needs to press advantages before Karthus reaches their power spikes, while Karthus should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in damage output, where Karthus leads by 620 DMG/min — a difference that heavily influences the outcome of trades and skirmishes. Karthus has a statistical edge, but the margin is close enough that respecting Seraphine's strengths is important. Trade when cooldowns are favorable, track the enemy jungler, and build toward your strongest item spikes to convert the slight advantage into a decisive lead. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Karthus vs Seraphine Laning Phase Breakdown
Karthus is favored during the laning phase against Seraphine, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.
Best Karthus Build Against Seraphine
Sorcerer's Shoes is the optimal boots choice against Seraphine, providing the mobility and stats Karthus needs most in this matchup. The top-performing core items for Karthus against Seraphine are Liandry's Torment, Void Staff and Malignance. This combination gives Karthus an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Seraphine. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Karthus vs Seraphine matchup.
Early Game vs Late Game
Karthus25.0%Seraphine75.0%Karthus75.0%Seraphine25.0%Seraphine dominates the early game (first 15 minutes) with a commanding 75.0% win rate — a 50.0 percentage point lead over Karthus. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Karthus is far superior in the late game (25+ minutes), boasting a 75.0% win rate — 50.0 points above Seraphine. Extended games heavily favor Karthus, whose kit and scaling make them a dominant force in team fights and objective control.
This matchup features a dramatic power shift: Seraphine must aggressively press their early advantage and close out the game before Karthus reaches their scaling breakpoints. If Karthus survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.
Best Karthus Runes Against Seraphine
Domination
Sorcery
The Domination primary with Sorcery secondary combination helps Karthus maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Seraphine.
Karthus matchup data for League of Legends patch 26.9. The table below shows Karthus's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Karthus build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 60.47% | 43 | 1.5 | 1,211 | 14,745 | 46.7% | 67.9% | |
| 59.52% | 42 | 1.4 | 1,146 | 14,120 | 47.6% | 71.4% | |
| 43.59% | 39 | 1.3 | 1,142 | 13,127 | 47.1% | 40.9% | |
| 63.89% | 36 | 6.6 | 1,285 | 14,803 | 41.7% | 75.0% | |
| 45.45% | 33 | 1.5 | 1,230 | 15,245 | 61.5% | 35.0% | |
| 61.29% | 31 | 1.6 | 1,184 | 15,087 | 50.0% | 66.7% | |
| 35.48% | 31 | 1.4 | 1,302 | 12,720 | 33.3% | 37.5% | |
| 40.00% | 30 | 1.9 | 1,231 | 13,754 | 50.0% | 33.3% | |
| 58.62% | 29 | 1.3 | 1,152 | 14,889 | 77.8% | 50.0% | |
| 55.17% | 29 | 7.0 | 1,461 | 14,739 | 46.1% | 62.5% | |
| 55.17% | 29 | 6.8 | 1,360 | 14,776 | 53.9% | 56.3% | |
| 64.29% | 28 | 6.8 | 1,500 | 15,246 | 70.0% | 61.1% | |
| 57.69% | 26 | 1.4 | 1,395 | 16,572 | 85.7% | 47.4% | |
| 48.00% | 25 | 1.3 | 1,253 | 14,194 | 50.0% | 47.1% | |
