Vayne - League of Legends Champion
Win Rate
50.4%
Pick Rate
4.9%

Vaynevs Twisted Fate

BMarksmanAssassin
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 4, 2026
MethodologyData Methodology

Vayne vs Twisted Fate is a decisive matchup in LoL patch 26.11. Twisted Fate wins with a 57.1% win rate (+14.3%) over Vayne based on 14 games. Vayne wins the early laning phase while Twisted Fate scales better into the late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Twisted Fate matchup.

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Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 42.9% win rate in this matchup
Vayne
42.9% WR
VS
Twisted Fate vs Vayne matchup - 57.1% win rate
Twisted Fate
57.1% WR

Who Wins the Vayne vs Twisted Fate Matchup?

Twisted Fate wins the Vayne vs Twisted Fate matchup
Winner
Twisted Fate
Matches: 14
42.9%
Win Rate
57.1%
6.4
CS / min
5.8
824
DMG / min
741
13,966
Gold / game
15,066
222
Heal / min
150
532
DMG Mitigated / min
422
0.3
CC / min
1.1
75.0%
Early Game WR
25.0%
30.0%
Late Game WR
70.0%

Vayne vs Twisted Fate Matchup Summary

The Vayne vs Twisted Fate matchup is a decisive matchup in League of Legends ranked play. Based on 14 recent matches analyzed, Twisted Fate wins with a 57.1% win rate compared to Vayne's 42.9%, giving Twisted Fate a 14.3 percentage point advantage. Game phase dynamics play a critical role here: Vayne controls the early laning stage, but Twisted Fate outscales as the game goes longer. The matchup shifts dramatically depending on game length — Vayne needs to press advantages before Twisted Fate reaches their power spikes, while Twisted Fate should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Twisted Fate leads by 0.7s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Twisted Fate has a strong advantage in this matchup. Vayne players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Twisted Fate overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Twisted Fate Laning Phase Breakdown

Vayne wins the laning phase against Twisted Fate in League of Legends

Vayne is favored during the laning phase against Twisted Fate, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, damage and sustain, making them the stronger laner in this matchup.

Farming
6.4Vayne
5.8Twisted Fate
Vayne edges out Twisted Fate by 0.6 CS per minute — a moderate farming advantage that adds up to roughly 9 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Vayne.
Damage
824Vayne
741Twisted Fate
Vayne heavily out-damages Twisted Fate by 84 DMG/min, dominating both short trades and all-in fights. Twisted Fate should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Vayne's sustained damage advantage take over.
Economy
13,966Vayne
15,066Twisted Fate
Twisted Fate generates a commanding 1,099 more gold per game than Vayne. This substantial economic advantage means Twisted Fate consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Vayne should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.3Vayne
1.1Twisted Fate
Twisted Fate provides 0.7 seconds more crowd control per minute than Vayne, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Twisted Fate coordinate with their jungler and control the pace of skirmishes.
Sustain
754Vayne
572Twisted Fate
Vayne vastly out-sustains Twisted Fate, healing and mitigating 183 more damage per minute. This massive durability gap means Vayne can absorb significant punishment and remain in lane while Twisted Fate is forced to recall. Building grievous wounds early is essential for Twisted Fate, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against Twisted Fate

Mercury's Treads is the optimal boots choice against Twisted Fate, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Twisted Fate are Essence Reaver, Experimental Hexplate and Fiendhunter Bolts. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Twisted Fate matchup.

Early Game vs Late Game

Early Game
Vayne
75.0%
+50.0% advantage
Vayne early game win rateVayne75.0%
Twisted Fate early game win rateTwisted Fate25.0%
Late Game
Twisted Fate
70.0%
+40.0% advantage
Vayne late game win rateVayne30.0%
Twisted Fate late game win rateTwisted Fate70.0%

Vayne dominates the early game (first 15 minutes) with a commanding 75.0% win rate — a 50.0 percentage point lead over Twisted Fate. This lopsided early game means Vayne can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Twisted Fate is far superior in the late game (25+ minutes), boasting a 70.0% win rate — 40.0 points above Vayne. Extended games heavily favor Twisted Fate, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Vayne must aggressively press their early advantage and close out the game before Twisted Fate reaches their scaling breakpoints. If Twisted Fate survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Vayne Runes Against Twisted Fate

