Dr. Mundo - League of Legends Champion
Win Rate
49.5%
Pick Rate
3.2%

Dr. Mundovs Lissandra

CTankFighter
Patch26.10
Matches683,599
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 18, 2026
MethodologyData Methodology

Dr. Mundo vs Lissandra is a decisive matchup in LoL patch 26.10. Dr. Mundo wins with a 80.0% win rate (+60.0%) over Lissandra based on 5 games. Dr. Mundo holds the advantage in both the early and late game. Below you'll find the best Dr. Mundo build, runes, laning stats, and strategies for the Dr. Mundo vs Lissandra matchup.

Dr. Mundo Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Dr. Mundo performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 80.0% win rateLissandra(80.0%)
Dr. Mundo - 80.0% win rate in this matchup
Dr. Mundo
80.0% WR
VS
Lissandra vs Dr. Mundo matchup - 20.0% win rate
Lissandra
20.0% WR

Who Wins the Dr. Mundo vs Lissandra Matchup?

Dr. Mundo wins the Dr. Mundo vs Lissandra matchup
Winner
Dr. Mundo
Matches: 5
80.0%
Win Rate
20.0%
5.9
CS / min
6.6
936
DMG / min
929
10,813
Gold / game
10,160
602
Heal / min
157
2,226
DMG Mitigated / min
556
0.5
CC / min
1.3
50.0%
Early Game WR
50.0%
100.0%
Late Game WR
0.0%

Dr. Mundo vs Lissandra Matchup Summary

The Dr. Mundo vs Lissandra matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Dr. Mundo wins with a 80.0% win rate compared to Lissandra's 20.0%, giving Dr. Mundo a 60.0 percentage point advantage. Dr. Mundo dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Lissandra players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Dr. Mundo leads by 2,114 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Dr. Mundo players can confidently pick into Lissandra and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Lissandra away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Dr. Mundo vs Lissandra Laning Phase Breakdown

Dr. Mundo wins the laning phase against Lissandra in League of Legends

Dr. Mundo is favored during the laning phase against Lissandra, winning 3 out of 5 key stat categories. Dr. Mundo holds advantages in damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
5.9Dr. Mundo
6.6Lissandra
Lissandra edges out Dr. Mundo by 0.7 CS per minute — a moderate farming advantage that adds up to roughly 10 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Lissandra.
Damage
936Dr. Mundo
929Lissandra
Damage output is virtually even between Dr. Mundo and Lissandra, with only 8 DMG/min separating them. Fights in this matchup are decided more by ability timing and positioning than raw damage numbers, making mechanical skill the deciding factor in trades.
Economy
10,813Dr. Mundo
10,160Lissandra
Dr. Mundo earns 653 more gold per game than Lissandra, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Dr. Mundo slightly faster item completions.
Utility
0.5Dr. Mundo
1.3Lissandra
Lissandra brings significantly more crowd control than Dr. Mundo, with 0.8 more seconds of CC per minute. This large utility gap makes Lissandra far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Dr. Mundo should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
2,827Dr. Mundo
713Lissandra
Dr. Mundo vastly out-sustains Lissandra, healing and mitigating 2,114 more damage per minute. This massive durability gap means Dr. Mundo can absorb significant punishment and remain in lane while Lissandra is forced to recall. Building grievous wounds early is essential for Lissandra, and focusing on burst trade patterns rather than sustained fights is critical.

Best Dr. Mundo Build Against Lissandra

Boots of Swiftness is the optimal boots choice against Lissandra, providing the mobility and stats Dr. Mundo needs most in this matchup. The top-performing core items for Dr. Mundo against Lissandra are Heartsteel, Warmog's Armor and Thornmail. This combination gives Dr. Mundo an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 2 games — well above average and making it the top item path against Lissandra. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Dr. Mundo vs Lissandra matchup.

Early Game vs Late Game

Early Game
Dr. Mundo
50.0%
+0.0% advantage
Dr. Mundo early game win rateDr. Mundo50.0%
Lissandra early game win rateLissandra50.0%
Late Game
Dr. Mundo
100.0%
+100.0% advantage
Dr. Mundo late game win rateDr. Mundo100.0%
Lissandra late game win rateLissandra0.0%

The early game (first 15 minutes) is a toss-up between Dr. Mundo and Lissandra, with Dr. Mundo holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Dr. Mundo is far superior in the late game (25+ minutes), boasting a 100.0% win rate — 100.0 points above Lissandra. Extended games heavily favor Dr. Mundo, whose kit and scaling make them a dominant force in team fights and objective control.

