
Twitch Runes
Best Twitch runes for LoL Patch 26.1 - Press the Attack from the Precision tree with Domination secondary (65.9% WR, 0.9% pick rate). Twitch's optimal primary runes are Press the Attack, Presence of Mind, Legend: Alacrity, Cut Down. Secondary tree: Sudden Impact, Ultimate Hunter.


Deadly Venom
Twitch's basic attacks infect the target, dealing true damage each second.


Ambush
Twitch becomes Camouflaged for a short duration and gains Move Speed. When leaving Camouflage, Twitch gains Attack Speed for a short duration.
When an enemy champion with Deadly Venom dies, Ambush's cooldown is reset.Cost:- 40
Cooldown:- 16
Range:- 20


Venom Cask
Twitch hurls a cask of venom that explodes in an area, slowing targets and applying deadly venom to the target.
Cost:- 70
Cooldown:- 13/
- 12/
- 11/
- 10/
- 9
Range:- 950


Contaminate
Twitch wreaks further havoc on poisoned enemies with a blast of his vile diseases.
Cost:- 50/
- 60/
- 70/
- 80/
- 90
Cooldown:- 12/
- 11/
- 10/
- 9/
- 8
Range:- 1200


Spray and Pray
Twitch unleashes the full power of his crossbow, shooting bolts over a great distance that pierce all enemies caught in their path.
Cost:- 100
Cooldown:- 90
Range:- 1200
- Marksman,
- Assassin
Twitch performs best with Press the Attack as the keystone rune from the Precision tree. Twitch's optimal primary runes are Press the Attack, Presence of Mind, Legend: Alacrity, Cut Down. Twitch's secondary rune tree is Domination with Sudden Impact, Ultimate Hunter. This rune setup achieves a 65.91% win rate (+15.2% win rate difference) with a 0.9% pick rate across 44 Twitch games.
Primary Tree
Precision
Press the AttackHitting an enemy champion with 3 consecutive basic attacks deals 40 - 160 bonus
Presence of MindDamaging an enemy champion restores 6-50 (80% for ranged) mana or 6 energy.
Takedowns restore 15% of your maximum mana or energy.
Cooldown for damage restoration: 8s
Legend: AlacrityGain 3% attack speed plus an additional 1.5% for every Legend stack (
Earn progress toward Legend stacks for every champion takedown, epic monster takedown, large monster kill, and minion kill.
Cut DownDeal 8% more damage to champions who have more than 60% health.
Sudden ImpactDamaging basic attacks and abilities deal a bonus
Cooldown: 10s
Ultimate HunterYour ultimate gains
This alternative Twitch rune build uses Lethal Tempo as the keystone from the Precision tree. The primary runes are Lethal Tempo, Presence of Mind, Legend: Alacrity, Cut Down. Twitch's secondary rune tree is Sorcery with Gathering Storm, Axiom Arcanist. This setup achieves a 60.00% win rate (+9.3% win rate difference) with a 0.4% pick rate across 20 games.
Primary Tree
Precision
Lethal TempoAttacking an enemy champion grants you [6% Melee || 4% Ranged] Attack Speed for 6 seconds, up to 6. At max stacks, deal [9 - 30 Melee || 6 - 24 Ranged]
Presence of MindDamaging an enemy champion restores 6-50 (80% for ranged) mana or 6 energy.
Takedowns restore 15% of your maximum mana or energy.
Cooldown for damage restoration: 8s
Legend: AlacrityGain 3% attack speed plus an additional 1.5% for every Legend stack (
Earn progress toward Legend stacks for every champion takedown, epic monster takedown, large monster kill, and minion kill.
Cut DownDeal 8% more damage to champions who have more than 60% health.
Gathering StormEvery 10 min gain AP or AD,
10 min: + 8 AP or 5 AD
20 min: + 24 AP or 14 AD
30 min: + 48 AP or 29 AD
40 min: + 80 AP or 48 AD
50 min: + 120 AP or 72 AD
60 min: + 168 AP or 101 AD
etc...
Axiom ArcanistYour Ultimate has 12% increased damage, healing, and shielding.
(AoE damage is reduced to a 8% increase)
Scoring a takedown on an enemy champion reduces your Ultimate's current cooldown by 7%.
Twitch Runes - Frequently Asked Questions
What are the best Twitch runes in patch 26.1?
The best Twitch runes in patch 26.1 use the Precision tree with Press the Attack, Presence of Mind, Legend: Alacrity, and Cut Down, and the Domination tree with Sudden Impact and Ultimate Hunter. This rune setup achieves a 65.9% win rate with a 0.9% pick rate.
What is the win rate for Twitch's best rune page?
Twitch's best rune page has a 65.9% win rate in patch 26.1, which is +15.2% compared to Twitch's average win rate. This rune setup has a 0.9% pick rate among Twitch players.
What keystone should I use on Twitch?
Press the Attack from the Precision tree is the best keystone rune for Twitch in patch 26.1. This keystone synergizes well with Twitch's kit and provides a 65.9% win rate.
What is Twitch's primary rune tree?
Twitch's primary rune tree is Precision. The optimal Precision runes for Twitch are Press the Attack, Presence of Mind, Legend: Alacrity, and Cut Down, with Press the Attack being the keystone of choice.
What is Twitch's secondary rune tree?
Twitch's best secondary rune tree is Domination. The recommended Domination runes are Sudden Impact and Ultimate Hunter, which complement Twitch's Precision primary tree.
What are alternative rune setups for Twitch?
An alternative Twitch rune setup uses Lethal Tempo from the Precision tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.
How popular are Twitch's runes?
Twitch's top rune page has a 0.9% pick rate in patch 26.1. This indicates that 0.9% of Twitch players use the Press the Attack setup with Precision and Domination trees.







