Precision rune tree - Vayne primary runes vs Twisted FatePrecision
Press the Attack - best Vayne rune vs Twisted FateTriumph - best Vayne rune vs Twisted FateLegend: Alacrity - best Vayne rune vs Twisted FateCoup de Grace - best Vayne rune vs Twisted Fate
Domination rune tree - Vayne secondary runes vs Twisted FateDomination
Sudden Impact - best Vayne rune vs Twisted FateRelentless Hunter - best Vayne rune vs Twisted Fate
100.0% WR

The Precision and Domination rune setup gives Vayne the best tools to compete against Twisted Fate in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Vayne matchup data for League of Legends patch 26.11. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
46.01%4766.078912,87544.3%47.4%
47.20%4476.079112,72545.4%48.6%
46.26%4285.779612,71544.9%47.3%
53.92%3956.085712,96853.2%54.6%
47.85%3726.289413,18946.8%48.6%
52.99%3516.284313,14252.5%53.4%
52.98%2856.390413,45646.2%58.8%
53.90%2696.387713,73748.2%58.0%
52.38%1895.988612,46846.1%58.2%
51.92%1566.591311,98950.0%53.4%
54.30%1516.185913,22758.5%51.2%
50.33%1516.180413,00743.8%55.2%
45.95%1485.978013,60345.3%46.3%
45.38%1306.177613,08138.2%50.7%
47.83%1156.481213,76538.5%52.6%
42.61%1156.178112,08234.0%49.2%
50.88%1145.886612,98941.2%58.7%
45.19%1046.489913,17548.7%43.1%
59.80%1026.585413,18963.5%56.0%
31.00%1005.563510,36011.1%47.3%
45.83%965.885713,16444.4%46.7%
50.53%956.31,12012,73751.6%50.0%
58.06%936.379613,00854.8%60.8%
44.09%935.862511,33042.4%45.0%
45.56%905.883011,35543.6%47.1%
45.98%876.385113,57237.9%50.0%
55.81%866.189910,74843.2%65.3%
55.95%846.21,29211,54651.4%59.2%
56.41%786.388313,43557.1%55.8%
54.84%625.981412,06158.3%52.6%
45.76%596.287712,77548.0%44.1%
51.92%526.091311,59248.1%56.0%
45.10%516.592112,14440.9%48.3%
52.00%506.087513,62147.8%55.6%
35.42%486.272110,98228.0%43.5%
58.33%486.198911,81064.0%52.2%
45.83%486.21,00510,83851.9%38.1%
50.00%466.297013,36447.4%51.9%
58.70%466.291413,67162.5%54.5%
54.55%446.287414,06357.1%53.3%
44.19%436.683913,74455.0%34.8%
26.19%425.987411,67823.5%28.0%
48.78%415.983611,64443.5%55.6%
52.50%405.683813,60737.5%56.3%
38.46%396.785410,96150.0%28.6%
41.03%396.07439,57128.6%55.6%
67.57%376.589811,52662.5%76.9%
45.95%375.683211,99840.0%50.0%
52.94%346.475912,24550.0%54.5%
52.94%346.41,05111,47452.6%53.3%
66.67%336.393813,52461.5%70.0%
48.48%336.478411,26950.0%46.1%
48.48%336.597913,30562.5%44.0%
40.63%325.382011,34442.1%38.5%
62.50%325.779613,16341.7%75.0%
40.63%326.267610,36931.6%53.9%
58.06%316.484912,13864.3%52.9%
53.33%305.685512,15255.6%52.4%
60.00%306.095312,30876.9%47.1%
43.33%306.664611,44137.5%50.0%
55.56%275.379211,00650.0%60.0%
48.15%276.283411,46543.8%54.5%
50.00%265.969311,80141.7%57.1%
50.00%266.171011,42146.1%53.9%
30.77%265.370011,00127.3%33.3%
50.00%265.883412,30154.5%46.7%
48.00%256.081612,91020.0%66.7%
44.00%256.475811,84450.0%38.5%
54.17%246.399112,32564.3%40.0%
45.83%246.085011,12557.1%30.0%
56.52%235.761010,29945.5%66.7%
45.45%226.573412,18438.5%55.6%
40.91%226.080612,81544.4%38.5%
42.11%196.292010,37245.5%37.5%
63.16%196.387012,58950.0%72.7%
42.11%195.881712,14257.1%33.3%
61.11%185.61,00813,43366.7%58.3%
62.50%166.188511,54762.5%62.5%
80.00%152.288517,36850.0%84.6%
53.33%156.498513,30150.0%54.5%
60.00%156.583311,24437.5%85.7%
46.67%156.687611,53050.0%42.9%
46.67%155.491613,99225.0%54.5%
42.86%146.482413,96675.0%30.0%
42.86%146.084113,4470.0%66.7%
53.85%136.584913,506100.0%33.3%
46.15%135.275011,57950.0%42.9%
66.67%125.61,02512,92880.0%57.1%
33.33%126.092711,90033.3%33.3%
54.55%115.61,00213,29850.0%57.1%
63.64%116.164210,20450.0%80.0%
54.55%112.982014,06866.7%40.0%
81.82%116.277512,783100.0%71.4%
54.55%113.484613,74333.3%62.5%
54.55%115.576111,64971.4%25.0%
45.45%115.69159,80875.0%28.6%
40.00%104.670811,73250.0%25.0%
60.00%105.782012,59750.0%62.5%
50.00%103.877113,23733.3%57.1%
40.00%105.592611,89340.0%40.0%
66.67%93.81,03913,79866.7%66.7%
33.33%96.11,07613,2730.0%50.0%
55.56%96.793013,145100.0%20.0%
33.33%96.085513,01833.3%33.3%
55.56%93.986012,86033.3%66.7%
50.00%85.887014,56550.0%50.0%
62.50%87.368411,84766.7%50.0%
50.00%83.288313,47975.0%25.0%
25.00%85.26909,10216.7%50.0%
37.50%85.85269,89450.0%25.0%
57.14%74.076010,75033.3%75.0%
71.43%73.674311,42580.0%50.0%
42.86%74.572311,69733.3%50.0%
28.57%74.567612,0460.0%40.0%
50.00%63.578115,0220.0%60.0%
33.33%66.882313,7790.0%50.0%
33.33%62.998912,89833.3%33.3%
66.67%65.91,00614,14350.0%75.0%
20.00%54.75778,99933.3%0.0%
40.00%52.161112,29050.0%0.0%
40.00%56.41,17614,5940.0%50.0%
80.00%56.21,02413,762100.0%66.7%
40.00%55.996213,2480.0%50.0%
40.00%56.06739,21850.0%0.0%
40.00%56.47269,89240.0%0.0%

