Vayne - League of Legends Champion
Win Rate
49.5%
Pick Rate
5.3%

VayneRunes

DMarksmanAssassin
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 20, 2026
MethodologyData Methodology

Best Vayne runes for LoL Patch 26.7 - Lethal Tempo from the Precision tree with Inspiration secondary (75.0% WR, 0.2% pick rate). Vayne's optimal primary runes are Lethal Tempo, Presence of Mind, Legend: Alacrity, Coup de Grace. Secondary tree: Cash Back, Biscuit Delivery.

Vayne performs best with Lethal Tempo as the keystone rune from the Precision tree. Vayne's optimal primary runes are Lethal Tempo, Presence of Mind, Legend: Alacrity, Coup de Grace. Vayne's secondary rune tree is Inspiration with Cash Back, Biscuit Delivery. This rune setup achieves a 75.00% win rate (+25.5% win rate difference) with a 0.2% pick rate across 16 Vayne games.
75.0%Win Rate
+25.5%WR Diff
0.2%Pick Rate
Lethal TempoLethal Tempo

Attacking an enemy champion grants you [6% Melee || 4% Ranged] Attack Speed for 6 seconds, up to 6. At max stacks, deal [9 - 30 Melee || 6 - 24 Ranged] bonus adaptive damage On-Attack, increased by 1% per 1% Bonus Attack Speed.

Presence of MindPresence of Mind

Damaging an enemy champion restores 6-50 (80% for ranged) mana or 6 energy.

Takedowns restore 15% of your maximum mana or energy.

Cooldown for damage restoration: 8s

Legend: AlacrityLegend: Alacrity

Gain 3% attack speed plus an additional 1.5% for every Legend stack (max 10 stacks).

Earn progress toward Legend stacks for every champion takedown, epic monster takedown, large monster kill, and minion kill.

Coup de GraceCoup de Grace

Deal 8% more damage to champions who have less than 40% health.

Cash BackCash Back

Get 7.5% Gold back when you purchase Legendary Items.

Biscuit DeliveryBiscuit Delivery

Biscuit Delivery: Gain a Total Biscuit of Everlasting Will every 2 mins, until 6 min.

Biscuits restore 20 + 2% of your maximum health, increased by up to 100% based on missing Health. Consuming or selling a Biscuit permanently increases your max health by 30.

This alternative Vayne rune build uses Press the Attack as the keystone from the Precision tree. The primary runes are Press the Attack, Triumph, Legend: Alacrity, Cut Down. Vayne's secondary rune tree is Domination with Sudden Impact, Treasure Hunter. This setup achieves a 74.07% win rate (+24.6% win rate difference) with a 0.3% pick rate across 27 games.
74.1%Win Rate
+24.6%WR Diff
0.3%Pick Rate
Press the AttackPress the Attack

Hitting an enemy champion with 3 consecutive basic attacks deals 40 - 160 bonus adaptive damage (based on level) and amplifies your damage dealt by 8% until you leave combat with champions.

TriumphTriumph

Takedowns restore 5% of your missing health, 2.5% of your max health, and grant an additional 20 gold.



'The most dangerous game brings the greatest glory.'
—Noxian Reckoner

Legend: AlacrityLegend: Alacrity

Gain 3% attack speed plus an additional 1.5% for every Legend stack (max 10 stacks).

Earn progress toward Legend stacks for every champion takedown, epic monster takedown, large monster kill, and minion kill.

Cut DownCut Down

Deal 8% more damage to champions who have more than 60% health.

Sudden ImpactSudden Impact

Damaging basic attacks and abilities deal a bonus 20 - 80 True Damage based on level to enemy champions after using a dash, leap, blink, teleport, or when leaving stealth for 4s.

Cooldown: 10s

Treasure HunterTreasure Hunter

Gain an additional 50 gold the next time you collect a Bounty Hunter stack. Increase the gold gained by 20 gold for each Bounty Hunter stack, up to 130 gold.

Bounty Hunter stacks are earned the first time you get a takedown on each enemy champion.

These champions share at least 4 runes with Vayne's recommended rune builds. use similar keystone and secondary runes, making them good alternatives if you enjoy Vayne's playstyle or want to learn champions with familiar rune setups.Jax, Jinx, Kindred

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Vayne Runes - Frequently Asked Questions

What are the best Vayne runes in patch 26.7?

The best Vayne runes in patch 26.7 use the Precision tree with Lethal Tempo, Presence of Mind, Legend: Alacrity, and Coup de Grace, and the Inspiration tree with Cash Back and Biscuit Delivery. This rune setup achieves a 75.0% win rate with a 0.2% pick rate.

What is the win rate for Vayne's best rune page?

Vayne's best rune page has a 75.0% win rate in patch 26.7, which is +25.5% compared to Vayne's average win rate. This rune setup has a 0.2% pick rate among Vayne players.

What keystone should I use on Vayne?

Lethal Tempo from the Precision tree is the best keystone rune for Vayne in patch 26.7. This keystone synergizes well with Vayne's kit and provides a 75.0% win rate.

What is Vayne's primary rune tree?

Vayne's primary rune tree is Precision. The optimal Precision runes for Vayne are Lethal Tempo, Presence of Mind, Legend: Alacrity, and Coup de Grace, with Lethal Tempo being the keystone of choice.

What is Vayne's secondary rune tree?

Vayne's best secondary rune tree is Inspiration. The recommended Inspiration runes are Cash Back and Biscuit Delivery, which complement Vayne's Precision primary tree.

What are alternative rune setups for Vayne?

An alternative Vayne rune setup uses Press the Attack from the Precision tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.

How popular are Vayne's runes?

Vayne's top rune page has a 0.2% pick rate in patch 26.7. This indicates that 0.2% of Vayne players use the Lethal Tempo setup with Precision and Inspiration trees.