| 44.00% | 25 | 6.7 | 1,351 | 12,583 | 66.7% | 23.1% | |
| 52.00% | 25 | 7.1 | 1,230 | 13,931 | 58.3% | 46.1% | |
| 29.17% | 24 | 1.6 | 1,307 | 15,285 | 16.7% | 33.3% | |
| 68.18% | 22 | 6.2 | 1,393 | 16,201 | 60.0% | 75.0% | |
| 52.38% | 21 | 2.4 | 993 | 13,089 | 37.5% | 61.5% | |
| 38.10% | 21 | 1.6 | 1,039 | 13,125 | 40.0% | 36.4% | |
| 66.67% | 21 | 7.3 | 1,391 | 13,871 | 80.0% | 54.5% | |
| 70.00% | 20 | 1.4 | 1,190 | 14,759 | 62.5% | 75.0% | |
| 42.11% | 19 | 2.6 | 1,067 | 12,406 | 55.6% | 30.0% | |
| 36.84% | 19 | 6.2 | 1,230 | 12,042 | 45.5% | 25.0% | |
| 73.68% | 19 | 5.2 | 1,134 | 12,162 | 76.9% | 66.7% | |
| 50.00% | 18 | 2.2 | 1,194 | 12,682 | 25.0% | 70.0% | |
| 41.18% | 17 | 1.6 | 1,230 | 13,529 | 33.3% | 45.5% | |
| 41.18% | 17 | 2.5 | 1,188 | 14,842 | 60.0% | 33.3% | |
| 47.06% | 17 | 1.9 | 1,262 | 14,046 | 50.0% | 45.5% | |
| 50.00% | 16 | 1.4 | 1,357 | 15,187 | 57.1% | 44.4% | |
| 62.50% | 16 | 6.5 | 1,384 | 15,947 | 71.4% | 55.6% | |
| 50.00% | 16 | 1.6 | 1,041 | 12,145 | 80.0% | 36.4% | |
| 60.00% | 15 | 1.6 | 1,378 | 13,280 | 57.1% | 62.5% | |
| 60.00% | 15 | 2.0 | 1,304 | 16,401 | 50.0% | 63.6% | |
| 60.00% | 15 | 1.2 | 1,155 | 14,707 | 50.0% | 66.7% | |
| 64.29% | 14 | 1.5 | 1,289 | 14,835 | 60.0% | 66.7% | |
| 35.71% | 14 | 1.5 | 1,168 | 11,789 | 37.5% | 33.3% | |
| 46.15% | 13 | 1.2 | 1,215 | 13,640 | 50.0% | 42.9% | |
| 23.08% | 13 | 2.7 | 1,107 | 13,726 | 0.0% | 30.0% | |
| 41.67% | 12 | 1.9 | 1,134 | 13,651 | 20.0% | 57.1% | |
| 41.67% | 12 | 1.3 | 1,432 | 15,342 | 40.0% | 42.9% | |
| 50.00% | 12 | 1.6 | 1,372 | 16,603 | 100.0% | 33.3% | |
| 45.45% | 11 | 3.4 | 1,000 | 14,202 | 33.3% | 50.0% | |
| 70.00% | 10 | 7.4 | 1,308 | 13,519 | 85.7% | 33.3% | |
| 70.00% | 10 | 6.3 | 1,144 | 13,819 | 75.0% | 66.7% | |
| 50.00% | 10 | 1.5 | 1,094 | 14,695 | 40.0% | 60.0% | |
| 66.67% | 9 | 5.3 | 1,275 | 11,167 | 80.0% | 50.0% | |
| 77.78% | 9 | 6.9 | 1,543 | 14,941 | 83.3% | 66.7% | |
| 77.78% | 9 | 6.4 | 1,426 | 17,292 | 100.0% | 75.0% | |
| 55.56% | 9 | 2.0 | 1,055 | 13,614 | 50.0% | 60.0% | |
| 55.56% | 9 | 6.7 | 1,320 | 10,347 | 50.0% | 60.0% | |
| 55.56% | 9 | 7.0 | 1,420 | 15,871 | 0.0% | 83.3% | |
| 87.50% | 8 | 6.0 | 1,209 | 13,528 | 66.7% | 100.0% | |
| 62.50% | 8 | 1.5 | 914 | 11,689 | 60.0% | 66.7% | |
| 75.00% | 8 | 3.3 | 1,181 | 15,187 | 66.7% | 80.0% | |
| 37.50% | 8 | 1.6 | 1,325 | 12,292 | 33.3% | 50.0% | |
| 25.00% | 8 | 1.0 | 1,177 | 9,882 | 40.0% | 0.0% | |
| 37.50% | 8 | 5.9 | 1,294 | 13,438 | 0.0% | 42.9% | |
| 87.50% | 8 | 1.1 | 930 | 11,739 | 100.0% | 66.7% | |
| 37.50% | 8 | 5.1 | 969 | 10,833 | 0.0% | 75.0% | |
| 50.00% | 8 | 4.7 | 1,247 | 15,161 | 25.0% | 75.0% | |
| 37.50% | 8 | 2.1 | 1,248 | 13,000 | 25.0% | 50.0% | |
| 12.50% | 8 | 4.5 | 969 | 11,572 | 16.7% | 0.0% | |
| 75.00% | 8 | 1.4 | 1,012 | 11,309 | 75.0% | 75.0% | |
| 37.50% | 8 | 3.4 | 1,284 | 13,665 | 100.0% | 16.7% | |
| 42.86% | 7 | 4.8 | 1,059 | 11,281 | 0.0% | 75.0% | |
| 71.43% | 7 | 7.3 | 1,478 | 14,622 | 100.0% | 66.7% | |
| 42.86% | 7 | 2.6 | 1,213 | 13,765 | 40.0% | 50.0% | |
| 85.71% | 7 | 1.3 | 1,063 | 12,334 | 80.0% | 100.0% | |
| 71.43% | 7 | 1.7 | 1,248 | 9,768 | 100.0% | 50.0% | |
