Vayne - League of Legends Champion
Win Rate
48.8%
Pick Rate
7.2%

Vaynevs Zyra

DMarksmanAssassin
Patch26.9
Matches514,344
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 10, 2026
MethodologyData Methodology

Vayne vs Zyra is a decisive matchup in LoL patch 26.9. Zyra wins with a 85.7% win rate (+71.4%) over Vayne based on 7 games. Zyra holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Zyra matchup.

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Zyra - 14.3% win rateZyra(14.3%)
Vayne - 14.3% win rate in this matchup
Vayne
14.3% WR
VS
Zyra vs Vayne matchup - 85.7% win rate
Zyra
85.7% WR

Who Wins the Vayne vs Zyra Matchup?

Zyra wins the Vayne vs Zyra matchup
Winner
Zyra
Matches: 7
14.3%
Win Rate
85.7%
6.2
CS / min
6.1
645
DMG / min
971
11,359
Gold / game
11,275
203
Heal / min
71
538
DMG Mitigated / min
316
0.3
CC / min
1.5
25.0%
Early Game WR
75.0%
0.0%
Late Game WR
100.0%

Vayne vs Zyra Matchup Summary

The Vayne vs Zyra matchup is a decisive matchup in League of Legends ranked play. Based on 7 recent matches analyzed, Zyra wins with a 85.7% win rate compared to Vayne's 14.3%, giving Zyra a 71.4 percentage point advantage. Zyra dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Vayne players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Zyra leads by 1.1s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Zyra has a strong advantage in this matchup. Vayne players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Zyra overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Zyra Laning Phase Breakdown

Vayne wins the laning phase against Zyra in League of Legends

Vayne is favored during the laning phase against Zyra, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, gold income and sustain, making them the stronger laner in this matchup.

Farming
6.2Vayne
6.1Zyra
Vayne and Zyra farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
645Vayne
971Zyra
Zyra heavily out-damages Vayne by 326 DMG/min, dominating both short trades and all-in fights. Vayne should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Zyra's sustained damage advantage take over.
Economy
11,359Vayne
11,275Zyra
Vayne and Zyra generate nearly equal gold per game, with just a 84 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
0.3Vayne
1.5Zyra
Zyra brings significantly more crowd control than Vayne, with 1.1 more seconds of CC per minute. This large utility gap makes Zyra far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Vayne should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
741Vayne
387Zyra
Vayne vastly out-sustains Zyra, healing and mitigating 354 more damage per minute. This massive durability gap means Vayne can absorb significant punishment and remain in lane while Zyra is forced to recall. Building grievous wounds early is essential for Zyra, and focusing on burst trade patterns rather than sustained fights is critical.

Early Game vs Late Game

Early Game
Zyra
75.0%
+50.0% advantage
Vayne early game win rateVayne25.0%
Zyra early game win rateZyra75.0%
Late Game
Zyra
100.0%
+100.0% advantage
Vayne late game win rateVayne0.0%
Zyra late game win rateZyra100.0%

Zyra dominates the early game (first 15 minutes) with a commanding 75.0% win rate — a 50.0 percentage point lead over Vayne. This lopsided early game means Zyra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Zyra is far superior in the late game (25+ minutes), boasting a 100.0% win rate — 100.0 points above Vayne. Extended games heavily favor Zyra, whose kit and scaling make them a dominant force in team fights and objective control.

Zyra holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Vayne players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Vayne Runes Against Zyra

Precision rune tree - Vayne primary runes vs ZyraPrecision
Lethal Tempo - best Vayne rune vs ZyraTriumph - best Vayne rune vs ZyraLegend: Alacrity - best Vayne rune vs ZyraCoup de Grace - best Vayne rune vs Zyra
Resolve rune tree - Vayne secondary runes vs ZyraResolve
Conditioning - best Vayne rune vs ZyraOvergrowth - best Vayne rune vs Zyra
33.3% WR

