Zoevs Vayne
Zoe vs Vayne is a decisive matchup in LoL patch 26.4. Vayne wins with a 66.7% win rate (+33.3%) over Zoe based on 6 games. Zoe wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Zoe build, runes, laning stats, and strategies for the Zoe vs Vayne matchup.
Zoe Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Zoe performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Vayne(33.3%)Who Wins the Zoe vs Vayne Matchup?
Zoe vs Vayne Matchup Summary
The Zoe vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Vayne wins with a 66.7% win rate compared to Zoe's 33.3%, giving Vayne a 33.3 percentage point advantage. Game phase dynamics play a critical role here: Zoe controls the early laning stage, but Vayne outscales as the game goes longer. The matchup shifts dramatically depending on game length — Zoe needs to press advantages before Vayne reaches their power spikes, while Vayne should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Zoe leads by 1.2s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne has a strong advantage in this matchup. Zoe players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Vayne overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Zoe vs Vayne Laning Phase Breakdown
Vayne is favored during the laning phase against Zoe, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, gold income and sustain, making them the stronger laner in this matchup.
Best Zoe Build Against Vayne
Sorcerer's Shoes is the optimal boots choice against Vayne, providing the mobility and stats Zoe needs most in this matchup. The top-performing core items for Zoe against Vayne are Luden's Echo, Shadowflame and Lich Bane. This combination gives Zoe an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Zoe vs Vayne matchup.
Early Game vs Late Game
Zoe50.0%Vayne50.0%Zoe25.0%Vayne75.0%The early game (first 15 minutes) is a toss-up between Zoe and Vayne, with Zoe holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.
Vayne is far superior in the late game (25+ minutes), boasting a 75.0% win rate — 50.0 points above Zoe. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.
The power dynamics shift as the game progresses — Zoe has the edge early, but Vayne gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.
Best Zoe Runes Against Vayne
Domination
Sorcery
The Domination and Sorcery rune setup gives Zoe the best tools to compete against Vayne in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.
Zoe matchup data for League of Legends patch 26.4. The table below shows Zoe's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Zoe build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 44.67% | 245 | 6.1 | 912 | 11,547 | 45.0% | 44.4% | |
| 50.98% | 153 | 5.9 | 860 | 11,234 | 50.0% | 51.8% | |
| 42.34% | 137 | 6.2 | 845 | 12,246 | 47.2% | 39.3% | |
| 47.27% | 110 | 4.9 | 800 | 10,668 | 54.7% | 40.4% | |
| 52.58% | 97 | 5.9 | 916 | 11,441 | 51.3% | 53.5% | |
| 56.38% | 94 | 6.0 | 948 | 11,561 | 63.4% | 50.9% | |
| 53.33% | 91 | 6.0 | 980 | 11,812 | 52.9% | 53.6% | |
| 51.14% | 89 | 6.2 | 952 | 11,845 | 44.4% | 58.1% | |
| 50.00% | 86 | 6.0 | 860 | 11,627 | 47.4% | 52.1% | |
| 50.60% | 83 | 5.7 | 923 | 11,621 | 58.5% | 42.9% | |
| 32.93% | 82 | 5.3 | 787 | 11,429 | 20.0% | 40.4% | |
| 53.16% | 79 | 6.4 | 841 | 11,427 | 48.7% | 57.5% | |
| 50.00% | 74 | 5.6 | 854 | 10,782 | 51.4% | 48.6% | |
| 54.17% | 72 | 6.2 | 919 | 11,976 | 56.3% | 52.5% | |
| 51.43% | 70 | 6.3 | 894 | 12,088 | 61.5% | 45.5% | |
