Dr. Mundovs Vayne
Dr. Mundo vs Vayne is a decisive matchup in LoL patch 26.11. Vayne wins with a 56.0% win rate (+11.9%) over Dr. Mundo based on 84 games. Vayne holds the advantage in both the early and late game. Below you'll find the best Dr. Mundo build, runes, laning stats, and strategies for the Dr. Mundo vs Vayne matchup.
Dr. Mundo Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Dr. Mundo performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Who Wins the Dr. Mundo vs Vayne Matchup?
Dr. Mundo vs Vayne Matchup Summary
The Dr. Mundo vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 84 recent matches analyzed, Vayne wins with a 56.0% win rate compared to Dr. Mundo's 44.0%, giving Vayne a 11.9 percentage point advantage. Vayne dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Dr. Mundo players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Dr. Mundo leads by 1,388 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne has a strong advantage in this matchup. Dr. Mundo players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Vayne overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Dr. Mundo vs Vayne Laning Phase Breakdown
Dr. Mundo is favored during the laning phase against Vayne, winning 3 out of 5 key stat categories. Dr. Mundo holds advantages in farming, crowd control and sustain, making them the stronger laner in this matchup.
Best Dr. Mundo Build Against Vayne
Boots of Swiftness is the optimal boots choice against Vayne, providing the mobility and stats Dr. Mundo needs most in this matchup. The top-performing core items for Dr. Mundo against Vayne are Titanic Hydra, Dead Man's Plate and Heartsteel. This combination gives Dr. Mundo an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 80.0% win rate across 5 games — well above average and making it the top item path against Vayne. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Dr. Mundo vs Vayne matchup.
Early Game vs Late Game
Dr. Mundo48.6%
Vayne51.4%Dr. Mundo40.8%Vayne59.2%During the early laning phase (first 15 minutes), Vayne has a meaningful 51.4% win rate, outperforming Dr. Mundo by 2.9 percentage points. Vayne players should look to press this advantage through aggressive trades, wave priority, and early jungle coordination.
Vayne is far superior in the late game (25+ minutes), boasting a 59.2% win rate — 18.4 points above Dr. Mundo. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.
Vayne holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Dr. Mundo players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.
Best Dr. Mundo Runes Against Vayne
Resolve
Inspiration
The Resolve and Inspiration rune setup gives Dr. Mundo the best tools to compete against Vayne in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.
