Lillia - League of Legends Champion
Win Rate
50.9%
Pick Rate
2.1%

Lilliavs Vayne

AFighterMage
Patch26.10
Matches1,120,787
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 19, 2026
MethodologyData Methodology

Lillia vs Vayne is a very close matchup in LoL patch 26.10. Lillia wins with a 50.0% win rate (+0.0%) over Vayne based on 6 games. Vayne wins the early laning phase while Lillia scales better into the late game. Below you'll find the best Lillia build, runes, laning stats, and strategies for the Lillia vs Vayne matchup.

Lillia Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Lillia performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 50.0% win rateVayne(50.0%)
Lillia - 50.0% win rate in this matchup
Lillia
50.0% WR
VS
Vayne vs Lillia matchup - 50.0% win rate
Vayne
50.0% WR

Who Wins the Lillia vs Vayne Matchup?

Lillia wins the Lillia vs Vayne matchup
Winner
Lillia
Matches: 6
50.0%
Win Rate
50.0%
2.5
CS / min
3.2
679
DMG / min
1,128
12,925
Gold / game
17,178
521
Heal / min
306
836
DMG Mitigated / min
560
0.9
CC / min
0.5
0.0%
Early Game WR
100.0%
60.0%
Late Game WR
40.0%

Lillia vs Vayne Matchup Summary

The Lillia vs Vayne matchup is essentially a coin-flip matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Lillia wins with a 50.0% win rate compared to Vayne's 50.0%, giving Lillia a 0.0 percentage point advantage. Game phase dynamics play a critical role here: Vayne controls the early laning stage, but Lillia outscales as the game goes longer. The matchup shifts dramatically depending on game length — Vayne needs to press advantages before Lillia reaches their power spikes, while Lillia should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Lillia leads by 0.4s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Lillia has a statistical edge, but the margin is close enough that respecting Vayne's strengths is important. Trade when cooldowns are favorable, track the enemy jungler, and build toward your strongest item spikes to convert the slight advantage into a decisive lead. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Lillia vs Vayne Laning Phase Breakdown

Vayne wins the laning phase against Lillia in League of Legends

Vayne is favored during the laning phase against Lillia, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
2.5Lillia
3.2Vayne
Vayne edges out Lillia by 0.7 CS per minute — a moderate farming advantage that adds up to roughly 10 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Vayne.
Damage
679Lillia
1,128Vayne
Vayne heavily out-damages Lillia by 449 DMG/min, dominating both short trades and all-in fights. Lillia should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Vayne's sustained damage advantage take over.
Economy
12,925Lillia
17,178Vayne
Vayne generates a commanding 4,253 more gold per game than Lillia. This substantial economic advantage means Vayne consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Lillia should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.9Lillia
0.5Vayne
Lillia provides 0.4 seconds more crowd control per minute than Vayne, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Lillia coordinate with their jungler and control the pace of skirmishes.
Sustain
1,357Lillia
866Vayne
Lillia vastly out-sustains Vayne, healing and mitigating 491 more damage per minute. This massive durability gap means Lillia can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Best Lillia Build Against Vayne

Boots of Swiftness is the optimal boots choice against Vayne, providing the mobility and stats Lillia needs most in this matchup. The top-performing core items for Lillia against Vayne are Liandry's Torment, Cosmic Drive and Rylai's Crystal Scepter. This combination gives Lillia an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Vayne. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Lillia vs Vayne matchup.

Early Game vs Late Game

Early Game
Vayne
100.0%
+100.0% advantage
Lillia early game win rateLillia0.0%
Vayne early game win rateVayne100.0%
Late Game
Lillia
60.0%
+20.0% advantage
Lillia late game win rateLillia60.0%
Vayne late game win rateVayne40.0%

Vayne dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Lillia. This lopsided early game means Vayne can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Lillia is far superior in the late game (25+ minutes), boasting a 60.0% win rate — 20.0 points above Vayne. Extended games heavily favor Lillia, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Vayne must aggressively press their early advantage and close out the game before Lillia reaches their scaling breakpoints. If Lillia survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Lillia Runes Against Vayne

Sorcery rune tree - Lillia primary runes vs VayneSorcery
Deathfire Touch - best Lillia rune vs VayneManaflow Band - best Lillia rune vs VayneCelerity - best Lillia rune vs VayneScorch - best Lillia rune vs Vayne
Precision rune tree - Lillia secondary runes vs VaynePrecision
Presence of Mind - best Lillia rune vs VayneLegend: Haste - best Lillia rune vs Vayne
100.0% WR

The Sorcery primary with Precision secondary combination helps Lillia maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Vayne.


Lillia matchup data for League of Legends patch 26.10. The table below shows Lillia's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lillia build, runes, laning stats, and early vs late game analysis for that specific matchup.