The Precision and Resolve rune setup gives Vayne the best tools to compete against Zyra in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Vayne matchup data for League of Legends patch 26.9. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.9
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
46.84%4596.379112,83243.4%49.8%
48.25%4566.484913,46951.9%45.8%
48.01%4526.180612,91741.5%53.2%
46.51%3725.981012,61848.1%45.2%
53.50%3576.183912,56250.6%56.5%
47.98%3466.281212,99848.8%47.3%
49.84%3116.585213,16353.7%46.3%
57.91%2796.388813,57154.0%61.0%
54.78%1576.495012,34862.7%50.0%
52.45%1436.088112,71046.9%57.0%
44.85%1366.185413,03844.6%45.0%
45.38%1196.185713,45032.1%56.1%
54.31%1166.080212,86152.1%55.9%
52.68%1125.974512,58653.7%51.7%
51.82%1106.379213,21849.1%54.4%
40.40%996.061710,82734.7%46.0%
52.58%976.192513,75350.0%54.1%
50.54%936.079612,64941.0%57.4%
47.19%896.083012,39839.1%55.8%
42.86%846.379012,58542.9%42.9%
50.00%826.784513,66148.8%51.3%
62.67%756.283513,62668.0%60.0%
54.67%756.380011,19754.3%55.0%
52.17%696.487413,28754.5%50.0%
47.76%676.593211,21844.1%51.5%
55.38%656.298014,76761.1%53.2%
40.32%626.06149,67632.3%48.4%
38.33%606.199811,41442.9%34.4%
62.50%566.61,12613,48862.5%62.5%
43.64%556.51,20411,35240.7%46.4%
54.00%507.095611,17353.1%55.6%
55.10%496.391611,83857.1%53.6%
40.82%496.486112,99447.6%35.7%
50.00%486.096413,37343.8%53.1%
55.32%475.886311,03236.4%72.0%
48.89%455.788912,76842.9%51.6%
53.33%455.992915,08718.2%64.7%
61.36%446.296813,73352.9%66.7%
46.51%435.675410,92943.8%48.1%
54.76%426.71,07413,16961.1%50.0%
58.54%416.074711,55257.1%60.0%
46.15%396.281610,97258.8%36.4%
44.74%385.986012,49753.3%39.1%
47.37%386.081011,12043.8%50.0%
55.26%386.981612,61850.0%58.3%
48.65%376.388911,26447.6%50.0%
48.65%376.076212,23846.1%50.0%
45.71%357.193912,29246.7%45.0%
48.57%356.583212,24553.9%45.5%
47.06%346.097911,73740.0%52.6%
54.55%336.290411,57050.0%60.0%
59.38%326.31,00915,15058.3%60.0%
40.63%326.498513,38972.7%23.8%
67.74%316.071211,10558.3%73.7%
54.84%316.197911,28461.5%50.0%
64.52%316.288512,32292.9%41.2%
51.61%316.084511,77827.3%65.0%
43.33%306.389811,99261.5%29.4%
50.00%306.191212,57546.1%52.9%
46.15%266.379212,03040.0%50.0%
46.15%266.296511,86063.6%33.3%
60.00%255.693713,80085.7%50.0%
64.00%256.393516,36350.0%66.7%
66.67%246.391212,89050.0%72.2%
41.67%246.574811,15838.5%45.5%
43.48%235.972911,46542.9%44.4%
52.17%236.394511,04862.5%28.6%
43.48%235.568010,95045.5%41.7%
54.55%226.498612,63950.0%58.3%
40.91%225.772111,02650.0%33.3%
54.55%225.883114,683100.0%47.4%
45.45%226.276310,83640.0%50.0%
28.57%215.568610,35520.0%36.4%
33.33%214.286811,65916.7%40.0%
42.86%215.876011,69237.5%46.1%
28.57%216.389810,27328.6%28.6%
40.00%206.31,04314,31822.2%54.5%
50.00%206.683513,03260.0%46.7%
55.00%206.180914,43525.0%62.5%
52.63%196.683511,79940.0%66.7%
52.63%193.481312,59871.4%41.7%
44.44%185.887812,03342.9%45.5%
29.41%176.371212,14814.3%40.0%
37.50%165.71,00015,08328.6%44.4%
50.00%166.381712,61014.3%77.8%
73.33%156.392413,34466.7%77.8%
46.67%154.164210,36250.0%44.4%
64.29%146.078715,1130.0%75.0%
61.54%135.859711,55871.4%50.0%
38.46%136.081311,51660.0%25.0%
50.00%126.285013,47680.0%28.6%
25.00%125.397315,6650.0%30.0%
58.33%122.386813,12640.0%71.4%
41.67%126.593812,36050.0%37.5%
45.45%116.082710,69640.0%50.0%
40.00%105.397013,9450.0%57.1%
70.00%106.987511,11266.7%75.0%
33.33%95.575811,20960.0%0.0%
77.78%96.886811,80280.0%75.0%
22.22%96.370711,31933.3%0.0%
44.44%96.996212,8300.0%80.0%
37.50%86.478811,77166.7%20.0%
37.50%85.71,12913,8970.0%37.5%
50.00%82.965211,26150.0%50.0%
62.50%86.672913,28275.0%50.0%
71.43%73.67117,63180.0%50.0%
14.29%76.264511,35925.0%0.0%
42.86%75.889813,17333.3%50.0%
42.86%75.680910,67650.0%33.3%
14.29%71.561111,07833.3%0.0%
42.86%75.675114,3530.0%50.0%
33.33%67.387312,8800.0%50.0%
66.67%65.869912,59150.0%75.0%
66.67%63.064411,6530.0%80.0%
50.00%65.81,22214,13150.0%50.0%
50.00%66.597113,3620.0%75.0%
66.67%65.465411,3530.0%100.0%
50.00%65.91,01913,5620.0%60.0%
40.00%52.655213,111100.0%25.0%
60.00%53.280114,245100.0%50.0%
20.00%53.560111,8000.0%25.0%
20.00%51.593212,52025.0%0.0%
60.00%51.979111,244100.0%33.3%

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Vayne vs Zyra - Frequently Asked Questions

How does Vayne do against Zyra in League of Legends?

Zyra wins the Vayne vs Zyra matchup with a 85.7% win rate compared to Vayne's 14.3%, a 71.4 percentage point difference. This data is based on 7 recent ranked games in patch 26.9.

How does Vayne do against Zyra in the early game?

In the early game, Zyra has the advantage against Vayne with a 75.0% win rate versus 25.0%. Zyra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Zyra in the late game?

In the late game, Zyra takes over the Vayne vs Zyra matchup with a 100.0% win rate compared to 0.0%. Zyra scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Zyra matchup?

Zyra wins the matchup against Vayne with a 85.7% win rate in League of Legends patch 26.9. The 71.4 percentage point advantage means Zyra is significantly favored in this lane matchup based on 7 games analyzed.

What is the best Vayne build against Zyra?

The best Vayne build against Zyra includes optimized core items. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Zyra?

The best Vayne runes against Zyra use the Precision primary tree with Resolve secondary. This rune setup achieves a 33.3% win rate in the Vayne vs Zyra matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Zyra?

No, Vayne struggles against Zyra with only a 14.3% win rate. Zyra has the advantage in this matchup. Vayne players should focus on safe farming and avoiding extended trades to minimize Zyra's lead.

How do I play Vayne against Zyra?

When playing Vayne against Zyra, play cautiously and avoid Zyra's power spikes. Look for jungle assistance and team-dependent plays since Zyra has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.