Nasus - League of Legends Champion
Win Rate
50.3%
Pick Rate
4.1%

Nasusvs Karthus

BFighterTank
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 21, 2026
MethodologyData Methodology

Nasus vs Karthus is a decisive matchup in LoL patch 26.7. Nasus wins with a 57.1% win rate (+14.3%) over Karthus based on 7 games. Karthus wins the early laning phase while Nasus scales better into the late game. Below you'll find the best Nasus build, runes, laning stats, and strategies for the Nasus vs Karthus matchup.

Nasus Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Nasus performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Karthus - 57.1% win rateKarthus(57.1%)
Nasus - 57.1% win rate in this matchup
Nasus
57.1% WR
VS
Karthus vs Nasus matchup - 42.9% win rate
Karthus
42.9% WR

Who Wins the Nasus vs Karthus Matchup?

Nasus wins the Nasus vs Karthus matchup
Winner
Nasus
Matches: 7
57.1%
Win Rate
42.9%
2.0
CS / min
2.2
615
DMG / min
1,172
10,787
Gold / game
11,380
846
Heal / min
278
1,815
DMG Mitigated / min
549
0.6
CC / min
0.6
40.0%
Early Game WR
60.0%
100.0%
Late Game WR
0.0%

Nasus vs Karthus Matchup Summary

The Nasus vs Karthus matchup is a decisive matchup in League of Legends ranked play. Based on 7 recent matches analyzed, Nasus wins with a 57.1% win rate compared to Karthus's 42.9%, giving Nasus a 14.3 percentage point advantage. Game phase dynamics play a critical role here: Karthus controls the early laning stage, but Nasus outscales as the game goes longer. The matchup shifts dramatically depending on game length — Karthus needs to press advantages before Nasus reaches their power spikes, while Nasus should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Nasus leads by 1,834 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Nasus players can confidently pick into Karthus and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Karthus away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Nasus vs Karthus Laning Phase Breakdown

Karthus wins the laning phase against Nasus in League of Legends

Karthus is favored during the laning phase against Nasus, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
2.0Nasus
2.2Karthus
Nasus and Karthus farm at nearly identical rates in this matchup, with only a 0.2 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
615Nasus
1,172Karthus
Karthus heavily out-damages Nasus by 557 DMG/min, dominating both short trades and all-in fights. Nasus should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
10,787Nasus
11,380Karthus
Karthus earns 593 more gold per game than Nasus, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Karthus slightly faster item completions.
Utility
0.6Nasus
0.6Karthus
Both Nasus and Karthus provide similar amounts of crowd control (0.0s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
2,661Nasus
827Karthus
Nasus vastly out-sustains Karthus, healing and mitigating 1,834 more damage per minute. This massive durability gap means Nasus can absorb significant punishment and remain in lane while Karthus is forced to recall. Building grievous wounds early is essential for Karthus, and focusing on burst trade patterns rather than sustained fights is critical.

Best Nasus Build Against Karthus

Boots of Swiftness is the optimal boots choice against Karthus, providing the mobility and stats Nasus needs most in this matchup. The top-performing core items for Nasus against Karthus are Jak'Sho, The Protean, Trinity Force and Thornmail. This combination gives Nasus an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Karthus. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Nasus vs Karthus matchup.

Early Game vs Late Game

Early Game
Karthus
60.0%
+20.0% advantage
Nasus early game win rateNasus40.0%
Karthus early game win rateKarthus60.0%
Late Game
Nasus
100.0%
+100.0% advantage
Nasus late game win rateNasus100.0%
Karthus late game win rateKarthus0.0%

Karthus dominates the early game (first 15 minutes) with a commanding 60.0% win rate — a 20.0 percentage point lead over Nasus. This lopsided early game means Karthus can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Nasus is far superior in the late game (25+ minutes), boasting a 100.0% win rate — 100.0 points above Karthus. Extended games heavily favor Nasus, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Karthus must aggressively press their early advantage and close out the game before Nasus reaches their scaling breakpoints. If Nasus survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Nasus Runes Against Karthus

Precision rune tree - Nasus primary runes vs KarthusPrecision
Fleet Footwork - best Nasus rune vs KarthusTriumph - best Nasus rune vs KarthusLegend: Haste - best Nasus rune vs KarthusLast Stand - best Nasus rune vs Karthus
Resolve rune tree - Nasus secondary runes vs KarthusResolve
Bone Plating - best Nasus rune vs KarthusUnflinching - best Nasus rune vs Karthus
100.0% WR

Running Precision primary with Resolve secondary allows Nasus to press their advantage against Karthus, amplifying the strengths that make this a favorable matchup.


