Zoe - League of Legends Champion
Win Rate
50.4%
Pick Rate
1.9%

Zoevs Lissandra

BMage
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 22, 2026
MethodologyData Methodology

Zoe vs Lissandra is a decisive matchup in LoL patch 26.7. Lissandra wins with a 64.0% win rate (+28.0%) over Zoe based on 25 games. Zoe wins the early laning phase while Lissandra scales better into the late game. Below you'll find the best Zoe build, runes, laning stats, and strategies for the Zoe vs Lissandra matchup.

Zoe Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Zoe performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 36.0% win rateLissandra(36.0%)
Zoe - 36.0% win rate in this matchup
Zoe
36.0% WR
VS
Lissandra vs Zoe matchup - 64.0% win rate
Lissandra
64.0% WR

Who Wins the Zoe vs Lissandra Matchup?

Lissandra wins the Zoe vs Lissandra matchup
Winner
Lissandra
Matches: 25
36.0%
Win Rate
64.0%
6.2
CS / min
6.6
956
DMG / min
805
10,910
Gold / game
11,124
98
Heal / min
167
311
DMG Mitigated / min
394
1.2
CC / min
1.5
50.0%
Early Game WR
50.0%
26.7%
Late Game WR
73.3%

Zoe vs Lissandra Matchup Summary

The Zoe vs Lissandra matchup is a decisive matchup in League of Legends ranked play. Based on 25 recent matches analyzed, Lissandra wins with a 64.0% win rate compared to Zoe's 36.0%, giving Lissandra a 28.0 percentage point advantage. Game phase dynamics play a critical role here: Zoe controls the early laning stage, but Lissandra outscales as the game goes longer. The matchup shifts dramatically depending on game length — Zoe needs to press advantages before Lissandra reaches their power spikes, while Lissandra should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Lissandra leads by 153 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Lissandra has a strong advantage in this matchup. Zoe players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Lissandra overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Zoe vs Lissandra Laning Phase Breakdown

Lissandra wins the laning phase against Zoe in League of Legends

Lissandra is favored during the laning phase against Zoe, winning 4 out of 5 key stat categories. Lissandra holds advantages in farming, gold income, crowd control and sustain, making them the stronger laner in this matchup.

Farming
6.2Zoe
6.6Lissandra
Lissandra edges out Zoe by 0.4 CS per minute — a moderate farming advantage that adds up to roughly 6 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Lissandra.
Damage
956Zoe
805Lissandra
Zoe heavily out-damages Lissandra by 152 DMG/min, dominating both short trades and all-in fights. Lissandra should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Zoe's sustained damage advantage take over.
Economy
10,910Zoe
11,124Lissandra
Zoe and Lissandra generate nearly equal gold per game, with just a 213 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
1.2Zoe
1.5Lissandra
Lissandra provides 0.3 seconds more crowd control per minute than Zoe, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Lissandra coordinate with their jungler and control the pace of skirmishes.
Sustain
408Zoe
561Lissandra
Lissandra vastly out-sustains Zoe, healing and mitigating 153 more damage per minute. This massive durability gap means Lissandra can absorb significant punishment and remain in lane while Zoe is forced to recall. Building grievous wounds early is essential for Zoe, and focusing on burst trade patterns rather than sustained fights is critical.

Best Zoe Build Against Lissandra

Crimson Lucidity is the optimal boots choice against Lissandra, providing the mobility and stats Zoe needs most in this matchup. The top-performing core items for Zoe against Lissandra are Luden's Echo, Shadowflame and Rabadon's Deathcap. This combination gives Zoe an effective balance of damage, survivability, and utility for the matchup. This build has a 25.0% win rate across 4 games. While the overall matchup may be difficult, this item path gives Zoe the best chance to compete against Lissandra. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Zoe vs Lissandra matchup.

Early Game vs Late Game

Early Game
Zoe
50.0%
+0.0% advantage
Zoe early game win rateZoe50.0%
Lissandra early game win rateLissandra50.0%
Late Game
Lissandra
73.3%
+46.7% advantage
Zoe late game win rateZoe26.7%
Lissandra late game win rateLissandra73.3%

The early game (first 15 minutes) is a toss-up between Zoe and Lissandra, with Zoe holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Lissandra is far superior in the late game (25+ minutes), boasting a 73.3% win rate — 46.7 points above Zoe. Extended games heavily favor Lissandra, whose kit and scaling make them a dominant force in team fights and objective control.

The power dynamics shift as the game progresses — Zoe has the edge early, but Lissandra gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.

Best Zoe Runes Against Lissandra

Domination rune tree - Zoe primary runes vs LissandraDomination
Electrocute - best Zoe rune vs LissandraTaste of Blood - best Zoe rune vs LissandraDeep Ward - best Zoe rune vs LissandraRelentless Hunter - best Zoe rune vs Lissandra
Sorcery rune tree - Zoe secondary runes vs LissandraSorcery
Nimbus Cloak - best Zoe rune vs LissandraScorch - best Zoe rune vs Lissandra
100.0% WR

The Domination and Sorcery rune setup gives Zoe the best tools to compete against Lissandra in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Zoe matchup data for League of Legends patch 26.7. The table below shows Zoe's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Zoe build, runes, laning stats, and early vs late game analysis for that specific matchup.