| 85.71% | 7 | 6.8 | 1,105 | 8,884 | 85.7% | 0.0% | |
| 85.71% | 7 | 1.3 | 1,636 | 16,296 | 100.0% | 83.3% | |
| 42.86% | 7 | 6.6 | 1,343 | 14,336 | 50.0% | 33.3% | |
| 57.14% | 7 | 7.6 | 1,479 | 9,026 | 60.0% | 50.0% | |
| 42.86% | 7 | 6.1 | 1,302 | 14,164 | 75.0% | 0.0% | |
| 33.33% | 6 | 2.8 | 1,366 | 14,331 | 50.0% | 25.0% | |
| 16.67% | 6 | 7.3 | 1,711 | 16,785 | 0.0% | 20.0% | |
| 66.67% | 6 | 6.7 | 1,187 | 12,813 | 50.0% | 75.0% | |
| 83.33% | 6 | 2.7 | 1,187 | 13,782 | 66.7% | 100.0% | |
| 33.33% | 6 | 7.3 | 1,223 | 11,674 | 0.0% | 66.7% | |
| 33.33% | 6 | 7.0 | 1,508 | 12,645 | 33.3% | 33.3% | |
| 0.00% | 5 | 7.1 | 1,778 | 18,011 | 0.0% | 0.0% | |
| 40.00% | 5 | 6.7 | 1,033 | 9,567 | 25.0% | 100.0% | |
| 60.00% | 5 | 2.0 | 960 | 9,787 | 50.0% | 100.0% | |
| 20.00% | 5 | 6.3 | 1,376 | 15,117 | 0.0% | 33.3% | |
| 80.00% | 5 | 2.9 | 1,246 | 14,608 | 100.0% | 0.0% | |
| 80.00% | 5 | 1.3 | 1,271 | 14,686 | 50.0% | 100.0% | |
| 40.00% | 5 | 1.3 | 1,066 | 13,764 | 100.0% | 25.0% | |
| 80.00% | 5 | 7.4 | 1,062 | 14,081 | 75.0% | 100.0% | |
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Karthus vs Seraphine - Frequently Asked Questions
How does Karthus do against Seraphine in League of Legends?
Karthus wins the Karthus vs Seraphine matchup with a 50.0% win rate compared to Seraphine's 50.0%, a 0.0 percentage point difference. This data is based on 8 recent ranked games in patch 26.9.
How does Karthus do against Seraphine in the early game?
In the early game, Seraphine has the advantage against Karthus with a 75.0% win rate versus 25.0%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Karthus do against Seraphine in the late game?
In the late game, Karthus takes over the Karthus vs Seraphine matchup with a 75.0% win rate compared to 25.0%. Karthus scales better into team fights and objective contests after 25 minutes.
Who wins the Karthus vs Seraphine matchup?
Karthus wins the matchup against Seraphine with a 50.0% win rate in League of Legends patch 26.9. The 0.0 percentage point advantage means Karthus is slightly favored in this lane matchup based on 8 games analyzed.
What is the best Karthus build against Seraphine?
The best Karthus build against Seraphine includes Liandry's Torment, Void Staff, Malignance with Sorcerer's Shoes. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.
What are the best Karthus runes against Seraphine?
The best Karthus runes against Seraphine use the Domination primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Karthus vs Seraphine matchup. See the full rune breakdown in the matchup comparison above.
Does Karthus counter Seraphine?
Yes, Karthus has a favorable matchup against Seraphine with a 50.0% win rate. Karthus slightly edges out Seraphine in lane based on current patch 26.9 data.
How do I play Karthus against Seraphine?
When playing Karthus against Seraphine, leverage your statistical advantages by trading aggressively during favorable windows. Play safe early and scale into your power spikes where you outperform Seraphine. Build the recommended items and runes for this specific matchup for the best results.