Vayne Runes
Best Vayne runes for LoL Patch 26.1 - Lethal Tempo from the Precision tree with Inspiration secondary (76.5% WR, 0.3% pick rate). Vayne's optimal primary runes are Lethal Tempo, Triumph, Legend: Alacrity, Cut Down. Secondary tree: Cash Back, Triple Tonic.
Night Hunter
Vayne ruthlessly hunts evil-doers, gaining Move Speed when moving toward nearby enemy champions.
Tumble
Vayne tumbles, maneuvering to carefully place her next shot. Her next attack deals bonus damage.
Cost:- 30
Cooldown:- 6/
- 5/
- 4/
- 3/
- 2
Range:- 300
Silver Bolts
Vayne tips her bolts with a rare metal, toxic to evil things. The third consecutive attack or ability against the same target deals a percentage of the target's max health as bonus true damage.
Cost:- 0
Cooldown:- 0
Range:- 750
Condemn
Vayne draws a heavy crossbow from her back, and fires a huge bolt at her target, knocking them back and dealing damage. If they collide with terrain, they are impaled, dealing bonus damage and stunning them.
Cost:- 90
Cooldown:- 20/
- 18/
- 16/
- 14/
- 12
Range:- 550
Final Hour
Readying herself for an epic confrontation, Vayne gains increased Attack Damage, Invisibility during Tumble, reduced Tumble cooldown, and more bonus Move Speed from Night Hunter
Cost:- 80
Cooldown:- 100/
- 85/
- 70
Range:- 1
- Marksman,
- Assassin
Vayne performs best with Lethal Tempo as the keystone rune from the Precision tree. Vayne's optimal primary runes are Lethal Tempo, Triumph, Legend: Alacrity, Cut Down. Vayne's secondary rune tree is Inspiration with Cash Back, Triple Tonic. This rune setup achieves a 76.47% win rate (+25.6% win rate difference) with a 0.3% pick rate across 17 Vayne games.
Primary Tree
Precision
Lethal TempoAttacking an enemy champion grants you [6% Melee || 4% Ranged] Attack Speed for 6 seconds, up to 6. At max stacks, deal [9 - 30 Melee || 6 - 24 Ranged]
TriumphTakedowns restore 5% of your missing health, 2.5% of your max health, and grant an additional 20 gold.
'The most dangerous game brings the greatest glory.'
—Noxian Reckoner
Legend: AlacrityGain 3% attack speed plus an additional 1.5% for every Legend stack (
Earn progress toward Legend stacks for every champion takedown, epic monster takedown, large monster kill, and minion kill.
Cut DownDeal 8% more damage to champions who have more than 60% health.
Cash BackGet 8% Gold back when you purchase Legendary Items.
Triple TonicUpon reaching level 3, gain an Elixir of Avarice.
Upon reaching level 6, gain an Elixir of Force.
Upon reaching level 9, gain an Elixir of Skill.
This alternative Vayne rune build uses Lethal Tempo as the keystone from the Precision tree. The primary runes are Lethal Tempo, Triumph, Legend: Alacrity, Coup de Grace. Vayne's secondary rune tree is Domination with Sudden Impact, Ultimate Hunter. This setup achieves a 76.19% win rate (+25.4% win rate difference) with a 0.3% pick rate across 21 games.
Primary Tree
Precision
Lethal TempoAttacking an enemy champion grants you [6% Melee || 4% Ranged] Attack Speed for 6 seconds, up to 6. At max stacks, deal [9 - 30 Melee || 6 - 24 Ranged]
TriumphTakedowns restore 5% of your missing health, 2.5% of your max health, and grant an additional 20 gold.
'The most dangerous game brings the greatest glory.'
—Noxian Reckoner
Legend: AlacrityGain 3% attack speed plus an additional 1.5% for every Legend stack (
Earn progress toward Legend stacks for every champion takedown, epic monster takedown, large monster kill, and minion kill.
Coup de GraceDeal 8% more damage to champions who have less than 40% health.
Sudden ImpactDamaging basic attacks and abilities deal a bonus
Cooldown: 10s
Ultimate HunterYour ultimate gains
Vayne Runes - Frequently Asked Questions
What are the best Vayne runes in patch 26.1?
The best Vayne runes in patch 26.1 use the Precision tree with Lethal Tempo, Triumph, Legend: Alacrity, and Cut Down, and the Inspiration tree with Cash Back and Triple Tonic. This rune setup achieves a 76.5% win rate with a 0.3% pick rate.
What is the win rate for Vayne's best rune page?
Vayne's best rune page has a 76.5% win rate in patch 26.1, which is +25.6% compared to Vayne's average win rate. This rune setup has a 0.3% pick rate among Vayne players.
What keystone should I use on Vayne?
Lethal Tempo from the Precision tree is the best keystone rune for Vayne in patch 26.1. This keystone synergizes well with Vayne's kit and provides a 76.5% win rate.
What is Vayne's primary rune tree?
Vayne's primary rune tree is Precision. The optimal Precision runes for Vayne are Lethal Tempo, Triumph, Legend: Alacrity, and Cut Down, with Lethal Tempo being the keystone of choice.
What is Vayne's secondary rune tree?
Vayne's best secondary rune tree is Inspiration. The recommended Inspiration runes are Cash Back and Triple Tonic, which complement Vayne's Precision primary tree.
What are alternative rune setups for Vayne?
An alternative Vayne rune setup uses Lethal Tempo from the Precision tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.
How popular are Vayne's runes?
Vayne's top rune page has a 0.3% pick rate in patch 26.1. This indicates that 0.3% of Vayne players use the Lethal Tempo setup with Precision and Inspiration trees.