Zyra - League of Legends Champion
Win Rate
51.1%
Pick Rate
3.3%

ZyraRunes

AMageSupport
Patch26.3
Matches599,680
LaneAll Lanes
TierAll Tiers
Last UpdatedFeb 11, 2026
MethodologyData Methodology

Best Zyra runes for LoL Patch 26.3 - Arcane Comet from the Sorcery tree with Domination secondary (66.7% WR, 0.4% pick rate). Zyra's optimal primary runes are Arcane Comet, Manaflow Band, Transcendence, Scorch. Secondary tree: Relentless Hunter, Taste of Blood.

Zyra performs best with Arcane Comet as the keystone rune from the Sorcery tree. Zyra's optimal primary runes are Arcane Comet, Manaflow Band, Transcendence, Scorch. Zyra's secondary rune tree is Domination with Relentless Hunter, Taste of Blood. This rune setup achieves a 66.67% win rate (+15.5% win rate difference) with a 0.4% pick rate across 15 Zyra games.
66.7%Win Rate
+15.5%WR Diff
0.4%Pick Rate
Arcane CometArcane Comet

Damaging a champion with an ability hurls a comet at their location, or, if Arcane Comet is on cooldown, reduces its remaining cooldown.

Adaptive Damage: 30 - 130 based on level (+0.05 AP and +0.1 bonus AD)
Cooldown: 20 - 8s

Cooldown Reduction:
Single Target: 20%.
Area of Effect: 10%.
Damage over Time: 5%.

Manaflow BandManaflow Band

Hitting an enemy champion with an ability permanently increases your maximum mana by 25, up to 250 mana.

After reaching 250 bonus mana, restore 1% of your missing mana every 5 seconds.

Cooldown: 15 seconds

TranscendenceTranscendence

Gain bonuses upon reaching the following levels:
Level 5: +5 Ability Haste
Level 8: +5 Ability Haste
Level 11: On Champion takedown, reduce the remaining cooldown of basic abilities by 20%.

ScorchScorch

Your next damaging ability hit sets champions on fire dealing 20 - 40 bonus magic damage based on level after 1s.

Cooldown: 10s

Relentless HunterRelentless Hunter

Gain 8 Move Speed out of combat per Bounty Hunter stack. Bounty Hunter stacks are earned the first time you get a takedown on each enemy champion.

Taste of BloodTaste of Blood

Heal when you damage an enemy champion.

Healing: 16-40 (+0.1 bonus AD, +0.05 AP) health (based on level)

Cooldown: 20s

This alternative Zyra rune build uses Dark Harvest as the keystone from the Domination tree. The primary runes are Dark Harvest, Cheap Shot, Grisly Mementos, Ultimate Hunter. Zyra's secondary rune tree is Sorcery with Manaflow Band, Transcendence. This setup achieves a 61.11% win rate (+10.0% win rate difference) with a 0.9% pick rate across 36 games.
61.1%Win Rate
+10.0%WR Diff
0.9%Pick Rate
Dark HarvestDark Harvest

Damaging a Champion below 50% health deals adaptive damage and harvests their soul, permanently increasing Dark Harvest's damage by 11.

Dark Harvest damage: 30 (+11 damage per soul) (+0.1 bonus AD) (+0.05 AP)
Cooldown: 35s (resets to 1.0s on takedown)

Cheap ShotCheap Shot

Damaging champions with impaired movement or actions deals 10 - 45 bonus true damage (based on level).

Cooldown: 4s
Activates on damage occurring after the impairment.

Grisly MementosGrisly Mementos

Collect 1 memento on champion takedowns, up to 18 total.

Gain 6 Trinket Haste for each collected. In game modes where vision Trinkets do not exist, instead gain 3 Summoner Spell Haste.

Ultimate HunterUltimate Hunter

Your ultimate gains 6 Ability Haste, plus an additional 5 Ability Haste per Bounty Hunter stack. Bounty Hunter stacks are earned the first time you get a takedown on each enemy champion.

Manaflow BandManaflow Band

Hitting an enemy champion with an ability permanently increases your maximum mana by 25, up to 250 mana.

After reaching 250 bonus mana, restore 1% of your missing mana every 5 seconds.

Cooldown: 15 seconds

TranscendenceTranscendence

Gain bonuses upon reaching the following levels:
Level 5: +5 Ability Haste
Level 8: +5 Ability Haste
Level 11: On Champion takedown, reduce the remaining cooldown of basic abilities by 20%.

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Zyra Runes - Frequently Asked Questions

What are the best Zyra runes in patch 26.3?

The best Zyra runes in patch 26.3 use the Sorcery tree with Arcane Comet, Manaflow Band, Transcendence, and Scorch, and the Domination tree with Relentless Hunter and Taste of Blood. This rune setup achieves a 66.7% win rate with a 0.4% pick rate.

What is the win rate for Zyra's best rune page?

Zyra's best rune page has a 66.7% win rate in patch 26.3, which is +15.5% compared to Zyra's average win rate. This rune setup has a 0.4% pick rate among Zyra players.

What keystone should I use on Zyra?

Arcane Comet from the Sorcery tree is the best keystone rune for Zyra in patch 26.3. This keystone synergizes well with Zyra's kit and provides a 66.7% win rate.

What is Zyra's primary rune tree?

Zyra's primary rune tree is Sorcery. The optimal Sorcery runes for Zyra are Arcane Comet, Manaflow Band, Transcendence, and Scorch, with Arcane Comet being the keystone of choice.

What is Zyra's secondary rune tree?

Zyra's best secondary rune tree is Domination. The recommended Domination runes are Relentless Hunter and Taste of Blood, which complement Zyra's Sorcery primary tree.

What are alternative rune setups for Zyra?

An alternative Zyra rune setup uses Dark Harvest from the Domination tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.

How popular are Zyra's runes?

Zyra's top rune page has a 0.4% pick rate in patch 26.3. This indicates that 0.4% of Zyra players use the Arcane Comet setup with Sorcery and Domination trees.