Twisted Fate - League of Legends Champion
Win Rate
47.8%
Pick Rate
1.9%

Twisted Fatevs Vayne

FMageMarksman
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 17, 2026
MethodologyData Methodology

Twisted Fate vs Vayne is a decisive matchup in LoL patch 26.7. Vayne wins with a 71.4% win rate (+42.9%) over Twisted Fate based on 7 games. Vayne holds the advantage in both the early and late game. Below you'll find the best Twisted Fate build, runes, laning stats, and strategies for the Twisted Fate vs Vayne matchup.

Twisted Fate Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Twisted Fate performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 28.6% win rateVayne(28.6%)
Twisted Fate - 28.6% win rate in this matchup
Twisted Fate
28.6% WR
VS
Vayne vs Twisted Fate matchup - 71.4% win rate
Vayne
71.4% WR

Who Wins the Twisted Fate vs Vayne Matchup?

Vayne wins the Twisted Fate vs Vayne matchup
Winner
Vayne
Matches: 7
28.6%
Win Rate
71.4%
6.0
CS / min
6.1
665
DMG / min
682
14,085
Gold / game
13,126
153
Heal / min
230
430
DMG Mitigated / min
573
1.3
CC / min
0.4
25.0%
Early Game WR
75.0%
33.3%
Late Game WR
66.7%

Twisted Fate vs Vayne Matchup Summary

The Twisted Fate vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 7 recent matches analyzed, Vayne wins with a 71.4% win rate compared to Twisted Fate's 28.6%, giving Vayne a 42.9 percentage point advantage. Vayne dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Twisted Fate players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Twisted Fate leads by 0.9s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne has a strong advantage in this matchup. Twisted Fate players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Vayne overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Twisted Fate vs Vayne Laning Phase Breakdown

Vayne wins the laning phase against Twisted Fate in League of Legends

Vayne is favored during the laning phase against Twisted Fate, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, damage and sustain, making them the stronger laner in this matchup.

Farming
6.0Twisted Fate
6.1Vayne
Twisted Fate and Vayne farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
665Twisted Fate
682Vayne
Damage output is virtually even between Twisted Fate and Vayne, with only 16 DMG/min separating them. Fights in this matchup are decided more by ability timing and positioning than raw damage numbers, making mechanical skill the deciding factor in trades.
Economy
14,085Twisted Fate
13,126Vayne
Twisted Fate generates a commanding 959 more gold per game than Vayne. This substantial economic advantage means Twisted Fate consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Vayne should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.3Twisted Fate
0.4Vayne
Twisted Fate brings significantly more crowd control than Vayne, with 0.9 more seconds of CC per minute. This large utility gap makes Twisted Fate far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Vayne should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
584Twisted Fate
804Vayne
Vayne vastly out-sustains Twisted Fate, healing and mitigating 220 more damage per minute. This massive durability gap means Vayne can absorb significant punishment and remain in lane while Twisted Fate is forced to recall. Building grievous wounds early is essential for Twisted Fate, and focusing on burst trade patterns rather than sustained fights is critical.

Best Twisted Fate Build Against Vayne

Swiftmarch is the optimal boots choice against Vayne, providing the mobility and stats Twisted Fate needs most in this matchup. The top-performing core items for Twisted Fate against Vayne are Rod of Ages, Zhonya's Hourglass and Lich Bane. This combination gives Twisted Fate an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Vayne. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Twisted Fate vs Vayne matchup.

Early Game vs Late Game

Early Game
Vayne
75.0%
+50.0% advantage
Twisted Fate early game win rateTwisted Fate25.0%
Vayne early game win rateVayne75.0%
Late Game
Vayne
66.7%
+33.3% advantage
Twisted Fate late game win rateTwisted Fate33.3%
Vayne late game win rateVayne66.7%

Vayne dominates the early game (first 15 minutes) with a commanding 75.0% win rate — a 50.0 percentage point lead over Twisted Fate. This lopsided early game means Vayne can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Vayne is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Twisted Fate. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.

Vayne holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Twisted Fate players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Twisted Fate Runes Against Vayne

Sorcery rune tree - Twisted Fate primary runes vs VayneSorcery
Arcane Comet - best Twisted Fate rune vs VayneManaflow Band - best Twisted Fate rune vs VayneTranscendence - best Twisted Fate rune vs VayneScorch - best Twisted Fate rune vs Vayne
Inspiration rune tree - Twisted Fate secondary runes vs VayneInspiration
Magical Footwear - best Twisted Fate rune vs VayneTriple Tonic - best Twisted Fate rune vs Vayne
100.0% WR

The Sorcery and Inspiration rune setup gives Twisted Fate the best tools to compete against Vayne in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Twisted Fate matchup data for League of Legends patch 26.7. The table below shows Twisted Fate's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Twisted Fate build, runes, laning stats, and early vs late game analysis for that specific matchup.

