- Win Rate
- 48.9%
- Pick Rate
- 3.9%
- Ban Rate
- 5.4%
Vayne Synergies & Best Teammates
- Patch
- 26.20
- Games
- 7,774
- Lane
- All Lanes
- Tier
- All Tiers
- Last Updated
- Oct 17, 2026 UTC
- Methodology
- Data Methodology
- Author
- Dakota Chinnick
Who Vayne wins with in Patch 26.20: every teammate in every role, measured against what both champions win on their own, so a strong pair is real synergy and not two strong champions.
- Best support
- Seraphine55.2% · 317 games
- Best jungler
- Sejuani62.2% · 82 games
- Best mid laner
- Vladimir58.3% · 151 games
- Best top laner
- Dr. Mundo59.3% · 86 games
Vayne Synergies - Patch 26.20
160 teammate pairings measuredVayne (Bot) wins most with Sejuani as jungler (62.2%, +10.0 over expected) and Dr. Mundo as top laner (59.3%, +9.6). The weakest pairing is Nautilus as support at 42.0%, 6.7 points below expected. The most common lane partner is Lulu, in 8.0% of Vayne's games.
Best supports for Vayne
| Teammate | Win Rate | Synergy | Games |
|---|---|---|---|
 Seraphine | 55.2% | +4.1 | 317 |
 Pyke | 54.6% | +5.7 | 163 |
 Lulu | 51.8% | +2.4 | 490 |
 Mel | 56.1% | +9.7 | 66 |
 Zilean | 56.2% | +6.3 | 89 |
 Nami | 52.0% | +1.4 | 304 |
Weakest pairings
Best junglers for Vayne
| Teammate | Win Rate | Synergy | Games |
|---|---|---|---|
 Bel'Veth | 62.7% | +13.2 | 59 |
 Elise | 65.9% | +14.8 | 44 |
 Sejuani | 62.2% | +9.9 | 82 |
 Lillia | 58.0% | +6.2 | 138 |
 Trundle | 59.5% | +12.3 | 42 |
 Shaco | 52.5% | +4.0 | 217 |
Weakest pairings
Strongest and weakest Vayne pairings
- Sejuani · jungler
Dr. Mundo · top laner
Vladimir · mid laner
Senna · support
Kayn · jungler
Nautilus · support
Vayne (Top) wins most with Jhin as ADC (57.3%, +9.7 over expected) and Caitlyn as ADC (52.4%, +5.8). The weakest pairing is Jinx as ADC at 41.9%, 6.9 points below expected.
Best junglers for Vayne
Weakest pairings
Best supports for Vayne
| Teammate | Win Rate | Synergy | Games |
|---|---|---|---|
 Lux | 55.7% | +9.5 | 61 |
 Leona | 57.4% | +8.1 | 47 |
 Thresh | 49.2% | +1.5 | 65 |
| Seraphine | 49.2% | +1.0 | 65 |
 Milio | 50.0% | +0.4 | 40 |
Weakest pairings
Best mid laners with Vayne
Weakest pairings
Strongest and weakest Vayne pairings
Jhin · ADC
Caitlyn · ADC- Kayn · jungler
Kai'Sa · ADC
Jinx · ADC
Synergy is the win rate with that teammate minus the win rate the two champions would be expected to reach together from their own win rates in their roles (log5). Lists are ranked by the low end of each synergy's 95% range, so a small sample cannot lead a list on luck alone.
Vayne Team Synergy Checker
Pick your teammates
Pick your teammates to see how each one moves Vayne's Bot win rate, and an estimate for the whole team.
An estimate: it adds each pairing's measured synergy on the odds scale and assumes the pairings are independent. Real teams also depend on the enemy draft and the players.
Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.
Vayne Synergies FAQ - Patch 26.20
Who is the best support for Vayne?
Seraphine. Vayne (Bot) wins 55.2% of 317 ranked games with Seraphine as support, 4.1 points above what the two champions win separately. Also strong: Pyke, Lulu.
Who is the best jungler for Vayne?
Sejuani. Vayne (Bot) wins 62.2% of 82 ranked games with Sejuani as jungler, 10.0 points above what the two champions win separately. Also strong: Lillia, Shaco.
Who is the best mid laner for Vayne?
Vladimir. Vayne (Bot) wins 58.3% of 151 ranked games with Vladimir as mid laner, 6.7 points above what the two champions win separately. Also strong: Viktor, Katarina.
Which champions does Vayne synergize with?
This patch, Vayne (Bot) gets the biggest lift from Sejuani (jungler, 62.2%), Dr. Mundo (top laner, 59.3%), Vladimir (mid laner, 58.3%).
Which teammates are bad with Vayne?
Vayne (Bot) does worst next to Nautilus (support, 42.0%), Kayn (jungler, 45.4%), Senna (support, 40.7%) — each below what the two champions win on their own.
How is synergy calculated?
From ranked solo and flex games this patch: the win rate when both champions are on the same team, minus the win rate expected from each champion's own win rate in its role. A positive number means the pair wins more together than their individual strength explains. Pairings need at least 40 games to be listed.