Zyra - League of Legends Champion
Win Rate
49.9%
Pick Rate
3.3%

Zyravs Vayne

CMageSupport
Patch26.9
Matches514,344
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 10, 2026
MethodologyData Methodology

Zyra vs Vayne is a decisive matchup in LoL patch 26.9. Zyra wins with a 85.7% win rate (+71.4%) over Vayne based on 7 games. Zyra holds the advantage in both the early and late game. Below you'll find the best Zyra build, runes, laning stats, and strategies for the Zyra vs Vayne matchup.

Zyra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Zyra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 85.7% win rateVayne(85.7%)
Zyra - 85.7% win rate in this matchup
Zyra
85.7% WR
VS
Vayne vs Zyra matchup - 14.3% win rate
Vayne
14.3% WR

Who Wins the Zyra vs Vayne Matchup?

Zyra wins the Zyra vs Vayne matchup
Winner
Zyra
Matches: 7
85.7%
Win Rate
14.3%
6.1
CS / min
6.2
971
DMG / min
645
11,275
Gold / game
11,359
71
Heal / min
203
316
DMG Mitigated / min
538
1.5
CC / min
0.3
75.0%
Early Game WR
25.0%
100.0%
Late Game WR
0.0%

Zyra vs Vayne Matchup Summary

The Zyra vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 7 recent matches analyzed, Zyra wins with a 85.7% win rate compared to Vayne's 14.3%, giving Zyra a 71.4 percentage point advantage. Zyra dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Vayne players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Zyra leads by 1.1s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Zyra players can confidently pick into Vayne and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Vayne away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Zyra vs Vayne Laning Phase Breakdown

Vayne wins the laning phase against Zyra in League of Legends

Vayne is favored during the laning phase against Zyra, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, gold income and sustain, making them the stronger laner in this matchup.

Farming
6.1Zyra
6.2Vayne
Zyra and Vayne farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
971Zyra
645Vayne
Zyra heavily out-damages Vayne by 326 DMG/min, dominating both short trades and all-in fights. Vayne should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Zyra's sustained damage advantage take over.
Economy
11,275Zyra
11,359Vayne
Zyra and Vayne generate nearly equal gold per game, with just a 84 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
1.5Zyra
0.3Vayne
Zyra brings significantly more crowd control than Vayne, with 1.1 more seconds of CC per minute. This large utility gap makes Zyra far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Vayne should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
387Zyra
741Vayne
Vayne vastly out-sustains Zyra, healing and mitigating 354 more damage per minute. This massive durability gap means Vayne can absorb significant punishment and remain in lane while Zyra is forced to recall. Building grievous wounds early is essential for Zyra, and focusing on burst trade patterns rather than sustained fights is critical.

Early Game vs Late Game

Early Game
Zyra
75.0%
+50.0% advantage
Zyra early game win rateZyra75.0%
Vayne early game win rateVayne25.0%
Late Game
Zyra
100.0%
+100.0% advantage
Zyra late game win rateZyra100.0%
Vayne late game win rateVayne0.0%

Zyra dominates the early game (first 15 minutes) with a commanding 75.0% win rate — a 50.0 percentage point lead over Vayne. This lopsided early game means Zyra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Zyra is far superior in the late game (25+ minutes), boasting a 100.0% win rate — 100.0 points above Vayne. Extended games heavily favor Zyra, whose kit and scaling make them a dominant force in team fights and objective control.

Zyra holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Vayne players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Zyra Runes Against Vayne

Sorcery rune tree - Zyra primary runes vs VayneSorcery
Arcane Comet - best Zyra rune vs VayneManaflow Band - best Zyra rune vs VayneTranscendence - best Zyra rune vs VayneGathering Storm - best Zyra rune vs Vayne
Precision rune tree - Zyra secondary runes vs VaynePrecision
Legend: Haste - best Zyra rune vs VayneCut Down - best Zyra rune vs Vayne
100.0% WR

Running Sorcery primary with Precision secondary allows Zyra to press their advantage against Vayne, amplifying the strengths that make this a favorable matchup.