Twisted Fate matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
45.28%1066.670512,64441.7%48.3%
48.84%866.973813,28545.5%52.4%
51.61%626.370512,16742.4%62.1%
59.32%596.473311,70665.7%50.0%
44.23%526.268713,26150.0%42.1%
52.94%516.874313,23363.0%41.7%
60.42%486.280512,05665.4%54.5%
46.81%476.276011,66750.0%43.5%
28.26%466.069112,23129.4%27.6%
58.70%466.174912,29654.5%62.5%
50.00%446.371312,30247.6%52.2%
53.49%436.864711,98861.9%45.5%
41.86%436.078613,33046.1%40.0%
51.28%396.477012,11254.5%47.1%
37.84%376.263511,31635.0%41.2%
55.88%346.372012,19346.7%63.2%
62.50%326.668811,49557.9%69.2%
34.38%326.266512,53236.4%33.3%
64.52%316.473611,61675.0%53.3%
48.39%316.284112,74140.0%56.3%
50.00%306.585513,96930.8%64.7%
37.93%296.378213,25916.7%52.9%
44.44%276.369811,83826.7%66.7%
29.63%276.467411,60929.4%30.0%
48.00%256.178512,83612.5%64.7%
52.00%256.273613,43933.3%62.5%
45.83%245.867412,76655.6%40.0%
61.90%217.278613,97160.0%63.6%
55.00%206.176812,18262.5%50.0%
55.00%206.971111,55653.9%57.1%
52.63%195.968312,37766.7%40.0%
55.56%187.470011,38258.3%50.0%
58.82%176.775512,18560.0%57.1%
58.82%177.181613,82675.0%44.4%
50.00%166.351710,10763.6%20.0%
50.00%166.266910,48466.7%28.6%
43.75%166.172812,27742.9%44.4%
20.00%156.685312,22825.0%14.3%
50.00%146.989513,63850.0%50.0%
21.43%146.062911,72740.0%11.1%
30.77%136.780512,41150.0%0.0%
30.77%135.964511,90220.0%37.5%
41.67%125.776511,62457.1%20.0%
54.55%115.471813,67860.0%50.0%
54.55%116.279714,46566.7%40.0%
50.00%106.278512,85066.7%25.0%
80.00%106.365012,125100.0%75.0%
50.00%105.87409,39750.0%50.0%
50.00%107.070513,45425.0%66.7%
44.44%95.679710,26250.0%33.3%
44.44%96.070311,02640.0%50.0%
33.33%96.05749,36740.0%25.0%
22.22%95.776112,9870.0%40.0%
55.56%95.683617,8530.0%62.5%
37.50%84.357511,1680.0%100.0%
62.50%86.373212,62450.0%75.0%
62.50%86.371214,79933.3%80.0%
0.00%86.15079,3040.0%0.0%
62.50%85.678514,49550.0%66.7%
75.00%86.885913,34775.0%75.0%
28.57%76.066514,08525.0%33.3%
85.71%75.359612,20580.0%100.0%
42.86%76.272314,8950.0%60.0%
42.86%75.562213,60533.3%50.0%
42.86%76.178812,89166.7%25.0%
50.00%66.658811,34075.0%0.0%
50.00%67.681614,41550.0%50.0%
50.00%65.460615,416100.0%40.0%
60.00%54.27889,01766.7%50.0%
100.00%56.571816,188100.0%100.0%
40.00%55.479613,27133.3%50.0%
20.00%56.461112,51633.3%0.0%
20.00%54.099211,8730.0%25.0%
80.00%53.961713,15166.7%100.0%
60.00%56.496714,86533.3%100.0%
60.00%57.098810,43033.3%100.0%
40.00%51.65349,28166.7%0.0%

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Twisted Fate vs Vayne - Frequently Asked Questions

How does Twisted Fate do against Vayne in League of Legends?

Vayne wins the Twisted Fate vs Vayne matchup with a 71.4% win rate compared to Twisted Fate's 28.6%, a 42.9 percentage point difference. This data is based on 7 recent ranked games in patch 26.7.

How does Twisted Fate do against Vayne in the early game?

In the early game, Vayne has the advantage against Twisted Fate with a 75.0% win rate versus 25.0%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Twisted Fate do against Vayne in the late game?

In the late game, Vayne takes over the Twisted Fate vs Vayne matchup with a 66.7% win rate compared to 33.3%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Twisted Fate vs Vayne matchup?

Vayne wins the matchup against Twisted Fate with a 71.4% win rate in League of Legends patch 26.7. The 42.9 percentage point advantage means Vayne is significantly favored in this lane matchup based on 7 games analyzed.

What is the best Twisted Fate build against Vayne?

The best Twisted Fate build against Vayne includes Rod of Ages, Zhonya's Hourglass, Lich Bane with Swiftmarch. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Twisted Fate runes against Vayne?

The best Twisted Fate runes against Vayne use the Sorcery primary tree with Inspiration secondary. This rune setup achieves a 100.0% win rate in the Twisted Fate vs Vayne matchup. See the full rune breakdown in the matchup comparison above.

Does Twisted Fate counter Vayne?

No, Twisted Fate struggles against Vayne with only a 28.6% win rate. Vayne has the advantage in this matchup. Twisted Fate players should focus on safe farming and avoiding extended trades to minimize Vayne's lead.

How do I play Twisted Fate against Vayne?

When playing Twisted Fate against Vayne, play cautiously and avoid Vayne's power spikes. Look for jungle assistance and team-dependent plays since Vayne has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.