Zoe - League of Legends Champion
Win Rate
49.2%
Pick Rate
2.0%

Zoevs Cassiopeia

DMage
Patch26.9
Matches514,344
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 9, 2026
MethodologyData Methodology

Zoe vs Cassiopeia is a decisive matchup in LoL patch 26.9. Zoe wins with a 58.3% win rate (+16.7%) over Cassiopeia based on 12 games. Zoe holds the advantage in both the early and late game. Below you'll find the best Zoe build, runes, laning stats, and strategies for the Zoe vs Cassiopeia matchup.

Zoe Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Zoe performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Cassiopeia - 58.3% win rateCassiopeia(58.3%)
Zoe - 58.3% win rate in this matchup
Zoe
58.3% WR
VS
Cassiopeia vs Zoe matchup - 41.7% win rate
Cassiopeia
41.7% WR

Who Wins the Zoe vs Cassiopeia Matchup?

Zoe wins the Zoe vs Cassiopeia matchup
Winner
Zoe
Matches: 12
58.3%
Win Rate
41.7%
5.7
CS / min
6.2
946
DMG / min
951
12,600
Gold / game
12,814
100
Heal / min
338
338
DMG Mitigated / min
680
1.3
CC / min
1.2
60.0%
Early Game WR
40.0%
57.1%
Late Game WR
42.9%

Zoe vs Cassiopeia Matchup Summary

The Zoe vs Cassiopeia matchup is a decisive matchup in League of Legends ranked play. Based on 12 recent matches analyzed, Zoe wins with a 58.3% win rate compared to Cassiopeia's 41.7%, giving Zoe a 16.7 percentage point advantage. Zoe dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Cassiopeia players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Cassiopeia leads by 580 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Zoe players can confidently pick into Cassiopeia and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Cassiopeia away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Zoe vs Cassiopeia Laning Phase Breakdown

Cassiopeia wins the laning phase against Zoe in League of Legends

Cassiopeia is favored during the laning phase against Zoe, winning 4 out of 5 key stat categories. Cassiopeia holds advantages in farming, damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
5.7Zoe
6.2Cassiopeia
Cassiopeia edges out Zoe by 0.5 CS per minute — a moderate farming advantage that adds up to roughly 7 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Cassiopeia.
Damage
946Zoe
951Cassiopeia
Damage output is virtually even between Zoe and Cassiopeia, with only 5 DMG/min separating them. Fights in this matchup are decided more by ability timing and positioning than raw damage numbers, making mechanical skill the deciding factor in trades.
Economy
12,600Zoe
12,814Cassiopeia
Zoe and Cassiopeia generate nearly equal gold per game, with just a 215 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
1.3Zoe
1.2Cassiopeia
Both Zoe and Cassiopeia provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
438Zoe
1,017Cassiopeia
Cassiopeia vastly out-sustains Zoe, healing and mitigating 580 more damage per minute. This massive durability gap means Cassiopeia can absorb significant punishment and remain in lane while Zoe is forced to recall. Building grievous wounds early is essential for Zoe, and focusing on burst trade patterns rather than sustained fights is critical.

Best Zoe Build Against Cassiopeia

Spellslinger's Shoes is the optimal boots choice against Cassiopeia, providing the mobility and stats Zoe needs most in this matchup. The top-performing core items for Zoe against Cassiopeia are Luden's Echo, Shadowflame and Rabadon's Deathcap. This combination gives Zoe an effective balance of damage, survivability, and utility for the matchup. This build has a 25.0% win rate across 4 games. While the overall matchup may be difficult, this item path gives Zoe the best chance to compete against Cassiopeia. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Zoe vs Cassiopeia matchup.

Early Game vs Late Game

Early Game
Zoe
60.0%
+20.0% advantage
Zoe early game win rateZoe60.0%
Cassiopeia early game win rateCassiopeia40.0%
Late Game
Zoe
57.1%
+14.3% advantage
Zoe late game win rateZoe57.1%
Cassiopeia late game win rateCassiopeia42.9%

Zoe dominates the early game (first 15 minutes) with a commanding 60.0% win rate — a 20.0 percentage point lead over Cassiopeia. This lopsided early game means Zoe can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Zoe is far superior in the late game (25+ minutes), boasting a 57.1% win rate — 14.3 points above Cassiopeia. Extended games heavily favor Zoe, whose kit and scaling make them a dominant force in team fights and objective control.

Zoe holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Cassiopeia players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Zoe Runes Against Cassiopeia

Domination rune tree - Zoe primary runes vs CassiopeiaDomination
Electrocute - best Zoe rune vs CassiopeiaTaste of Blood - best Zoe rune vs CassiopeiaGrisly Mementos - best Zoe rune vs CassiopeiaRelentless Hunter - best Zoe rune vs Cassiopeia
Sorcery rune tree - Zoe secondary runes vs CassiopeiaSorcery
Nimbus Cloak - best Zoe rune vs CassiopeiaScorch - best Zoe rune vs Cassiopeia
100.0% WR

Running Domination primary with Sorcery secondary allows Zoe to press their advantage against Cassiopeia, amplifying the strengths that make this a favorable matchup.


Zoe matchup data for League of Legends patch 26.9. The table below shows Zoe's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Zoe build, runes, laning stats, and early vs late game analysis for that specific matchup.

