Vayne - League of Legends Champion
Win Rate
49.5%
Pick Rate
5.3%

Vaynevs Twisted Fate

DMarksmanAssassin
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 19, 2026
MethodologyData Methodology

Vayne vs Twisted Fate is a decisive matchup in LoL patch 26.7. Vayne wins with a 71.4% win rate (+42.9%) over Twisted Fate based on 7 games. Vayne holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Twisted Fate matchup.

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Twisted Fate - 71.4% win rateTwisted Fate(71.4%)
Vayne - 71.4% win rate in this matchup
Vayne
71.4% WR
VS
Twisted Fate vs Vayne matchup - 28.6% win rate
Twisted Fate
28.6% WR

Who Wins the Vayne vs Twisted Fate Matchup?

Vayne wins the Vayne vs Twisted Fate matchup
Winner
Vayne
Matches: 7
71.4%
Win Rate
28.6%
6.1
CS / min
6.0
682
DMG / min
665
13,126
Gold / game
14,085
230
Heal / min
153
573
DMG Mitigated / min
430
0.4
CC / min
1.3
75.0%
Early Game WR
25.0%
66.7%
Late Game WR
33.3%

Vayne vs Twisted Fate Matchup Summary

The Vayne vs Twisted Fate matchup is a decisive matchup in League of Legends ranked play. Based on 7 recent matches analyzed, Vayne wins with a 71.4% win rate compared to Twisted Fate's 28.6%, giving Vayne a 42.9 percentage point advantage. Vayne dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Twisted Fate players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Twisted Fate leads by 0.9s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne players can confidently pick into Twisted Fate and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Twisted Fate away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Twisted Fate Laning Phase Breakdown

Vayne wins the laning phase against Twisted Fate in League of Legends

Vayne is favored during the laning phase against Twisted Fate, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, damage and sustain, making them the stronger laner in this matchup.

Farming
6.1Vayne
6.0Twisted Fate
Vayne and Twisted Fate farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
682Vayne
665Twisted Fate
Damage output is virtually even between Vayne and Twisted Fate, with only 16 DMG/min separating them. Fights in this matchup are decided more by ability timing and positioning than raw damage numbers, making mechanical skill the deciding factor in trades.
Economy
13,126Vayne
14,085Twisted Fate
Twisted Fate generates a commanding 959 more gold per game than Vayne. This substantial economic advantage means Twisted Fate consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Vayne should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.4Vayne
1.3Twisted Fate
Twisted Fate brings significantly more crowd control than Vayne, with 0.9 more seconds of CC per minute. This large utility gap makes Twisted Fate far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Vayne should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
804Vayne
584Twisted Fate
Vayne vastly out-sustains Twisted Fate, healing and mitigating 220 more damage per minute. This massive durability gap means Vayne can absorb significant punishment and remain in lane while Twisted Fate is forced to recall. Building grievous wounds early is essential for Twisted Fate, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against Twisted Fate

Chainlaced Crushers is the optimal boots choice against Twisted Fate, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Twisted Fate are Kraken Slayer, Blade of The Ruined King and Mercurial Scimitar. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Twisted Fate matchup.

Early Game vs Late Game

Early Game
Vayne
75.0%
+50.0% advantage
Vayne early game win rateVayne75.0%
Twisted Fate early game win rateTwisted Fate25.0%
Late Game
Vayne
66.7%
+33.3% advantage
Vayne late game win rateVayne66.7%
Twisted Fate late game win rateTwisted Fate33.3%

Vayne dominates the early game (first 15 minutes) with a commanding 75.0% win rate — a 50.0 percentage point lead over Twisted Fate. This lopsided early game means Vayne can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Vayne is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Twisted Fate. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.

Vayne holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Twisted Fate players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Vayne Runes Against Twisted Fate

Precision rune tree - Vayne primary runes vs Twisted FatePrecision
Lethal Tempo - best Vayne rune vs Twisted FateTriumph - best Vayne rune vs Twisted FateLegend: Alacrity - best Vayne rune vs Twisted FateCoup de Grace - best Vayne rune vs Twisted Fate
Resolve rune tree - Vayne secondary runes vs Twisted FateResolve
Bone Plating - best Vayne rune vs Twisted FateUnflinching - best Vayne rune vs Twisted Fate
100.0% WR

Running Precision primary with Resolve secondary allows Vayne to press their advantage against Twisted Fate, amplifying the strengths that make this a favorable matchup.


