Ryze - League of Legends Champion
Win Rate
51.3%
Pick Rate
1.4%

Ryzevs Karthus

AMage
Patch26.10
Matches1,492,117
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 20, 2026
MethodologyData Methodology

Ryze vs Karthus is a decisive matchup in LoL patch 26.10. Ryze wins with a 60.0% win rate (+20.0%) over Karthus based on 5 games. Ryze holds the advantage in both the early and late game. Below you'll find the best Ryze build, runes, laning stats, and strategies for the Ryze vs Karthus matchup.

Ryze Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Ryze performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Karthus - 60.0% win rateKarthus(60.0%)
Ryze - 60.0% win rate in this matchup
Ryze
60.0% WR
VS
Karthus vs Ryze matchup - 40.0% win rate
Karthus
40.0% WR

Who Wins the Ryze vs Karthus Matchup?

Ryze wins the Ryze vs Karthus matchup
Winner
Ryze
Matches: 5
60.0%
Win Rate
40.0%
7.5
CS / min
7.0
827
DMG / min
1,053
14,015
Gold / game
13,515
216
Heal / min
89
534
DMG Mitigated / min
403
0.7
CC / min
0.5
100.0%
Early Game WR
0.0%
50.0%
Late Game WR
50.0%

Ryze vs Karthus Matchup Summary

The Ryze vs Karthus matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Ryze wins with a 60.0% win rate compared to Karthus's 40.0%, giving Ryze a 20.0 percentage point advantage. Ryze dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Karthus players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Ryze leads by 259 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Ryze players can confidently pick into Karthus and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Karthus away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Ryze vs Karthus Laning Phase Breakdown

Ryze wins the laning phase against Karthus in League of Legends

Ryze is favored during the laning phase against Karthus, winning 4 out of 5 key stat categories. Ryze holds advantages in farming, gold income, crowd control and sustain, making them the stronger laner in this matchup.

Farming
7.5Ryze
7.0Karthus
Ryze edges out Karthus by 0.5 CS per minute — a moderate farming advantage that adds up to roughly 7 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Ryze.
Damage
827Ryze
1,053Karthus
Karthus heavily out-damages Ryze by 226 DMG/min, dominating both short trades and all-in fights. Ryze should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
14,015Ryze
13,515Karthus
Ryze earns 500 more gold per game than Karthus, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Ryze slightly faster item completions.
Utility
0.7Ryze
0.5Karthus
Both Ryze and Karthus provide similar amounts of crowd control (0.2s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
750Ryze
492Karthus
Ryze vastly out-sustains Karthus, healing and mitigating 259 more damage per minute. This massive durability gap means Ryze can absorb significant punishment and remain in lane while Karthus is forced to recall. Building grievous wounds early is essential for Karthus, and focusing on burst trade patterns rather than sustained fights is critical.

Best Ryze Build Against Karthus

Immortal Path is the optimal boots choice against Karthus, providing the mobility and stats Ryze needs most in this matchup. The top-performing core items for Ryze against Karthus are Frozen Heart, Rabadon's Deathcap and Seraph's Embrace. This combination gives Ryze an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Ryze vs Karthus matchup.

Early Game vs Late Game

Early Game
Ryze
100.0%
+100.0% advantage
Ryze early game win rateRyze100.0%
Karthus early game win rateKarthus0.0%
Late Game
Ryze
50.0%
+0.0% advantage
Ryze late game win rateRyze50.0%
Karthus late game win rateKarthus50.0%

Ryze dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Karthus. This lopsided early game means Ryze can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Ryze at 50.0% win rate — only 0.0 points ahead of Karthus. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

Ryze holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Karthus players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Ryze Runes Against Karthus

Sorcery rune tree - Ryze primary runes vs KarthusSorcery
Deathfire Touch - best Ryze rune vs KarthusManaflow Band - best Ryze rune vs KarthusCelerity - best Ryze rune vs KarthusScorch - best Ryze rune vs Karthus
Resolve rune tree - Ryze secondary runes vs KarthusResolve
Overgrowth - best Ryze rune vs KarthusBone Plating - best Ryze rune vs Karthus
100.0% WR

Running Sorcery primary with Resolve secondary allows Ryze to press their advantage against Karthus, amplifying the strengths that make this a favorable matchup.


Ryze matchup data for League of Legends patch 26.10. The table below shows Ryze's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Ryze build, runes, laning stats, and early vs late game analysis for that specific matchup.