Dr. Mundo matchup data for League of Legends patch 26.11. The table below shows Dr. Mundo's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Dr. Mundo build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 49.06% | 212 | 7.0 | 916 | 11,720 | 42.5% | 53.0% | |
| 55.56% | 207 | 6.6 | 741 | 11,977 | 61.5% | 51.9% | |
| 43.32% | 187 | 6.3 | 878 | 11,293 | 42.9% | 43.7% | |
| 58.19% | 177 | 6.8 | 937 | 11,396 | 59.8% | 56.7% | |
| 61.22% | 147 | 6.9 | 923 | 11,395 | 55.4% | 67.1% | |
| 55.40% | 139 | 6.3 | 1,032 | 11,821 | 48.2% | 60.2% | |
| 47.01% | 117 | 6.7 | 837 | 11,854 | 44.4% | 48.6% | |
| 38.60% | 114 | 6.6 | 755 | 10,182 | 24.1% | 53.6% | |
| 63.83% | 94 | 6.3 | 940 | 12,753 | 63.6% | 64.0% | |
| 49.46% | 93 | 6.2 | 898 | 10,623 | 46.8% | 52.2% | |
| 58.70% | 92 | 6.9 | 1,041 | 12,194 | 60.6% | 57.6% | |
| 48.84% | 86 | 7.3 | 1,180 | 12,302 | 57.6% | 43.4% | |
| 54.65% | 86 | 6.3 | 871 | 10,635 | 48.8% | 60.0% | |
| 55.81% | 86 | 7.0 | 834 | 11,752 | 47.4% | 62.5% | |
| 49.41% | 85 | 6.5 | 896 | 11,176 | 50.0% | 48.9% | |
| 44.05% | 84 | 6.3 | 775 | 11,460 | 48.6% | 40.8% | |
| 56.79% | 81 | 5.7 | 893 | 11,673 | 50.0% | 63.4% | |
| 46.91% | 81 | 6.4 | 1,036 | 11,146 | 54.8% | 38.5% | |
| 43.21% | 81 | 5.8 | 943 | 10,155 | 44.4% | 41.7% | |
| 48.05% | 77 | 7.0 | 1,016 | 11,763 | 51.5% | 45.5% | |
| 56.16% | 73 | 6.8 | 821 | 11,731 | 61.1% | 51.4% | |
| 48.61% | 72 | 6.7 | 784 | 10,312 | 48.7% | 48.5% | |
| 63.38% | 71 | 7.0 | 809 | 12,103 | 64.3% | 62.8% | |
| 52.17% | 69 | 6.3 | 866 | 11,067 | 55.3% | 48.4% | |
| 50.75% | 67 | 5.7 | 886 | 10,850 | 50.0% | 51.4% | |
| 50.00% | 66 | 2.5 | 716 | 10,968 | 46.0% | 55.2% | |
| 43.94% | 66 | 3.4 | 786 | 11,337 | 41.4% | 46.0% | |
| 56.92% | 65 | 6.7 | 1,122 | 11,084 | 60.5% | 51.9% | |
| 62.50% | 64 | 6.2 | 904 | 11,809 | 54.8% | 69.7% | |
| 55.56% | 63 | 6.6 | 920 | 10,806 | 61.8% | 48.3% | |
| 50.00% | 60 | 5.7 | 976 | 10,441 | 48.6% | 52.2% | |
| 39.66% | 58 | 7.0 | 864 | 11,668 | 52.2% | 31.4% | |
| 61.40% | 57 | 6.5 | 1,238 | 10,655 | 57.1% | 68.2% | |
| 48.21% | 56 | 6.9 | 815 | 11,536 | 57.7% | 40.0% | |
| 44.44% | 54 | 7.5 | 906 | 11,726 | 40.0% | 48.3% | |
| 44.90% | 49 | 6.4 | 1,040 | 11,028 | 44.4% | 45.5% | |
| 36.17% | 47 | 6.6 | 826 | 11,805 | 27.8% | 41.4% | |
| 46.67% | 45 | 2.8 | 741 | 11,029 | 44.0% | 50.0% | |
| 45.45% | 44 | 6.6 | 963 | 11,385 | 30.0% | 58.3% | |
| 58.14% | 43 | 1.1 | 789 | 12,110 | 42.1% | 70.8% | |
| 48.84% | 43 | 6.7 | 837 | 12,024 | 47.1% | 50.0% | |
| 64.29% | 42 | 7.1 | 875 | 13,318 | 61.5% | 65.5% | |
| 52.38% | 42 | 1.4 | 686 | 11,880 | 61.1% | 45.8% | |
| 65.85% | 41 | 6.6 | 774 | 12,139 | 42.9% | 77.8% | |
| 58.97% | 39 | 6.8 | 1,111 | 11,565 | 60.0% | 57.9% | |
| 45.95% | 37 | 1.7 | 667 | 10,976 | 52.6% | 38.9% | |
| 59.46% | 37 | 6.5 | 868 | 10,048 | 55.6% | 63.2% | |
