Nasus - League of Legends Champion
Win Rate
50.1%
Pick Rate
3.0%

Nasusvs Karthus

BFighterTank
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 7, 2026
MethodologyData Methodology

Nasus vs Karthus is a decisive matchup in LoL patch 26.11. Nasus wins with a 75.0% win rate (+50.0%) over Karthus based on 8 games. Nasus holds the advantage in both the early and late game. Below you'll find the best Nasus build, runes, laning stats, and strategies for the Nasus vs Karthus matchup.

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Nasus Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Nasus performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Nasus - 75.0% win rate in this matchup
Nasus
75.0% WR
VS
Karthus vs Nasus matchup - 25.0% win rate
Karthus
25.0% WR

Who Wins the Nasus vs Karthus Matchup?

Nasus wins the Nasus vs Karthus matchup
Winner
Nasus
Matches: 8
75.0%
Win Rate
25.0%
1.2
CS / min
1.3
809
DMG / min
1,285
13,893
Gold / game
13,222
827
Heal / min
317
1,755
DMG Mitigated / min
530
0.6
CC / min
0.7
50.0%
Early Game WR
50.0%
83.3%
Late Game WR
16.7%

Nasus vs Karthus Matchup Summary

The Nasus vs Karthus matchup is a decisive matchup in League of Legends ranked play. Based on 8 recent matches analyzed, Nasus wins with a 75.0% win rate compared to Karthus's 25.0%, giving Nasus a 50.0 percentage point advantage. Nasus dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Karthus players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Nasus leads by 1,734 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Nasus players can confidently pick into Karthus and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Karthus away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Nasus vs Karthus Laning Phase Breakdown

Karthus wins the laning phase against Nasus in League of Legends

Karthus is favored during the laning phase against Nasus, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and crowd control, making them the stronger laner in this matchup.

Farming
1.2Nasus
1.3Karthus
Nasus and Karthus farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
809Nasus
1,285Karthus
Karthus heavily out-damages Nasus by 476 DMG/min, dominating both short trades and all-in fights. Nasus should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
13,893Nasus
13,222Karthus
Nasus earns 672 more gold per game than Karthus, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Nasus slightly faster item completions.
Utility
0.6Nasus
0.7Karthus
Both Nasus and Karthus provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
2,581Nasus
847Karthus
Nasus vastly out-sustains Karthus, healing and mitigating 1,734 more damage per minute. This massive durability gap means Nasus can absorb significant punishment and remain in lane while Karthus is forced to recall. Building grievous wounds early is essential for Karthus, and focusing on burst trade patterns rather than sustained fights is critical.

Best Nasus Build Against Karthus

Mercury's Treads is the optimal boots choice against Karthus, providing the mobility and stats Nasus needs most in this matchup. The top-performing core items for Nasus against Karthus are Frozen Heart, Trinity Force and Thornmail. This combination gives Nasus an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Karthus. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Nasus vs Karthus matchup.

Early Game vs Late Game

Early Game
Nasus
50.0%
+0.0% advantage
Nasus early game win rateNasus50.0%
Karthus early game win rateKarthus50.0%
Late Game
Nasus
83.3%
+66.7% advantage
Nasus late game win rateNasus83.3%
Karthus late game win rateKarthus16.7%

The early game (first 15 minutes) is a toss-up between Nasus and Karthus, with Nasus holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Nasus is far superior in the late game (25+ minutes), boasting a 83.3% win rate — 66.7 points above Karthus. Extended games heavily favor Nasus, whose kit and scaling make them a dominant force in team fights and objective control.

Nasus holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Karthus players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Nasus Runes Against Karthus

Resolve rune tree - Nasus primary runes vs KarthusResolve
Grasp of the Undying - best Nasus rune vs KarthusDemolish - best Nasus rune vs KarthusBone Plating - best Nasus rune vs KarthusOvergrowth - best Nasus rune vs Karthus
Precision rune tree - Nasus secondary runes vs KarthusPrecision
Last Stand - best Nasus rune vs KarthusLegend: Haste - best Nasus rune vs Karthus
100.0% WR

Running Resolve primary with Precision secondary allows Nasus to press their advantage against Karthus, amplifying the strengths that make this a favorable matchup.


