Karthus - League of Legends Champion
Win Rate
52.6%
Pick Rate
0.9%

KarthusRunes

SMage
Patch26.14
Matches491,560
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 25, 2026
MethodologyData Methodology

Best Karthus runes for LoL Patch 26.14 - Deathfire Touch from the Sorcery tree with Domination secondary (75.0% WR, 1.8% pick rate). Karthus's optimal primary runes are Deathfire Touch, Axiom Arcanist, Absolute Focus, Gathering Storm. Secondary tree: Cheap Shot, Grisly Mementos.

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Karthus performs best with Deathfire Touch as the keystone rune from the Sorcery tree. Karthus's optimal primary runes are Deathfire Touch, Axiom Arcanist, Absolute Focus, Gathering Storm. Karthus's secondary rune tree is Domination with Cheap Shot, Grisly Mementos. This rune setup achieves a 75.00% win rate (+22.4% win rate difference) with a 1.8% pick rate across 16 Karthus games.
75.0%Win Rate
+22.4%WR Diff
1.8%Pick Rate
Deathfire TouchDeathfire Touch

Damaging a champion with an ability burns them for 3 - 12 based on level (+2.5% AP) (+7% bonus AD) magic damage per second. After burning for 3 seconds, the damage of the burn increases by 75% while they remain on fire.

Duration:
Single Target: 4s
Area of Effect: 2s
Damage over Time: 1s

Axiom ArcanistAxiom Arcanist

Your Ultimate has 12% increased damage, healing, and shielding.
(AoE damage is reduced to a 8% increase)

Scoring a takedown on an enemy champion reduces your Ultimate's current cooldown by 7%.

Absolute FocusAbsolute Focus

While above 70% health, gain an adaptive bonus of up to 18 Attack Damage or 30 Ability Power (based on level).

Grants 1.8 Attack Damage or 3 Ability Power at level 1.

Gathering StormGathering Storm

Every 10 min gain AP or AD, adaptive.

10 min: + 8 AP or 5 AD
20 min: + 24 AP or 14 AD
30 min: + 48 AP or 29 AD
40 min: + 80 AP or 48 AD
50 min: + 120 AP or 72 AD
60 min: + 168 AP or 101 AD
etc...

Cheap ShotCheap Shot

Damaging champions with impaired movement or actions deals 10 - 45 bonus true damage (based on level).

Cooldown: 4s
Activates on damage occurring after the impairment.

Grisly MementosGrisly Mementos

Collect 1 memento on champion takedowns, up to 18 total.

Gain 6 Trinket Haste for each collected. In game modes where vision Trinkets do not exist, instead gain 3 Summoner Spell Haste.

This alternative Karthus rune build uses Dark Harvest as the keystone from the Domination tree. The primary runes are Dark Harvest, Cheap Shot, Grisly Mementos, Ultimate Hunter. Karthus's secondary rune tree is Sorcery with Axiom Arcanist, Gathering Storm. This setup achieves a 51.16% win rate (-1.5% win rate difference) with a 28.8% pick rate across 258 games.
51.2%Win Rate
-1.5%WR Diff
28.8%Pick Rate
Dark HarvestDark Harvest

Damaging a Champion below 50% health deals adaptive damage and harvests their soul, permanently increasing Dark Harvest's damage by 11.

Dark Harvest damage: 30 (+11 damage per soul) (+0.1 bonus AD) (+0.05 AP)
Cooldown: 35s (resets to 1.0s on takedown)

Cheap ShotCheap Shot

Damaging champions with impaired movement or actions deals 10 - 45 bonus true damage (based on level).

Cooldown: 4s
Activates on damage occurring after the impairment.

Grisly MementosGrisly Mementos

Collect 1 memento on champion takedowns, up to 18 total.

Gain 6 Trinket Haste for each collected. In game modes where vision Trinkets do not exist, instead gain 3 Summoner Spell Haste.

Ultimate HunterUltimate Hunter

Your ultimate gains 6 Ability Haste, plus an additional 5 Ability Haste per Bounty Hunter stack. Bounty Hunter stacks are earned the first time you get a takedown on each enemy champion.

Axiom ArcanistAxiom Arcanist

Your Ultimate has 12% increased damage, healing, and shielding.
(AoE damage is reduced to a 8% increase)

Scoring a takedown on an enemy champion reduces your Ultimate's current cooldown by 7%.

Gathering StormGathering Storm

Every 10 min gain AP or AD, adaptive.

10 min: + 8 AP or 5 AD
20 min: + 24 AP or 14 AD
30 min: + 48 AP or 29 AD
40 min: + 80 AP or 48 AD
50 min: + 120 AP or 72 AD
60 min: + 168 AP or 101 AD
etc...

These champions share at least 4 runes with Karthus's recommended rune builds. use similar keystone and secondary runes, making them good alternatives if you enjoy Karthus's playstyle or want to learn champions with familiar rune setups.Annie, Cho'Gath
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Karthus Runes - Frequently Asked Questions

What are the best Karthus runes in patch 26.14?

The best Karthus runes in patch 26.14 use the Sorcery tree with Deathfire Touch, Axiom Arcanist, Absolute Focus, and Gathering Storm, and the Domination tree with Cheap Shot and Grisly Mementos. This rune setup achieves a 75.0% win rate with a 1.8% pick rate.

What is the win rate for Karthus's best rune page?

Karthus's best rune page has a 75.0% win rate in patch 26.14, which is +22.4% compared to Karthus's average win rate. This rune setup has a 1.8% pick rate among Karthus players.

What keystone should I use on Karthus?

Deathfire Touch from the Sorcery tree is the best keystone rune for Karthus in patch 26.14. This keystone synergizes well with Karthus's kit and provides a 75.0% win rate.

What is Karthus's primary rune tree?

Karthus's primary rune tree is Sorcery. The optimal Sorcery runes for Karthus are Deathfire Touch, Axiom Arcanist, Absolute Focus, and Gathering Storm, with Deathfire Touch being the keystone of choice.

What is Karthus's secondary rune tree?

Karthus's best secondary rune tree is Domination. The recommended Domination runes are Cheap Shot and Grisly Mementos, which complement Karthus's Sorcery primary tree.

What are alternative rune setups for Karthus?

An alternative Karthus rune setup uses Dark Harvest from the Domination tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.

How popular are Karthus's runes?

Karthus's top rune page has a 1.8% pick rate in patch 26.14. This indicates that 1.8% of Karthus players use the Deathfire Touch setup with Sorcery and Domination trees.