Nasus - League of Legends Champion
Win Rate
50.3%
Pick Rate
4.1%

Nasusvs Vayne

BFighterTank
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 21, 2026
MethodologyData Methodology

Nasus vs Vayne is a decisive matchup in LoL patch 26.7. Nasus wins with a 56.8% win rate (+13.6%) over Vayne based on 44 games. Nasus holds the advantage in both the early and late game. Below you'll find the best Nasus build, runes, laning stats, and strategies for the Nasus vs Vayne matchup.

Nasus Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Nasus performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 56.8% win rateVayne(56.8%)
Nasus - 56.8% win rate in this matchup
Nasus
56.8% WR
VS
Vayne vs Nasus matchup - 43.2% win rate
Vayne
43.2% WR

Who Wins the Nasus vs Vayne Matchup?

Nasus wins the Nasus vs Vayne matchup
Winner
Nasus
Matches: 44
56.8%
Win Rate
43.2%
6.1
CS / min
5.7
755
DMG / min
996
12,180
Gold / game
11,548
540
Heal / min
261
1,602
DMG Mitigated / min
549
0.7
CC / min
0.4
68.8%
Early Game WR
31.3%
50.0%
Late Game WR
50.0%

Nasus vs Vayne Matchup Summary

The Nasus vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 44 recent matches analyzed, Nasus wins with a 56.8% win rate compared to Vayne's 43.2%, giving Nasus a 13.6 percentage point advantage. Nasus dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Vayne players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Nasus leads by 1,333 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Nasus players can confidently pick into Vayne and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Vayne away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Nasus vs Vayne Laning Phase Breakdown

Nasus wins the laning phase against Vayne in League of Legends

Nasus is favored during the laning phase against Vayne, winning 4 out of 5 key stat categories. Nasus holds advantages in farming, gold income, crowd control and sustain, making them the stronger laner in this matchup.

Farming
6.1Nasus
5.7Vayne
Nasus edges out Vayne by 0.3 CS per minute — a moderate farming advantage that adds up to roughly 5 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Nasus.
Damage
755Nasus
996Vayne
Vayne heavily out-damages Nasus by 241 DMG/min, dominating both short trades and all-in fights. Nasus should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Vayne's sustained damage advantage take over.
Economy
12,180Nasus
11,548Vayne
Nasus earns 631 more gold per game than Vayne, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Nasus slightly faster item completions.
Utility
0.7Nasus
0.4Vayne
Both Nasus and Vayne provide similar amounts of crowd control (0.3s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
2,143Nasus
810Vayne
Nasus vastly out-sustains Vayne, healing and mitigating 1,333 more damage per minute. This massive durability gap means Nasus can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Best Nasus Build Against Vayne

Ionian Boots of Lucidity is the optimal boots choice against Vayne, providing the mobility and stats Nasus needs most in this matchup. The top-performing core items for Nasus against Vayne are Frozen Heart, Trinity Force and Spirit Visage. This combination gives Nasus an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 80.0% win rate across 5 games — well above average and making it the top item path against Vayne. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Nasus vs Vayne matchup.

Early Game vs Late Game

Early Game
Nasus
68.8%
+37.5% advantage
Nasus early game win rateNasus68.8%
Vayne early game win rateVayne31.3%
Late Game
Nasus
50.0%
+0.0% advantage
Nasus late game win rateNasus50.0%
Vayne late game win rateVayne50.0%

Nasus dominates the early game (first 15 minutes) with a commanding 68.8% win rate — a 37.5 percentage point lead over Vayne. This lopsided early game means Nasus can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Nasus at 50.0% win rate — only 0.0 points ahead of Vayne. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

Nasus holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Vayne players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Nasus Runes Against Vayne

Resolve rune tree - Nasus primary runes vs VayneResolve
Grasp of the Undying - best Nasus rune vs VayneDemolish - best Nasus rune vs VayneSecond Wind - best Nasus rune vs VayneOvergrowth - best Nasus rune vs Vayne
Precision rune tree - Nasus secondary runes vs VaynePrecision
Legend: Haste - best Nasus rune vs VayneLast Stand - best Nasus rune vs Vayne
100.0% WR

Running Resolve primary with Precision secondary allows Nasus to press their advantage against Vayne, amplifying the strengths that make this a favorable matchup.