Nasus matchup data for League of Legends patch 26.7. The table below shows Nasus's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Nasus build, runes, laning stats, and early vs late game analysis for that specific matchup.

Nasus matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
45.95%2226.775711,69047.4%44.9%
46.62%1335.876911,92947.1%46.3%
42.61%1155.574111,11347.1%39.1%
51.38%1095.01,04810,82149.2%54.5%
55.77%1046.580712,50646.8%63.2%
46.53%1012.777312,63044.7%48.1%
51.22%836.268212,39955.9%47.9%
41.98%811.372711,96642.5%41.5%
48.15%816.273012,02138.2%55.3%
50.00%805.978611,20439.4%57.5%
50.67%756.180011,80863.6%40.5%
52.70%747.074012,64860.0%46.1%
50.00%724.578311,88136.4%61.5%
45.83%725.575312,26946.4%45.5%
50.00%706.083312,84642.3%54.5%
46.38%694.770211,75041.7%51.5%
39.71%682.366611,47846.0%32.3%
62.12%666.578212,20353.6%68.4%
59.38%646.080411,85653.6%63.9%
47.37%576.371311,07456.7%37.0%
52.63%575.170010,41645.7%63.6%
54.39%571.972711,42359.3%50.0%
60.71%562.185513,46856.5%63.6%
50.91%556.485511,64334.8%62.5%
56.36%551.670412,27246.9%69.6%
35.19%546.265011,68636.4%34.4%
55.56%546.473011,68554.2%56.7%
59.26%545.781011,87162.1%56.0%
49.02%515.896412,40651.7%45.5%
41.67%486.378211,37928.0%56.5%
52.08%486.266211,08144.8%63.2%
58.33%486.578911,58661.5%54.5%
61.70%471.473812,64454.2%69.6%
40.43%477.286511,76939.1%41.7%
50.00%466.886611,79262.5%36.4%
60.87%464.773212,89550.0%66.7%
47.83%466.291812,95750.0%46.7%
56.82%446.175512,18068.8%50.0%
48.84%432.280813,17661.1%40.0%
39.02%416.469311,17942.9%35.0%
50.00%405.782611,35744.4%54.5%
51.28%395.574311,31447.8%56.3%
55.26%381.470612,24538.9%70.0%
54.05%372.668912,93835.0%76.5%
44.12%341.675613,86942.9%45.0%
51.52%334.670412,38453.9%50.0%
63.64%332.470312,67372.2%53.3%
59.38%326.580612,72336.4%71.4%
51.61%313.577712,11362.5%40.0%
56.67%302.679411,97555.6%58.3%
58.62%296.373812,42950.0%63.2%
55.17%296.361310,50158.8%50.0%
51.85%272.175011,75642.9%61.5%
57.69%266.168110,85960.0%54.5%
42.31%261.864112,02523.1%61.5%
42.31%265.872810,50540.0%45.5%
30.77%261.972111,64245.5%20.0%
75.00%245.973911,79076.9%72.7%
79.17%242.180113,21191.7%66.7%
29.17%245.675611,85037.5%25.0%
65.22%235.885712,89128.6%81.3%
72.73%227.16059,72960.0%100.0%
45.45%223.371412,68922.2%61.5%
42.86%217.366811,33430.0%54.5%
60.00%202.382813,27050.0%66.7%
25.00%206.874312,05928.6%23.1%
65.00%201.776614,37557.1%69.2%
65.00%201.170312,78444.4%81.8%
78.95%191.370712,544100.0%60.0%
47.37%196.481610,88440.0%55.6%
52.63%196.174411,30160.0%44.4%
50.00%185.272713,33228.6%63.6%
50.00%184.576811,99050.0%50.0%
47.06%173.786512,60244.4%50.0%
52.94%172.686514,93050.0%53.9%
56.25%165.869011,79277.8%28.6%
81.25%166.689013,13657.1%100.0%
50.00%161.569313,31940.0%66.7%
53.33%152.479313,82725.0%63.6%
53.33%155.866511,86266.7%44.4%
60.00%156.870913,76760.0%60.0%
53.33%157.178112,33857.1%50.0%
53.33%155.674011,44557.1%50.0%
80.00%154.767811,48185.7%75.0%
46.67%151.171713,79862.5%28.6%
60.00%151.074812,47140.0%70.0%
64.29%144.568013,12862.5%66.7%
57.14%146.872512,81683.3%37.5%
64.29%146.755510,83871.4%57.1%
38.46%136.276710,36433.3%42.9%
58.33%126.674612,53350.0%66.7%
16.67%126.960512,09320.0%14.3%
33.33%126.966411,78750.0%16.7%
50.00%126.378212,28562.5%25.0%
54.55%116.36849,73957.1%50.0%
54.55%116.796912,10271.4%25.0%
72.73%113.574111,21480.0%66.7%
40.00%101.973311,72940.0%40.0%
50.00%104.45278,07050.0%50.0%
40.00%104.561410,98160.0%20.0%
66.67%91.249910,11450.0%80.0%
66.67%97.168212,27471.4%50.0%
77.78%92.31,13115,150100.0%66.7%
66.67%98.067812,98860.0%75.0%
22.22%91.064411,0110.0%50.0%
55.56%95.960711,51966.7%50.0%
55.56%96.874812,38666.7%50.0%
44.44%96.868111,82825.0%60.0%
62.50%83.176412,94466.7%60.0%
25.00%86.962711,45125.0%25.0%
50.00%86.257411,95966.7%40.0%
57.14%77.479413,34766.7%50.0%
57.14%72.860110,88125.0%100.0%
57.14%71.552211,146100.0%40.0%
57.14%72.061510,78740.0%100.0%
28.57%76.464710,98866.7%0.0%
66.67%67.180911,50560.0%100.0%
20.00%56.976311,28933.3%0.0%
80.00%56.288513,53075.0%100.0%
60.00%55.950912,071100.0%33.3%
80.00%56.569814,377100.0%75.0%
60.00%56.457410,96750.0%66.7%

