Dr. Mundovs Vayne
Dr. Mundo vs Vayne is a decisive matchup in LoL patch 26.3. Dr. Mundo wins with a 53.3% win rate (+6.7%) over Vayne based on 45 games. Vayne wins the early laning phase while Dr. Mundo scales better into the late game. Below you'll find the best Dr. Mundo build, runes, laning stats, and strategies for the Dr. Mundo vs Vayne matchup.
Dr. Mundo Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Dr. Mundo performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Vayne(53.3%)Who Wins the Dr. Mundo vs Vayne Matchup?
Dr. Mundo vs Vayne Matchup Summary
The Dr. Mundo vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 45 recent matches analyzed, Dr. Mundo wins with a 53.3% win rate compared to Vayne's 46.7%, giving Dr. Mundo a 6.7 percentage point advantage. Game phase dynamics play a critical role here: Vayne controls the early laning stage, but Dr. Mundo outscales as the game goes longer. The matchup shifts dramatically depending on game length — Vayne needs to press advantages before Dr. Mundo reaches their power spikes, while Dr. Mundo should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Dr. Mundo leads by 1,092 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Dr. Mundo players can confidently pick into Vayne and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Vayne away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Dr. Mundo vs Vayne Laning Phase Breakdown
Dr. Mundo is favored during the laning phase against Vayne, winning 3 out of 5 key stat categories. Dr. Mundo holds advantages in farming, crowd control and sustain, making them the stronger laner in this matchup.
Best Dr. Mundo Build Against Vayne
Boots of Swiftness is the optimal boots choice against Vayne, providing the mobility and stats Dr. Mundo needs most in this matchup. The top-performing core items for Dr. Mundo against Vayne are Heartsteel, Warmog's Armor and Spirit Visage. This combination gives Dr. Mundo an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 3 games — well above average and making it the top item path against Vayne. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Dr. Mundo vs Vayne matchup.
Early Game vs Late Game
Dr. Mundo45.5%Vayne54.5%Dr. Mundo60.9%Vayne39.1%Vayne dominates the early game (first 15 minutes) with a commanding 54.5% win rate — a 9.1 percentage point lead over Dr. Mundo. This lopsided early game means Vayne can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Dr. Mundo is far superior in the late game (25+ minutes), boasting a 60.9% win rate — 21.7 points above Vayne. Extended games heavily favor Dr. Mundo, whose kit and scaling make them a dominant force in team fights and objective control.
This matchup features a dramatic power shift: Vayne must aggressively press their early advantage and close out the game before Dr. Mundo reaches their scaling breakpoints. If Dr. Mundo survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.
Best Dr. Mundo Runes Against Vayne
Precision
Inspiration
