Zac - League of Legends Champion
Win Rate
48.6%
Pick Rate
1.3%

Zacvs Karthus

FTankFighter
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 7, 2026
MethodologyData Methodology

Zac vs Karthus is a decisive matchup in LoL patch 26.11. Zac wins with a 64.3% win rate (+28.6%) over Karthus based on 14 games. Zac holds the advantage in both the early and late game. Below you'll find the best Zac build, runes, laning stats, and strategies for the Zac vs Karthus matchup.

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Zac Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Zac performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Zac - 64.3% win rate in this matchup
Zac
64.3% WR
VS
Karthus vs Zac matchup - 35.7% win rate
Karthus
35.7% WR

Who Wins the Zac vs Karthus Matchup?

Zac wins the Zac vs Karthus matchup
Winner
Zac
Matches: 14
64.3%
Win Rate
35.7%
1.1
CS / min
1.6
541
DMG / min
1,239
11,583
Gold / game
13,567
1,766
Heal / min
275
1,350
DMG Mitigated / min
444
1.3
CC / min
0.7
55.6%
Early Game WR
44.4%
80.0%
Late Game WR
20.0%

Zac vs Karthus Matchup Summary

The Zac vs Karthus matchup is a decisive matchup in League of Legends ranked play. Based on 14 recent matches analyzed, Zac wins with a 64.3% win rate compared to Karthus's 35.7%, giving Zac a 28.6 percentage point advantage. Zac dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Karthus players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Zac leads by 2,397 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Zac players can confidently pick into Karthus and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Karthus away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Zac vs Karthus Laning Phase Breakdown

Karthus wins the laning phase against Zac in League of Legends

Karthus is favored during the laning phase against Zac, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
1.1Zac
1.6Karthus
Karthus edges out Zac by 0.5 CS per minute — a moderate farming advantage that adds up to roughly 8 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Karthus.
Damage
541Zac
1,239Karthus
Karthus heavily out-damages Zac by 698 DMG/min, dominating both short trades and all-in fights. Zac should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
11,583Zac
13,567Karthus
Karthus generates a commanding 1,984 more gold per game than Zac. This substantial economic advantage means Karthus consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Zac should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.3Zac
0.7Karthus
Zac provides 0.6 seconds more crowd control per minute than Karthus, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Zac coordinate with their jungler and control the pace of skirmishes.
Sustain
3,117Zac
719Karthus
Zac vastly out-sustains Karthus, healing and mitigating 2,397 more damage per minute. This massive durability gap means Zac can absorb significant punishment and remain in lane while Karthus is forced to recall. Building grievous wounds early is essential for Karthus, and focusing on burst trade patterns rather than sustained fights is critical.

Best Zac Build Against Karthus

Ionian Boots of Lucidity is the optimal boots choice against Karthus, providing the mobility and stats Zac needs most in this matchup. The top-performing core items for Zac against Karthus are Thornmail, Sunfire Aegis and Spirit Visage. This combination gives Zac an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Karthus. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Zac vs Karthus matchup.

Early Game vs Late Game

Early Game
Zac
55.6%
+11.1% advantage
Zac early game win rateZac55.6%
Karthus early game win rateKarthus44.4%
Late Game
Zac
80.0%
+60.0% advantage
Zac late game win rateZac80.0%
Karthus late game win rateKarthus20.0%

Zac dominates the early game (first 15 minutes) with a commanding 55.6% win rate — a 11.1 percentage point lead over Karthus. This lopsided early game means Zac can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Zac is far superior in the late game (25+ minutes), boasting a 80.0% win rate — 60.0 points above Karthus. Extended games heavily favor Zac, whose kit and scaling make them a dominant force in team fights and objective control.

Zac holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Karthus players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Zac Runes Against Karthus

Resolve rune tree - Zac primary runes vs KarthusResolve
Aftershock - best Zac rune vs KarthusFont of Life - best Zac rune vs KarthusConditioning - best Zac rune vs KarthusRevitalize - best Zac rune vs Karthus
Inspiration rune tree - Zac secondary runes vs KarthusInspiration
Magical Footwear - best Zac rune vs KarthusCosmic Insight - best Zac rune vs Karthus
100.0% WR

Running Resolve primary with Inspiration secondary allows Zac to press their advantage against Karthus, amplifying the strengths that make this a favorable matchup.


Zac matchup data for League of Legends patch 26.11. The table below shows Zac's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Zac build, runes, laning stats, and early vs late game analysis for that specific matchup.

