Vayne - League of Legends Champion
Win Rate
50.5%
Pick Rate
4.6%

Vaynevs Twisted Fate

BMarksmanAssassin
Patch26.4
Matches1,089,240
LaneAll Lanes
TierAll Tiers
Last UpdatedMar 4, 2026
MethodologyData Methodology

Vayne vs Twisted Fate is a decisive matchup in LoL patch 26.4. Twisted Fate wins with a 85.7% win rate (+71.4%) over Vayne based on 7 games. Twisted Fate holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Twisted Fate matchup.

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Twisted Fate - 14.3% win rateTwisted Fate(14.3%)
Vayne - 14.3% win rate in this matchup
Vayne
14.3% WR
VS
Twisted Fate vs Vayne matchup - 85.7% win rate
Twisted Fate
85.7% WR

Who Wins the Vayne vs Twisted Fate Matchup?

Twisted Fate wins the Vayne vs Twisted Fate matchup
Winner
Twisted Fate
Matches: 7
14.3%
Win Rate
85.7%
6.0
CS / min
6.2
1,054
DMG / min
908
15,482
Gold / game
18,596
287
Heal / min
206
698
DMG Mitigated / min
509
0.3
CC / min
1.2
0.0%
Early Game WR
100.0%
16.7%
Late Game WR
83.3%

Vayne vs Twisted Fate Matchup Summary

The Vayne vs Twisted Fate matchup is a decisive matchup in League of Legends ranked play. Based on 7 recent matches analyzed, Twisted Fate wins with a 85.7% win rate compared to Vayne's 14.3%, giving Twisted Fate a 71.4 percentage point advantage. Twisted Fate dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Vayne players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Twisted Fate leads by 0.9s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Twisted Fate has a strong advantage in this matchup. Vayne players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Twisted Fate overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Twisted Fate Laning Phase Breakdown

Twisted Fate wins the laning phase against Vayne in League of Legends

Twisted Fate is favored during the laning phase against Vayne, winning 3 out of 5 key stat categories. Twisted Fate holds advantages in farming, gold income and crowd control, making them the stronger laner in this matchup.

Farming
6.0Vayne
6.2Twisted Fate
Vayne and Twisted Fate farm at nearly identical rates in this matchup, with only a 0.3 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
1,054Vayne
908Twisted Fate
Vayne heavily out-damages Twisted Fate by 146 DMG/min, dominating both short trades and all-in fights. Twisted Fate should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Vayne's sustained damage advantage take over.
Economy
15,482Vayne
18,596Twisted Fate
Twisted Fate generates a commanding 3,115 more gold per game than Vayne. This substantial economic advantage means Twisted Fate consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Vayne should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.3Vayne
1.2Twisted Fate
Twisted Fate brings significantly more crowd control than Vayne, with 0.9 more seconds of CC per minute. This large utility gap makes Twisted Fate far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Vayne should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
985Vayne
715Twisted Fate
Vayne vastly out-sustains Twisted Fate, healing and mitigating 270 more damage per minute. This massive durability gap means Vayne can absorb significant punishment and remain in lane while Twisted Fate is forced to recall. Building grievous wounds early is essential for Twisted Fate, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against Twisted Fate

Gunmetal Greaves is the optimal boots choice against Twisted Fate, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Twisted Fate are Kraken Slayer, Blade of The Ruined King and Guinsoo's Rageblade. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Twisted Fate matchup.

Early Game vs Late Game

Early Game
Twisted Fate
100.0%
+100.0% advantage
Vayne early game win rateVayne0.0%
Twisted Fate early game win rateTwisted Fate100.0%
Late Game
Twisted Fate
83.3%
+66.7% advantage
Vayne late game win rateVayne16.7%
Twisted Fate late game win rateTwisted Fate83.3%

Twisted Fate dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Vayne. This lopsided early game means Twisted Fate can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Twisted Fate is far superior in the late game (25+ minutes), boasting a 83.3% win rate — 66.7 points above Vayne. Extended games heavily favor Twisted Fate, whose kit and scaling make them a dominant force in team fights and objective control.