Running Precision primary with Inspiration secondary allows Dr. Mundo to press their advantage against Vayne, amplifying the strengths that make this a favorable matchup.
Dr. Mundo matchup data for League of Legends patch 26.3. The table below shows Dr. Mundo's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Dr. Mundo build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 60.71% | 280 | 1.1 | 711 | 12,327 | 60.6% | 60.8% | |
| 46.91% | 243 | 4.7 | 817 | 11,555 | 46.6% | 47.2% | |
| 54.62% | 238 | 3.1 | 818 | 11,979 | 50.9% | 58.1% | |
| 49.14% | 232 | 6.7 | 882 | 11,121 | 44.7% | 53.4% | |
| 53.25% | 231 | 5.2 | 992 | 12,412 | 49.5% | 56.3% | |
| 52.00% | 225 | 6.0 | 861 | 11,279 | 53.1% | 50.9% | |
| 49.02% | 204 | 4.8 | 888 | 12,497 | 50.0% | 48.1% | |
| 50.77% | 195 | 6.6 | 994 | 11,992 | 50.6% | 50.9% | |
| 52.36% | 191 | 1.6 | 685 | 11,598 | 48.9% | 55.6% | |
| 57.89% | 190 | 5.5 | 875 | 11,758 | 58.6% | 57.1% | |
| 48.52% | 169 | 6.5 | 1,016 | 11,239 | 50.0% | 47.3% | |
| 46.99% | 166 | 6.3 | 1,134 | 12,433 | 41.8% | 50.5% | |
| 55.00% | 160 | 6.0 | 741 | 12,045 | 63.4% | 48.3% | |
| 52.50% | 160 | 1.4 | 723 | 12,182 | 53.8% | 51.3% | |
| 56.58% | 152 | 6.3 | 767 | 11,249 | 42.9% | 66.3% | |
| 51.77% | 141 | 1.7 | 808 | 12,124 | 53.2% | 50.6% | |
| 51.43% | 140 | 7.1 | 892 | 11,805 | 55.7% | 47.1% | |
| 46.32% | 136 | 2.0 | 780 | 11,636 | 47.6% | 45.2% | |
| 44.36% | 133 | 5.7 | 860 | 11,201 | 42.6% | 46.1% | |
| 60.63% | 127 | 1.4 | 774 | 12,665 | 54.4% | 65.7% | |
| 54.76% | 126 | 4.5 | 868 | 12,144 | 57.6% | 51.7% | |
| 45.00% | 120 | 6.8 | 1,002 | 11,705 | 51.7% | 38.3% | |
| 50.85% | 118 | 1.3 | 758 | 12,253 | 59.3% | 43.8% | |
| 57.66% | 111 | 6.0 | 1,137 | 12,472 | 53.2% | 60.9% | |
| 53.64% | 110 | 7.2 | 878 | 11,542 | 58.2% | 49.1% | |
| 54.13% | 109 | 7.0 | 902 | 12,399 | 47.9% | 59.0% | |
| 51.85% | 108 | 1.0 | 725 | 12,364 | 56.9% | 46.0% | |
| 46.23% | 106 | 6.6 | 838 | 11,188 | 37.3% | 54.5% | |
| 57.69% | 104 | 1.3 | 742 | 12,409 | 52.0% | 63.0% | |
| 53.47% | 101 | 6.3 | 932 | 11,303 | 47.1% | 60.0% | |
| 47.52% | 101 | 6.2 | 1,105 | 10,545 | 41.7% | 52.8% | |
| 52.04% | 98 | 6.6 | 1,070 | 11,607 | 60.0% | 43.8% | |
| 48.91% | 92 | 1.6 | 809 | 11,692 | 44.0% | 54.8% | |
| 43.68% | 87 | 7.2 | 903 | 12,168 | 50.0% | 38.3% | |
| 54.02% | 87 | 6.3 | 935 | 11,865 | 56.8% | 51.2% | |
| 54.65% | 86 | 7.0 | 1,029 | 12,109 | 53.9% | 55.3% | |
| 70.59% | 85 | 1.4 | 755 | 12,424 | 63.2% | 76.6% | |
| 44.05% | 84 | 1.3 | 643 | 11,764 | 47.6% | 40.5% | |
| 51.81% | 83 | 6.3 | 954 | 11,245 | 35.9% | 65.9% | |
| 48.78% | 82 | 1.3 | 703 | 11,881 | 55.9% | 43.8% | |
| 52.44% | 82 | 3.9 | 755 | 11,514 | 48.9% | 57.1% | |
| 56.79% | 81 | 2.0 | 819 | 12,244 | 55.0% | 58.5% | |
| 49.37% | 79 | 6.8 | 850 | 11,098 | 29.7% | 66.7% | |
| 59.21% | 76 | 1.6 | 768 | 11,562 | 55.6% | 62.5% | |
| 33.33% | 75 | 1.3 | 744 | 11,528 | 33.3% | 33.3% | |
| 57.53% | 73 | 6.7 | 862 | 12,565 | 64.9% | 50.0% | |
| 58.33% | 72 | 6.8 | 897 | 12,006 | 59.5% | 57.1% | |
| 61.97% | 71 | 2.4 | 799 | 12,354 | 53.1% | 69.2% | |
| 46.48% | 71 | 6.4 | 717 | 10,906 | 48.7% | 43.8% | |
| 57.97% | 69 | 1.3 | 741 | 12,885 | 61.8% | 54.3% | |
