Karthus - League of Legends Champion
Win Rate
52.9%
Pick Rate
0.9%

Karthusvs Miss Fortune

SMage
Patch26.14
Matches226,800
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 21, 2026
MethodologyData Methodology

Karthus vs Miss Fortune is a decisive matchup in LoL patch 26.14. Karthus wins with a 71.4% win rate (+42.9%) over Miss Fortune based on 7 games. Karthus holds the advantage in both the early and late game. Below you'll find the best Karthus build, runes, laning stats, and strategies for the Karthus vs Miss Fortune matchup.

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Karthus Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Karthus performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Karthus - 71.4% win rate in this matchup
Karthus
71.4% WR
VS
Miss Fortune vs Karthus matchup - 28.6% win rate
Miss Fortune
28.6% WR

Who Wins the Karthus vs Miss Fortune Matchup?

Karthus wins the Karthus vs Miss Fortune matchup
Winner
Karthus
Matches: 7
71.4%
Win Rate
28.6%
5.9
CS / min
5.8
1,210
DMG / min
870
11,767
Gold / game
12,536
95
Heal / min
156
388
DMG Mitigated / min
473
0.7
CC / min
0.3
100.0%
Early Game WR
0.0%
60.0%
Late Game WR
40.0%

Karthus vs Miss Fortune Matchup Summary

The Karthus vs Miss Fortune matchup is a decisive matchup in League of Legends ranked play. Based on 7 recent matches analyzed, Karthus wins with a 71.4% win rate compared to Miss Fortune's 28.6%, giving Karthus a 42.9 percentage point advantage. Karthus dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Miss Fortune players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Karthus leads by 0.3s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Karthus players can confidently pick into Miss Fortune and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Miss Fortune away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Karthus vs Miss Fortune Laning Phase Breakdown

Karthus wins the laning phase against Miss Fortune in League of Legends

Karthus is favored during the laning phase against Miss Fortune, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and crowd control, making them the stronger laner in this matchup.

Farming
5.9Karthus
5.8Miss Fortune
Karthus and Miss Fortune farm at nearly identical rates in this matchup, with only a 0.2 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
1,210Karthus
870Miss Fortune
Karthus heavily out-damages Miss Fortune by 341 DMG/min, dominating both short trades and all-in fights. Miss Fortune should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
11,767Karthus
12,536Miss Fortune
Miss Fortune earns 769 more gold per game than Karthus, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Miss Fortune slightly faster item completions.
Utility
0.7Karthus
0.3Miss Fortune
Karthus provides 0.3 seconds more crowd control per minute than Miss Fortune, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Karthus coordinate with their jungler and control the pace of skirmishes.
Sustain
483Karthus
629Miss Fortune
Miss Fortune heals and mitigates 146 more damage per minute than Karthus, providing moderate extra durability. This sustain edge allows Miss Fortune to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Karthus.

Early Game vs Late Game

Early Game
Karthus
100.0%
+100.0% advantage
Karthus early game win rateKarthus100.0%
Miss Fortune early game win rateMiss Fortune0.0%
Late Game
Karthus
60.0%
+20.0% advantage
Karthus late game win rateKarthus60.0%
Miss Fortune late game win rateMiss Fortune40.0%

Karthus dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Miss Fortune. This lopsided early game means Karthus can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Karthus is far superior in the late game (25+ minutes), boasting a 60.0% win rate — 20.0 points above Miss Fortune. Extended games heavily favor Karthus, whose kit and scaling make them a dominant force in team fights and objective control.

Karthus holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Miss Fortune players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Karthus Runes Against Miss Fortune

Domination rune tree - Karthus primary runes vs Miss FortuneDomination
Dark Harvest - best Karthus rune vs Miss FortuneCheap Shot - best Karthus rune vs Miss FortuneGrisly Mementos - best Karthus rune vs Miss FortuneUltimate Hunter - best Karthus rune vs Miss Fortune
Sorcery rune tree - Karthus secondary runes vs Miss FortuneSorcery
Axiom Arcanist - best Karthus rune vs Miss FortuneGathering Storm - best Karthus rune vs Miss Fortune
100.0% WR

Running Domination primary with Sorcery secondary allows Karthus to press their advantage against Miss Fortune, amplifying the strengths that make this a favorable matchup.


