Zoevs Vayne
Zoe vs Vayne is a decisive matchup in LoL patch 26.9. Zoe wins with a 66.7% win rate (+33.3%) over Vayne based on 6 games. Zoe holds the advantage in both the early and late game. Below you'll find the best Zoe build, runes, laning stats, and strategies for the Zoe vs Vayne matchup.
Zoe Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Zoe performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Vayne(66.7%)Who Wins the Zoe vs Vayne Matchup?
Zoe vs Vayne Matchup Summary
The Zoe vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Zoe wins with a 66.7% win rate compared to Vayne's 33.3%, giving Zoe a 33.3 percentage point advantage. Zoe dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Vayne players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Zoe leads by 0.6s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Zoe players can confidently pick into Vayne and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Vayne away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Zoe vs Vayne Laning Phase Breakdown
Vayne is favored during the laning phase against Zoe, winning 4 out of 5 key stat categories. Vayne holds advantages in farming, damage, gold income and sustain, making them the stronger laner in this matchup.
Best Zoe Build Against Vayne
Ionian Boots of Lucidity is the optimal boots choice against Vayne, providing the mobility and stats Zoe needs most in this matchup. The top-performing core items for Zoe against Vayne are Cosmic Drive, Hextech Rocketbelt and Cryptbloom. This combination gives Zoe an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Zoe vs Vayne matchup.
Early Game vs Late Game
Zoe100.0%Vayne0.0%Zoe50.0%Vayne50.0%Zoe dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Vayne. This lopsided early game means Zoe can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Late game (25+ minutes) is equally balanced, with Zoe at 50.0% win rate — only 0.0 points ahead of Vayne. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.
Zoe holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Vayne players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.
Best Zoe Runes Against Vayne
Domination
Sorcery
Running Domination primary with Sorcery secondary allows Zoe to press their advantage against Vayne, amplifying the strengths that make this a favorable matchup.
Zoe matchup data for League of Legends patch 26.9. The table below shows Zoe's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Zoe build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 50.63% | 79 | 5.7 | 769 | 11,153 | 53.3% | 49.0% | |
| 53.25% | 77 | 6.1 | 917 | 11,177 | 63.9% | 43.9% | |
| 35.14% | 74 | 5.8 | 885 | 11,436 | 30.3% | 39.0% | |
| 50.88% | 57 | 4.7 | 812 | 11,009 | 34.8% | 61.8% | |
| 52.73% | 55 | 5.9 | 901 | 11,592 | 56.5% | 50.0% | |
| 48.00% | 50 | 5.8 | 1,000 | 13,061 | 43.8% | 50.0% | |
| 51.02% | 49 | 5.6 | 831 | 11,337 | 42.1% | 56.7% | |
| 36.73% | 49 | 5.0 | 826 | 11,008 | 23.8% | 46.4% | |
| 51.16% | 43 | 5.5 | 912 | 10,980 | 47.4% | 54.2% | |