Vayne matchup data for League of Legends patch 26.7. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
49.02%3576.081713,23145.3%52.0%
52.47%3246.289813,59649.3%55.2%
48.09%3146.283212,81944.0%52.7%
49.01%3025.982512,93747.5%50.3%
52.94%2726.083913,07152.8%53.1%
45.37%2276.496014,25446.9%44.2%
50.00%2226.493713,71750.0%50.0%
52.71%2036.585613,74148.9%56.0%
52.32%1516.582813,28755.4%49.4%
58.39%1496.695312,70051.6%63.5%
51.30%1155.881313,71761.5%42.9%
47.71%1096.088213,23938.2%57.4%
55.67%976.488012,62559.6%51.1%
51.55%976.380612,73552.5%50.0%
50.00%945.983213,59546.7%53.1%
36.36%886.279012,98330.0%41.7%
47.44%786.692813,28446.3%48.6%
61.33%756.692412,10266.7%55.6%
55.56%726.185813,24745.2%63.4%
57.35%686.085313,57456.0%58.1%
36.76%686.288112,39436.7%36.8%
52.54%596.383712,51848.5%57.7%
42.37%596.287012,82834.4%51.9%
38.60%575.760511,22540.0%37.0%
37.50%565.560110,77030.4%42.4%
43.40%536.21,04512,46744.4%42.3%
44.00%506.188613,06147.8%40.7%
53.06%496.11,21413,80450.0%55.2%
65.91%446.186913,29266.7%65.4%
56.82%445.692114,04761.1%53.9%
43.18%445.799611,54831.3%50.0%
50.00%406.384813,58435.3%60.9%
55.00%405.989314,58823.1%70.4%
57.50%406.395114,24860.0%56.7%
48.72%396.595213,49157.9%40.0%
57.89%386.01,02912,41355.0%61.1%
42.11%386.192313,74144.4%40.0%
54.05%377.092811,69252.4%56.3%
40.54%375.880412,22541.2%40.0%
40.00%355.71,14111,80838.9%41.2%
55.88%346.585611,12557.9%53.3%
50.00%326.098613,59966.7%43.5%
66.67%306.289612,54050.0%81.3%
56.67%306.298113,89653.9%58.8%
48.28%296.785812,18028.6%66.7%
55.17%296.31,02413,69462.5%46.1%
51.85%275.798412,39145.5%56.3%
61.54%266.185111,71961.5%61.5%
64.00%256.080811,77055.6%68.8%
44.00%256.892712,26342.9%45.5%
33.33%246.483511,60541.7%25.0%
56.52%235.592112,42462.5%53.3%
43.48%236.383712,92160.0%30.8%
40.91%226.678811,10141.7%40.0%
52.38%215.992313,47740.0%63.6%
60.00%205.290914,35220.0%73.3%
47.37%196.91,00811,89263.6%25.0%
50.00%186.273213,04560.0%37.5%
50.00%186.21,05312,78455.6%44.4%
44.44%186.483711,79542.9%45.5%
50.00%185.875412,37328.6%63.6%
76.47%176.91,02114,29680.0%75.0%
29.41%176.982911,89737.5%22.2%
41.18%176.086215,19160.0%33.3%
43.75%166.083811,77362.5%25.0%
56.25%166.690711,52757.1%55.6%
37.50%165.465913,20816.7%50.0%
68.75%166.793713,92583.3%60.0%
53.33%155.968611,41937.5%71.4%
73.33%156.485112,62177.8%66.7%
50.00%145.785111,11416.7%75.0%
42.86%144.364512,05114.3%71.4%
53.85%133.388514,16275.0%44.4%
53.85%135.71,05513,76250.0%55.6%
58.33%125.656210,02757.1%60.0%
25.00%124.586213,08325.0%25.0%
50.00%126.378413,32833.3%66.7%
27.27%116.277113,46233.3%25.0%
63.64%116.387415,82666.7%62.5%
36.36%116.665110,70650.0%20.0%
45.45%115.591912,62950.0%40.0%
72.73%116.474510,85071.4%75.0%
45.45%116.01,06414,50840.0%50.0%
70.00%106.699613,49075.0%66.7%
40.00%106.887613,21633.3%50.0%
55.56%96.393712,28633.3%100.0%
44.44%96.21,07715,702100.0%28.6%
33.33%96.877411,06920.0%50.0%
25.00%85.569310,37825.0%25.0%
50.00%85.99738,78533.3%100.0%
37.50%81.983414,72733.3%40.0%
42.86%75.690112,809100.0%20.0%
0.00%76.655810,7000.0%0.0%
42.86%74.665114,53850.0%40.0%
71.43%76.168213,12675.0%66.7%
57.14%75.588812,31625.0%100.0%
57.14%75.489512,10050.0%66.7%
42.86%74.077311,64333.3%50.0%
57.14%72.51,31315,57625.0%100.0%
33.33%64.65709,10525.0%50.0%
66.67%65.91,08915,49350.0%75.0%
50.00%65.776213,18250.0%50.0%
50.00%61.989114,832100.0%40.0%
16.67%65.384410,4420.0%33.3%
0.00%65.979510,7240.0%0.0%
83.33%66.196311,361100.0%50.0%
50.00%66.380413,574100.0%40.0%
40.00%54.793914,778100.0%0.0%
60.00%51.71,19517,6480.0%75.0%
20.00%51.56919,37833.3%0.0%
60.00%55.31,10015,380100.0%50.0%
20.00%56.891512,5530.0%33.3%
40.00%56.51,02117,6030.0%40.0%

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Vayne vs Twisted Fate - Frequently Asked Questions

How does Vayne do against Twisted Fate in League of Legends?

Vayne wins the Vayne vs Twisted Fate matchup with a 71.4% win rate compared to Twisted Fate's 28.6%, a 42.9 percentage point difference. This data is based on 7 recent ranked games in patch 26.7.

How does Vayne do against Twisted Fate in the early game?

In the early game, Vayne has the advantage against Twisted Fate with a 75.0% win rate versus 25.0%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Twisted Fate in the late game?

In the late game, Vayne takes over the Vayne vs Twisted Fate matchup with a 66.7% win rate compared to 33.3%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Twisted Fate matchup?

Vayne wins the matchup against Twisted Fate with a 71.4% win rate in League of Legends patch 26.7. The 42.9 percentage point advantage means Vayne is significantly favored in this lane matchup based on 7 games analyzed.

What is the best Vayne build against Twisted Fate?

The best Vayne build against Twisted Fate includes Kraken Slayer, Blade of The Ruined King, Mercurial Scimitar with Chainlaced Crushers. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Twisted Fate?

The best Vayne runes against Twisted Fate use the Precision primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Twisted Fate matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Twisted Fate?

Yes, Vayne has a favorable matchup against Twisted Fate with a 71.4% win rate. Vayne strongly counters Twisted Fate in lane based on current patch 26.7 data.

How do I play Vayne against Twisted Fate?

When playing Vayne against Twisted Fate, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.