Miss Fortunevs Vayne
Miss Fortune vs Vayne is a very close matchup in LoL patch 26.4. Vayne wins with a 50.5% win rate (+0.9%) over Miss Fortune based on 643 games. Vayne wins the early laning phase while Miss Fortune scales better into the late game. Below you'll find the best Miss Fortune build, runes, laning stats, and strategies for the Miss Fortune vs Vayne matchup.
Miss Fortune Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Miss Fortune performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Vayne(49.5%)Who Wins the Miss Fortune vs Vayne Matchup?
Miss Fortune vs Vayne Matchup Summary
The Miss Fortune vs Vayne matchup is essentially a coin-flip matchup in League of Legends ranked play. Based on 643 recent matches analyzed, Vayne wins with a 50.5% win rate compared to Miss Fortune's 49.5%, giving Vayne a 0.9 percentage point advantage. Game phase dynamics play a critical role here: Vayne controls the early laning stage, but Miss Fortune outscales as the game goes longer. The matchup shifts dramatically depending on game length — Vayne needs to press advantages before Miss Fortune reaches their power spikes, while Miss Fortune should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Vayne leads by 0.1s CC/min — a difference that heavily influences the outcome of trades and skirmishes. While Vayne is slightly favored, Miss Fortune can absolutely win this lane through smart trading patterns and wave management. Focus on playing around your cooldowns, conceding CS only when necessary, and capitalizing on Vayne's mistakes. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Miss Fortune vs Vayne Laning Phase Breakdown
Miss Fortune is favored during the laning phase against Vayne, winning 3 out of 5 key stat categories. Miss Fortune holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.
Early Game vs Late Game
Miss Fortune48.2%Vayne51.8%Miss Fortune50.5%Vayne49.5%During the early laning phase (first 15 minutes), Vayne has a meaningful 51.8% win rate, outperforming Miss Fortune by 3.6 percentage points. Vayne players should look to press this advantage through aggressive trades, wave priority, and early jungle coordination.
Late game (25+ minutes) is equally balanced, with Miss Fortune at 50.5% win rate — only 1.1 points ahead of Vayne. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.
The power dynamics shift as the game progresses — Vayne has the edge early, but Miss Fortune gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.
Best Miss Fortune Runes Against Vayne
Precision
Inspiration
The Precision primary with Inspiration secondary combination helps Miss Fortune maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Vayne.
Miss Fortune matchup data for League of Legends patch 26.4. The table below shows Miss Fortune's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Miss Fortune build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 52.18% | 2,105 | 6.5 | 868 | 14,482 | 51.0% | 53.1% | |
