Zac - League of Legends Champion
Win Rate
51.7%
Pick Rate
1.5%

Zacvs Karthus

STankFighter
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 22, 2026
MethodologyData Methodology

Zac vs Karthus is a decisive matchup in LoL patch 26.7. Karthus wins with a 66.7% win rate (+33.3%) over Zac based on 9 games. Karthus wins the early laning phase while Zac scales better into the late game. Below you'll find the best Zac build, runes, laning stats, and strategies for the Zac vs Karthus matchup.

Zac Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Zac performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Karthus - 33.3% win rateKarthus(33.3%)
Zac - 33.3% win rate in this matchup
Zac
33.3% WR
VS
Karthus vs Zac matchup - 66.7% win rate
Karthus
66.7% WR

Who Wins the Zac vs Karthus Matchup?

Karthus wins the Zac vs Karthus matchup
Winner
Karthus
Matches: 9
33.3%
Win Rate
66.7%
1.4
CS / min
1.8
681
DMG / min
1,227
12,074
Gold / game
14,337
1,823
Heal / min
307
1,640
DMG Mitigated / min
483
1.5
CC / min
0.7
20.0%
Early Game WR
80.0%
50.0%
Late Game WR
50.0%

Zac vs Karthus Matchup Summary

The Zac vs Karthus matchup is a decisive matchup in League of Legends ranked play. Based on 9 recent matches analyzed, Karthus wins with a 66.7% win rate compared to Zac's 33.3%, giving Karthus a 33.3 percentage point advantage. Game phase dynamics play a critical role here: Karthus controls the early laning stage, but Zac outscales as the game goes longer. The matchup shifts dramatically depending on game length — Karthus needs to press advantages before Zac reaches their power spikes, while Zac should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Zac leads by 2,674 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Karthus has a strong advantage in this matchup. Zac players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Karthus overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Zac vs Karthus Laning Phase Breakdown

Karthus wins the laning phase against Zac in League of Legends

Karthus is favored during the laning phase against Zac, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
1.4Zac
1.8Karthus
Karthus edges out Zac by 0.4 CS per minute — a moderate farming advantage that adds up to roughly 7 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Karthus.
Damage
681Zac
1,227Karthus
Karthus heavily out-damages Zac by 546 DMG/min, dominating both short trades and all-in fights. Zac should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
12,074Zac
14,337Karthus
Karthus generates a commanding 2,263 more gold per game than Zac. This substantial economic advantage means Karthus consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Zac should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.5Zac
0.7Karthus
Zac brings significantly more crowd control than Karthus, with 0.9 more seconds of CC per minute. This large utility gap makes Zac far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Karthus should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
3,463Zac
789Karthus
Zac vastly out-sustains Karthus, healing and mitigating 2,674 more damage per minute. This massive durability gap means Zac can absorb significant punishment and remain in lane while Karthus is forced to recall. Building grievous wounds early is essential for Karthus, and focusing on burst trade patterns rather than sustained fights is critical.

Best Zac Build Against Karthus

Ionian Boots of Lucidity is the optimal boots choice against Karthus, providing the mobility and stats Zac needs most in this matchup. The top-performing core items for Zac against Karthus are Jak'Sho, The Protean, Randuin's Omen and Thornmail. This combination gives Zac an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Karthus. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Zac vs Karthus matchup.

Early Game vs Late Game

Early Game
Karthus
80.0%
+60.0% advantage
Zac early game win rateZac20.0%
Karthus early game win rateKarthus80.0%
Late Game
Zac
50.0%
+0.0% advantage
Zac late game win rateZac50.0%
Karthus late game win rateKarthus50.0%

Karthus dominates the early game (first 15 minutes) with a commanding 80.0% win rate — a 60.0 percentage point lead over Zac. This lopsided early game means Karthus can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Zac at 50.0% win rate — only 0.0 points ahead of Karthus. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

The power dynamics shift as the game progresses — Karthus has the edge early, but Zac gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.

Best Zac Runes Against Karthus

Precision rune tree - Zac primary runes vs KarthusPrecision
Conqueror - best Zac rune vs KarthusTriumph - best Zac rune vs KarthusLegend: Haste - best Zac rune vs KarthusLast Stand - best Zac rune vs Karthus
Inspiration rune tree - Zac secondary runes vs KarthusInspiration
Cash Back - best Zac rune vs KarthusCosmic Insight - best Zac rune vs Karthus
100.0% WR

The Precision and Inspiration rune setup gives Zac the best tools to compete against Karthus in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Zac matchup data for League of Legends patch 26.7. The table below shows Zac's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Zac build, runes, laning stats, and early vs late game analysis for that specific matchup.