| 54.69% | 65 | 5.6 | 938 | 11,688 | 55.6% | 54.0% | |
| 45.16% | 63 | 6.1 | 761 | 10,494 | 42.4% | 48.3% | |
| 55.00% | 60 | 6.2 | 845 | 11,292 | 58.1% | 51.7% | |
| 50.88% | 58 | 6.0 | 990 | 11,970 | 42.3% | 58.1% | |
| 54.39% | 57 | 5.7 | 875 | 11,136 | 65.5% | 42.9% | |
| 61.11% | 54 | 6.2 | 896 | 11,583 | 64.5% | 56.5% | |
| 55.77% | 52 | 4.7 | 917 | 11,466 | 66.7% | 46.4% | |
| 53.19% | 47 | 5.8 | 993 | 11,687 | 60.0% | 45.5% | |
| 62.22% | 46 | 6.4 | 958 | 12,432 | 77.8% | 51.9% | |
| 54.35% | 46 | 5.6 | 892 | 10,651 | 52.0% | 57.1% | |
| 55.56% | 45 | 6.6 | 996 | 11,369 | 60.0% | 52.0% | |
| 50.00% | 45 | 6.1 | 843 | 11,470 | 62.5% | 35.0% | |
| 36.36% | 44 | 4.1 | 762 | 10,945 | 21.4% | 43.3% | |
| 48.84% | 43 | 5.8 | 979 | 11,292 | 63.2% | 37.5% | |
| 48.84% | 43 | 6.3 | 858 | 11,306 | 60.0% | 39.1% | |
| 46.34% | 42 | 6.2 | 955 | 11,636 | 47.4% | 45.5% | |
| 40.00% | 40 | 1.7 | 757 | 10,294 | 43.8% | 37.5% | |
| 66.67% | 39 | 6.7 | 1,049 | 11,811 | 69.6% | 62.5% | |
| 44.74% | 38 | 6.0 | 933 | 11,557 | 42.1% | 47.4% | |
| 54.05% | 37 | 6.1 | 828 | 10,700 | 57.9% | 50.0% | |
| 51.52% | 33 | 1.8 | 677 | 9,710 | 35.3% | 68.8% | |
| 60.61% | 33 | 1.6 | 705 | 10,419 | 71.4% | 52.6% | |
| 51.52% | 33 | 4.4 | 858 | 11,208 | 72.7% | 40.9% | |
| 38.71% | 31 | 6.2 | 836 | 10,779 | 43.8% | 33.3% | |
| 51.72% | 29 | 2.6 | 764 | 10,777 | 57.1% | 46.7% | |
| 46.43% | 29 | 1.3 | 707 | 9,787 | 40.0% | 50.0% | |
| 44.83% | 29 | 2.1 | 787 | 10,609 | 53.9% | 37.5% | |
| 42.86% | 28 | 5.5 | 920 | 10,411 | 56.3% | 25.0% | |
| 37.04% | 27 | 5.0 | 988 | 11,316 | 35.7% | 38.5% | |
| 44.44% | 27 | 1.5 | 717 | 8,943 | 47.1% | 40.0% | |
| 50.00% | 26 | 5.6 | 957 | 10,971 | 60.0% | 43.8% | |
| 23.08% | 26 | 1.6 | 664 | 9,848 | 40.0% | 12.5% | |
| 56.00% | 26 | 1.5 | 728 | 9,522 | 60.0% | 50.0% | |
| 53.85% | 26 | 6.1 | 945 | 11,336 | 33.3% | 71.4% | |
| 56.00% | 25 | 6.0 | 890 | 10,326 | 46.1% | 66.7% | |
| 48.00% | 25 | 6.2 | 861 | 10,327 | 50.0% | 45.5% | |
| 45.83% | 24 | 2.6 | 727 | 9,701 | 50.0% | 42.9% | |
| 45.45% | 22 | 4.0 | 816 | 10,824 | 50.0% | 41.7% | |
| 31.82% | 22 | 1.6 | 604 | 10,375 | 55.6% | 15.4% | |
| 45.00% | 21 | 4.6 | 760 | 9,542 | 30.0% | 60.0% | |
| 42.86% | 21 | 6.7 | 940 | 12,787 | 55.6% | 33.3% | |
| 45.00% | 20 | 1.6 | 759 | 10,960 | 71.4% | 30.8% | |
| 36.84% | 19 | 5.9 | 912 | 11,939 | 28.6% | 41.7% | |
| 63.16% | 19 | 1.7 | 704 | 10,726 | 57.1% | 66.7% | |
| 61.11% | 18 | 1.4 | 707 | 9,133 | 58.3% | 66.7% | |
| 35.29% | 17 | 1.8 | 687 | 9,477 | 55.6% | 12.5% | |
| 37.50% | 16 | 1.7 | 644 | 11,046 | 20.0% | 45.5% | |
| 53.33% | 15 | 6.1 | 864 | 9,106 | 44.4% | 66.7% | |
| 64.29% | 14 | 6.4 | 1,054 | 9,884 | 66.7% | 60.0% | |
| 71.43% | 14 | 6.3 | 1,178 | 12,332 | 71.4% | 71.4% | |
| 21.43% | 14 | 2.9 | 793 | 9,758 | 25.0% | 16.7% | |
| 64.29% | 14 | 5.5 | 1,100 | 13,075 | 40.0% | 77.8% | |
| 28.57% | 14 | 5.8 | 920 | 12,964 | 0.0% | 36.4% | |
| 38.46% | 13 | 1.8 | 666 | 10,188 | 33.3% | 42.9% | |
| 50.00% | 12 | 6.5 | 835 | 11,310 | 66.7% | 33.3% | |
| 58.33% | 12 | 5.6 | 971 | 13,936 | 66.7% | 55.6% | |
| 63.64% | 12 | 5.9 | 776 | 10,233 | 66.7% | 50.0% | |
| 33.33% | 12 | 1.3 | 620 | 9,515 | 42.9% | 20.0% | |
| 30.00% | 10 | 6.3 | 903 | 12,072 | 40.0% | 20.0% | |
| 44.44% | 9 | 1.5 | 673 | 9,250 | 33.3% | 50.0% | |
| 66.67% | 9 | 6.0 | 950 | 12,077 | 60.0% | 75.0% | |
| 33.33% | 9 | 6.6 | 1,025 | 10,181 | 16.7% | 66.7% | |
| 50.00% | 8 | 6.1 | 1,141 | 11,035 | 33.3% | 60.0% | |
| 37.50% | 8 | 3.9 | 869 | 11,132 | 50.0% | 33.3% | |