| 45.71% | 35 | 6.5 | 754 | 12,912 | 30.0% | 52.0% | |
| 60.00% | 35 | 2.3 | 682 | 11,582 | 66.7% | 56.5% | |
| 47.06% | 34 | 3.1 | 753 | 12,022 | 38.5% | 52.4% | |
| 50.00% | 34 | 3.7 | 734 | 12,317 | 46.7% | 52.6% | |
| 53.13% | 32 | 6.8 | 961 | 10,805 | 56.3% | 50.0% | |
| 51.61% | 31 | 6.5 | 1,035 | 9,798 | 47.4% | 58.3% | |
| 67.74% | 31 | 7.1 | 793 | 11,623 | 79.0% | 50.0% | |
| 43.33% | 30 | 1.9 | 810 | 11,258 | 46.7% | 40.0% | |
| 51.72% | 29 | 2.1 | 609 | 10,488 | 46.7% | 57.1% | |
| 66.67% | 27 | 6.5 | 962 | 12,618 | 63.6% | 68.8% | |
| 43.48% | 23 | 4.3 | 775 | 11,411 | 35.7% | 55.6% | |
| 52.17% | 23 | 1.4 | 617 | 10,628 | 63.6% | 41.7% | |
| 66.67% | 21 | 6.8 | 1,086 | 14,269 | 100.0% | 61.1% | |
| 61.90% | 21 | 6.1 | 762 | 12,385 | 63.6% | 60.0% | |
| 61.90% | 21 | 7.0 | 955 | 10,824 | 75.0% | 44.4% | |
| 57.14% | 21 | 3.2 | 850 | 12,145 | 50.0% | 63.6% | |
| 55.00% | 20 | 1.1 | 757 | 12,734 | 50.0% | 58.3% | |
| 36.84% | 19 | 2.2 | 694 | 11,448 | 44.4% | 30.0% | |
| 44.44% | 18 | 2.3 | 689 | 12,169 | 50.0% | 40.0% | |
| 38.89% | 18 | 2.5 | 817 | 11,642 | 14.3% | 54.5% | |
| 52.94% | 17 | 2.0 | 757 | 12,352 | 33.3% | 63.6% | |
| 70.59% | 17 | 2.2 | 757 | 11,996 | 66.7% | 72.7% | |
| 58.82% | 17 | 1.7 | 811 | 12,587 | 37.5% | 77.8% | |
| 41.18% | 17 | 0.8 | 666 | 10,863 | 54.5% | 16.7% | |
| 41.18% | 17 | 3.8 | 970 | 12,660 | 75.0% | 30.8% | |
| 50.00% | 16 | 2.8 | 747 | 12,045 | 66.7% | 40.0% | |
| 60.00% | 15 | 0.9 | 713 | 11,985 | 71.4% | 50.0% | |
| 53.33% | 15 | 6.1 | 744 | 12,637 | 60.0% | 50.0% | |
| 60.00% | 15 | 7.4 | 693 | 12,659 | 50.0% | 66.7% | |
| 71.43% | 14 | 2.5 | 840 | 11,939 | 75.0% | 70.0% | |
| 61.54% | 13 | 1.4 | 653 | 10,359 | 50.0% | 80.0% | |
| 38.46% | 13 | 7.4 | 878 | 11,467 | 57.1% | 16.7% | |
| 61.54% | 13 | 4.2 | 689 | 10,223 | 50.0% | 66.7% | |
| 41.67% | 12 | 3.3 | 873 | 14,030 | 100.0% | 30.0% | |
| 41.67% | 12 | 6.7 | 800 | 11,352 | 25.0% | 50.0% | |
| 72.73% | 11 | 1.9 | 759 | 11,980 | 83.3% | 60.0% | |
| 36.36% | 11 | 1.0 | 578 | 9,609 | 22.2% | 100.0% | |
| 40.00% | 10 | 6.8 | 819 | 12,082 | 40.0% | 40.0% | |
| 90.00% | 10 | 5.9 | 1,252 | 12,589 | 66.7% | 100.0% | |
| 50.00% | 10 | 7.6 | 805 | 10,864 | 66.7% | 25.0% | |
| 55.56% | 9 | 6.0 | 833 | 9,368 | 80.0% | 25.0% | |
| 66.67% | 9 | 2.0 | 831 | 12,172 | 50.0% | 80.0% | |
| 44.44% | 9 | 4.3 | 726 | 11,019 | 50.0% | 33.3% | |
| 66.67% | 9 | 1.8 | 794 | 14,233 | 66.7% | 66.7% | |
| 55.56% | 9 | 6.1 | 850 | 10,728 | 50.0% | 60.0% | |
| 50.00% | 8 | 3.7 | 589 | 10,723 | 50.0% | 50.0% | |
| 37.50% | 8 | 3.6 | 748 | 12,092 | 0.0% | 60.0% | |
| 62.50% | 8 | 6.3 | 863 | 10,851 | 60.0% | 66.7% | |
| 28.57% | 7 | 2.4 | 790 | 11,252 | 66.7% | 0.0% | |
| 57.14% | 7 | 3.3 | 737 | 8,690 | 60.0% | 50.0% | |
| 57.14% | 7 | 3.9 | 1,025 | 11,414 | 75.0% | 33.3% | |
