- Win Rate
- 50.0%
- Pick Rate
- 7.5%
- Ban Rate
- 4.3%
Miss Fortune vs Vayne
- Patch
- 26.20
- Games
- 15,078
- Lane
- All Lanes
- Tier
- All Tiers
- Last Updated
- Oct 18, 2026 UTC
- Methodology
- Data Methodology
- Author
- Dakota Chinnick
Miss Fortune vs Vayne is a decisive matchup in LoL patch 26.20. Miss Fortune wins with a 54.3% win rate (+8.5%) over Vayne based on 518 games. Miss Fortune holds the advantage in both the early and late game. Below you'll find the best Miss Fortune build, runes, laning stats, and strategies for the Miss Fortune vs Vayne matchup.
Miss Fortune Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Miss Fortune performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Who wins Miss Fortune vs Vayne?
Miss Fortune wins 53.6% of these games. With this many games the true rate is most likely between 49.2% and 58.0% (95% range).
- Expected
- 50.5% From both champions' overall Bot win rates
- Matchup effect
- +3.1 pts Observed minus expected
- Sample
- 494 games Lane: Bot
- vs patch 26.19
- −0.9 pts Within normal patch-to-patch noise
Lane: Bot · Ranked Solo/Duo & Flex · North America server · All ranks · Patch 26.20 · Oct 9 – Oct 18
Key takeaways
- Current data slightly favors Miss Fortune, but the sample is too limited for a strong conclusion: Miss Fortune wins 53.6% of 494 games (95% range 49.2–58.0%).
- Both champions' overall Bot win rates predict 50.5% for Miss Fortune; the result is within the margin of error of that, so this matchup mostly reflects the two champions' general strength.
- Miss Fortune usually wins the lane: 393 gold ahead of Vayne at 15 minutes on average (489 games with a 15-minute snapshot).
- Miss Fortune players pick Berserker's Greaves far more often against Vayne: 46.1% of their other Bot games, 50.8% here.
How we calculate this
Games: ranked Solo/Duo and Flex games on the North America server from the patch shown. Remakes (games under 5 minutes) are excluded.
A game only counts when Miss Fortune and Vayne played the same position on opposite teams, so roaming, lane swaps within a team or a champion merely being in the same game never count as this matchup.
The 95% range is a Wilson score interval. Confidence comes from how wide that range is: within ±3 points is very high, ±5 high, ±8 moderate, anything wider low. Below 20 games a matchup is not classified at all.
Expected win rate combines both champions’ win rates in this lane (same games and filters) with the log5 formula: E = A(1−B) / (A(1−B) + B(1−A)). Matchup effect = observed − expected.
"What changes" compares Miss Fortune's choices in this matchup with the same champion's other games in the same lane, and lists a change only when it is at least 3 points and statistically significant (two-proportion z-test, |z| ≥ 2, 20+ games).
Results are not split by rank: the sample per rank is too small for honest per-rank matchup numbers.
Miss Fortune vs Vayne Laning Stats
At 15 minutes
Whole-game averages
Miss Fortune vs Vayne Win Rate by Game Length
Miss Fortune's win rate against Vayne by game length. The dot is the win rate, the bar its 95% range and the dashed line the champion's usual win rate at that length. Lengths with fewer than 25 games are left blank.
No game length stands out: Miss Fortune's results against Vayne in short and long games are within the margin of error of each other.
Miss Fortune vs Vayne Power Spikes
Who is ahead at each stage, measured from these games. A stage reads "Even" when the difference is inside the margin of error, and "Insufficient data" when there are too few games to tell.
- Lane (15 min)Miss FortuneMiss Fortune gold at 15: +393
- First itemMiss FortuneMiss Fortune: 11.4 min · Vayne: 13.7 min
- Games under 20 minInsufficient data
- 20–30 min gamesEvenMiss Fortune wins 56.1% of 155 games
- 30+ min gamesEvenMiss Fortune wins 52.1% of 307 games
What Miss Fortune Changes Against Vayne
Choices Miss Fortune players make noticeably more or less often in this matchup than in their other Bot games.
Berserker's GreavesBootsUsually46.1%vs Vayne50.8%+4.7 pts49.8% WR here
BloodthirsterItemUsually29.4%vs Vayne33.6%+4.2 pts59.6% WR here
Best Miss Fortune Build vs Vayne
Usual Miss Fortune build (Bot)
90.0% win rate · 10 games
Limited sample: 40 of 383 games finished this exact core, so treat it as an observation rather than a recommendation.
- Miss Fortune usually completes The Collector first, at 11.4 min (median of 204 games).
- Vayne usually completes Blade of The Ruined King first, at 13.7 min (median of 242 games).
- Skill priority: Q > W > E — the same as usual.
Builds are ranked by the lower edge of their win rate range, not the raw win rate, so a build seen in a handful of wins never outranks a proven one.
Best Miss Fortune Runes vs Vayne
Usual Miss Fortune runes (Bot)
First Strike
56.7% win rate · 942 games
Against Vayne
First Strike
61.4% win rate · 57 games
Plan your Miss Fortune draft in Draft Lab
Draft Lab lays out both teams lane by lane with live matchup win rates, damage profiles and game-phase lean, and suggests picks and bans from current meta data.
- Full 5v5 draft board
- Lane matchup win rates
- Pick and ban suggestions
Miss Fortune matchup data for League of Legends patch 26.20. The table below shows Miss Fortune's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Miss Fortune build, runes, laning stats, and early vs late game analysis for that specific matchup.
Other Miss Fortune Matchups
Hardest for Miss Fortune
Easiest for Miss Fortune
Win rate and games for each matchup. Lists are ranked by the edge of the 95% range so small samples cannot top them; matchups with at least 50 games only.
Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.
Miss Fortune vs Vayne FAQ - Patch 26.20
Who wins Miss Fortune vs Vayne?
Current data slightly favors Miss Fortune, but the sample is too limited for a strong conclusion: Miss Fortune wins 53.6% of 494 games (95% range 49.2–58.0%).
What is Miss Fortune's win rate against Vayne?
Miss Fortune wins 53.6% of 494 Bot games against Vayne on patch 26.20 (95% range 49.2–58.0%). Based on both champions' overall Bot win rates, 50.5% would be expected.
Does Miss Fortune counter Vayne?
Not clearly. Miss Fortune wins 53.6% of 494 games against Vayne, and the 95% range (49.2–58.0%) includes 50%, so neither champion reliably counters the other on current data.
Who wins lane, Miss Fortune or Vayne?
Miss Fortune usually wins the lane: 393 gold ahead of Vayne at 15 minutes on average (489 games with a 15-minute snapshot).
Does Miss Fortune outscale Vayne?
Not measurably: Miss Fortune's win rate against Vayne in games of 25 minutes or less and in longer games is within the margin of error of each other.
When is Vayne strongest against Miss Fortune?
On current data there is no stage of the game where Vayne is ahead of Miss Fortune beyond the margin of error.
What should Miss Fortune build against Vayne?
The most successful Miss Fortune core against Vayne is Hubris, The Collector, Bloodthirster (67.5% over 40 games). The biggest change against Vayne: Berserker's Greaves (46.1% usually, 50.8% here).
What runes should Miss Fortune use against Vayne?
First Strike with Inspiration and Sorcery — 61.4% over 57 games against Vayne.