| 75.00% | 8 | 6.7 | 1,120 | 13,464 | 66.7% | 80.0% | |
| 42.86% | 7 | 4.2 | 697 | 9,322 | 40.0% | 50.0% | |
| 14.29% | 7 | 2.6 | 759 | 10,458 | 25.0% | 0.0% | |
| 57.14% | 7 | 4.2 | 1,026 | 12,449 | 66.7% | 50.0% | |
| 57.14% | 7 | 5.0 | 1,157 | 11,523 | 66.7% | 50.0% | |
| 42.86% | 7 | 6.7 | 1,028 | 12,586 | 40.0% | 50.0% | |
| 42.86% | 7 | 6.2 | 993 | 12,673 | 40.0% | 50.0% | |
| 28.57% | 7 | 1.9 | 816 | 11,205 | 0.0% | 40.0% | |
| 85.71% | 7 | 5.0 | 977 | 14,318 | 100.0% | 66.7% | |
| 71.43% | 7 | 5.8 | 836 | 10,299 | 100.0% | 50.0% | |
| 14.29% | 7 | 5.9 | 881 | 11,219 | 0.0% | 20.0% | |
| 33.33% | 6 | 4.1 | 983 | 11,274 | 66.7% | 0.0% | |
| 33.33% | 6 | 6.6 | 913 | 13,001 | 0.0% | 50.0% | |
| 66.67% | 6 | 5.9 | 1,104 | 11,392 | 75.0% | 50.0% | |
| 0.00% | 6 | 2.5 | 667 | 9,558 | 0.0% | 0.0% | |
| 66.67% | 6 | 5.8 | 875 | 10,992 | 75.0% | 50.0% | |
| 33.33% | 6 | 6.3 | 836 | 11,921 | 50.0% | 25.0% | |
| 66.67% | 6 | 6.3 | 887 | 12,048 | 100.0% | 50.0% | |
| 66.67% | 6 | 6.4 | 891 | 12,254 | 75.0% | 50.0% | |
| 60.00% | 5 | 6.5 | 1,174 | 14,940 | 66.7% | 50.0% | |
| 60.00% | 5 | 6.0 | 936 | 11,845 | 66.7% | 50.0% | |
| 100.00% | 5 | 5.3 | 889 | 12,378 | 100.0% | 100.0% | |
| 60.00% | 5 | 8.0 | 884 | 10,469 | 50.0% | 100.0% | |
| 60.00% | 5 | 5.3 | 1,090 | 16,647 | 0.0% | 60.0% | |
| 80.00% | 5 | 1.6 | 665 | 10,636 | 100.0% | 66.7% | |
| 80.00% | 5 | 5.8 | 1,064 | 11,147 | 100.0% | 75.0% | |
| 40.00% | 5 | 5.3 | 1,055 | 11,689 | 50.0% | 33.3% | |
| 0.00% | 5 | 6.4 | 716 | 11,422 | 0.0% | 0.0% | |
| 60.00% | 5 | 1.5 | 765 | 10,933 | 50.0% | 66.7% | |
| 60.00% | 5 | 3.5 | 677 | 10,437 | 66.7% | 50.0% | |
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Zoe vs Vayne - Frequently Asked Questions
How does Zoe do against Vayne in League of Legends?
Vayne wins the Zoe vs Vayne matchup with a 66.7% win rate compared to Zoe's 33.3%, a 33.3 percentage point difference. This data is based on 6 recent ranked games in patch 26.4.
How does Zoe do against Vayne in the early game?
In the early game, Zoe has the advantage against Vayne with a 50.0% win rate versus 50.0%. Zoe players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Zoe do against Vayne in the late game?
In the late game, Vayne takes over the Zoe vs Vayne matchup with a 75.0% win rate compared to 25.0%. Vayne scales better into team fights and objective contests after 25 minutes.
Who wins the Zoe vs Vayne matchup?
Vayne wins the matchup against Zoe with a 66.7% win rate in League of Legends patch 26.4. The 33.3 percentage point advantage means Vayne is significantly favored in this lane matchup based on 6 games analyzed.
What is the best Zoe build against Vayne?
The best Zoe build against Vayne includes Luden's Echo, Shadowflame, Lich Bane with Sorcerer's Shoes. Check the matchup breakdown above for the full item path and build order.
What are the best Zoe runes against Vayne?
The best Zoe runes against Vayne use the Domination primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Zoe vs Vayne matchup. See the full rune breakdown in the matchup comparison above.
Does Zoe counter Vayne?
No, Zoe struggles against Vayne with only a 33.3% win rate. Vayne has the advantage in this matchup. Zoe players should focus on safe farming and avoiding extended trades to minimize Vayne's lead.
How do I play Zoe against Vayne?
When playing Zoe against Vayne, play cautiously and avoid Vayne's power spikes. Look for jungle assistance and team-dependent plays since Vayne has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.