| 57.14% | 7 | 5.4 | 693 | 10,685 | 66.7% | 50.0% | |
| 71.43% | 7 | 2.5 | 765 | 11,790 | 50.0% | 100.0% | |
| 14.29% | 7 | 6.9 | 562 | 11,229 | 50.0% | 0.0% | |
| 42.86% | 7 | 7.1 | 665 | 11,401 | 66.7% | 25.0% | |
| 33.33% | 6 | 5.1 | 656 | 10,556 | 33.3% | 33.3% | |
| 33.33% | 6 | 3.7 | 968 | 14,040 | 0.0% | 50.0% | |
| 83.33% | 6 | 6.5 | 999 | 12,478 | 66.7% | 100.0% | |
| 16.67% | 6 | 6.6 | 983 | 10,739 | 0.0% | 25.0% | |
| 50.00% | 6 | 6.5 | 977 | 13,723 | 0.0% | 60.0% | |
| 66.67% | 6 | 5.4 | 744 | 11,352 | 75.0% | 50.0% | |
| 60.00% | 5 | 5.9 | 976 | 15,346 | 100.0% | 50.0% | |
| 60.00% | 5 | 4.3 | 1,197 | 12,981 | 0.0% | 75.0% | |
| 40.00% | 5 | 6.2 | 954 | 11,099 | 33.3% | 50.0% | |
| 60.00% | 5 | 6.0 | 979 | 11,537 | 50.0% | 66.7% | |
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Dr. Mundo vs Vayne - Frequently Asked Questions
How does Dr. Mundo do against Vayne in League of Legends?
Vayne wins the Dr. Mundo vs Vayne matchup with a 56.0% win rate compared to Dr. Mundo's 44.0%, a 11.9 percentage point difference. This data is based on 84 recent ranked games in patch 26.11.
How does Dr. Mundo do against Vayne in the early game?
In the early game, Vayne has the advantage against Dr. Mundo with a 51.4% win rate versus 48.6%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Dr. Mundo do against Vayne in the late game?
In the late game, Vayne takes over the Dr. Mundo vs Vayne matchup with a 59.2% win rate compared to 40.8%. Vayne scales better into team fights and objective contests after 25 minutes.
Who wins the Dr. Mundo vs Vayne matchup?
Vayne wins the matchup against Dr. Mundo with a 56.0% win rate in League of Legends patch 26.11. The 11.9 percentage point advantage means Vayne is significantly favored in this lane matchup based on 84 games analyzed.
What is the best Dr. Mundo build against Vayne?
The best Dr. Mundo build against Vayne includes Titanic Hydra, Dead Man's Plate, Heartsteel with Boots of Swiftness. This build achieves a 80.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.
What are the best Dr. Mundo runes against Vayne?
The best Dr. Mundo runes against Vayne use the Resolve primary tree with Inspiration secondary. This rune setup achieves a 41.7% win rate in the Dr. Mundo vs Vayne matchup. See the full rune breakdown in the matchup comparison above.
Does Dr. Mundo counter Vayne?
No, Dr. Mundo struggles against Vayne with only a 44.0% win rate. Vayne has the advantage in this matchup. Dr. Mundo players should focus on safe farming and avoiding extended trades to minimize Vayne's lead.
How do I play Dr. Mundo against Vayne?
When playing Dr. Mundo against Vayne, play cautiously and avoid Vayne's power spikes. Look for jungle assistance and team-dependent plays since Vayne has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.