Karthus Runes
The top Karthus runes in LoL patch 25.23 are Dark Harvest, Cheap Shot, Deep Ward, Ultimate Hunter for Karthus's primary runes. Karthus's runes in his secondary tree best utilizes Triumph and Coup de Grace. These Karthus rune choices provide the best Karthus rune build for ranked.
Death Defied
Upon dying, Karthus enters a spirit form that allows him to continue casting spells.
Lay Waste
Karthus unleashes a delayed blast at a location, dealing damage to nearby enemies. Deals increased damage to isolated enemies.
Cost:- 20/
- 25/
- 30/
- 35/
- 40
Cooldown:- 0
Range:- 875
Wall of Pain
Karthus creates a passable screen of leeching energy. Any enemy units that walk through the screen have their Move Speed and Magic Resist reduced for a period.
Cost:- 70
Cooldown:- 15
Range:- 1000
Defile
Karthus passively steals energy from his victims, gaining Mana on each kill. Alternatively, Karthus can surround himself in the souls of his prey, dealing damage to nearby enemies, but quickly draining his own Mana.
Cost:- 30/
- 42/
- 54/
- 66/
- 78
Cooldown:- 1
Range:- 550
Requiem
After channeling for 3 seconds, Karthus deals damage to all enemy champions.
Cost:- 100
Cooldown:- 200/
- 180/
- 160
Range:- 10000
- Mage
Karthus performs best with Dark Harvest as the keystone rune. The optimal primary runes for Karthus include Dark Harvest, Cheap Shot, Deep Ward. This rune setup achieves a 1.00% win rate across 1 Karthus games.
Primary Tree
Domination
This alternative Karthus rune build uses Dark Harvest as the keystone. This setup provides a different playstyle for Karthus and achieves a 1.00% win rate. Consider this rune page when facing specific matchups or team compositions.
Primary Tree
DominationKarthus Runes - Frequently Asked Questions
What are the best Karthus runes?
The best Karthus runes in patch 25.23 are Dark Harvest, Cheap Shot, Deep Ward, and Ultimate Hunter for the primary tree, and Triumph and Coup de Grace for the secondary tree. These runes provide optimal performance for Karthus.
What keystone should I use on Karthus?
Dark Harvest is the best keystone rune for Karthus. This keystone synergizes well with Karthus's abilities and provides maximum value in most matchups.
What are Karthus's secondary runes?
Karthus's best secondary runes are Triumph and Coup de Grace. These secondary runes complement Karthus's primary rune choices and enhance overall effectiveness.
Can I use different rune setups on Karthus?
Yes, Karthus can utilize different rune setups depending on matchup and playstyle. While Dark Harvest is most popular, alternative keystones may work better in specific situations.