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Vayne vs Twisted Fate - Frequently Asked Questions

How does Vayne do against Twisted Fate in League of Legends?

Twisted Fate wins the Vayne vs Twisted Fate matchup with a 57.1% win rate compared to Vayne's 42.9%, a 14.3 percentage point difference. This data is based on 14 recent ranked games in patch 26.11.

How does Vayne do against Twisted Fate in the early game?

In the early game, Vayne has the advantage against Twisted Fate with a 75.0% win rate versus 25.0%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Twisted Fate in the late game?

In the late game, Twisted Fate takes over the Vayne vs Twisted Fate matchup with a 70.0% win rate compared to 30.0%. Twisted Fate scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Twisted Fate matchup?

Twisted Fate wins the matchup against Vayne with a 57.1% win rate in League of Legends patch 26.11. The 14.3 percentage point advantage means Twisted Fate is significantly favored in this lane matchup based on 14 games analyzed.

What is the best Vayne build against Twisted Fate?

The best Vayne build against Twisted Fate includes Essence Reaver, Experimental Hexplate, Fiendhunter Bolts with Mercury's Treads. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Twisted Fate?

The best Vayne runes against Twisted Fate use the Precision primary tree with Domination secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Twisted Fate matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Twisted Fate?

No, Vayne struggles against Twisted Fate with only a 42.9% win rate. Twisted Fate has the advantage in this matchup. Vayne players should focus on safe farming and avoiding extended trades to minimize Twisted Fate's lead.

How do I play Vayne against Twisted Fate?

When playing Vayne against Twisted Fate, play cautiously and avoid Twisted Fate's power spikes. Look for jungle assistance and team-dependent plays since Twisted Fate has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.