Lillia matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
50.93%2161.277612,13651.5%50.4%
49.21%1911.174812,22163.4%38.5%
56.45%1861.377112,73556.8%56.2%
44.32%1851.277812,30646.4%42.6%
47.80%1821.370712,30048.0%47.6%
51.50%1671.280213,09048.4%53.3%
54.22%1661.270912,53257.3%51.6%
52.38%1471.279912,33050.8%53.7%
53.28%1371.381012,84351.9%54.2%
53.44%1311.281712,35756.0%51.9%
53.91%1281.278613,21659.1%51.2%
53.91%1151.278812,01252.8%54.8%
50.00%941.283812,50152.6%48.2%
42.53%871.370411,92555.3%32.6%
50.00%861.375612,99346.9%51.9%
46.51%861.376612,62348.8%44.4%
52.56%781.678212,56253.1%52.2%
51.39%721.474312,22054.8%48.8%
57.35%681.279312,12960.6%54.3%
50.75%671.271412,22564.3%41.0%
37.88%661.288312,94444.0%34.1%
46.03%631.488312,92453.9%40.5%
49.21%631.477912,80248.1%50.0%
41.94%621.374712,86742.3%41.7%
48.33%601.169312,27148.1%48.5%
60.00%601.373712,93850.0%66.7%
49.09%551.275811,40141.9%58.3%
52.73%551.675912,05556.5%50.0%
48.08%521.575412,04047.8%48.3%
46.94%491.264811,58045.0%48.3%
38.78%491.372212,67045.0%34.5%
52.17%461.370110,81168.2%37.5%
54.55%441.597713,51975.0%42.9%
51.16%431.41,00413,71261.1%44.0%
46.51%431.267611,36842.3%52.9%
56.41%392.188814,32054.5%57.1%
61.11%361.275911,65252.6%70.6%
50.00%341.284411,94650.0%50.0%
64.52%311.978612,44560.0%66.7%
48.28%292.21,13212,97050.0%47.6%
41.38%291.482412,53453.9%31.3%
51.72%291.573713,18333.3%60.0%
64.29%282.185813,34436.4%82.3%
60.71%281.263811,46858.8%63.6%
53.57%281.883114,28966.7%47.4%
60.87%232.682812,77855.6%64.3%
45.45%221.881013,92728.6%53.3%
61.90%211.479312,00766.7%58.3%
50.00%202.31,01214,79975.0%43.8%
73.68%193.088811,22988.9%60.0%
68.42%192.378310,93275.0%57.1%
36.84%191.297911,68933.3%40.0%
63.16%191.385412,63863.6%62.5%
50.00%182.090113,64733.3%53.3%
64.71%171.372812,68957.1%70.0%
43.75%161.171412,17837.5%50.0%
31.25%161.487112,98820.0%36.4%
40.00%151.268411,86050.0%28.6%
60.00%151.176612,75857.1%62.5%
50.00%142.01,01715,21825.0%60.0%
50.00%141.982814,46740.0%55.6%
41.67%121.071410,71850.0%37.5%
66.67%121.271810,65362.5%75.0%
50.00%102.073811,902100.0%28.6%
77.78%92.078712,72675.0%80.0%
37.50%81.463212,8770.0%60.0%
50.00%83.190913,3910.0%66.7%
57.14%71.179814,384100.0%50.0%
57.14%73.79369,76860.0%50.0%
57.14%71.489111,77433.3%75.0%
66.67%64.491211,146100.0%50.0%
66.67%65.458710,761100.0%0.0%
50.00%62.567912,9250.0%60.0%
50.00%65.61,05814,1010.0%75.0%
60.00%55.18496,39850.0%100.0%
60.00%54.31,08812,35050.0%66.7%
40.00%53.394311,237100.0%25.0%
20.00%52.064910,4170.0%33.3%
20.00%56.37189,4830.0%33.3%
60.00%56.61,01112,2130.0%100.0%

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Lillia vs Vayne - Frequently Asked Questions

How does Lillia do against Vayne in League of Legends?

Lillia wins the Lillia vs Vayne matchup with a 50.0% win rate compared to Vayne's 50.0%, a 0.0 percentage point difference. This data is based on 6 recent ranked games in patch 26.10.

How does Lillia do against Vayne in the early game?

In the early game, Vayne has the advantage against Lillia with a 100.0% win rate versus 0.0%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Lillia do against Vayne in the late game?

In the late game, Lillia takes over the Lillia vs Vayne matchup with a 60.0% win rate compared to 40.0%. Lillia scales better into team fights and objective contests after 25 minutes.

Who wins the Lillia vs Vayne matchup?

Lillia wins the matchup against Vayne with a 50.0% win rate in League of Legends patch 26.10. The 0.0 percentage point advantage means Lillia is slightly favored in this lane matchup based on 6 games analyzed.

What is the best Lillia build against Vayne?

The best Lillia build against Vayne includes Liandry's Torment, Cosmic Drive, Rylai's Crystal Scepter with Boots of Swiftness. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Lillia runes against Vayne?

The best Lillia runes against Vayne use the Sorcery primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Lillia vs Vayne matchup. See the full rune breakdown in the matchup comparison above.

Does Lillia counter Vayne?

Yes, Lillia has a favorable matchup against Vayne with a 50.0% win rate. Lillia slightly edges out Vayne in lane based on current patch 26.10 data.

How do I play Lillia against Vayne?

When playing Lillia against Vayne, leverage your statistical advantages by trading aggressively during favorable windows. Play safe early and scale into your power spikes where you outperform Vayne. Build the recommended items and runes for this specific matchup for the best results.