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Nasus vs Karthus - Frequently Asked Questions

How does Nasus do against Karthus in League of Legends?

Nasus wins the Nasus vs Karthus matchup with a 57.1% win rate compared to Karthus's 42.9%, a 14.3 percentage point difference. This data is based on 7 recent ranked games in patch 26.7.

How does Nasus do against Karthus in the early game?

In the early game, Karthus has the advantage against Nasus with a 60.0% win rate versus 40.0%. Karthus players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Nasus do against Karthus in the late game?

In the late game, Nasus takes over the Nasus vs Karthus matchup with a 100.0% win rate compared to 0.0%. Nasus scales better into team fights and objective contests after 25 minutes.

Who wins the Nasus vs Karthus matchup?

Nasus wins the matchup against Karthus with a 57.1% win rate in League of Legends patch 26.7. The 14.3 percentage point advantage means Nasus is significantly favored in this lane matchup based on 7 games analyzed.

What is the best Nasus build against Karthus?

The best Nasus build against Karthus includes Jak'Sho, The Protean, Trinity Force, Thornmail with Boots of Swiftness. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Nasus runes against Karthus?

The best Nasus runes against Karthus use the Precision primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Nasus vs Karthus matchup. See the full rune breakdown in the matchup comparison above.

Does Nasus counter Karthus?

Yes, Nasus has a favorable matchup against Karthus with a 57.1% win rate. Nasus strongly counters Karthus in lane based on current patch 26.7 data.

How do I play Nasus against Karthus?

When playing Nasus against Karthus, leverage your statistical advantages by trading aggressively during favorable windows. Play safe early and scale into your power spikes where you outperform Karthus. Build the recommended items and runes for this specific matchup for the best results.