Ryze matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
43.33%1207.586912,17852.1%37.5%
49.52%1057.174612,01946.5%51.6%
53.19%946.987411,84348.8%56.9%
58.70%927.190111,29664.3%54.0%
46.59%886.892811,26035.9%55.1%
45.12%827.181910,97941.9%48.7%
62.34%777.088411,94351.5%70.5%
57.89%766.888011,73257.1%58.5%
50.72%697.284612,22148.3%52.5%
64.62%657.31,06811,83354.8%73.5%
41.67%607.080011,66548.4%34.5%
43.10%587.11,00912,79950.0%36.7%
56.90%587.290512,51546.1%65.6%
41.82%557.077411,07337.0%46.4%
43.14%517.283711,98741.7%44.4%
45.65%467.489812,61744.4%46.4%
39.53%436.979911,27940.9%38.1%
42.50%407.584711,91952.4%31.6%
46.15%397.799612,23338.9%52.4%
56.41%397.493912,08961.9%50.0%
47.37%387.374711,60444.4%50.0%
48.65%377.388810,95952.9%45.0%
55.56%367.31,01913,76266.7%50.0%
60.00%357.276411,37064.3%57.1%
48.57%356.888911,69236.4%54.2%
51.43%357.582912,80053.9%50.0%
45.71%357.380512,56527.3%54.2%
47.06%346.989511,75229.4%64.7%
47.06%347.278511,02852.9%41.2%
54.55%337.192311,69961.5%50.0%
53.13%326.61,05112,42856.3%50.0%
37.50%327.495412,89346.1%31.6%
28.13%327.179811,54120.0%35.3%
40.00%306.778911,80140.0%40.0%
53.85%267.796912,62944.4%58.8%
57.69%267.290313,69655.6%58.8%
44.00%257.195712,91844.4%43.8%
47.83%236.680112,55762.5%40.0%
45.45%227.282412,52555.6%38.5%
31.82%227.691612,80237.5%28.6%
50.00%207.388711,53550.0%50.0%
50.00%207.586012,48850.0%50.0%
70.00%207.191213,36477.8%63.6%
45.00%207.480610,91345.5%44.4%
42.11%197.691010,92445.5%37.5%
61.11%187.01,00312,38857.1%63.6%
56.25%167.183512,09255.6%57.1%
50.00%167.56767,92261.5%0.0%
56.25%166.284312,57480.0%45.5%
53.33%157.21,07713,43240.0%60.0%
46.67%157.198611,74955.6%33.3%
64.29%148.41,07814,152100.0%37.5%
50.00%147.61,04413,01142.9%57.1%
50.00%147.889612,80050.0%50.0%
46.15%137.479210,84950.0%42.9%
38.46%137.61,09011,9100.0%55.6%
53.85%136.576010,04033.3%71.4%
46.15%137.11,24411,32250.0%42.9%
50.00%126.973212,10566.7%44.4%
58.33%127.287311,67557.1%60.0%
36.36%116.381211,65833.3%40.0%
36.36%117.61,00114,79060.0%16.7%
54.55%116.81,20211,46360.0%50.0%
27.27%117.576212,9210.0%33.3%
40.00%107.01,03112,5080.0%57.1%
60.00%106.71,09810,74840.0%80.0%
60.00%106.71,15913,929100.0%42.9%
33.33%96.676911,2450.0%50.0%
22.22%96.382311,2160.0%33.3%
33.33%97.282411,14550.0%20.0%
44.44%96.784610,73960.0%25.0%
55.56%97.475910,49650.0%66.7%
75.00%87.41,06913,3650.0%85.7%
62.50%87.485810,05860.0%66.7%
37.50%87.697313,48950.0%33.3%
62.50%87.282312,554100.0%50.0%
50.00%87.91,19312,63350.0%50.0%
62.50%86.884611,15833.3%80.0%
75.00%86.491513,274100.0%60.0%
62.50%87.399713,730100.0%50.0%
37.50%87.01,08912,17350.0%33.3%
42.86%78.067912,58750.0%40.0%
57.14%76.41,01912,01733.3%75.0%
42.86%77.782810,24750.0%0.0%
42.86%77.562712,08866.7%25.0%
42.86%76.682713,6680.0%75.0%
28.57%77.074111,1970.0%50.0%
57.14%77.591013,847100.0%40.0%
33.33%66.565410,97150.0%25.0%
33.33%66.986710,58650.0%0.0%
33.33%67.588013,20750.0%25.0%
50.00%65.891813,6680.0%60.0%
33.33%67.695014,0150.0%33.3%
50.00%68.31,06610,9990.0%100.0%
80.00%56.074710,82266.7%100.0%
60.00%57.15838,60533.3%100.0%
60.00%57.35239,25860.0%0.0%
20.00%57.587513,7580.0%25.0%
60.00%57.582714,015100.0%50.0%
80.00%57.21,01212,57066.7%100.0%
20.00%56.91,31715,38050.0%0.0%
60.00%57.51,09910,93166.7%50.0%

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Ryze vs Karthus - Frequently Asked Questions

How does Ryze do against Karthus in League of Legends?

Ryze wins the Ryze vs Karthus matchup with a 60.0% win rate compared to Karthus's 40.0%, a 20.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.10.

How does Ryze do against Karthus in the early game?

In the early game, Ryze has the advantage against Karthus with a 100.0% win rate versus 0.0%. Ryze players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Ryze do against Karthus in the late game?

In the late game, Ryze takes over the Ryze vs Karthus matchup with a 50.0% win rate compared to 50.0%. Ryze scales better into team fights and objective contests after 25 minutes.

Who wins the Ryze vs Karthus matchup?

Ryze wins the matchup against Karthus with a 60.0% win rate in League of Legends patch 26.10. The 20.0 percentage point advantage means Ryze is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Ryze build against Karthus?

The best Ryze build against Karthus includes Frozen Heart, Rabadon's Deathcap, Seraph's Embrace with Immortal Path. Check the matchup breakdown above for the full item path and build order.

What are the best Ryze runes against Karthus?

The best Ryze runes against Karthus use the Sorcery primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Ryze vs Karthus matchup. See the full rune breakdown in the matchup comparison above.

Does Ryze counter Karthus?

Yes, Ryze has a favorable matchup against Karthus with a 60.0% win rate. Ryze strongly counters Karthus in lane based on current patch 26.10 data.

How do I play Ryze against Karthus?

When playing Ryze against Karthus, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.