Zyra matchup data for League of Legends patch 26.9. The table below shows Zyra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Zyra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Zyra matchup win rates and stats in League of Legends patch 26.9
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
41.86%1721.97419,61746.3%39.0%
48.73%1581.87689,57544.8%51.6%
51.32%1522.073610,35251.8%51.0%
55.26%1142.178810,41558.7%52.9%
45.79%1071.87979,93241.9%48.4%
49.48%971.87379,96855.6%45.9%
44.68%941.87699,44336.8%50.0%
60.00%901.76329,21659.5%60.4%
50.00%902.185610,99550.0%50.0%
39.53%861.982410,04937.0%40.7%
54.88%821.77999,50563.9%47.8%
48.57%701.87479,20348.1%48.8%
53.03%661.85859,20851.7%54.0%
53.97%631.97749,23265.5%44.1%
59.68%622.07749,75465.2%56.4%
48.39%622.178410,47545.0%50.0%
56.45%621.778610,40871.4%48.8%
60.00%551.98009,85063.3%56.0%
55.77%521.982010,86761.1%52.9%
62.50%482.37149,89966.7%59.3%
39.58%482.690210,34837.5%40.6%
56.25%481.886310,53261.5%54.3%
51.11%452.17519,85682.3%32.1%
55.56%452.884410,55357.9%53.9%
48.72%391.985311,22844.4%50.0%
48.57%352.885311,53560.0%40.0%
57.58%331.675010,12491.7%38.1%
63.64%331.77068,64856.3%70.6%
48.39%311.87289,21142.9%52.9%
43.33%301.88499,26840.0%45.0%
41.38%292.077810,33815.4%62.5%
44.83%291.088013,13755.6%40.0%
59.26%272.076611,08954.5%62.5%
48.15%275.58839,86058.3%40.0%
65.38%261.280011,51071.4%58.3%
68.00%252.174710,83571.4%66.7%
54.55%221.971010,70171.4%46.7%
40.00%204.787810,70333.3%50.0%
35.00%201.880911,94557.1%23.1%
65.00%201.691412,99885.7%53.9%
52.63%191.692413,57050.0%53.9%
44.44%181.489912,89657.1%36.4%
44.44%182.186510,13833.3%50.0%
35.29%172.37639,01133.3%40.0%
47.06%171.87139,91742.9%50.0%
47.06%171.587414,11150.0%46.1%
75.00%161.692013,22550.0%90.0%
43.75%162.07658,09850.0%37.5%
56.25%161.699413,19866.7%50.0%
60.00%153.782910,34650.0%66.7%
33.33%155.086311,9460.0%50.0%
35.71%142.281411,44316.7%50.0%
35.71%141.876810,71060.0%22.2%
61.54%133.988910,13380.0%50.0%
46.15%136.41,06914,15333.3%50.0%
61.54%131.888512,815100.0%50.0%
66.67%121.493712,21266.7%66.7%
41.67%121.567611,47828.6%60.0%
25.00%121.488212,2100.0%50.0%
41.67%121.789013,14033.3%44.4%
41.67%123.177810,76240.0%42.9%
54.55%114.080310,66140.0%66.7%
63.64%116.91,11713,94466.7%62.5%
63.64%111.482213,6010.0%77.8%
54.55%112.47899,31180.0%33.3%
70.00%101.782511,907100.0%62.5%
40.00%104.61,01212,3950.0%50.0%
77.78%96.81,14810,39985.7%50.0%
55.56%92.477311,57375.0%40.0%
44.44%93.582510,38075.0%20.0%
66.67%95.685412,341100.0%62.5%
55.56%93.086413,030100.0%42.9%
55.56%96.31,32611,23850.0%66.7%
50.00%82.51,1489,56475.0%25.0%
37.50%86.685810,14566.7%20.0%
37.50%84.79049,88740.0%33.3%
37.50%82.581411,1580.0%50.0%
37.50%81.286911,76350.0%25.0%
62.50%81.264811,03675.0%50.0%
62.50%81.582114,26133.3%80.0%
50.00%86.083010,42760.0%33.3%
85.71%76.197111,27575.0%100.0%
85.71%71.378110,846100.0%80.0%
42.86%73.671110,4320.0%50.0%
42.86%72.11,09515,0770.0%50.0%
42.86%73.296911,0830.0%50.0%
57.14%74.093711,4320.0%66.7%
42.86%75.69539,31375.0%0.0%
57.14%72.46719,65675.0%33.3%
71.43%71.686114,007100.0%60.0%
71.43%73.679111,488100.0%60.0%
57.14%76.290811,60850.0%60.0%
57.14%75.57147,91640.0%100.0%
28.57%71.275710,26440.0%0.0%
33.33%61.31,04615,14650.0%25.0%
33.33%62.081710,72150.0%0.0%
50.00%62.894213,7420.0%50.0%
66.67%62.789811,4030.0%80.0%
66.67%61.569112,62166.7%66.7%
66.67%61.267510,73275.0%50.0%
33.33%62.081112,0650.0%50.0%
16.67%66.46707,50320.0%0.0%
83.33%61.490513,37950.0%100.0%
80.00%51.61,21814,7410.0%80.0%
20.00%51.878811,34150.0%0.0%
60.00%51.177011,587100.0%33.3%
80.00%54.47898,096100.0%50.0%
80.00%51.358310,33275.0%100.0%
20.00%54.01,18512,6000.0%33.3%
60.00%52.078510,818100.0%33.3%
60.00%51.21,02113,6940.0%75.0%

Get the MetaBot Desktop App

Level up your gameplay with real-time overlays, automatic game detection, and instant stats — all on your desktop.

In-game overlaysAuto game detectionMulti-game supportPersonal dashboard
Download NowFree download
🔍

Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.

Report an Issue

Zyra vs Vayne - Frequently Asked Questions

How does Zyra do against Vayne in League of Legends?

Zyra wins the Zyra vs Vayne matchup with a 85.7% win rate compared to Vayne's 14.3%, a 71.4 percentage point difference. This data is based on 7 recent ranked games in patch 26.9.

How does Zyra do against Vayne in the early game?

In the early game, Zyra has the advantage against Vayne with a 75.0% win rate versus 25.0%. Zyra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Zyra do against Vayne in the late game?

In the late game, Zyra takes over the Zyra vs Vayne matchup with a 100.0% win rate compared to 0.0%. Zyra scales better into team fights and objective contests after 25 minutes.

Who wins the Zyra vs Vayne matchup?

Zyra wins the matchup against Vayne with a 85.7% win rate in League of Legends patch 26.9. The 71.4 percentage point advantage means Zyra is significantly favored in this lane matchup based on 7 games analyzed.

What is the best Zyra build against Vayne?

The best Zyra build against Vayne includes optimized core items. Check the matchup breakdown above for the full item path and build order.

What are the best Zyra runes against Vayne?

The best Zyra runes against Vayne use the Sorcery primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Zyra vs Vayne matchup. See the full rune breakdown in the matchup comparison above.

Does Zyra counter Vayne?

Yes, Zyra has a favorable matchup against Vayne with a 85.7% win rate. Zyra strongly counters Vayne in lane based on current patch 26.9 data.

How do I play Zyra against Vayne?

When playing Zyra against Vayne, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.