Annie - League of Legends Champion
Win Rate
57.5%
Pick Rate
0.9%
Ban Rate
0.9%

AnnieRunes (Mid)

SMageSupport
Patch26.19
Games247
LaneMid
TierAll Tiers
Last UpdatedSep 25, 2026 UTC
MethodologyData Methodology

Best Mid Annie runes for LoL Patch 26.19 - Electrocute from the Domination tree with Inspiration secondary (65.2% WR, 9.3% pick rate). Annie's optimal primary runes are Electrocute, Cheap Shot, Grisly Mementos, Ultimate Hunter. Secondary tree: Biscuit Delivery, Cosmic Insight.

Annie performs best with Electrocute as the keystone rune from the Domination tree. Annie's optimal primary runes are Electrocute, Cheap Shot, Grisly Mementos, Ultimate Hunter. Annie's secondary rune tree is Inspiration with Biscuit Delivery, Cosmic Insight. This rune setup achieves a 65.22% win rate (+7.7% win rate difference) with a 9.3% pick rate across 23 Annie games.
65.2%Win Rate
+7.7%WR Diff
9.3%Pick Rate
ElectrocuteElectrocute

Hitting a champion with 3 separate attacks or abilities within 3s deals bonus adaptive damage.

Damage: 70 - 240 (+0.1 bonus AD, +0.05 AP) damage.
Cooldown: 20s

'We called them the Thunderlords, for to speak of their lightning was to invite disaster.'

Cheap ShotCheap Shot

Damaging champions with impaired movement or actions deals 10 - 45 bonus true damage (based on level).

Cooldown: 4s
Activates on damage occurring after the impairment.

Grisly MementosGrisly Mementos

Collect 1 memento on champion takedowns, up to 18 total.

Gain 6 Trinket Haste for each collected. In game modes where vision Trinkets do not exist, instead gain 3 Summoner Spell Haste.

Ultimate HunterUltimate Hunter

Your ultimate gains 6 Ability Haste, plus an additional 5 Ability Haste per Bounty Hunter stack. Bounty Hunter stacks are earned the first time you get a takedown on each enemy champion.

Biscuit DeliveryBiscuit Delivery

Biscuit Delivery: Gain a Total Biscuit of Everlasting Will every 2 mins, until 6 min.

Biscuits restore 20 + 2% of your maximum health, increased by up to 100% based on missing Health. Consuming or selling a Biscuit permanently increases your max health by 30.

Cosmic InsightCosmic Insight

+18 Summoner Spell Haste
+10 Item Haste

This alternative Annie rune build uses Electrocute as the keystone from the Domination tree. The primary runes are Electrocute, Cheap Shot, Grisly Mementos, Relentless Hunter. Annie's secondary rune tree is Sorcery with Absolute Focus, Axiom Arcanist. This setup achieves a 50.62% win rate (-6.9% win rate difference) with a 32.8% pick rate across 81 games.
50.6%Win Rate
-6.9%WR Diff
32.8%Pick Rate
ElectrocuteElectrocute

Hitting a champion with 3 separate attacks or abilities within 3s deals bonus adaptive damage.

Damage: 70 - 240 (+0.1 bonus AD, +0.05 AP) damage.
Cooldown: 20s

'We called them the Thunderlords, for to speak of their lightning was to invite disaster.'

Cheap ShotCheap Shot

Damaging champions with impaired movement or actions deals 10 - 45 bonus true damage (based on level).

Cooldown: 4s
Activates on damage occurring after the impairment.

Grisly MementosGrisly Mementos

Collect 1 memento on champion takedowns, up to 18 total.

Gain 6 Trinket Haste for each collected. In game modes where vision Trinkets do not exist, instead gain 3 Summoner Spell Haste.

Relentless HunterRelentless Hunter

Gain 8 Move Speed out of combat per Bounty Hunter stack. Bounty Hunter stacks are earned the first time you get a takedown on each enemy champion.

Absolute FocusAbsolute Focus

While above 70% health, gain an adaptive bonus of up to 18 Attack Damage or 30 Ability Power (based on level).

Grants 1.8 Attack Damage or 3 Ability Power at level 1.

Axiom ArcanistAxiom Arcanist

Your Ultimate has 12% increased damage, healing, and shielding.
(AoE damage is reduced to a 8% increase)

Scoring a takedown on an enemy champion reduces your Ultimate's current cooldown by 7%.

These champions share at least 4 runes with Annie's recommended rune builds. use similar keystone and secondary runes, making them good alternatives if you enjoy Annie's playstyle or want to learn champions with familiar rune setups.Lissandra
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Annie Runes - Frequently Asked Questions

What are the best Annie runes in patch 26.19?

The best Annie runes in patch 26.19 use the Domination tree with Electrocute, Cheap Shot, Grisly Mementos, and Ultimate Hunter, and the Inspiration tree with Biscuit Delivery and Cosmic Insight. This rune setup achieves a 65.2% win rate with a 9.3% pick rate.

What is the win rate for Annie's best rune page?

Annie's best rune page has a 65.2% win rate in patch 26.19, which is +7.7% compared to Annie's average win rate. This rune setup has a 9.3% pick rate among Annie players.

What keystone should I use on Annie?

Electrocute from the Domination tree is the best keystone rune for Annie in patch 26.19. This keystone synergizes well with Annie's kit and provides a 65.2% win rate.

What is Annie's primary rune tree?

Annie's primary rune tree is Domination. The optimal Domination runes for Annie are Electrocute, Cheap Shot, Grisly Mementos, and Ultimate Hunter, with Electrocute being the keystone of choice.

What is Annie's secondary rune tree?

Annie's best secondary rune tree is Inspiration. The recommended Inspiration runes are Biscuit Delivery and Cosmic Insight, which complement Annie's Domination primary tree.

What are alternative rune setups for Annie?

An alternative Annie rune setup uses Electrocute from the Domination tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.

How popular are Annie's runes?

Annie's top rune page has a 9.3% pick rate in patch 26.19. This indicates that 9.3% of Annie players use the Electrocute setup with Domination and Inspiration trees.