| 47.62% | 42 | 5.2 | 914 | 10,864 | 50.0% | 45.5% | |
| 43.90% | 41 | 5.8 | 903 | 11,232 | 60.0% | 28.6% | |
| 45.71% | 35 | 5.8 | 1,043 | 10,559 | 46.7% | 45.0% | |
| 51.43% | 35 | 5.7 | 788 | 10,835 | 33.3% | 65.0% | |
| 51.43% | 35 | 5.6 | 915 | 11,506 | 57.9% | 43.8% | |
| 63.64% | 33 | 6.0 | 892 | 11,397 | 82.3% | 43.8% | |
| 28.13% | 32 | 6.0 | 892 | 11,747 | 36.4% | 23.8% | |
| 64.52% | 31 | 6.2 | 926 | 12,025 | 69.2% | 61.1% | |
| 51.61% | 31 | 5.9 | 972 | 12,084 | 38.5% | 61.1% | |
| 54.84% | 31 | 6.1 | 827 | 10,950 | 66.7% | 43.8% | |
| 58.06% | 31 | 1.6 | 727 | 10,691 | 63.6% | 55.0% | |
| 43.33% | 30 | 1.5 | 750 | 10,504 | 55.6% | 38.1% | |
| 46.67% | 30 | 1.7 | 639 | 8,967 | 43.8% | 50.0% | |
| 59.26% | 27 | 6.1 | 924 | 11,268 | 61.5% | 57.1% | |
| 59.26% | 27 | 6.0 | 937 | 12,554 | 44.4% | 66.7% | |
| 42.31% | 26 | 6.0 | 826 | 9,411 | 50.0% | 30.0% | |
| 50.00% | 26 | 6.2 | 869 | 11,817 | 57.1% | 41.7% | |
| 54.17% | 24 | 5.6 | 933 | 12,265 | 62.5% | 50.0% | |
| 69.57% | 23 | 6.2 | 1,032 | 11,680 | 69.2% | 70.0% | |
| 60.87% | 23 | 6.0 | 1,091 | 12,701 | 63.6% | 58.3% | |
| 31.82% | 22 | 6.5 | 876 | 10,940 | 38.5% | 22.2% | |
| 45.45% | 22 | 3.6 | 796 | 11,098 | 44.4% | 46.1% | |
| 68.18% | 22 | 4.2 | 966 | 11,463 | 63.6% | 72.7% | |
| 47.62% | 21 | 5.5 | 772 | 11,214 | 50.0% | 46.7% | |
| 52.38% | 21 | 4.8 | 982 | 10,620 | 46.1% | 62.5% | |
| 52.38% | 21 | 5.9 | 957 | 9,934 | 58.3% | 44.4% | |
| 28.57% | 21 | 5.5 | 829 | 11,094 | 33.3% | 22.2% | |
| 66.67% | 21 | 5.6 | 853 | 12,266 | 28.6% | 85.7% | |
| 52.38% | 21 | 5.8 | 844 | 10,413 | 50.0% | 54.5% | |
| 45.00% | 20 | 1.7 | 652 | 9,165 | 54.5% | 33.3% | |
| 65.00% | 20 | 6.0 | 968 | 12,773 | 83.3% | 57.1% | |
| 63.16% | 19 | 6.1 | 844 | 10,862 | 60.0% | 66.7% | |
| 57.89% | 19 | 1.6 | 647 | 9,895 | 57.1% | 58.3% | |
| 68.42% | 19 | 1.5 | 772 | 9,579 | 85.7% | 58.3% | |
| 50.00% | 18 | 1.5 | 731 | 9,638 | 50.0% | 50.0% | |
| 33.33% | 18 | 2.1 | 772 | 9,571 | 33.3% | 33.3% | |
| 64.71% | 17 | 1.4 | 700 | 10,477 | 75.0% | 61.5% | |
| 70.59% | 17 | 1.5 | 656 | 11,251 | 66.7% | 71.4% | |
| 73.33% | 15 | 4.7 | 957 | 12,119 | 75.0% | 72.7% | |
| 50.00% | 14 | 5.3 | 871 | 10,667 | 57.1% | 42.9% | |
| 71.43% | 14 | 6.4 | 1,050 | 12,336 | 60.0% | 77.8% | |
| 50.00% | 14 | 6.4 | 847 | 11,469 | 55.6% | 40.0% | |
| 71.43% | 14 | 1.7 | 648 | 10,220 | 75.0% | 66.7% | |
| 53.85% | 13 | 6.5 | 916 | 11,662 | 75.0% | 44.4% | |
| 46.15% | 13 | 7.1 | 965 | 11,612 | 42.9% | 50.0% | |
| 41.67% | 12 | 1.8 | 655 | 11,648 | 50.0% | 40.0% | |
| 58.33% | 12 | 5.7 | 946 | 12,600 | 60.0% | 57.1% | |
| 50.00% | 12 | 1.8 | 730 | 10,443 | 33.3% | 55.6% | |
| 45.45% | 11 | 2.2 | 868 | 9,865 | 20.0% | 66.7% | |
| 27.27% | 11 | 1.4 | 719 | 8,722 | 50.0% | 14.3% | |
| 54.55% | 11 | 1.4 | 755 | 11,371 | 33.3% | 62.5% | |
| 36.36% | 11 | 4.6 | 949 | 11,791 | 50.0% | 28.6% | |
| 36.36% | 11 | 5.2 | 1,179 | 11,614 | 100.0% | 12.5% | |
| 70.00% | 10 | 4.3 | 828 | 10,986 | 71.4% | 66.7% | |
