Karthus - League of Legends Champion
Win Rate
49.3%
Pick Rate
1.3%

KarthusRunes

DMage
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 25, 2026
MethodologyData Methodology

Best Karthus runes for LoL Patch 26.7 - Dark Harvest from the Domination tree with Precision secondary (66.7% WR, 0.6% pick rate). Karthus's optimal primary runes are Dark Harvest, Cheap Shot, Grisly Mementos, Ultimate Hunter. Secondary tree: Triumph, Last Stand.

Karthus performs best with Dark Harvest as the keystone rune from the Domination tree. Karthus's optimal primary runes are Dark Harvest, Cheap Shot, Grisly Mementos, Ultimate Hunter. Karthus's secondary rune tree is Precision with Triumph, Last Stand. This rune setup achieves a 66.67% win rate (+17.4% win rate difference) with a 0.6% pick rate across 15 Karthus games.
66.7%Win Rate
+17.4%WR Diff
0.6%Pick Rate
Dark HarvestDark Harvest

Damaging a Champion below 50% health deals adaptive damage and harvests their soul, permanently increasing Dark Harvest's damage by 11.

Dark Harvest damage: 30 (+11 damage per soul) (+0.1 bonus AD) (+0.05 AP)
Cooldown: 35s (resets to 1.0s on takedown)

Cheap ShotCheap Shot

Damaging champions with impaired movement or actions deals 10 - 45 bonus true damage (based on level).

Cooldown: 4s
Activates on damage occurring after the impairment.

Grisly MementosGrisly Mementos

Collect 1 memento on champion takedowns, up to 18 total.

Gain 6 Trinket Haste for each collected. In game modes where vision Trinkets do not exist, instead gain 3 Summoner Spell Haste.

Ultimate HunterUltimate Hunter

Your ultimate gains 6 Ability Haste, plus an additional 5 Ability Haste per Bounty Hunter stack. Bounty Hunter stacks are earned the first time you get a takedown on each enemy champion.

TriumphTriumph

Takedowns restore 5% of your missing health, 2.5% of your max health, and grant an additional 20 gold.



'The most dangerous game brings the greatest glory.'
—Noxian Reckoner

Last StandLast Stand

Deal 5% - 11% increased damage to champions while you are below 60% health. Max damage gained at 30% health.

This alternative Karthus rune build uses Summon Aery as the keystone from the Sorcery tree. The primary runes are Summon Aery, Axiom Arcanist, Transcendence, Scorch. Karthus's secondary rune tree is Precision with Presence of Mind, Last Stand. This setup achieves a 64.71% win rate (+15.5% win rate difference) with a 0.7% pick rate across 17 games.
64.7%Win Rate
+15.5%WR Diff
0.7%Pick Rate
Summon AerySummon Aery

Damaging enemy champions with basic attacks or abilities sends Aery to them, dealing 10 - 50 based on level (+0.05 AP) (+0.1 bonus AD).

Empowering or protecting allies with abilities sends Aery to them, shielding them for 30 - 100 based on level (+0.05 AP) (+0.1 bonus AD).

Aery cannot be sent out again until she returns to you.

Axiom ArcanistAxiom Arcanist

Your Ultimate has 12% increased damage, healing, and shielding.
(AoE damage is reduced to a 8% increase)

Scoring a takedown on an enemy champion reduces your Ultimate's current cooldown by 7%.

TranscendenceTranscendence

Gain bonuses upon reaching the following levels:
Level 5: +5 Ability Haste
Level 8: +5 Ability Haste
Level 11: On Champion takedown, reduce the remaining cooldown of basic abilities by 20%.

ScorchScorch

Your next damaging ability hit sets champions on fire dealing 20 - 40 bonus magic damage based on level after 1s.

Cooldown: 10s

Presence of MindPresence of Mind

Damaging an enemy champion restores 6-50 (80% for ranged) mana or 6 energy.

Takedowns restore 15% of your maximum mana or energy.

Cooldown for damage restoration: 8s

Last StandLast Stand

Deal 5% - 11% increased damage to champions while you are below 60% health. Max damage gained at 30% health.

These champions share at least 4 runes with Karthus's recommended rune builds. use similar keystone and secondary runes, making them good alternatives if you enjoy Karthus's playstyle or want to learn champions with familiar rune setups.Zyra, Lux, Fiddlesticks, Zilean

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Karthus Runes - Frequently Asked Questions

What are the best Karthus runes in patch 26.7?

The best Karthus runes in patch 26.7 use the Domination tree with Dark Harvest, Cheap Shot, Grisly Mementos, and Ultimate Hunter, and the Precision tree with Triumph and Last Stand. This rune setup achieves a 66.7% win rate with a 0.6% pick rate.

What is the win rate for Karthus's best rune page?

Karthus's best rune page has a 66.7% win rate in patch 26.7, which is +17.4% compared to Karthus's average win rate. This rune setup has a 0.6% pick rate among Karthus players.

What keystone should I use on Karthus?

Dark Harvest from the Domination tree is the best keystone rune for Karthus in patch 26.7. This keystone synergizes well with Karthus's kit and provides a 66.7% win rate.

What is Karthus's primary rune tree?

Karthus's primary rune tree is Domination. The optimal Domination runes for Karthus are Dark Harvest, Cheap Shot, Grisly Mementos, and Ultimate Hunter, with Dark Harvest being the keystone of choice.

What is Karthus's secondary rune tree?

Karthus's best secondary rune tree is Precision. The recommended Precision runes are Triumph and Last Stand, which complement Karthus's Domination primary tree.

What are alternative rune setups for Karthus?

An alternative Karthus rune setup uses alternative keystone from the Sorcery tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.

How popular are Karthus's runes?

Karthus's top rune page has a 0.6% pick rate in patch 26.7. This indicates that 0.6% of Karthus players use the Dark Harvest setup with Domination and Precision trees.