Dr. Mundo holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Lissandra players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Dr. Mundo Runes Against Lissandra

Resolve rune tree - Dr. Mundo primary runes vs LissandraResolve
Grasp of the Undying - best Dr. Mundo rune vs LissandraDemolish - best Dr. Mundo rune vs LissandraSecond Wind - best Dr. Mundo rune vs LissandraOvergrowth - best Dr. Mundo rune vs Lissandra
Inspiration rune tree - Dr. Mundo secondary runes vs LissandraInspiration
Approach Velocity - best Dr. Mundo rune vs LissandraMagical Footwear - best Dr. Mundo rune vs Lissandra
100.0% WR

Running Resolve primary with Inspiration secondary allows Dr. Mundo to press their advantage against Lissandra, amplifying the strengths that make this a favorable matchup.


Dr. Mundo matchup data for League of Legends patch 26.10. The table below shows Dr. Mundo's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Dr. Mundo build, runes, laning stats, and early vs late game analysis for that specific matchup.

Dr. Mundo matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
52.87%1746.772011,87250.0%54.5%
56.90%1746.792211,16655.8%58.0%
50.31%1636.387211,14753.5%47.8%
45.28%1596.684410,69440.0%50.0%
42.31%1306.890311,41640.4%43.4%
54.69%1286.61,03011,47050.0%57.7%
36.45%1076.577610,61336.8%36.0%
44.21%956.292310,60237.8%50.0%
52.22%906.696910,78258.8%43.6%
42.17%836.378210,69738.9%44.7%
51.25%806.493111,68651.6%51.0%
54.67%755.688512,61258.1%52.3%
50.68%736.91,14011,88634.4%63.4%
51.47%687.389813,47052.2%51.1%
60.29%686.91,09411,74658.3%61.4%
46.15%657.184711,28642.4%50.0%
46.88%642.976111,68645.5%48.4%
45.31%642.379211,90950.0%41.7%
40.63%646.187711,05438.5%42.1%
43.55%626.284810,26137.0%48.6%
57.38%616.71,04612,00455.0%58.5%
45.00%605.283211,20541.4%48.4%
59.32%592.774912,04248.1%68.8%
61.02%596.21,09611,83470.4%53.1%
38.60%576.293510,74037.5%39.4%
52.83%536.377411,74856.0%50.0%
33.96%537.184711,84326.1%40.0%
54.90%516.092710,93147.6%60.0%
50.00%506.781711,19942.9%55.2%
55.10%496.51,20410,88351.9%59.1%
60.42%481.359611,03666.7%55.6%
44.68%477.599112,94238.5%47.1%
48.94%474.295711,58350.0%47.8%
42.22%452.678711,86335.3%46.4%
44.19%431.470111,55147.6%40.9%
52.38%425.080611,73062.5%46.1%
52.38%426.383211,69870.6%40.0%
40.00%403.468110,77033.3%45.5%
57.50%405.073011,17260.0%55.0%
53.85%396.993411,81646.7%58.3%
51.28%391.375512,20456.3%47.8%
41.03%396.881711,72042.1%40.0%
44.74%386.678011,26142.1%47.4%
63.16%386.51,13612,15157.1%66.7%
42.11%382.267111,68455.0%27.8%
48.65%377.080011,90056.3%42.9%
38.89%366.977110,97845.0%31.3%
60.00%351.666912,65569.2%54.5%
51.43%357.191210,95757.9%43.8%
48.57%350.862010,94435.7%57.1%
54.84%315.696912,00941.7%63.2%
65.52%296.472210,70969.2%62.5%
51.72%296.491611,92554.5%50.0%
60.71%286.797814,05380.0%56.5%
53.57%282.977712,73263.6%47.1%
42.31%263.168110,75846.1%38.5%
57.69%266.588712,68255.6%58.8%
42.31%266.19329,89153.9%30.8%
45.83%241.461810,09953.3%33.3%
62.50%246.284811,12555.6%66.7%
56.52%236.583410,87963.6%50.0%
65.22%233.397411,42072.7%58.3%
47.83%231.667410,41946.1%50.0%
57.14%211.363211,55845.5%70.0%
50.00%203.391511,41945.5%55.6%
45.00%202.983411,61550.0%41.7%
52.63%191.269712,62450.0%54.5%
36.84%196.69689,81125.0%57.1%
38.89%186.58529,77536.4%42.9%
58.82%172.699312,28677.8%37.5%
62.50%165.591811,55366.7%60.0%
68.75%161.470811,78462.5%75.0%
56.25%162.469511,46266.7%42.9%
33.33%156.394613,93633.3%33.3%
66.67%151.062911,35371.4%62.5%
35.71%147.478212,13320.0%44.4%
38.46%130.750111,7920.0%50.0%
61.54%131.067813,509100.0%54.5%
41.67%124.574011,55733.3%50.0%
41.67%121.657710,94133.3%50.0%
54.55%112.981812,2410.0%75.0%
63.64%112.571913,19160.0%66.7%
54.55%114.679312,26325.0%71.4%
63.64%115.682011,49060.0%66.7%
50.00%106.987612,21550.0%50.0%
70.00%101.062110,24460.0%80.0%
44.44%91.768012,97666.7%33.3%
55.56%96.81,32111,77850.0%60.0%
77.78%91.874411,65066.7%83.3%
33.33%95.26188,84940.0%25.0%
33.33%91.675913,13650.0%28.6%
25.00%80.86009,99225.0%25.0%
25.00%84.06209,47033.3%20.0%
71.43%71.075410,29480.0%50.0%
100.00%76.192612,322100.0%100.0%
57.14%76.81,07412,75133.3%75.0%
28.57%76.46919,06833.3%25.0%
50.00%62.477811,75950.0%50.0%
66.67%66.26049,758100.0%50.0%
66.67%66.994012,544100.0%50.0%
50.00%67.174411,42525.0%100.0%
83.33%67.77739,272100.0%50.0%
60.00%53.06079,44333.3%100.0%
40.00%51.463410,44933.3%50.0%
40.00%53.071911,6330.0%50.0%
80.00%55.993610,81350.0%100.0%
40.00%56.572210,6210.0%66.7%
60.00%53.354010,15266.7%50.0%
20.00%56.170012,7890.0%25.0%

