
Twitch Runes
The top Twitch runes in LoL patch 25.23 are Lethal Tempo, Presence of Mind, Legend: Bloodline, Cut Down for Twitch's primary runes. Twitch's runes in his secondary tree best utilizes Absolute Focus and Gathering Storm. These Twitch rune choices provide the best Twitch rune build for ranked.


Deadly Venom
Twitch's basic attacks infect the target, dealing true damage each second.


Ambush
Twitch becomes Camouflaged for a short duration and gains Move Speed. When leaving Camouflage, Twitch gains Attack Speed for a short duration.
When an enemy champion with Deadly Venom dies, Ambush's cooldown is reset.Cost:- 40
Cooldown:- 16
Range:- 20


Venom Cask
Twitch hurls a cask of venom that explodes in an area, slowing targets and applying deadly venom to the target.
Cost:- 70
Cooldown:- 13/
- 12/
- 11/
- 10/
- 9
Range:- 950


Contaminate
Twitch wreaks further havoc on poisoned enemies with a blast of his vile diseases.
Cost:- 50/
- 60/
- 70/
- 80/
- 90
Cooldown:- 12/
- 11/
- 10/
- 9/
- 8
Range:- 1200


Spray and Pray
Twitch unleashes the full power of his crossbow, shooting bolts over a great distance that pierce all enemies caught in their path.
Cost:- 100
Cooldown:- 90
Range:- 1200
- Marksman,
- Assassin

Twitch performs best with Lethal Tempo as the keystone rune. The optimal primary runes for Twitch include Lethal Tempo, Presence of Mind, Legend: Bloodline. This rune setup achieves a 1.00% win rate across 2 Twitch games.
Primary Tree
PrecisionThis alternative Twitch rune build uses Dark Harvest as the keystone. This setup provides a different playstyle for Twitch and achieves a 1.00% win rate. Consider this rune page when facing specific matchups or team compositions.
Primary Tree
DominationTwitch Runes - Frequently Asked Questions
What are the best Twitch runes?
The best Twitch runes in patch 25.23 are Lethal Tempo, Presence of Mind, Legend: Bloodline, and Cut Down for the primary tree, and Absolute Focus and Gathering Storm for the secondary tree. These runes provide optimal performance for Twitch.
What keystone should I use on Twitch?
Lethal Tempo is the best keystone rune for Twitch. This keystone synergizes well with Twitch's abilities and provides maximum value in most matchups.
What are Twitch's secondary runes?
Twitch's best secondary runes are Absolute Focus and Gathering Storm. These secondary runes complement Twitch's primary rune choices and enhance overall effectiveness.
Can I use different rune setups on Twitch?
Yes, Twitch can utilize different rune setups depending on matchup and playstyle. While Lethal Tempo is most popular, alternative keystones may work better in specific situations.






