Nasus matchup data for League of Legends patch 26.11. The table below shows Nasus's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Nasus build, runes, laning stats, and early vs late game analysis for that specific matchup.

Nasus matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
45.83%2166.371911,29038.5%51.2%
40.11%1825.964211,61746.4%36.3%
57.76%1615.875411,79154.8%59.6%
48.18%1376.085111,61552.6%45.0%
53.33%1355.770911,46456.4%51.3%
48.06%1296.471912,08350.0%46.8%
48.00%1256.472511,58250.9%45.8%
49.14%1166.170711,74940.8%55.2%
45.10%1026.582511,87636.8%50.0%
43.16%955.776810,82236.2%50.0%
48.39%935.172811,18942.9%52.9%
45.98%876.482311,80741.0%50.0%
48.24%855.776211,93455.2%44.6%
38.55%835.978911,12136.1%40.4%
53.09%816.11,12811,53845.2%61.5%
48.65%742.669711,51847.2%50.0%
54.79%736.583711,92661.5%51.1%
54.29%707.181012,80736.7%67.5%
42.03%696.262310,95945.5%38.9%
36.92%656.477711,16555.6%23.7%
49.23%655.576211,50350.0%48.6%
50.77%652.072512,62550.0%51.1%
41.54%655.986912,54530.8%48.7%
64.62%656.778813,30575.0%58.5%
55.56%636.575011,42856.7%54.5%
56.45%626.370412,24847.8%61.5%
54.24%596.572211,84256.5%52.8%
55.17%583.781612,24866.7%42.9%
51.79%566.166111,06848.1%55.2%
52.73%556.578113,08070.0%42.9%
59.26%543.377512,12864.0%55.2%
55.56%546.072412,31855.0%55.9%
44.44%545.578110,45140.0%48.3%
53.70%542.370712,30538.1%63.6%
54.72%536.366512,45852.9%55.6%
48.08%526.163611,71051.9%44.0%
66.67%512.176713,43763.6%69.0%
35.42%485.680310,25431.8%38.5%
45.83%485.477610,58744.0%47.8%
48.94%476.580712,31242.1%53.6%
67.44%431.477212,94270.6%65.4%
59.52%426.477612,34952.9%64.0%
52.38%421.163412,53350.0%53.3%
59.52%423.966412,61560.0%59.3%
31.71%415.388612,13642.9%25.9%
51.22%416.073211,68762.5%44.0%
52.50%402.379912,92141.2%60.9%
50.00%401.870612,59650.0%50.0%
61.54%395.873012,35766.7%59.3%
61.54%396.271011,31247.6%77.8%
63.64%336.172813,15360.0%65.2%
56.25%324.171713,26554.5%57.1%
58.06%313.778911,79243.8%73.3%
53.33%303.765012,29442.9%62.5%
58.62%296.677210,66941.7%70.6%
50.00%281.974913,92257.1%47.6%
46.43%286.681210,95661.5%33.3%
77.78%276.081112,165100.0%64.7%
51.85%271.675513,24550.0%52.6%
53.85%261.977212,45750.0%57.1%
50.00%246.870711,74272.7%30.8%
52.17%233.574112,32541.7%63.6%
65.22%234.885312,35845.5%83.3%
59.09%226.468212,36150.0%64.3%
63.64%226.868110,18566.7%60.0%
47.62%216.575311,16955.6%41.7%
40.00%205.664011,22750.0%30.0%
40.00%202.066912,70242.9%38.5%
30.00%201.277412,34618.2%44.4%
42.11%192.566611,06550.0%33.3%
50.00%182.182112,97837.5%60.0%
50.00%186.78299,71750.0%50.0%
55.56%183.280011,99450.0%60.0%
23.53%176.161411,48122.2%25.0%
64.71%171.981713,17550.0%72.7%
25.00%161.972713,55750.0%10.0%
37.50%167.277513,20262.5%12.5%
56.25%162.972913,07950.0%60.0%
31.25%161.671212,10014.3%44.4%
50.00%166.773311,32140.0%54.5%
50.00%165.969113,52366.7%40.0%
43.75%166.692810,35733.3%57.1%
46.67%155.762712,59450.0%44.4%
46.67%154.91,02312,14066.7%33.3%
46.67%151.978312,81733.3%55.6%
66.67%155.387414,64033.3%88.9%
57.14%146.664812,21857.1%57.1%
50.00%141.168111,34242.9%57.1%
50.00%142.759910,57044.4%60.0%
35.71%141.860811,85633.3%40.0%
53.85%136.369711,11742.9%66.7%
61.54%135.971612,30450.0%71.4%
41.67%126.182610,28442.9%40.0%
58.33%124.41,04013,86966.7%55.6%
63.64%116.060613,05366.7%60.0%
60.00%105.773710,57340.0%80.0%
55.56%96.765413,240100.0%42.9%
44.44%94.363811,39433.3%50.0%
55.56%96.774110,79660.0%50.0%
66.67%95.571313,79666.7%66.7%
44.44%95.171812,98066.7%33.3%
50.00%83.04439,95666.7%40.0%
50.00%85.880611,35460.0%33.3%
25.00%86.261110,0510.0%40.0%
25.00%86.555711,10733.3%20.0%
75.00%81.280913,89350.0%83.3%
14.29%76.34829,3850.0%33.3%
28.57%72.966711,98666.7%0.0%
28.57%70.84378,99420.0%50.0%
42.86%71.157511,481100.0%20.0%
66.67%61.686914,6380.0%66.7%
66.67%67.388012,43750.0%75.0%
0.00%63.261210,3180.0%0.0%
50.00%66.175813,39333.3%66.7%
50.00%66.782311,08333.3%66.7%
40.00%54.777212,76750.0%33.3%
40.00%54.365113,4990.0%66.7%
20.00%55.861212,870100.0%0.0%
80.00%56.376814,17166.7%100.0%
40.00%52.663512,3990.0%66.7%
60.00%55.26417,98766.7%50.0%