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Dr. Mundo vs Lissandra - Frequently Asked Questions

How does Dr. Mundo do against Lissandra in League of Legends?

Dr. Mundo wins the Dr. Mundo vs Lissandra matchup with a 80.0% win rate compared to Lissandra's 20.0%, a 60.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.10.

How does Dr. Mundo do against Lissandra in the early game?

In the early game, Dr. Mundo has the advantage against Lissandra with a 50.0% win rate versus 50.0%. Dr. Mundo players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Dr. Mundo do against Lissandra in the late game?

In the late game, Dr. Mundo takes over the Dr. Mundo vs Lissandra matchup with a 100.0% win rate compared to 0.0%. Dr. Mundo scales better into team fights and objective contests after 25 minutes.

Who wins the Dr. Mundo vs Lissandra matchup?

Dr. Mundo wins the matchup against Lissandra with a 80.0% win rate in League of Legends patch 26.10. The 60.0 percentage point advantage means Dr. Mundo is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Dr. Mundo build against Lissandra?

The best Dr. Mundo build against Lissandra includes Heartsteel, Warmog's Armor, Thornmail with Boots of Swiftness. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Dr. Mundo runes against Lissandra?

The best Dr. Mundo runes against Lissandra use the Resolve primary tree with Inspiration secondary. This rune setup achieves a 100.0% win rate in the Dr. Mundo vs Lissandra matchup. See the full rune breakdown in the matchup comparison above.

Does Dr. Mundo counter Lissandra?

Yes, Dr. Mundo has a favorable matchup against Lissandra with a 80.0% win rate. Dr. Mundo strongly counters Lissandra in lane based on current patch 26.10 data.

How do I play Dr. Mundo against Lissandra?

When playing Dr. Mundo against Lissandra, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.