| 49.25% | 1,466 | 6.5 | 900 | 14,429 | 53.6% | 45.3% | |
| 53.25% | 1,267 | 6.4 | 872 | 14,491 | 51.0% | 54.9% | |
| 49.85% | 1,035 | 6.2 | 870 | 14,649 | 46.9% | 52.0% | |
| 53.33% | 816 | 6.7 | 951 | 15,157 | 54.5% | 52.4% | |
| 49.75% | 795 | 6.7 | 924 | 15,418 | 50.3% | 49.4% | |
| 54.00% | 790 | 6.6 | 903 | 14,529 | 46.8% | 60.1% | |
| 49.53% | 643 | 6.5 | 936 | 15,201 | 48.2% | 50.5% | |
| 50.25% | 597 | 6.3 | 919 | 14,296 | 47.7% | 52.6% | |
| 47.17% | 587 | 6.1 | 842 | 14,408 | 48.8% | 46.0% | |
| 55.43% | 526 | 6.3 | 897 | 14,633 | 57.1% | 54.2% | |
| 52.57% | 489 | 6.6 | 876 | 14,486 | 51.8% | 53.2% | |
| 54.45% | 484 | 6.8 | 865 | 14,793 | 53.5% | 55.2% | |
| 54.44% | 420 | 6.8 | 941 | 14,977 | 60.7% | 48.3% | |
| 51.23% | 408 | 6.6 | 917 | 14,982 | 51.7% | 50.9% | |
| 53.09% | 408 | 6.5 | 902 | 14,505 | 56.8% | 50.0% | |
| 50.42% | 356 | 6.4 | 875 | 14,482 | 47.6% | 52.9% | |
| 51.54% | 326 | 6.4 | 866 | 14,542 | 49.6% | 52.9% | |
| 43.16% | 236 | 6.4 | 869 | 14,840 | 35.6% | 47.6% | |
| 52.04% | 222 | 6.7 | 878 | 14,941 | 52.9% | 51.3% | |
| 46.58% | 219 | 6.2 | 988 | 14,058 | 39.4% | 52.0% | |
| 45.59% | 205 | 6.7 | 915 | 14,467 | 44.3% | 46.5% | |
| 40.80% | 201 | 6.3 | 873 | 14,982 | 37.8% | 42.5% | |
| 48.22% | 198 | 6.5 | 794 | 14,299 | 42.2% | 52.6% | |
| 56.45% | 187 | 6.6 | 977 | 15,007 | 60.7% | 52.9% | |
| 54.07% | 174 | 6.3 | 977 | 15,516 | 52.9% | 54.9% | |
| 45.56% | 170 | 6.6 | 956 | 14,486 | 45.5% | 45.6% | |
| 53.85% | 143 | 6.4 | 835 | 14,087 | 59.7% | 49.4% | |
| 46.55% | 117 | 5.2 | 756 | 13,764 | 25.7% | 55.6% | |
| 55.10% | 98 | 6.1 | 818 | 13,752 | 53.7% | 56.1% | |
| 44.05% | 84 | 6.4 | 948 | 14,913 | 39.3% | 46.4% | |
| 53.73% | 68 | 6.3 | 1,023 | 15,922 | 61.5% | 48.8% | |
| 39.34% | 61 | 5.9 | 800 | 13,349 | 33.3% | 44.1% | |
| 42.22% | 45 | 6.0 | 849 | 13,417 | 30.4% | 54.5% | |
| 52.38% | 42 | 6.2 | 871 | 14,296 | 38.5% | 58.6% | |
| 42.86% | 42 | 6.2 | 840 | 13,892 | 35.3% | 48.0% | |
| 48.72% | 40 | 5.6 | 865 | 14,088 | 58.8% | 40.9% | |
| 35.29% | 34 | 6.5 | 947 | 15,775 | 11.1% | 44.0% | |
| 51.72% | 30 | 6.4 | 877 | 12,680 | 69.2% | 37.5% | |
| 50.00% | 28 | 3.9 | 752 | 11,734 | 58.3% | 43.8% | |
| 38.46% | 26 | 5.5 | 912 | 11,639 | 35.7% | 41.7% | |
| 40.00% | 25 | 6.4 | 856 | 13,808 | 41.7% | 38.5% | |
| 45.83% | 24 | 4.6 | 983 | 12,192 | 50.0% | 41.7% | |
| 36.36% | 22 | 6.3 | 1,055 | 12,671 | 41.7% | 30.0% | |
| 45.45% | 22 | 1.9 | 685 | 9,565 | 50.0% | 42.9% | |
| 36.84% | 21 | 6.7 | 856 | 15,109 | 44.4% | 30.0% | |
| 40.00% | 20 | 5.9 | 741 | 13,364 | 33.3% | 45.5% | |
| 52.63% | 19 | 4.5 | 755 | 11,576 | 62.5% | 45.5% | |
| 42.11% | 19 | 2.8 | 813 | 11,312 | 40.0% | 42.9% | |