Zoe matchup win rates and stats in League of Legends patch 26.9
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
50.63%795.776911,15353.3%49.0%
53.25%776.191711,17763.9%43.9%
35.14%745.888511,43630.3%39.0%
50.88%574.781211,00934.8%61.8%
52.73%555.990111,59256.5%50.0%
48.00%505.81,00013,06143.8%50.0%
51.02%495.683111,33742.1%56.7%
36.73%495.082611,00823.8%46.4%
51.16%435.591210,98047.4%54.2%
47.62%425.291410,86450.0%45.5%
43.90%415.890311,23260.0%28.6%
45.71%355.81,04310,55946.7%45.0%
51.43%355.778810,83533.3%65.0%
51.43%355.691511,50657.9%43.8%
63.64%336.089211,39782.3%43.8%
28.13%326.089211,74736.4%23.8%
64.52%316.292612,02569.2%61.1%
51.61%315.997212,08438.5%61.1%
54.84%316.182710,95066.7%43.8%
58.06%311.672710,69163.6%55.0%
43.33%301.575010,50455.6%38.1%
46.67%301.76398,96743.8%50.0%
59.26%276.192411,26861.5%57.1%
59.26%276.093712,55444.4%66.7%
42.31%266.08269,41150.0%30.0%
50.00%266.286911,81757.1%41.7%
54.17%245.693312,26562.5%50.0%
69.57%236.21,03211,68069.2%70.0%
60.87%236.01,09112,70163.6%58.3%
31.82%226.587610,94038.5%22.2%
45.45%223.679611,09844.4%46.1%
68.18%224.296611,46363.6%72.7%
47.62%215.577211,21450.0%46.7%
52.38%214.898210,62046.1%62.5%
52.38%215.99579,93458.3%44.4%
28.57%215.582911,09433.3%22.2%
66.67%215.685312,26628.6%85.7%
52.38%215.884410,41350.0%54.5%
45.00%201.76529,16554.5%33.3%
65.00%206.096812,77383.3%57.1%
63.16%196.184410,86260.0%66.7%
57.89%191.66479,89557.1%58.3%
68.42%191.57729,57985.7%58.3%
50.00%181.57319,63850.0%50.0%
33.33%182.17729,57133.3%33.3%
64.71%171.470010,47775.0%61.5%
70.59%171.565611,25166.7%71.4%
73.33%154.795712,11975.0%72.7%
50.00%145.387110,66757.1%42.9%
71.43%146.41,05012,33660.0%77.8%
50.00%146.484711,46955.6%40.0%
71.43%141.764810,22075.0%66.7%
53.85%136.591611,66275.0%44.4%
46.15%137.196511,61242.9%50.0%
41.67%121.865511,64850.0%40.0%
58.33%125.794612,60060.0%57.1%
50.00%121.873010,44333.3%55.6%
45.45%112.28689,86520.0%66.7%
27.27%111.47198,72250.0%14.3%
54.55%111.475511,37133.3%62.5%
36.36%114.694911,79150.0%28.6%
36.36%115.21,17911,614100.0%12.5%
70.00%104.382810,98671.4%66.7%
40.00%102.569110,51950.0%33.3%
55.56%92.084110,70850.0%57.1%
33.33%95.71,02113,473100.0%25.0%
37.50%81.44868,29675.0%0.0%
50.00%83.898913,79650.0%50.0%
50.00%85.89229,86957.1%0.0%
37.50%85.18339,90840.0%33.3%
28.57%75.573010,03233.3%25.0%
28.57%72.973010,22225.0%33.3%
71.43%76.41,05412,43150.0%80.0%
28.57%74.88259,70533.3%25.0%
71.43%71.45229,00475.0%66.7%
71.43%77.47369,98266.7%100.0%
14.29%71.674010,98850.0%0.0%
50.00%66.95059,88250.0%50.0%
33.33%64.06256,79620.0%100.0%
66.67%66.372811,495100.0%50.0%
33.33%64.879311,88450.0%25.0%
60.00%55.27899,84250.0%66.7%
20.00%56.183311,42825.0%0.0%
40.00%52.177212,8220.0%50.0%
0.00%54.51,03013,4180.0%0.0%
60.00%56.01,00211,536100.0%50.0%
20.00%56.91,18713,1620.0%50.0%

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Zoe vs Cassiopeia - Frequently Asked Questions

How does Zoe do against Cassiopeia in League of Legends?

Zoe wins the Zoe vs Cassiopeia matchup with a 58.3% win rate compared to Cassiopeia's 41.7%, a 16.7 percentage point difference. This data is based on 12 recent ranked games in patch 26.9.

How does Zoe do against Cassiopeia in the early game?

In the early game, Zoe has the advantage against Cassiopeia with a 60.0% win rate versus 40.0%. Zoe players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Zoe do against Cassiopeia in the late game?

In the late game, Zoe takes over the Zoe vs Cassiopeia matchup with a 57.1% win rate compared to 42.9%. Zoe scales better into team fights and objective contests after 25 minutes.

Who wins the Zoe vs Cassiopeia matchup?

Zoe wins the matchup against Cassiopeia with a 58.3% win rate in League of Legends patch 26.9. The 16.7 percentage point advantage means Zoe is significantly favored in this lane matchup based on 12 games analyzed.

What is the best Zoe build against Cassiopeia?

The best Zoe build against Cassiopeia includes Luden's Echo, Shadowflame, Rabadon's Deathcap with Spellslinger's Shoes. This build achieves a 25.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Zoe runes against Cassiopeia?

The best Zoe runes against Cassiopeia use the Domination primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Zoe vs Cassiopeia matchup. See the full rune breakdown in the matchup comparison above.

Does Zoe counter Cassiopeia?

Yes, Zoe has a favorable matchup against Cassiopeia with a 58.3% win rate. Zoe strongly counters Cassiopeia in lane based on current patch 26.9 data.

How do I play Zoe against Cassiopeia?

When playing Zoe against Cassiopeia, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.