Zac matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
45.74%941.161512,30740.6%48.4%
50.55%911.054311,66643.6%55.8%
53.01%831.060212,27640.7%58.9%
41.56%771.156411,04343.2%40.0%
57.75%711.053311,45563.3%53.7%
50.72%691.157112,15550.0%51.2%
52.24%671.357611,75744.8%57.9%
50.00%641.055711,01154.5%45.2%
47.46%591.051411,65450.0%45.5%
48.28%581.052811,42445.5%50.0%
54.90%511.150511,20645.8%63.0%
35.56%451.155611,42947.4%26.9%
53.85%391.258011,40461.1%47.6%
41.67%361.358711,44038.9%44.4%
57.58%331.367812,32360.0%55.6%
54.55%331.267212,20850.0%57.9%
42.42%330.963210,78561.5%30.0%
34.38%320.959812,06522.2%39.1%
51.61%310.947910,81740.0%62.5%
56.67%301.062713,04845.5%63.2%
57.14%281.052011,41440.0%66.7%
32.14%281.165012,36018.2%41.2%
42.31%261.257911,26038.5%46.1%
54.17%241.456010,59553.3%55.6%
45.45%221.357111,36825.0%70.0%
59.09%223.376713,18466.7%53.9%
54.55%222.070811,41250.0%58.3%
65.00%201.764311,16280.0%50.0%
60.00%201.959013,23337.5%75.0%
36.84%191.852011,12342.9%33.3%
36.84%191.65709,05741.7%28.6%
44.44%184.063411,35150.0%41.7%
50.00%181.060511,87771.4%36.4%
55.56%181.058511,09237.5%70.0%
25.00%163.46049,11333.3%14.3%
50.00%163.569911,42050.0%50.0%
43.75%160.965211,86362.5%25.0%
43.75%160.854710,66257.1%33.3%
20.00%151.252811,33120.0%20.0%
46.67%153.075511,26742.9%50.0%
66.67%151.158312,065100.0%54.5%
40.00%151.157811,29842.9%37.5%
42.86%145.582811,38375.0%30.0%
35.71%141.264810,87528.6%42.9%
50.00%145.380410,64550.0%50.0%
64.29%141.961012,88280.0%55.6%
57.14%140.952912,13557.1%57.1%
35.71%143.36489,71644.4%20.0%
64.29%141.154111,58355.6%80.0%
35.71%142.25149,39733.3%37.5%
30.77%133.963910,9420.0%40.0%
41.67%123.987513,02333.3%44.4%
66.67%122.564011,13955.6%100.0%
25.00%121.150810,65016.7%33.3%
33.33%120.85069,76150.0%0.0%
58.33%121.661510,30657.1%60.0%
54.55%111.558512,71440.0%66.7%
36.36%111.755010,14433.3%40.0%
70.00%102.571413,43375.0%66.7%
30.00%101.958810,74920.0%40.0%
40.00%101.34418,36350.0%33.3%
50.00%100.965710,72866.7%25.0%
22.22%91.25749,28020.0%25.0%
77.78%91.859611,31875.0%80.0%
22.22%93.373910,77225.0%20.0%
55.56%96.391912,70040.0%75.0%
44.44%95.86738,52837.5%100.0%
44.44%92.373812,63550.0%40.0%
37.50%82.766810,75766.7%20.0%
25.00%85.881710,65425.0%25.0%
25.00%84.872210,9500.0%40.0%
62.50%81.478213,164100.0%40.0%
12.50%82.855211,7860.0%14.3%
62.50%81.459610,853100.0%50.0%
62.50%81.355710,37975.0%50.0%
37.50%85.869610,08075.0%0.0%
42.86%73.095810,16625.0%66.7%
71.43%74.362311,620100.0%50.0%
57.14%75.569210,57025.0%100.0%
50.00%61.45109,48433.3%66.7%
50.00%62.156011,76650.0%50.0%
66.67%62.14466,36080.0%0.0%
66.67%61.45378,88966.7%66.7%
20.00%51.54116,97033.3%0.0%
40.00%55.382712,6890.0%50.0%
80.00%51.66587,138100.0%0.0%
40.00%51.24056,96266.7%0.0%
60.00%55.699911,75250.0%66.7%
100.00%51.949810,122100.0%100.0%
0.00%51.94487,5440.0%0.0%
80.00%56.379412,45566.7%100.0%
40.00%55.76159,868100.0%25.0%
60.00%52.666210,106100.0%33.3%

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Zac vs Karthus - Frequently Asked Questions

How does Zac do against Karthus in League of Legends?

Zac wins the Zac vs Karthus matchup with a 64.3% win rate compared to Karthus's 35.7%, a 28.6 percentage point difference. This data is based on 14 recent ranked games in patch 26.11.

How does Zac do against Karthus in the early game?

In the early game, Zac has the advantage against Karthus with a 55.6% win rate versus 44.4%. Zac players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Zac do against Karthus in the late game?

In the late game, Zac takes over the Zac vs Karthus matchup with a 80.0% win rate compared to 20.0%. Zac scales better into team fights and objective contests after 25 minutes.

Who wins the Zac vs Karthus matchup?

Zac wins the matchup against Karthus with a 64.3% win rate in League of Legends patch 26.11. The 28.6 percentage point advantage means Zac is significantly favored in this lane matchup based on 14 games analyzed.

What is the best Zac build against Karthus?

The best Zac build against Karthus includes Thornmail, Sunfire Aegis, Spirit Visage with Ionian Boots of Lucidity. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Zac runes against Karthus?

The best Zac runes against Karthus use the Resolve primary tree with Inspiration secondary. This rune setup achieves a 100.0% win rate in the Zac vs Karthus matchup. See the full rune breakdown in the matchup comparison above.

Does Zac counter Karthus?

Yes, Zac has a favorable matchup against Karthus with a 64.3% win rate. Zac strongly counters Karthus in lane based on current patch 26.11 data.

How do I play Zac against Karthus?

When playing Zac against Karthus, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.