Seraphine - League of Legends Champion
Win Rate
50.9%
Pick Rate
4.9%

SeraphineRunes

ASupportMage
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 20, 2026
MethodologyData Methodology

Best Seraphine runes for LoL Patch 26.7 - Summon Aery from the Sorcery tree with Inspiration secondary (85.7% WR, 0.2% pick rate). Seraphine's optimal primary runes are Summon Aery, Manaflow Band, Transcendence, Gathering Storm. Secondary tree: Biscuit Delivery, Cosmic Insight.

Seraphine performs best with Summon Aery as the keystone rune from the Sorcery tree. Seraphine's optimal primary runes are Summon Aery, Manaflow Band, Transcendence, Gathering Storm. Seraphine's secondary rune tree is Inspiration with Biscuit Delivery, Cosmic Insight. This rune setup achieves a 85.71% win rate (+34.8% win rate difference) with a 0.2% pick rate across 21 Seraphine games.
85.7%Win Rate
+34.8%WR Diff
0.2%Pick Rate
Summon AerySummon Aery

Damaging enemy champions with basic attacks or abilities sends Aery to them, dealing 10 - 50 based on level (+0.05 AP) (+0.1 bonus AD).

Empowering or protecting allies with abilities sends Aery to them, shielding them for 30 - 100 based on level (+0.05 AP) (+0.1 bonus AD).

Aery cannot be sent out again until she returns to you.

Manaflow BandManaflow Band

Hitting an enemy champion with an ability permanently increases your maximum mana by 25, up to 250 mana.

After reaching 250 bonus mana, restore 1% of your missing mana every 5 seconds.

Cooldown: 15 seconds

TranscendenceTranscendence

Gain bonuses upon reaching the following levels:
Level 5: +5 Ability Haste
Level 8: +5 Ability Haste
Level 11: On Champion takedown, reduce the remaining cooldown of basic abilities by 20%.

Gathering StormGathering Storm

Every 10 min gain AP or AD, adaptive.

10 min: + 8 AP or 5 AD
20 min: + 24 AP or 14 AD
30 min: + 48 AP or 29 AD
40 min: + 80 AP or 48 AD
50 min: + 120 AP or 72 AD
60 min: + 168 AP or 101 AD
etc...

Biscuit DeliveryBiscuit Delivery

Biscuit Delivery: Gain a Total Biscuit of Everlasting Will every 2 mins, until 6 min.

Biscuits restore 20 + 2% of your maximum health, increased by up to 100% based on missing Health. Consuming or selling a Biscuit permanently increases your max health by 30.

Cosmic InsightCosmic Insight

+18 Summoner Spell Haste
+10 Item Haste

This alternative Seraphine rune build uses Arcane Comet as the keystone from the Sorcery tree. The primary runes are Arcane Comet, Manaflow Band, Transcendence, Scorch. Seraphine's secondary rune tree is Domination with Cheap Shot, Ultimate Hunter. This setup achieves a 80.77% win rate (+29.9% win rate difference) with a 0.3% pick rate across 26 games.
80.8%Win Rate
+29.9%WR Diff
0.3%Pick Rate
Arcane CometArcane Comet

Damaging a champion with an ability hurls a comet at their location, or, if Arcane Comet is on cooldown, reduces its remaining cooldown.

Adaptive Damage: 30 - 130 based on level (+0.05 AP and +0.1 bonus AD)
Cooldown: 20 - 8s

Cooldown Reduction:
Single Target: 20%.
Area of Effect: 10%.
Damage over Time: 5%.

Manaflow BandManaflow Band

Hitting an enemy champion with an ability permanently increases your maximum mana by 25, up to 250 mana.

After reaching 250 bonus mana, restore 1% of your missing mana every 5 seconds.

Cooldown: 15 seconds

TranscendenceTranscendence

Gain bonuses upon reaching the following levels:
Level 5: +5 Ability Haste
Level 8: +5 Ability Haste
Level 11: On Champion takedown, reduce the remaining cooldown of basic abilities by 20%.

ScorchScorch

Your next damaging ability hit sets champions on fire dealing 20 - 40 bonus magic damage based on level after 1s.

Cooldown: 10s

Cheap ShotCheap Shot

Damaging champions with impaired movement or actions deals 10 - 45 bonus true damage (based on level).

Cooldown: 4s
Activates on damage occurring after the impairment.

Ultimate HunterUltimate Hunter

Your ultimate gains 6 Ability Haste, plus an additional 5 Ability Haste per Bounty Hunter stack. Bounty Hunter stacks are earned the first time you get a takedown on each enemy champion.

These champions share at least 4 runes with Seraphine's recommended rune builds. use similar keystone and secondary runes, making them good alternatives if you enjoy Seraphine's playstyle or want to learn champions with familiar rune setups.Vel'Koz, Lissandra, Malphite, Lulu, Brand and 5 others

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Seraphine Runes - Frequently Asked Questions

What are the best Seraphine runes in patch 26.7?

The best Seraphine runes in patch 26.7 use the Sorcery tree with Summon Aery, Manaflow Band, Transcendence, and Gathering Storm, and the Inspiration tree with Biscuit Delivery and Cosmic Insight. This rune setup achieves a 85.7% win rate with a 0.2% pick rate.

What is the win rate for Seraphine's best rune page?

Seraphine's best rune page has a 85.7% win rate in patch 26.7, which is +34.8% compared to Seraphine's average win rate. This rune setup has a 0.2% pick rate among Seraphine players.

What keystone should I use on Seraphine?

Summon Aery from the Sorcery tree is the best keystone rune for Seraphine in patch 26.7. This keystone synergizes well with Seraphine's kit and provides a 85.7% win rate.

What is Seraphine's primary rune tree?

Seraphine's primary rune tree is Sorcery. The optimal Sorcery runes for Seraphine are Summon Aery, Manaflow Band, Transcendence, and Gathering Storm, with Summon Aery being the keystone of choice.

What is Seraphine's secondary rune tree?

Seraphine's best secondary rune tree is Inspiration. The recommended Inspiration runes are Biscuit Delivery and Cosmic Insight, which complement Seraphine's Sorcery primary tree.

What are alternative rune setups for Seraphine?

An alternative Seraphine rune setup uses Arcane Comet from the Sorcery tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.

How popular are Seraphine's runes?

Seraphine's top rune page has a 0.2% pick rate in patch 26.7. This indicates that 0.2% of Seraphine players use the Summon Aery setup with Sorcery and Inspiration trees.