Syndra - League of Legends Champion
Win Rate
48.1%
Pick Rate
2.3%
Ban Rate
9.0%

SyndraRunes (Mid)

FMage
Patch26.17
Games2,255
LaneMid
TierAll Tiers
Last UpdatedSep 7, 2026 UTC
MethodologyData Methodology

Best Mid Syndra runes for LoL Patch 26.17 - First Strike from the Inspiration tree with Sorcery secondary (49.0% WR, 31.3% pick rate). Syndra's optimal primary runes are First Strike, Magical Footwear, Biscuit Delivery, Cosmic Insight. Secondary tree: Manaflow Band, Transcendence.

Syndra performs best with First Strike as the keystone rune from the Inspiration tree. Syndra's optimal primary runes are First Strike, Magical Footwear, Biscuit Delivery, Cosmic Insight. Syndra's secondary rune tree is Sorcery with Manaflow Band, Transcendence. This rune setup achieves a 49.01% win rate (+0.9% win rate difference) with a 31.3% pick rate across 706 Syndra games.
49.0%Win Rate
+0.9%WR Diff
31.3%Pick Rate
First StrikeFirst Strike

Attacks or abilities against an enemy champion within 0.25s of entering champion combat grant 10 gold and First Strike for 3 seconds, causing you to deal 7% extra damage against champions, and granting 50% (35% for ranged champions) of bonus damage dealt as gold.

Cooldown: 25 - 15s

Magical FootwearMagical Footwear

You get free Slightly Magical Footwear at 12 min, but you cannot buy boots before then. For each takedown you acquire the boots 45s sooner.

Slightly Magical Footwear grants you an additional 10 Move Speed.

Biscuit DeliveryBiscuit Delivery

Biscuit Delivery: Gain a Total Biscuit of Everlasting Will every 2 mins, until 6 min.

Biscuits restore 20 + 2% of your maximum health, increased by up to 100% based on missing Health. Consuming or selling a Biscuit permanently increases your max health by 30.

Cosmic InsightCosmic Insight

+18 Summoner Spell Haste
+10 Item Haste

Manaflow BandManaflow Band

Hitting an enemy champion with an ability permanently increases your maximum mana by 25, up to 250 mana.

After reaching 250 bonus mana, restore 1% of your missing mana every 5 seconds.

Cooldown: 15 seconds

TranscendenceTranscendence

Gain bonuses upon reaching the following levels:
Level 5: +5 Ability Haste
Level 8: +5 Ability Haste
Level 11: On Champion takedown, reduce the remaining cooldown of basic abilities by 20%.

This alternative Syndra rune build uses Arcane Comet as the keystone from the Sorcery tree. The primary runes are Arcane Comet, Manaflow Band, Transcendence, Scorch. Syndra's secondary rune tree is Inspiration with Cosmic Insight, Triple Tonic. This setup achieves a 48.06% win rate (-0.1% win rate difference) with a 9.1% pick rate across 206 games.
48.1%Win Rate
-0.1%WR Diff
9.1%Pick Rate
Arcane CometArcane Comet

Damaging a champion with an ability hurls a comet at their location, dealing increased damage based on distance.

Adaptive Damage: 15 - 100 based on level (+0.05 AP and +0.1 bonus AD)
Cooldown: 20 - 8s

Damage amplification scales up to 100% at 750 range.

Manaflow BandManaflow Band

Hitting an enemy champion with an ability permanently increases your maximum mana by 25, up to 250 mana.

After reaching 250 bonus mana, restore 1% of your missing mana every 5 seconds.

Cooldown: 15 seconds

TranscendenceTranscendence

Gain bonuses upon reaching the following levels:
Level 5: +5 Ability Haste
Level 8: +5 Ability Haste
Level 11: On Champion takedown, reduce the remaining cooldown of basic abilities by 20%.

ScorchScorch

Your next damaging ability hit sets champions on fire dealing 20 - 40 bonus magic damage based on level after 1s.

Cooldown: 10s

Cosmic InsightCosmic Insight

+18 Summoner Spell Haste
+10 Item Haste

Triple TonicTriple Tonic

Upon reaching level 3, gain an Elixir of Avarice.
Upon reaching level 6, gain an Elixir of Force.
Upon reaching level 9, gain an Elixir of Skill.

These champions share at least 4 runes with Syndra's recommended rune builds. use similar keystone and secondary runes, making them good alternatives if you enjoy Syndra's playstyle or want to learn champions with familiar rune setups.Veigar, Neeko, Mel, Zed, Vel'Koz and 5 others
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Syndra Runes - Frequently Asked Questions

What are the best Syndra runes in patch 26.17?

The best Syndra runes in patch 26.17 use the Inspiration tree with First Strike, Magical Footwear, Biscuit Delivery, and Cosmic Insight, and the Sorcery tree with Manaflow Band and Transcendence. This rune setup achieves a 49.0% win rate with a 31.3% pick rate.

What is the win rate for Syndra's best rune page?

Syndra's best rune page has a 49.0% win rate in patch 26.17, which is +0.9% compared to Syndra's average win rate. This rune setup has a 31.3% pick rate among Syndra players.

What keystone should I use on Syndra?

First Strike from the Inspiration tree is the best keystone rune for Syndra in patch 26.17. This keystone synergizes well with Syndra's kit and provides a 49.0% win rate.

What is Syndra's primary rune tree?

Syndra's primary rune tree is Inspiration. The optimal Inspiration runes for Syndra are First Strike, Magical Footwear, Biscuit Delivery, and Cosmic Insight, with First Strike being the keystone of choice.

What is Syndra's secondary rune tree?

Syndra's best secondary rune tree is Sorcery. The recommended Sorcery runes are Manaflow Band and Transcendence, which complement Syndra's Inspiration primary tree.

What are alternative rune setups for Syndra?

An alternative Syndra rune setup uses Arcane Comet from the Sorcery tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.

How popular are Syndra's runes?

Syndra's top rune page has a 31.3% pick rate in patch 26.17. This indicates that 31.3% of Syndra players use the First Strike setup with Inspiration and Sorcery trees.