Zac matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
57.63%591.053510,90862.5%51.9%
50.91%551.057711,34743.3%60.0%
56.52%461.065111,99550.0%63.6%
56.52%461.163012,01160.9%52.2%
53.33%451.158912,02862.5%42.9%
43.59%391.984712,92250.0%38.1%
59.46%381.560912,36556.3%61.9%
37.84%371.167211,79833.3%40.9%
60.00%351.163912,07564.7%55.6%
43.75%321.065611,59068.8%18.8%
53.13%321.366411,99633.3%70.6%
44.83%291.065811,73157.1%33.3%
59.26%271.167511,81960.0%58.3%
73.08%261.069913,11160.0%81.3%
64.00%251.159311,89653.3%80.0%
58.33%241.272012,47350.0%70.0%
66.67%211.763312,48966.7%66.7%
40.00%202.273412,13350.0%33.3%
70.00%201.154710,60588.9%54.5%
47.37%191.168112,83157.1%41.7%
31.58%193.163111,49537.5%27.3%
57.89%191.364511,15557.1%58.3%
55.56%181.467311,98228.6%72.7%
44.44%181.163710,96950.0%37.5%
44.44%181.265911,52537.5%50.0%
72.22%180.972513,22180.0%62.5%
27.78%181.255011,52328.6%27.3%
29.41%173.664310,70112.5%44.4%
70.59%171.556910,00254.5%100.0%
64.71%171.353510,86770.0%57.1%
35.29%171.260611,41550.0%27.3%
62.50%161.460812,70380.0%54.5%
43.75%161.078112,32433.3%50.0%
50.00%166.470710,93555.6%42.9%
62.50%162.770311,82275.0%50.0%
56.25%163.068110,24958.3%50.0%
46.67%151.961411,01514.3%75.0%
60.00%151.068410,91963.6%50.0%
46.67%153.490211,99750.0%45.5%
64.29%141.463613,25450.0%70.0%
38.46%131.158611,60250.0%20.0%
46.15%131.162611,18675.0%0.0%
61.54%134.379311,49675.0%55.6%
58.33%122.171711,30971.4%40.0%
9.09%110.956310,7960.0%20.0%
40.00%101.367812,83450.0%37.5%
66.67%95.882010,86675.0%60.0%
33.33%96.05599,79433.3%33.3%
33.33%91.468112,07420.0%50.0%
44.44%92.664012,47433.3%50.0%
77.78%93.480913,14066.7%83.3%
44.44%91.558410,07550.0%40.0%
62.50%86.05329,09771.4%0.0%
50.00%85.471811,26050.0%50.0%
37.50%81.957811,34740.0%33.3%
57.14%73.168211,61560.0%50.0%
42.86%71.476614,494100.0%33.3%
14.29%70.74939,4160.0%25.0%
57.14%73.564211,15475.0%33.3%
28.57%72.976810,91120.0%50.0%
57.14%74.16379,35160.0%50.0%
57.14%71.441410,28750.0%60.0%
28.57%71.266512,2410.0%50.0%
66.67%65.481610,21866.7%66.7%
66.67%61.166810,79766.7%66.7%
83.33%67.01,00112,56966.7%100.0%
50.00%61.069213,6350.0%75.0%
50.00%65.27259,65766.7%33.3%
33.33%66.163310,88625.0%50.0%
50.00%64.36859,95733.3%66.7%
33.33%65.052211,1570.0%50.0%
33.33%61.65669,97733.3%33.3%
60.00%56.51,01610,41366.7%50.0%
0.00%52.55189,0950.0%0.0%
40.00%51.84647,12540.0%0.0%
40.00%52.379813,9430.0%40.0%
80.00%51.273210,363100.0%66.7%
40.00%53.04459,49166.7%0.0%
0.00%51.53859,2260.0%0.0%
40.00%51.448310,8100.0%50.0%
40.00%50.847710,76833.3%50.0%
80.00%55.65206,565100.0%50.0%
60.00%56.076112,5980.0%75.0%
100.00%54.390813,596100.0%100.0%
60.00%53.25419,36650.0%100.0%

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Zac vs Karthus - Frequently Asked Questions

How does Zac do against Karthus in League of Legends?

Karthus wins the Zac vs Karthus matchup with a 66.7% win rate compared to Zac's 33.3%, a 33.3 percentage point difference. This data is based on 9 recent ranked games in patch 26.7.

How does Zac do against Karthus in the early game?

In the early game, Karthus has the advantage against Zac with a 80.0% win rate versus 20.0%. Karthus players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Zac do against Karthus in the late game?

In the late game, Zac takes over the Zac vs Karthus matchup with a 50.0% win rate compared to 50.0%. Zac scales better into team fights and objective contests after 25 minutes.

Who wins the Zac vs Karthus matchup?

Karthus wins the matchup against Zac with a 66.7% win rate in League of Legends patch 26.7. The 33.3 percentage point advantage means Karthus is significantly favored in this lane matchup based on 9 games analyzed.

What is the best Zac build against Karthus?

The best Zac build against Karthus includes Jak'Sho, The Protean, Randuin's Omen, Thornmail with Ionian Boots of Lucidity. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Zac runes against Karthus?

The best Zac runes against Karthus use the Precision primary tree with Inspiration secondary. This rune setup achieves a 100.0% win rate in the Zac vs Karthus matchup. See the full rune breakdown in the matchup comparison above.

Does Zac counter Karthus?

No, Zac struggles against Karthus with only a 33.3% win rate. Karthus has the advantage in this matchup. Zac players should focus on safe farming and avoiding extended trades to minimize Karthus's lead.

How do I play Zac against Karthus?

When playing Zac against Karthus, play cautiously and avoid Karthus's power spikes. Focus on safe farming — you outscale Karthus in the late game. Use the matchup-specific build and runes above to optimize your chances.