Twisted Fate holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Vayne players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Vayne Runes Against Twisted Fate

Precision rune tree - Vayne primary runes vs Twisted FatePrecision
Press the Attack - best Vayne rune vs Twisted FateTriumph - best Vayne rune vs Twisted FateLegend: Alacrity - best Vayne rune vs Twisted FateCoup de Grace - best Vayne rune vs Twisted Fate
Domination rune tree - Vayne secondary runes vs Twisted FateDomination
Taste of Blood - best Vayne rune vs Twisted FateTreasure Hunter - best Vayne rune vs Twisted Fate
100.0% WR

The Precision and Domination rune setup gives Vayne the best tools to compete against Twisted Fate in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Vayne matchup data for League of Legends patch 26.4. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.4
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
50.82%7326.180313,25851.6%50.3%
50.47%6435.981913,61051.8%49.5%
50.16%6266.386013,31448.9%51.4%
53.35%5296.186813,34852.2%54.2%
49.25%4756.590413,93644.6%53.5%
56.36%4026.491813,99152.9%59.4%
46.70%3956.080213,25141.1%51.1%
52.87%3546.492214,14751.2%53.9%
48.04%2826.084313,50556.5%42.2%
51.29%2716.587013,47253.7%49.3%
52.54%2396.288813,13952.5%52.6%
54.25%2126.591714,46558.5%51.5%
51.26%2006.283713,33657.7%44.2%
55.00%2006.182113,16149.5%60.0%
47.40%1926.389113,42449.0%45.8%
55.56%1816.085813,65358.1%53.8%
49.11%1706.287313,70246.5%51.0%
49.63%1355.985414,04346.3%51.9%
55.65%1156.190213,63258.8%53.1%
53.15%1116.084211,67052.9%53.3%
57.41%1096.590812,76754.2%60.0%
50.00%1066.283813,92548.7%50.8%
60.20%996.199412,48161.9%58.9%
54.74%965.81,03114,05643.6%62.5%
51.09%926.191413,61256.1%47.1%
45.65%926.384513,98043.6%47.2%
51.65%916.489314,00447.4%54.7%
50.59%876.394912,10352.9%49.0%
45.88%866.185913,54056.8%37.5%
45.12%835.760311,33933.3%54.4%
46.15%786.089711,41528.9%62.5%
44.16%776.31,39112,48136.7%48.9%
39.47%776.288514,18028.0%45.1%
53.73%685.564011,62826.1%68.2%
45.45%666.696914,14246.9%44.1%
49.23%666.31,02112,93252.0%47.5%
53.13%646.01,00511,45151.5%54.8%
45.31%646.285813,54544.4%46.0%
50.00%646.398712,06041.4%57.1%
59.32%596.199711,68457.1%61.3%
50.00%566.591913,45255.6%44.8%
50.00%546.494912,10040.0%55.9%
57.14%496.384312,07754.2%60.0%
53.06%496.494512,15460.9%46.1%
47.92%486.380412,12534.8%60.0%
46.81%486.597012,45347.6%46.1%
51.06%476.592611,29546.1%57.1%
51.11%457.299813,30647.6%54.2%
32.56%435.87009,81520.7%57.1%
69.77%436.890315,25571.4%69.0%
51.16%436.198611,82545.8%57.9%
52.38%426.687712,78847.6%57.1%
55.00%406.097011,81355.6%54.5%
55.00%405.891414,58447.4%61.9%
58.97%396.081012,83146.7%66.7%
48.65%386.084011,26447.6%50.0%
43.24%375.782511,62740.0%47.1%
45.71%356.094612,63827.3%54.2%
33.33%336.588813,38920.0%39.1%
48.48%336.072813,05940.0%55.6%
48.39%326.292713,03146.1%50.0%
54.84%316.182311,63250.0%58.8%
46.67%306.076812,08346.1%47.1%
63.33%306.488612,70272.7%57.9%
44.44%275.495212,11458.3%33.3%
50.00%266.588911,51646.1%53.9%
61.54%266.81,08714,27762.5%61.1%
46.15%265.284913,31170.0%31.3%
50.00%266.579212,81066.7%35.7%
46.15%266.61,14412,90646.7%45.5%
50.00%266.81,09014,26366.7%41.2%
50.00%246.188512,72954.5%46.1%
40.91%236.587614,59940.0%41.7%
60.87%236.390914,13163.6%58.3%
52.38%225.586013,67055.6%50.0%
42.86%216.584511,53433.3%55.6%
50.00%206.073810,24154.5%44.4%
63.16%196.31,06115,663100.0%53.3%
52.63%195.983912,95142.9%58.3%
52.94%176.01,02012,52340.0%71.4%
43.75%165.762410,93325.0%62.5%
62.50%166.881711,30363.6%60.0%
26.67%156.56669,61722.2%33.3%
40.00%154.089712,23157.1%25.0%
35.71%146.463711,28033.3%40.0%
42.86%146.984611,76328.6%57.1%
42.86%146.392511,74442.9%42.9%
38.46%134.782713,52216.7%57.1%
46.15%135.896112,41620.0%62.5%
46.15%135.998214,62342.9%50.0%
50.00%125.789715,26533.3%55.6%
41.67%126.797615,74340.0%42.9%
58.33%124.583212,19950.0%62.5%
58.33%125.978111,83020.0%85.7%
41.67%124.476311,16450.0%25.0%
54.55%112.91,05515,23950.0%57.1%
36.36%116.675013,0070.0%44.4%
45.45%114.280712,51350.0%40.0%
36.36%116.390412,25950.0%28.6%
22.22%104.26589,34814.3%50.0%
50.00%105.91,13212,11860.0%40.0%
40.00%104.877312,40933.3%50.0%
33.33%93.473212,8440.0%42.9%
44.44%94.469512,82450.0%40.0%
62.50%86.066012,870100.0%50.0%
25.00%84.275811,7450.0%66.7%
62.50%85.889913,4690.0%100.0%
14.29%76.01,05415,4820.0%16.7%
71.43%76.684915,13250.0%80.0%
71.43%74.483412,500100.0%50.0%
66.67%66.778713,85750.0%75.0%
33.33%66.975311,851100.0%0.0%
50.00%65.195712,1060.0%60.0%
50.00%66.589810,84275.0%0.0%
33.33%61.280811,0650.0%100.0%
50.00%64.077515,502100.0%40.0%
60.00%56.31,18019,8650.0%60.0%
25.00%52.456711,13350.0%0.0%
40.00%56.385511,5310.0%66.7%
60.00%56.41,09915,068100.0%33.3%
40.00%55.187711,5370.0%100.0%
40.00%53.11,07012,85150.0%0.0%
40.00%52.770614,2870.0%50.0%
0.00%56.078112,1500.0%0.0%
60.00%56.91,19213,2620.0%100.0%
🔍

