- Win Rate
- 50.9%
- Pick Rate
- 2.4%
- Ban Rate
- 2.8%
Dr. Mundo vs Vayne
- Patch
- 26.22
- Games
- 4,737
- Lane
- All Lanes
- Tier
- All Tiers
- Last Updated
- Nov 14, 2026 UTC
- Author
- Dakota Chinnick
- Methodology
- Data Methodology
Dr. Mundo vs Vayne (Top): Dr. Mundo wins 60.6% of 66 ranked games over the last 2 patches (gold diff at 15: -148). Patch 26.22 build & runes.
Dr. Mundo60.6%
Current data slightly favors Dr. Mundo, but the sample is too limited for a strong conclusion: Dr. Mundo wins 60.6% of 66 games (95% range 48.5–71.5%).
Dr. Mundo Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Dr. Mundo performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Who wins Dr. Mundo vs Vayne?
Dr. Mundo wins 60.6% of these games. With this many games the true rate is most likely between 48.5% and 71.5% (95% range).
- Expected
- 51.9% From both champions' overall Top win rates
- Matchup effect
- +8.7 pts Observed minus expected
- Sample
- 66 games Lane: Top · Patch 26.21–26.22
- vs patch 26.21
- — Not enough games on both patches
Lane: Top · Ranked Solo/Duo & Flex · North America server · All ranks · Patch 26.21–26.22 · Oct 27 – Nov 14
The headline win rate covers patches 26.21–26.22 (66 games). The lane, game-length, build and rune sections below use patch 26.22 only (48 games).
Key takeaways
- Current data slightly favors Dr. Mundo, but the sample is too limited for a strong conclusion: Dr. Mundo wins 60.6% of 66 games (95% range 48.5–71.5%).
- Both champions' overall Top win rates predict 51.9% for Dr. Mundo; the result is within the margin of error of that, so this matchup mostly reflects the two champions' general strength.
- Neither side reliably wins the lane: the average gold difference at 15 minutes is 148, within the margin of error (48 games).
- Dr. Mundo players pick Plated Steelcaps far more often against Vayne: 26.6% of their other Top games, 43.8% here.
How we calculate this
Games: ranked Solo/Duo and Flex games on the North America server from the patch shown. Remakes (games under 5 minutes) are excluded.
A game only counts when Dr. Mundo and Vayne played the same position on opposite teams, so roaming, lane swaps within a team or a champion merely being in the same game never count as this matchup.
The 95% range is a Wilson score interval. Confidence comes from how wide that range is: within ±3 points is very high, ±5 high, ±8 moderate, anything wider low. Below 20 games a matchup is not classified at all.
Expected win rate combines both champions’ win rates in this lane (same games and filters) with the log5 formula: E = A(1−B) / (A(1−B) + B(1−A)). Matchup effect = observed − expected.
"What changes" compares Dr. Mundo's choices in this matchup with the same champion's other games in the same lane, and lists a change only when it is at least 3 points and statistically significant (two-proportion z-test, |z| ≥ 2, 20+ games).
Results are not split by rank: the sample per rank is too small for honest per-rank matchup numbers.
Dr. Mundo vs Vayne Laning Stats
At 15 minutes
Whole-game averages
Dr. Mundo vs Vayne Win Rate by Game Length
Dr. Mundo's win rate against Vayne by game length. The dot is the win rate, the bar its 95% range and the dashed line the champion's usual win rate at that length. Lengths with fewer than 25 games are left blank.
No game length stands out: Dr. Mundo's results against Vayne in short and long games are within the margin of error of each other.
Dr. Mundo vs Vayne Power Spikes
Who is ahead at each stage, measured from these games. A stage reads "Even" when the difference is inside the margin of error, and "Insufficient data" when there are too few games to tell.
- Lane (15 min)EvenDr. Mundo gold at 15: −148
- First itemDr. MundoDr. Mundo: 13.3 min · Vayne: 13.8 min
- Games under 20 minInsufficient data
- 20–30 min gamesInsufficient data
- 30+ min gamesInsufficient data
What Dr. Mundo Changes Against Vayne
Choices Dr. Mundo players make noticeably more or less often in this matchup than in their other Top games.