| 40.00% | 10 | 2.5 | 691 | 10,519 | 50.0% | 33.3% | |
| 55.56% | 9 | 2.0 | 841 | 10,708 | 50.0% | 57.1% | |
| 33.33% | 9 | 5.7 | 1,021 | 13,473 | 100.0% | 25.0% | |
| 37.50% | 8 | 1.4 | 486 | 8,296 | 75.0% | 0.0% | |
| 50.00% | 8 | 3.8 | 989 | 13,796 | 50.0% | 50.0% | |
| 50.00% | 8 | 5.8 | 922 | 9,869 | 57.1% | 0.0% | |
| 37.50% | 8 | 5.1 | 833 | 9,908 | 40.0% | 33.3% | |
| 28.57% | 7 | 5.5 | 730 | 10,032 | 33.3% | 25.0% | |
| 28.57% | 7 | 2.9 | 730 | 10,222 | 25.0% | 33.3% | |
| 71.43% | 7 | 6.4 | 1,054 | 12,431 | 50.0% | 80.0% | |
| 28.57% | 7 | 4.8 | 825 | 9,705 | 33.3% | 25.0% | |
| 71.43% | 7 | 1.4 | 522 | 9,004 | 75.0% | 66.7% | |
| 71.43% | 7 | 7.4 | 736 | 9,982 | 66.7% | 100.0% | |
| 14.29% | 7 | 1.6 | 740 | 10,988 | 50.0% | 0.0% | |
| 50.00% | 6 | 6.9 | 505 | 9,882 | 50.0% | 50.0% | |
| 33.33% | 6 | 4.0 | 625 | 6,796 | 20.0% | 100.0% | |
| 66.67% | 6 | 6.3 | 728 | 11,495 | 100.0% | 50.0% | |
| 33.33% | 6 | 4.8 | 793 | 11,884 | 50.0% | 25.0% | |
| 60.00% | 5 | 5.2 | 789 | 9,842 | 50.0% | 66.7% | |
| 20.00% | 5 | 6.1 | 833 | 11,428 | 25.0% | 0.0% | |
| 40.00% | 5 | 2.1 | 772 | 12,822 | 0.0% | 50.0% | |
| 0.00% | 5 | 4.5 | 1,030 | 13,418 | 0.0% | 0.0% | |
| 60.00% | 5 | 6.0 | 1,002 | 11,536 | 100.0% | 50.0% | |
| 20.00% | 5 | 6.9 | 1,187 | 13,162 | 0.0% | 50.0% | |
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Zoe vs Vayne - Frequently Asked Questions
How does Zoe do against Vayne in League of Legends?
Zoe wins the Zoe vs Vayne matchup with a 66.7% win rate compared to Vayne's 33.3%, a 33.3 percentage point difference. This data is based on 6 recent ranked games in patch 26.9.
How does Zoe do against Vayne in the early game?
In the early game, Zoe has the advantage against Vayne with a 100.0% win rate versus 0.0%. Zoe players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Zoe do against Vayne in the late game?
In the late game, Zoe takes over the Zoe vs Vayne matchup with a 50.0% win rate compared to 50.0%. Zoe scales better into team fights and objective contests after 25 minutes.
Who wins the Zoe vs Vayne matchup?
Zoe wins the matchup against Vayne with a 66.7% win rate in League of Legends patch 26.9. The 33.3 percentage point advantage means Zoe is significantly favored in this lane matchup based on 6 games analyzed.
What is the best Zoe build against Vayne?
The best Zoe build against Vayne includes Cosmic Drive, Hextech Rocketbelt, Cryptbloom with Ionian Boots of Lucidity. Check the matchup breakdown above for the full item path and build order.
What are the best Zoe runes against Vayne?
The best Zoe runes against Vayne use the Domination primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Zoe vs Vayne matchup. See the full rune breakdown in the matchup comparison above.
Does Zoe counter Vayne?
Yes, Zoe has a favorable matchup against Vayne with a 66.7% win rate. Zoe strongly counters Vayne in lane based on current patch 26.9 data.
How do I play Zoe against Vayne?
When playing Zoe against Vayne, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.