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Nasus vs Karthus - Frequently Asked Questions

How does Nasus do against Karthus in League of Legends?

Nasus wins the Nasus vs Karthus matchup with a 75.0% win rate compared to Karthus's 25.0%, a 50.0 percentage point difference. This data is based on 8 recent ranked games in patch 26.11.

How does Nasus do against Karthus in the early game?

In the early game, Nasus has the advantage against Karthus with a 50.0% win rate versus 50.0%. Nasus players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Nasus do against Karthus in the late game?

In the late game, Nasus takes over the Nasus vs Karthus matchup with a 83.3% win rate compared to 16.7%. Nasus scales better into team fights and objective contests after 25 minutes.

Who wins the Nasus vs Karthus matchup?

Nasus wins the matchup against Karthus with a 75.0% win rate in League of Legends patch 26.11. The 50.0 percentage point advantage means Nasus is significantly favored in this lane matchup based on 8 games analyzed.

What is the best Nasus build against Karthus?

The best Nasus build against Karthus includes Frozen Heart, Trinity Force, Thornmail with Mercury's Treads. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Nasus runes against Karthus?

The best Nasus runes against Karthus use the Resolve primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Nasus vs Karthus matchup. See the full rune breakdown in the matchup comparison above.

Does Nasus counter Karthus?

Yes, Nasus has a favorable matchup against Karthus with a 75.0% win rate. Nasus strongly counters Karthus in lane based on current patch 26.11 data.

How do I play Nasus against Karthus?

When playing Nasus against Karthus, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.