
Karthus Runes
The top Karthus runes in LoL patch 25.21 are Dark Harvest, Cheap Shot, Grisly Mementos, Treasure Hunter for Karthus's primary runes. Karthus's runes in his secondary tree best utilizes Coup de Grace and Triumph. These Karthus rune choices provide the best Karthus rune build for ranked.


Death Defied
Upon dying, Karthus enters a spirit form that allows him to continue casting spells.


Lay Waste
Karthus unleashes a delayed blast at a location, dealing damage to nearby enemies. Deals increased damage to isolated enemies.
Cost:- 20/
- 25/
- 30/
- 35/
- 40
Cooldown:- 0
Range:- 875


Wall of Pain
Karthus creates a passable screen of leeching energy. Any enemy units that walk through the screen have their Move Speed and Magic Resist reduced for a period.
Cost:- 70
Cooldown:- 15
Range:- 1000


Defile
Karthus passively steals energy from his victims, gaining Mana on each kill. Alternatively, Karthus can surround himself in the souls of his prey, dealing damage to nearby enemies, but quickly draining his own Mana.
Cost:- 30/
- 42/
- 54/
- 66/
- 78
Cooldown:- 1
Range:- 550


Requiem
After channeling for 3 seconds, Karthus deals damage to all enemy champions.
Cost:- 100
Cooldown:- 200/
- 180/
- 160
Range:- 10000
- Mage
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Karthus Runes
Primary Tree
DominationKarthus Runes - Alternative
Primary Tree
Sorcery
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