| 54.55% | 66 | 1.4 | 713 | 11,993 | 54.8% | 54.3% | |
| 60.94% | 64 | 6.8 | 864 | 12,178 | 63.3% | 58.8% | |
| 47.62% | 63 | 1.6 | 710 | 12,269 | 40.7% | 52.8% | |
| 56.45% | 62 | 6.8 | 833 | 12,695 | 58.3% | 55.3% | |
| 47.54% | 61 | 0.9 | 768 | 11,165 | 43.2% | 54.2% | |
| 51.67% | 60 | 0.9 | 642 | 11,399 | 50.0% | 53.6% | |
| 48.33% | 60 | 2.2 | 786 | 12,232 | 33.3% | 58.3% | |
| 49.15% | 59 | 6.5 | 990 | 10,812 | 36.4% | 65.4% | |
| 47.46% | 59 | 1.8 | 779 | 13,015 | 48.0% | 47.1% | |
| 46.55% | 58 | 1.2 | 766 | 11,821 | 48.4% | 44.4% | |
| 60.34% | 58 | 7.0 | 861 | 12,561 | 63.3% | 57.1% | |
| 56.14% | 57 | 4.7 | 889 | 12,471 | 62.1% | 50.0% | |
| 57.89% | 57 | 1.0 | 737 | 11,917 | 55.2% | 60.7% | |
| 66.67% | 57 | 2.2 | 841 | 11,589 | 72.2% | 57.1% | |
| 60.71% | 56 | 6.2 | 843 | 11,475 | 60.0% | 61.5% | |
| 40.74% | 54 | 1.5 | 734 | 11,659 | 41.9% | 39.1% | |
| 55.56% | 54 | 1.1 | 745 | 12,604 | 66.7% | 44.4% | |
| 50.00% | 52 | 4.8 | 768 | 12,771 | 42.9% | 52.6% | |
| 66.67% | 48 | 6.8 | 1,005 | 11,089 | 60.0% | 73.9% | |
| 45.83% | 48 | 2.0 | 822 | 11,775 | 47.8% | 44.0% | |
| 63.04% | 46 | 3.0 | 718 | 12,268 | 60.0% | 65.4% | |
| 53.33% | 45 | 6.2 | 699 | 10,663 | 45.5% | 60.9% | |
| 50.00% | 44 | 6.0 | 800 | 11,923 | 41.7% | 60.0% | |
| 60.00% | 40 | 1.1 | 642 | 10,779 | 54.2% | 68.8% | |
| 52.63% | 38 | 6.3 | 817 | 13,757 | 50.0% | 53.3% | |
| 69.44% | 36 | 6.6 | 924 | 12,126 | 73.3% | 66.7% | |
| 50.00% | 34 | 4.3 | 919 | 13,098 | 40.0% | 54.2% | |
| 58.82% | 34 | 1.1 | 858 | 13,033 | 37.5% | 77.8% | |
| 73.53% | 34 | 6.3 | 822 | 11,452 | 68.2% | 83.3% | |
| 34.38% | 32 | 1.3 | 687 | 11,779 | 30.8% | 36.8% | |
| 41.94% | 31 | 1.2 | 721 | 12,852 | 38.5% | 44.4% | |
| 58.62% | 29 | 1.5 | 741 | 12,755 | 63.6% | 55.6% | |
| 61.54% | 26 | 1.6 | 792 | 13,751 | 60.0% | 62.5% | |
| 50.00% | 26 | 5.8 | 941 | 12,020 | 40.0% | 56.3% | |
| 56.00% | 25 | 6.9 | 929 | 11,414 | 42.9% | 72.7% | |
| 39.13% | 23 | 3.1 | 743 | 10,088 | 42.9% | 33.3% | |
| 47.83% | 23 | 7.1 | 1,123 | 14,222 | 66.7% | 35.7% | |
| 40.91% | 22 | 3.0 | 778 | 11,873 | 18.2% | 63.6% | |
| 66.67% | 21 | 6.1 | 1,169 | 12,397 | 85.7% | 57.1% | |
| 52.38% | 21 | 6.8 | 876 | 13,223 | 55.6% | 50.0% | |
| 61.90% | 21 | 6.8 | 1,172 | 13,063 | 33.3% | 73.3% | |
| 57.14% | 21 | 1.6 | 772 | 12,438 | 50.0% | 66.7% | |
| 30.00% | 20 | 3.7 | 739 | 11,225 | 16.7% | 50.0% | |
| 84.21% | 19 | 1.5 | 670 | 11,763 | 90.9% | 75.0% | |
| 64.71% | 17 | 6.4 | 802 | 11,219 | 75.0% | 55.6% | |
| 75.00% | 16 | 7.4 | 929 | 12,250 | 87.5% | 62.5% | |
| 80.00% | 15 | 6.1 | 896 | 11,984 | 57.1% | 100.0% | |
| 53.33% | 15 | 7.2 | 789 | 11,585 | 83.3% | 33.3% | |
| 64.29% | 14 | 0.9 | 646 | 13,901 | 25.0% | 80.0% | |
| 69.23% | 13 | 6.9 | 866 | 13,090 | 66.7% | 71.4% | |
| 58.33% | 12 | 4.7 | 860 | 11,019 | 66.7% | 50.0% | |
| 36.36% | 11 | 5.5 | 984 | 14,325 | 0.0% | 40.0% | |
| 50.00% | 10 | 2.0 | 844 | 13,212 | 75.0% | 33.3% | |
| 60.00% | 10 | 7.5 | 730 | 11,061 | 75.0% | 0.0% | |
| 44.44% | 9 | 5.1 | 729 | 11,449 | 66.7% | 33.3% | |