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Vayne vs Twisted Fate - Frequently Asked Questions

How does Vayne do against Twisted Fate in League of Legends?

Twisted Fate wins the Vayne vs Twisted Fate matchup with a 85.7% win rate compared to Vayne's 14.3%, a 71.4 percentage point difference. This data is based on 7 recent ranked games in patch 26.4.

How does Vayne do against Twisted Fate in the early game?

In the early game, Twisted Fate has the advantage against Vayne with a 100.0% win rate versus 0.0%. Twisted Fate players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Twisted Fate in the late game?

In the late game, Twisted Fate takes over the Vayne vs Twisted Fate matchup with a 83.3% win rate compared to 16.7%. Twisted Fate scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Twisted Fate matchup?

Twisted Fate wins the matchup against Vayne with a 85.7% win rate in League of Legends patch 26.4. The 71.4 percentage point advantage means Twisted Fate is significantly favored in this lane matchup based on 7 games analyzed.

What is the best Vayne build against Twisted Fate?

The best Vayne build against Twisted Fate includes Kraken Slayer, Blade of The Ruined King, Guinsoo's Rageblade with Gunmetal Greaves. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Twisted Fate?

The best Vayne runes against Twisted Fate use the Precision primary tree with Domination secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Twisted Fate matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Twisted Fate?

No, Vayne struggles against Twisted Fate with only a 14.3% win rate. Twisted Fate has the advantage in this matchup. Vayne players should focus on safe farming and avoiding extended trades to minimize Twisted Fate's lead.

How do I play Vayne against Twisted Fate?

When playing Vayne against Twisted Fate, play cautiously and avoid Twisted Fate's power spikes. Look for jungle assistance and team-dependent plays since Twisted Fate has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.