Plated SteelcapsBootsUsually26.6%vs Vayne43.8%+17.2 pts66.7% WR here
Doran's Shield + Health Potion + Stealth WardStarting itemsUsually24.3%vs Vayne37.5%+13.2 pts
Grasp of the UndyingKeystoneUsually95.1%vs Vayne83.3%−11.8 pts60.0% WR here
OvergrowthRuneUsually94.7%vs Vayne83.3%−11.3 pts62.5% WR here
HeartsteelItemUsually89.3%vs Vayne79.2%−10.2 pts63.2% WR here
DemolishRuneUsually95.4%vs Vayne85.4%−10.0 pts61.0% WR here
Fleet FootworkKeystoneUsually3.2%vs Vayne10.4%+7.3 pts
Frozen HeartItemUsuallyunder 0.5%vs Vayne6.3%+6.3 pts
Best Dr. Mundo Build vs Vayne
Usual Dr. Mundo build (Top)
60.0% win rate · 618 games
Against Vayne
Not enough matchup-specific build data: only 9 of 34 Dr. Mundo games against Vayne carried a complete build, which is too few to recommend an item path from. Use Dr. Mundo's standard build instead.
- Dr. Mundo usually completes Warmog's Armor first, at 13.3 min (median of 30 games).
- Vayne usually completes Blade of The Ruined King first, at 13.8 min (median of 35 games).
- Skill priority: Q > E > W — the same as usual.
Builds are ranked by the lower edge of their win rate range, not the raw win rate, so a build seen in a handful of wins never outranks a proven one.
Best Dr. Mundo Runes vs Vayne
Usual Dr. Mundo runes (Top)
Grasp of the Undying
52.9% win rate · 1,330 games
Against Vayne
Too few games for a matchup-specific rune page yet — use the usual page.
Plan your Dr. Mundo draft in Draft Lab
Draft Lab lays out both teams lane by lane with live matchup win rates, damage profiles and game-phase lean, and suggests picks and bans from current meta data.
- Full 5v5 draft board
- Lane matchup win rates
- Pick and ban suggestions
Dr. Mundo matchup data for League of Legends patch 26.22. The table below shows Dr. Mundo's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Dr. Mundo build, runes, laning stats, and early vs late game analysis for that specific matchup.
Other Dr. Mundo Matchups
Hardest for Dr. Mundo
Easiest for Dr. Mundo
Win rate and games for each matchup. Lists are ranked by the edge of the 95% range so small samples cannot top them; matchups with at least 50 games only.
Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.
Dr. Mundo vs Vayne FAQ - Patch 26.21–26.22
Who wins Dr. Mundo vs Vayne?
Current data slightly favors Dr. Mundo, but the sample is too limited for a strong conclusion: Dr. Mundo wins 60.6% of 66 games (95% range 48.5–71.5%).
What is Dr. Mundo's win rate against Vayne?
Dr. Mundo wins 60.6% of 66 Top games against Vayne on patch 26.21–26.22 (95% range 48.5–71.5%). Based on both champions' overall Top win rates, 51.9% would be expected.
Does Dr. Mundo counter Vayne?
Not clearly. Dr. Mundo wins 60.6% of 66 games against Vayne, and the 95% range (48.5–71.5%) includes 50%, so neither champion reliably counters the other on current data.
Who wins lane, Dr. Mundo or Vayne?
Neither side reliably wins the lane: the average gold difference at 15 minutes is 148, within the margin of error (48 games).
Does Dr. Mundo outscale Vayne?
There are too few games of each length to tell yet.
When is Vayne strongest against Dr. Mundo?
On current data there is no stage of the game where Vayne is ahead of Dr. Mundo beyond the margin of error.
What should Dr. Mundo build against Vayne?
There are not enough games for a matchup-specific core, so use Dr. Mundo's usual Top core: Titanic Hydra, Heartsteel, Warmog's Armor. The biggest change against Vayne: Plated Steelcaps (26.6% usually, 43.8% here).
What runes should Dr. Mundo use against Vayne?
Use Dr. Mundo's usual Grasp of the Undying page (Resolve + Inspiration); there are too few games for a matchup-specific page. The biggest change against Vayne: Grasp of the Undying (95.1% usually, 83.3% here).