| 44.44% | 18 | 4.1 | 786 | 13,189 | 66.7% | 33.3% | |
| 66.67% | 18 | 7.0 | 1,037 | 14,937 | 77.8% | 55.6% | |
| 52.94% | 17 | 2.4 | 765 | 11,507 | 50.0% | 54.5% | |
| 64.71% | 17 | 2.8 | 805 | 11,178 | 60.0% | 66.7% | |
| 56.25% | 16 | 6.7 | 880 | 13,649 | 50.0% | 62.5% | |
| 56.25% | 16 | 6.0 | 930 | 13,795 | 50.0% | 66.7% | |
| 53.33% | 15 | 6.2 | 922 | 15,140 | 40.0% | 60.0% | |
| 57.14% | 14 | 5.4 | 914 | 14,860 | 66.7% | 54.5% | |
| 69.23% | 13 | 3.2 | 857 | 12,730 | 100.0% | 60.0% | |
| 76.92% | 13 | 7.2 | 1,063 | 17,764 | 100.0% | 72.7% | |
| 46.15% | 13 | 5.5 | 879 | 13,580 | 42.9% | 50.0% | |
| 41.67% | 12 | 5.8 | 872 | 11,239 | 28.6% | 60.0% | |
| 66.67% | 12 | 2.8 | 638 | 8,561 | 85.7% | 40.0% | |
| 66.67% | 12 | 5.8 | 913 | 13,286 | 80.0% | 57.1% | |
| 25.00% | 12 | 5.4 | 620 | 8,972 | 22.2% | 33.3% | |
| 54.55% | 11 | 5.9 | 934 | 14,594 | 50.0% | 55.6% | |
| 54.55% | 11 | 6.6 | 1,039 | 12,819 | 33.3% | 80.0% | |
| 54.55% | 11 | 5.8 | 841 | 15,174 | 40.0% | 66.7% | |
| 20.00% | 10 | 6.7 | 804 | 12,184 | 0.0% | 66.7% | |
| 30.00% | 10 | 6.1 | 677 | 11,427 | 0.0% | 60.0% | |
| 40.00% | 10 | 5.2 | 970 | 12,610 | 66.7% | 28.6% | |
| 50.00% | 10 | 2.3 | 923 | 10,497 | 66.7% | 25.0% | |
| 20.00% | 10 | 3.6 | 774 | 11,715 | 25.0% | 16.7% | |
| 55.56% | 9 | 5.8 | 662 | 11,035 | 80.0% | 25.0% | |
| 44.44% | 9 | 5.9 | 837 | 13,624 | 33.3% | 50.0% | |
| 44.44% | 9 | 2.3 | 658 | 10,741 | 0.0% | 57.1% | |
| 66.67% | 9 | 4.1 | 741 | 11,355 | 50.0% | 80.0% | |
| 77.78% | 9 | 5.6 | 842 | 15,944 | 100.0% | 75.0% | |
| 33.33% | 9 | 5.9 | 918 | 14,409 | 0.0% | 42.9% | |
| 22.22% | 9 | 5.3 | 1,007 | 15,010 | 33.3% | 16.7% | |
| 88.89% | 9 | 6.3 | 1,138 | 17,831 | 100.0% | 85.7% | |
| 100.00% | 9 | 6.1 | 959 | 14,682 | 100.0% | 100.0% | |
| 37.50% | 8 | 2.9 | 766 | 11,018 | 33.3% | 40.0% | |
| 37.50% | 8 | 2.4 | 710 | 10,468 | 100.0% | 28.6% | |
| 25.00% | 8 | 6.6 | 985 | 16,674 | 0.0% | 28.6% | |
| 87.50% | 8 | 5.8 | 907 | 11,929 | 75.0% | 100.0% | |
| 50.00% | 8 | 5.5 | 1,025 | 14,632 | 50.0% | 50.0% | |
| 62.50% | 8 | 5.9 | 849 | 12,626 | 60.0% | 66.7% | |
| 50.00% | 8 | 2.0 | 867 | 12,205 | 50.0% | 50.0% | |
| 25.00% | 8 | 6.0 | 776 | 10,725 | 25.0% | 25.0% | |
| 28.57% | 7 | 5.7 | 852 | 11,772 | 50.0% | 20.0% | |
| 14.29% | 7 | 5.9 | 892 | 15,627 | 0.0% | 16.7% | |
| 28.57% | 7 | 5.4 | 725 | 11,021 | 16.7% | 100.0% | |
| 57.14% | 7 | 6.6 | 862 | 13,741 | 0.0% | 66.7% | |
| 57.14% | 7 | 6.8 | 1,205 | 14,341 | 100.0% | 40.0% | |
| 33.33% | 6 | 5.9 | 927 | 12,987 | 33.3% | 33.3% | |
| 50.00% | 6 | 5.7 | 805 | 15,469 | 0.0% | 75.0% | |
| 50.00% | 6 | 6.9 | 1,052 | 16,690 | 50.0% | 50.0% | |
| 33.33% | 6 | 5.1 | 838 | 16,343 | 50.0% | 25.0% | |
| 33.33% | 6 | 5.7 | 739 | 10,363 | 50.0% | 0.0% | |
| 16.67% | 6 | 5.9 | 729 | 10,100 | 25.0% | 0.0% | |
| 16.67% | 6 | 6.2 | 791 | 16,247 | 0.0% | 16.7% | |