| 88.89% | 9 | 6.5 | 998 | 14,488 | 100.0% | 85.7% | |
| 33.33% | 9 | 6.9 | 941 | 14,325 | 0.0% | 42.9% | |
| 50.00% | 8 | 6.4 | 1,022 | 13,577 | 0.0% | 80.0% | |
| 62.50% | 8 | 2.4 | 923 | 11,984 | 33.3% | 80.0% | |
| 37.50% | 8 | 5.0 | 889 | 12,335 | 0.0% | 75.0% | |
| 75.00% | 8 | 6.5 | 862 | 12,614 | 50.0% | 100.0% | |
| 71.43% | 7 | 6.5 | 847 | 13,084 | 100.0% | 60.0% | |
| 42.86% | 7 | 1.8 | 765 | 10,353 | 50.0% | 33.3% | |
| 42.86% | 7 | 7.1 | 861 | 10,745 | 40.0% | 50.0% | |
| 85.71% | 7 | 2.2 | 926 | 11,283 | 100.0% | 75.0% | |
| 42.86% | 7 | 6.6 | 1,053 | 13,462 | 0.0% | 60.0% | |
| 33.33% | 6 | 6.8 | 585 | 9,214 | 40.0% | 0.0% | |
| 66.67% | 6 | 2.9 | 776 | 13,552 | 50.0% | 75.0% | |
| 50.00% | 6 | 3.9 | 998 | 10,719 | 75.0% | 0.0% | |
| 50.00% | 6 | 2.7 | 877 | 11,489 | 100.0% | 25.0% | |
| 50.00% | 6 | 6.4 | 792 | 12,144 | 25.0% | 100.0% | |
| 100.00% | 5 | 6.4 | 892 | 12,588 | 100.0% | 100.0% | |
| 60.00% | 5 | 7.6 | 977 | 11,955 | 0.0% | 100.0% | |
| 60.00% | 5 | 7.2 | 808 | 10,973 | 66.7% | 50.0% | |
Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.
Dr. Mundo vs Vayne - Frequently Asked Questions
How does Dr. Mundo do against Vayne in League of Legends?
Dr. Mundo wins the Dr. Mundo vs Vayne matchup with a 53.3% win rate compared to Vayne's 46.7%, a 6.7 percentage point difference. This data is based on 45 recent ranked games in patch 26.3.
How does Dr. Mundo do against Vayne in the early game?
In the early game, Vayne has the advantage against Dr. Mundo with a 54.5% win rate versus 45.5%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Dr. Mundo do against Vayne in the late game?
In the late game, Dr. Mundo takes over the Dr. Mundo vs Vayne matchup with a 60.9% win rate compared to 39.1%. Dr. Mundo scales better into team fights and objective contests after 25 minutes.
Who wins the Dr. Mundo vs Vayne matchup?
Dr. Mundo wins the matchup against Vayne with a 53.3% win rate in League of Legends patch 26.3. The 6.7 percentage point advantage means Dr. Mundo is significantly favored in this lane matchup based on 45 games analyzed.
What is the best Dr. Mundo build against Vayne?
The best Dr. Mundo build against Vayne includes Heartsteel, Warmog's Armor, Spirit Visage with Boots of Swiftness. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.
What are the best Dr. Mundo runes against Vayne?
The best Dr. Mundo runes against Vayne use the Precision primary tree with Inspiration secondary. This rune setup achieves a 66.7% win rate in the Dr. Mundo vs Vayne matchup. See the full rune breakdown in the matchup comparison above.
Does Dr. Mundo counter Vayne?
Yes, Dr. Mundo has a favorable matchup against Vayne with a 53.3% win rate. Dr. Mundo strongly counters Vayne in lane based on current patch 26.3 data.
How do I play Dr. Mundo against Vayne?
When playing Dr. Mundo against Vayne, leverage your statistical advantages by trading aggressively during favorable windows. Play safe early and scale into your power spikes where you outperform Vayne. Build the recommended items and runes for this specific matchup for the best results.