Nasus matchup data for League of Legends patch 26.7. The table below shows Nasus's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Nasus build, runes, laning stats, and early vs late game analysis for that specific matchup.

Nasus matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
45.95%2226.775711,69047.4%44.9%
46.62%1335.876911,92947.1%46.3%
42.61%1155.574111,11347.1%39.1%
51.38%1095.01,04810,82149.2%54.5%
55.77%1046.580712,50646.8%63.2%
46.53%1012.777312,63044.7%48.1%
51.22%836.268212,39955.9%47.9%
41.98%811.372711,96642.5%41.5%
48.15%816.273012,02138.2%55.3%
50.00%805.978611,20439.4%57.5%
50.67%756.180011,80863.6%40.5%
52.70%747.074012,64860.0%46.1%
50.00%724.578311,88136.4%61.5%
45.83%725.575312,26946.4%45.5%
50.00%706.083312,84642.3%54.5%
46.38%694.770211,75041.7%51.5%
39.71%682.366611,47846.0%32.3%
62.12%666.578212,20353.6%68.4%
59.38%646.080411,85653.6%63.9%
47.37%576.371311,07456.7%37.0%
52.63%575.170010,41645.7%63.6%
54.39%571.972711,42359.3%50.0%
60.71%562.185513,46856.5%63.6%
50.91%556.485511,64334.8%62.5%
56.36%551.670412,27246.9%69.6%
35.19%546.265011,68636.4%34.4%
55.56%546.473011,68554.2%56.7%
59.26%545.781011,87162.1%56.0%
49.02%515.896412,40651.7%45.5%
41.67%486.378211,37928.0%56.5%
52.08%486.266211,08144.8%63.2%
58.33%486.578911,58661.5%54.5%
61.70%471.473812,64454.2%69.6%
40.43%477.286511,76939.1%41.7%
50.00%466.886611,79262.5%36.4%
60.87%464.773212,89550.0%66.7%
47.83%466.291812,95750.0%46.7%
56.82%446.175512,18068.8%50.0%
48.84%432.280813,17661.1%40.0%
39.02%416.469311,17942.9%35.0%
50.00%405.782611,35744.4%54.5%
51.28%395.574311,31447.8%56.3%
55.26%381.470612,24538.9%70.0%
54.05%372.668912,93835.0%76.5%
44.12%341.675613,86942.9%45.0%
51.52%334.670412,38453.9%50.0%
63.64%332.470312,67372.2%53.3%
59.38%326.580612,72336.4%71.4%
51.61%313.577712,11362.5%40.0%
56.67%302.679411,97555.6%58.3%
58.62%296.373812,42950.0%63.2%
55.17%296.361310,50158.8%50.0%
51.85%272.175011,75642.9%61.5%
57.69%266.168110,85960.0%54.5%
42.31%261.864112,02523.1%61.5%
42.31%265.872810,50540.0%45.5%
30.77%261.972111,64245.5%20.0%
75.00%245.973911,79076.9%72.7%
79.17%242.180113,21191.7%66.7%
29.17%245.675611,85037.5%25.0%
65.22%235.885712,89128.6%81.3%
72.73%227.16059,72960.0%100.0%
45.45%223.371412,68922.2%61.5%
42.86%217.366811,33430.0%54.5%
60.00%202.382813,27050.0%66.7%
25.00%206.874312,05928.6%23.1%
65.00%201.776614,37557.1%69.2%
65.00%201.170312,78444.4%81.8%
78.95%191.370712,544100.0%60.0%
47.37%196.481610,88440.0%55.6%
52.63%196.174411,30160.0%44.4%
50.00%185.272713,33228.6%63.6%
50.00%184.576811,99050.0%50.0%
47.06%173.786512,60244.4%50.0%
52.94%172.686514,93050.0%53.9%
56.25%165.869011,79277.8%28.6%
81.25%166.689013,13657.1%100.0%
50.00%161.569313,31940.0%66.7%
53.33%152.479313,82725.0%63.6%
53.33%155.866511,86266.7%44.4%
60.00%156.870913,76760.0%60.0%
53.33%157.178112,33857.1%50.0%
53.33%155.674011,44557.1%50.0%
80.00%154.767811,48185.7%75.0%
46.67%151.171713,79862.5%28.6%
60.00%151.074812,47140.0%70.0%
64.29%144.568013,12862.5%66.7%
57.14%146.872512,81683.3%37.5%
64.29%146.755510,83871.4%57.1%
38.46%136.276710,36433.3%42.9%
58.33%126.674612,53350.0%66.7%
16.67%126.960512,09320.0%14.3%
33.33%126.966411,78750.0%16.7%
50.00%126.378212,28562.5%25.0%
54.55%116.36849,73957.1%50.0%
54.55%116.796912,10271.4%25.0%
72.73%113.574111,21480.0%66.7%
40.00%101.973311,72940.0%40.0%
50.00%104.45278,07050.0%50.0%
40.00%104.561410,98160.0%20.0%
66.67%91.249910,11450.0%80.0%
66.67%97.168212,27471.4%50.0%
77.78%92.31,13115,150100.0%66.7%
66.67%98.067812,98860.0%75.0%
22.22%91.064411,0110.0%50.0%
55.56%95.960711,51966.7%50.0%
55.56%96.874812,38666.7%50.0%
44.44%96.868111,82825.0%60.0%
62.50%83.176412,94466.7%60.0%
25.00%86.962711,45125.0%25.0%
50.00%86.257411,95966.7%40.0%
57.14%77.479413,34766.7%50.0%
57.14%72.860110,88125.0%100.0%
57.14%71.552211,146100.0%40.0%
57.14%72.061510,78740.0%100.0%
28.57%76.464710,98866.7%0.0%
66.67%67.180911,50560.0%100.0%
20.00%56.976311,28933.3%0.0%
80.00%56.288513,53075.0%100.0%
60.00%55.950912,071100.0%33.3%
80.00%56.569814,377100.0%75.0%
60.00%56.457410,96750.0%66.7%