| 83.33% | 6 | 2.4 | 883 | 13,585 | 0.0% | 83.3% | |
| 66.67% | 6 | 6.6 | 865 | 15,248 | 0.0% | 80.0% | |
| 16.67% | 6 | 1.8 | 593 | 10,092 | 0.0% | 25.0% | |
| 60.00% | 5 | 3.6 | 716 | 12,326 | 33.3% | 100.0% | |
| 60.00% | 5 | 5.6 | 655 | 10,147 | 50.0% | 66.7% | |
| 20.00% | 5 | 4.1 | 1,190 | 10,870 | 0.0% | 33.3% | |
| 25.00% | 5 | 5.6 | 573 | 11,525 | 0.0% | 33.3% | |
| 40.00% | 5 | 6.7 | 769 | 10,109 | 50.0% | 0.0% | |
| 40.00% | 5 | 4.5 | 783 | 13,154 | 33.3% | 50.0% | |
| 60.00% | 5 | 3.9 | 872 | 15,127 | 50.0% | 66.7% | |
| 60.00% | 5 | 2.9 | 809 | 9,108 | 50.0% | 100.0% | |
| 80.00% | 5 | 7.1 | 979 | 12,298 | 66.7% | 100.0% | |
| 80.00% | 5 | 6.6 | 987 | 15,894 | 50.0% | 100.0% | |
| 40.00% | 5 | 7.6 | 546 | 9,041 | 50.0% | 33.3% | |
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Miss Fortune vs Vayne - Frequently Asked Questions
How does Miss Fortune do against Vayne in League of Legends?
Vayne wins the Miss Fortune vs Vayne matchup with a 50.5% win rate compared to Miss Fortune's 49.5%, a 0.9 percentage point difference. This data is based on 643 recent ranked games in patch 26.4.
How does Miss Fortune do against Vayne in the early game?
In the early game, Vayne has the advantage against Miss Fortune with a 51.8% win rate versus 48.2%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Miss Fortune do against Vayne in the late game?
In the late game, Miss Fortune takes over the Miss Fortune vs Vayne matchup with a 50.5% win rate compared to 49.5%. Miss Fortune scales better into team fights and objective contests after 25 minutes.
Who wins the Miss Fortune vs Vayne matchup?
Vayne wins the matchup against Miss Fortune with a 50.5% win rate in League of Legends patch 26.4. The 0.9 percentage point advantage means Vayne is slightly favored in this lane matchup based on 643 games analyzed.
What is the best Miss Fortune build against Vayne?
The best Miss Fortune build against Vayne includes optimized core items. Check the matchup breakdown above for the full item path and build order.
What are the best Miss Fortune runes against Vayne?
The best Miss Fortune runes against Vayne use the Precision primary tree with Inspiration secondary. This rune setup achieves a 66.0% win rate in the Miss Fortune vs Vayne matchup. See the full rune breakdown in the matchup comparison above.
Does Miss Fortune counter Vayne?
No, Miss Fortune struggles against Vayne with only a 49.5% win rate. Vayne has the advantage in this matchup. Miss Fortune players should focus on safe farming and avoiding extended trades to minimize Vayne's lead.
How do I play Miss Fortune against Vayne?
When playing Miss Fortune against Vayne, play cautiously and avoid Vayne's power spikes. Focus on safe farming — you outscale Vayne in the late game. Use the matchup-specific build and runes above to optimize your chances.