Miss Fortune - League of Legends Champion
Win Rate
49.5%
Pick Rate
7.7%

Miss Fortunevs Karthus

DMarksmanMage
Patch26.13
Matches265,623
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 10, 2026
MethodologyData Methodology

Miss Fortune vs Karthus is a decisive matchup in LoL patch 26.13. Miss Fortune wins with a 66.7% win rate (+33.3%) over Karthus based on 6 games. Miss Fortune holds the advantage in both the early and late game. Below you'll find the best Miss Fortune build, runes, laning stats, and strategies for the Miss Fortune vs Karthus matchup.

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Miss Fortune Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Miss Fortune performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Miss Fortune - 66.7% win rate in this matchup
Miss Fortune
66.7% WR
VS
Karthus vs Miss Fortune matchup - 33.3% win rate
Karthus
33.3% WR

Who Wins the Miss Fortune vs Karthus Matchup?

Miss Fortune wins the Miss Fortune vs Karthus matchup
Winner
Miss Fortune
Matches: 6
66.7%
Win Rate
33.3%
6.7
CS / min
6.6
1,185
DMG / min
1,550
17,753
Gold / game
16,358
227
Heal / min
87
529
DMG Mitigated / min
488
0.4
CC / min
0.7
50.0%
Early Game WR
50.0%
75.0%
Late Game WR
25.0%

Miss Fortune vs Karthus Matchup Summary

The Miss Fortune vs Karthus matchup is a decisive matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Miss Fortune wins with a 66.7% win rate compared to Karthus's 33.3%, giving Miss Fortune a 33.3 percentage point advantage. Miss Fortune dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Karthus players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Karthus leads by 0.3s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Miss Fortune players can confidently pick into Karthus and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Karthus away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Miss Fortune vs Karthus Laning Phase Breakdown

Miss Fortune wins the laning phase against Karthus in League of Legends

Miss Fortune is favored during the laning phase against Karthus, winning 3 out of 5 key stat categories. Miss Fortune holds advantages in farming, gold income and sustain, making them the stronger laner in this matchup.

Farming
6.7Miss Fortune
6.6Karthus
Miss Fortune and Karthus farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
1,185Miss Fortune
1,550Karthus
Karthus heavily out-damages Miss Fortune by 366 DMG/min, dominating both short trades and all-in fights. Miss Fortune should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
17,753Miss Fortune
16,358Karthus
Miss Fortune generates a commanding 1,396 more gold per game than Karthus. This substantial economic advantage means Miss Fortune consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Karthus should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.4Miss Fortune
0.7Karthus
Karthus provides 0.3 seconds more crowd control per minute than Miss Fortune, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Karthus coordinate with their jungler and control the pace of skirmishes.
Sustain
756Miss Fortune
576Karthus
Miss Fortune vastly out-sustains Karthus, healing and mitigating 180 more damage per minute. This massive durability gap means Miss Fortune can absorb significant punishment and remain in lane while Karthus is forced to recall. Building grievous wounds early is essential for Karthus, and focusing on burst trade patterns rather than sustained fights is critical.

Early Game vs Late Game

Early Game
Miss Fortune
50.0%
+0.0% advantage
Miss Fortune early game win rateMiss Fortune50.0%
Karthus early game win rateKarthus50.0%
Late Game
Miss Fortune
75.0%
+50.0% advantage
Miss Fortune late game win rateMiss Fortune75.0%
Karthus late game win rateKarthus25.0%

The early game (first 15 minutes) is a toss-up between Miss Fortune and Karthus, with Miss Fortune holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Miss Fortune is far superior in the late game (25+ minutes), boasting a 75.0% win rate — 50.0 points above Karthus. Extended games heavily favor Miss Fortune, whose kit and scaling make them a dominant force in team fights and objective control.

Miss Fortune holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Karthus players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Miss Fortune Runes Against Karthus

Precision rune tree - Miss Fortune primary runes vs KarthusPrecision
Press the Attack - best Miss Fortune rune vs KarthusPresence of Mind - best Miss Fortune rune vs KarthusLegend: Bloodline - best Miss Fortune rune vs KarthusCoup de Grace - best Miss Fortune rune vs Karthus
Inspiration rune tree - Miss Fortune secondary runes vs KarthusInspiration
Biscuit Delivery - best Miss Fortune rune vs KarthusMagical Footwear - best Miss Fortune rune vs Karthus
100.0% WR

Running Precision primary with Inspiration secondary allows Miss Fortune to press their advantage against Karthus, amplifying the strengths that make this a favorable matchup.


Miss Fortune matchup data for League of Legends patch 26.13. The table below shows Miss Fortune's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Miss Fortune build, runes, laning stats, and early vs late game analysis for that specific matchup.