Zoe matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
44.76%1056.088311,86338.0%50.9%
45.83%725.786211,52946.0%45.7%
45.31%646.279211,33034.4%56.3%
53.97%635.584810,58550.0%57.6%
63.46%525.892212,14360.0%65.6%
56.00%506.388711,56259.1%53.6%
40.00%505.281411,56237.5%41.2%
55.10%495.994511,50359.1%51.9%
42.55%474.379410,86318.8%54.8%
44.44%456.096511,85037.5%48.3%
60.00%405.992311,97271.4%53.9%
50.00%385.783311,63056.3%45.5%
51.35%376.290210,96842.1%61.1%
43.24%375.893611,49243.8%42.9%
50.00%345.898612,86545.5%52.2%
48.48%336.387410,32338.1%66.7%
51.52%335.889411,68861.1%40.0%
46.88%325.789811,12447.1%46.7%
50.00%325.989010,47652.6%46.1%
62.07%296.591811,99058.3%64.7%
62.07%296.294513,00463.6%61.1%
44.83%293.881310,72744.4%45.0%
30.77%265.486610,53055.6%17.6%
44.00%255.882010,45123.1%66.7%
36.00%256.295610,91050.0%26.7%
54.17%243.795310,32458.3%50.0%
45.83%245.588711,93350.0%43.8%
54.55%226.394512,25862.5%50.0%
54.55%226.187110,69455.6%53.9%
50.00%225.692711,85175.0%35.7%
42.86%215.691712,05950.0%40.0%
52.38%214.187311,83050.0%53.9%
52.38%216.297712,87266.7%46.7%
47.37%196.589812,10433.3%60.0%
31.58%191.37008,78730.0%33.3%
52.63%195.791611,86687.5%27.3%
50.00%182.181810,08855.6%44.4%
47.06%171.57149,35233.3%62.5%
41.18%171.48059,54157.1%30.0%
46.67%153.789412,48275.0%36.4%
57.14%146.787111,04454.5%66.7%
35.71%145.581710,95733.3%37.5%
69.23%137.01,08313,22075.0%60.0%
53.85%131.775310,60875.0%44.4%
61.54%131.67089,68383.3%42.9%
66.67%121.687111,22466.7%66.7%
75.00%124.890412,41675.0%75.0%
50.00%126.094311,92666.7%44.4%
41.67%126.28759,65525.0%75.0%
41.67%122.07199,62760.0%28.6%
63.64%111.67779,79783.3%40.0%
80.00%102.181911,386100.0%60.0%
60.00%105.786510,11550.0%75.0%
80.00%105.51,07211,159100.0%71.4%
55.56%92.784911,94750.0%57.1%
66.67%95.899612,035100.0%50.0%
55.56%91.37519,43860.0%50.0%
33.33%95.079512,25150.0%28.6%
66.67%91.68069,51080.0%50.0%
11.11%96.088910,03816.7%0.0%
62.50%81.57549,55150.0%100.0%
75.00%85.91,32513,267100.0%66.7%
37.50%81.777111,59933.3%40.0%
25.00%81.888610,68233.3%20.0%
50.00%81.475510,71025.0%75.0%
42.86%71.46266,35533.3%100.0%
42.86%75.191012,66375.0%0.0%
16.67%66.77199,85125.0%0.0%
50.00%65.81,00811,7100.0%100.0%
50.00%62.27239,85650.0%50.0%
100.00%66.879813,448100.0%100.0%
66.67%64.885310,36580.0%0.0%
100.00%51.663410,257100.0%100.0%
60.00%55.71,01412,48150.0%66.7%
20.00%56.26108,04420.0%0.0%
80.00%56.31,21111,720100.0%66.7%
60.00%55.689312,47266.7%50.0%
60.00%56.51,07013,251100.0%33.3%

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Zoe vs Lissandra - Frequently Asked Questions

How does Zoe do against Lissandra in League of Legends?

Lissandra wins the Zoe vs Lissandra matchup with a 64.0% win rate compared to Zoe's 36.0%, a 28.0 percentage point difference. This data is based on 25 recent ranked games in patch 26.7.

How does Zoe do against Lissandra in the early game?

In the early game, Zoe has the advantage against Lissandra with a 50.0% win rate versus 50.0%. Zoe players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Zoe do against Lissandra in the late game?

In the late game, Lissandra takes over the Zoe vs Lissandra matchup with a 73.3% win rate compared to 26.7%. Lissandra scales better into team fights and objective contests after 25 minutes.

Who wins the Zoe vs Lissandra matchup?

Lissandra wins the matchup against Zoe with a 64.0% win rate in League of Legends patch 26.7. The 28.0 percentage point advantage means Lissandra is significantly favored in this lane matchup based on 25 games analyzed.

What is the best Zoe build against Lissandra?

The best Zoe build against Lissandra includes Luden's Echo, Shadowflame, Rabadon's Deathcap with Crimson Lucidity. This build achieves a 25.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Zoe runes against Lissandra?

The best Zoe runes against Lissandra use the Domination primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Zoe vs Lissandra matchup. See the full rune breakdown in the matchup comparison above.

Does Zoe counter Lissandra?

No, Zoe struggles against Lissandra with only a 36.0% win rate. Lissandra has the advantage in this matchup. Zoe players should focus on safe farming and avoiding extended trades to minimize Lissandra's lead.

How do I play Zoe against Lissandra?

When playing Zoe against Lissandra, play cautiously and avoid Lissandra's power spikes. Look for jungle assistance and team-dependent plays since Lissandra has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.