- Win Rate
- 42.7%
- Pick Rate
- 0.7%
- Ban Rate
- 0.7%
Karthus Jungle Runes: Keystone & Shards
- Patch
- 26.22
- Games
- 103
- Lane
- Jungle
- Tier
- All Tiers
- Last Updated
- Nov 5, 2026 UTC
- Author
- Dakota Chinnick
- Methodology
- Data Methodology
Best Jungle Karthus runes for LoL Patch 26.22 - Dark Harvest from the Domination tree with Sorcery secondary (41.9% WR, 41.7% pick rate). Karthus's optimal primary runes are Dark Harvest, Cheap Shot, Grisly Mementos, Ultimate Hunter. Secondary tree: Axiom Arcanist, Gathering Storm.
Primary Tree
Domination
Dark HarvestDamaging a Champion below 50% health deals
Dark Harvest damage: 30 (+11 damage per soul) (+0.1 bonus AD) (+0.05 AP)
Cooldown: 35s (resets to 1.0s on takedown)
Cheap ShotDamaging champions with impaired movement or actions deals 10 - 45 bonus true damage (based on level).
Cooldown: 4s
Grisly MementosCollect 1 memento on champion
Gain 6 Trinket Haste for each collected. In game modes where vision Trinkets do not exist, instead gain 3 Summoner Spell Haste.
Ultimate HunterYour ultimate gains
Axiom ArcanistYour Ultimate has 12% increased damage, healing, and shielding.
(AoE damage is reduced to a 8% increase)
Scoring a takedown on an enemy champion reduces your Ultimate's current cooldown by 7%.
Gathering StormEvery 10 min gain AP or AD,
10 min: + 8 AP or 5 AD
20 min: + 24 AP or 14 AD
30 min: + 48 AP or 29 AD
40 min: + 80 AP or 48 AD
50 min: + 120 AP or 72 AD
60 min: + 168 AP or 101 AD
etc...
Primary Tree
Secondary Tree
FiddlesticksEvery Karthus Jungle Keystone and Secondary Tree (Patch 26.22)
100 gamesKarthus Jungle runs Dark Harvest in 68% of games, with a 42.6% win rate. Sorcery is the usual secondary tree (54%). Standard stat shards: Adaptive Force (offense), Adaptive Force (flex), Health Scaling (defense).
Keystones
| Rune | Players | Win Rate | Games |
|---|---|---|---|
| Dark HarvestMost played | 68.0% | 42.6% | 68 |
Secondary trees
| Rune | Players | Win Rate | Games |
|---|---|---|---|
 SorceryMost played | 54.0% | 40.7% | 54 |
 Precision | 40.0% | 45.0% | 40 |
Pick rate is the share of Karthus games in this lane that used the rune; options under 40 games are left out. A higher win rate on a rarely picked rune is usually a matchup-specific choice, not a general upgrade.
Karthus Minor Runes by Tree
Every minor rune Karthus players take, grouped by rune tree, with how often it is picked and how often it wins.
Sorcery
| Rune | Players | Win Rate | Games |
|---|---|---|---|
| Axiom ArcanistMost played | 81.0% | 39.5% | 81 |
| Gathering Storm | 78.0% | 41.0% | 78 |
Domination
| Rune | Players | Win Rate | Games |
|---|---|---|---|
| Cheap ShotMost played | 69.0% | 40.6% | 69 |
| Ultimate Hunter | 59.0% | 40.7% | 59 |
| Grisly Mementos | 59.0% | 45.8% | 59 |
Karthus Stat Shards
Which stat shards Karthus players choose in each of the three shard rows, and the win rate of each.
| Rune | Players | Win Rate | Games |
|---|---|---|---|
 Adaptive Force (flex)Most played | 100.0% | 42.0% | 100 |
| Adaptive Force (offense) | 94.0% | 42.6% | 94 |
 Health Scaling (defense) | 83.0% | 41.0% | 83 |
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Karthus Runes FAQ - Patch 26.22
What is the best keystone for Karthus Jungle?
Dark Harvest: Karthus Jungle takes it in 68% of ranked games and wins 42.6% of 68 games.
What stat shards should Karthus take?
Most Karthus players take Adaptive Force (offense), Adaptive Force (flex), Health Scaling (defense) — one from each shard row.
What are the best Karthus runes in patch 26.22?
The best Karthus runes in patch 26.22 use the Domination tree with Dark Harvest, Cheap Shot, Grisly Mementos, and Ultimate Hunter, and the Sorcery tree with Axiom Arcanist and Gathering Storm. This rune setup achieves a 41.9% win rate with a 41.7% pick rate.
What is the win rate for Karthus's best rune page?
Karthus's best rune page has a 41.9% win rate in patch 26.22, which is -0.9% compared to Karthus's average win rate. This rune setup has a 41.7% pick rate among Karthus players.
What keystone should I use on Karthus?
Dark Harvest from the Domination tree is the best keystone rune for Karthus in patch 26.22. This keystone synergizes well with Karthus's kit and provides a 41.9% win rate.
What is Karthus's primary rune tree?
Karthus's primary rune tree is Domination. The optimal Domination runes for Karthus are Dark Harvest, Cheap Shot, Grisly Mementos, and Ultimate Hunter, with Dark Harvest being the keystone of choice.
What is Karthus's secondary rune tree?
Karthus's best secondary rune tree is Sorcery. The recommended Sorcery runes are Axiom Arcanist and Gathering Storm, which complement Karthus's Domination primary tree.
What are alternative rune setups for Karthus?
An alternative Karthus rune setup uses alternative keystone from the Primary tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.
How popular are Karthus's runes?
Karthus's top rune page has a 41.7% pick rate in patch 26.22. This indicates that 41.7% of Karthus players use the Dark Harvest setup with Domination and Sorcery trees.