Miss Fortune matchup win rates and stats in League of Legends patch 26.13
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
47.32%4486.383513,95949.1%46.1%
51.81%3596.283913,56755.6%49.0%
50.72%3496.285714,18744.4%55.1%
51.05%3336.385613,58849.3%52.5%
45.79%2146.285713,55942.7%48.6%
50.25%2016.588013,81344.8%55.2%
50.83%1816.486314,65949.2%51.7%
50.96%1576.284413,44552.2%50.0%
50.65%1546.590014,24456.9%46.9%
56.74%1416.388914,54164.3%51.8%
48.44%1286.090414,07254.8%42.4%
50.86%1165.975612,76351.9%50.0%
50.96%1046.286614,98451.4%50.7%
52.53%996.385313,52052.5%52.5%
46.81%946.484014,11850.0%44.8%
50.56%896.389913,80447.5%53.1%
50.62%816.678413,51448.7%52.4%
57.33%756.391214,62560.0%55.6%
53.62%696.089214,96239.1%60.9%
55.88%686.395815,64458.3%54.5%
50.94%536.780913,46042.1%55.9%
48.72%395.888913,63741.2%54.5%
47.22%366.378512,93843.8%50.0%
54.84%315.887414,26644.4%59.1%
43.33%306.693514,33846.1%41.2%
40.00%306.377911,99821.4%56.3%
41.38%295.282211,47850.0%33.3%
35.71%285.897914,45818.2%47.1%
37.04%276.071711,17854.5%25.0%
36.00%255.788611,71020.0%60.0%
65.22%236.682311,15762.5%71.4%
33.33%216.690013,75437.5%30.8%
36.84%195.860712,33530.0%44.4%
64.71%176.074513,66066.7%63.6%
53.33%155.298412,37471.4%37.5%
50.00%145.963012,6280.0%70.0%
50.00%145.788913,91050.0%50.0%
50.00%126.693313,17242.9%60.0%
54.55%116.684413,94560.0%50.0%
20.00%106.494813,30550.0%0.0%
44.44%96.583412,87850.0%40.0%
25.00%85.053410,72340.0%0.0%
25.00%86.273115,0720.0%40.0%
0.00%86.374813,0810.0%0.0%
57.14%73.490112,569100.0%25.0%
71.43%74.265411,695100.0%60.0%
42.86%77.21,21316,89033.3%50.0%
83.33%65.91,04418,106100.0%80.0%
50.00%65.464111,71525.0%100.0%
66.67%66.71,18517,75350.0%75.0%
60.00%56.31,12015,11550.0%66.7%
60.00%56.01,04311,07666.7%50.0%
40.00%53.384111,140100.0%25.0%
100.00%56.383011,847100.0%100.0%
40.00%55.272812,55133.3%50.0%
80.00%57.71,05016,323100.0%50.0%

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Miss Fortune vs Karthus - Frequently Asked Questions

How does Miss Fortune do against Karthus in League of Legends?

Miss Fortune wins the Miss Fortune vs Karthus matchup with a 66.7% win rate compared to Karthus's 33.3%, a 33.3 percentage point difference. This data is based on 6 recent ranked games in patch 26.13.

How does Miss Fortune do against Karthus in the early game?

In the early game, Miss Fortune has the advantage against Karthus with a 50.0% win rate versus 50.0%. Miss Fortune players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Miss Fortune do against Karthus in the late game?

In the late game, Miss Fortune takes over the Miss Fortune vs Karthus matchup with a 75.0% win rate compared to 25.0%. Miss Fortune scales better into team fights and objective contests after 25 minutes.

Who wins the Miss Fortune vs Karthus matchup?

Miss Fortune wins the matchup against Karthus with a 66.7% win rate in League of Legends patch 26.13. The 33.3 percentage point advantage means Miss Fortune is significantly favored in this lane matchup based on 6 games analyzed.

What is the best Miss Fortune build against Karthus?

The best Miss Fortune build against Karthus includes optimized core items. Check the matchup breakdown above for the full item path and build order.

What are the best Miss Fortune runes against Karthus?

The best Miss Fortune runes against Karthus use the Precision primary tree with Inspiration secondary. This rune setup achieves a 100.0% win rate in the Miss Fortune vs Karthus matchup. See the full rune breakdown in the matchup comparison above.

Does Miss Fortune counter Karthus?

Yes, Miss Fortune has a favorable matchup against Karthus with a 66.7% win rate. Miss Fortune strongly counters Karthus in lane based on current patch 26.13 data.

How do I play Miss Fortune against Karthus?

When playing Miss Fortune against Karthus, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.