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Nasus vs Vayne - Frequently Asked Questions

How does Nasus do against Vayne in League of Legends?

Nasus wins the Nasus vs Vayne matchup with a 56.8% win rate compared to Vayne's 43.2%, a 13.6 percentage point difference. This data is based on 44 recent ranked games in patch 26.7.

How does Nasus do against Vayne in the early game?

In the early game, Nasus has the advantage against Vayne with a 68.8% win rate versus 31.3%. Nasus players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Nasus do against Vayne in the late game?

In the late game, Nasus takes over the Nasus vs Vayne matchup with a 50.0% win rate compared to 50.0%. Nasus scales better into team fights and objective contests after 25 minutes.

Who wins the Nasus vs Vayne matchup?

Nasus wins the matchup against Vayne with a 56.8% win rate in League of Legends patch 26.7. The 13.6 percentage point advantage means Nasus is significantly favored in this lane matchup based on 44 games analyzed.

What is the best Nasus build against Vayne?

The best Nasus build against Vayne includes Frozen Heart, Trinity Force, Spirit Visage with Ionian Boots of Lucidity. This build achieves a 80.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Nasus runes against Vayne?

The best Nasus runes against Vayne use the Resolve primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Nasus vs Vayne matchup. See the full rune breakdown in the matchup comparison above.

Does Nasus counter Vayne?

Yes, Nasus has a favorable matchup against Vayne with a 56.8% win rate. Nasus strongly counters Vayne in lane based on current patch 26.7 data.

How do I play Nasus against Vayne?

When playing Nasus against Vayne, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.