Karthus matchup data for League of Legends patch 26.14. The table below shows Karthus's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Karthus build, runes, laning stats, and early vs late game analysis for that specific matchup.

Karthus matchup win rates and stats in League of Legends patch 26.14
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
64.71%171.61,30714,66766.7%64.3%
61.54%131.41,26816,483100.0%54.5%
38.46%131.71,13714,45550.0%33.3%
53.85%131.289010,32966.7%42.9%
66.67%127.01,13812,77283.3%50.0%
50.00%126.81,06013,5260.0%66.7%
66.67%121.21,22315,65033.3%77.8%
54.55%111.493212,47820.0%83.3%
54.55%111.31,25216,58775.0%42.9%
30.00%101.21,05811,5090.0%60.0%
77.78%96.91,58016,28933.3%100.0%
77.78%91.11,46516,15150.0%85.7%
50.00%81.41,36413,21550.0%50.0%
62.50%82.11,29411,38950.0%75.0%
75.00%81.71,19514,4940.0%85.7%
62.50%80.91,03211,64366.7%60.0%
0.00%81.29159,7700.0%0.0%
100.00%81.31,14611,386100.0%100.0%
71.43%75.91,21011,767100.0%60.0%
42.86%73.81,20014,23566.7%25.0%
50.00%61.81,15115,1510.0%60.0%
50.00%66.81,05414,8930.0%60.0%
33.33%65.61,01311,5230.0%100.0%
66.67%66.31,18714,6750.0%80.0%
40.00%50.91,14013,258100.0%25.0%
60.00%56.31,26410,41750.0%66.7%
40.00%50.91,00613,487100.0%25.0%
20.00%55.393411,78633.3%0.0%
40.00%51.21,37916,148100.0%25.0%
20.00%54.39793,1650.0%100.0%
60.00%51.31,04614,377100.0%50.0%
25.00%41.41,38413,8210.0%33.3%
25.00%42.31,12113,8860.0%33.3%
100.00%21.51,21814,599100.0%100.0%

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Karthus vs Miss Fortune - Frequently Asked Questions

How does Karthus do against Miss Fortune in League of Legends?

Karthus wins the Karthus vs Miss Fortune matchup with a 71.4% win rate compared to Miss Fortune's 28.6%, a 42.9 percentage point difference. This data is based on 7 recent ranked games in patch 26.14.

How does Karthus do against Miss Fortune in the early game?

In the early game, Karthus has the advantage against Miss Fortune with a 100.0% win rate versus 0.0%. Karthus players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Karthus do against Miss Fortune in the late game?

In the late game, Karthus takes over the Karthus vs Miss Fortune matchup with a 60.0% win rate compared to 40.0%. Karthus scales better into team fights and objective contests after 25 minutes.

Who wins the Karthus vs Miss Fortune matchup?

Karthus wins the matchup against Miss Fortune with a 71.4% win rate in League of Legends patch 26.14. The 42.9 percentage point advantage means Karthus is significantly favored in this lane matchup based on 7 games analyzed.

What is the best Karthus build against Miss Fortune?

The best Karthus build against Miss Fortune includes optimized core items. Check the matchup breakdown above for the full item path and build order.

What are the best Karthus runes against Miss Fortune?

The best Karthus runes against Miss Fortune use the Domination primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Karthus vs Miss Fortune matchup. See the full rune breakdown in the matchup comparison above.

Does Karthus counter Miss Fortune?

Yes, Karthus has a favorable matchup against Miss Fortune with a 71.4% win rate. Karthus strongly counters Miss Fortune in lane based on current patch 26.14 data.

How do I play Karthus against Miss Fortune?

When playing Karthus against Miss Fortune, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.