Zoe - League of Legends Champion
Win Rate
50.6%
Pick Rate
1.7%

Zoevs Lissandra

BMage
Patch26.14
Matches491,560
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 22, 2026
MethodologyData Methodology

Zoe vs Lissandra is a decisive matchup in LoL patch 26.14. Lissandra wins with a 57.1% win rate (+14.3%) over Zoe based on 14 games. Lissandra holds the advantage in both the early and late game. Below you'll find the best Zoe build, runes, laning stats, and strategies for the Zoe vs Lissandra matchup.

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Zoe Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Zoe performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Zoe - 42.9% win rate in this matchup
Zoe
42.9% WR
VS
Lissandra vs Zoe matchup - 57.1% win rate
Lissandra
57.1% WR

Who Wins the Zoe vs Lissandra Matchup?

Lissandra wins the Zoe vs Lissandra matchup
Winner
Lissandra
Matches: 14
42.9%
Win Rate
57.1%
5.3
CS / min
6.4
813
DMG / min
810
11,336
Gold / game
12,301
77
Heal / min
144
356
DMG Mitigated / min
430
1.2
CC / min
1.6
33.3%
Early Game WR
66.7%
45.5%
Late Game WR
54.5%

Zoe vs Lissandra Matchup Summary

The Zoe vs Lissandra matchup is a decisive matchup in League of Legends ranked play. Based on 14 recent matches analyzed, Lissandra wins with a 57.1% win rate compared to Zoe's 42.9%, giving Lissandra a 14.3 percentage point advantage. Lissandra dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Zoe players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Lissandra leads by 0.4s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Lissandra has a strong advantage in this matchup. Zoe players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Lissandra overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Zoe vs Lissandra Laning Phase Breakdown

Lissandra wins the laning phase against Zoe in League of Legends

Lissandra is favored during the laning phase against Zoe, winning 4 out of 5 key stat categories. Lissandra holds advantages in farming, gold income, crowd control and sustain, making them the stronger laner in this matchup.

Farming
5.3Zoe
6.4Lissandra
Lissandra significantly out-farms Zoe by 1.0 CS per minute, accumulating an estimated 15 CS lead by mid game. This substantial farming gap gives Lissandra a major gold advantage and earlier item completions. Zoe players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
813Zoe
810Lissandra
Damage output is virtually even between Zoe and Lissandra, with only 3 DMG/min separating them. Fights in this matchup are decided more by ability timing and positioning than raw damage numbers, making mechanical skill the deciding factor in trades.
Economy
11,336Zoe
12,301Lissandra
Lissandra generates a commanding 966 more gold per game than Zoe. This substantial economic advantage means Lissandra consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Zoe should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.2Zoe
1.6Lissandra
Lissandra provides 0.4 seconds more crowd control per minute than Zoe, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Lissandra coordinate with their jungler and control the pace of skirmishes.
Sustain
433Zoe
574Lissandra
Lissandra heals and mitigates 140 more damage per minute than Zoe, providing moderate extra durability. This sustain edge allows Lissandra to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Zoe.

Best Zoe Build Against Lissandra

Crimson Lucidity is the optimal boots choice against Lissandra, providing the mobility and stats Zoe needs most in this matchup. The top-performing core items for Zoe against Lissandra are Luden's Echo, Shadowflame and Lich Bane. This combination gives Zoe an effective balance of damage, survivability, and utility for the matchup. This build achieves a solid 50.0% win rate across 2 games, proving it to be a reliable item path when facing Lissandra. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Zoe vs Lissandra matchup.

Early Game vs Late Game

Early Game
Lissandra
66.7%
+33.3% advantage
Zoe early game win rateZoe33.3%
Lissandra early game win rateLissandra66.7%
Late Game
Lissandra
54.5%
+9.1% advantage
Zoe late game win rateZoe45.5%
Lissandra late game win rateLissandra54.5%

Lissandra dominates the early game (first 15 minutes) with a commanding 66.7% win rate — a 33.3 percentage point lead over Zoe. This lopsided early game means Lissandra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Lissandra is far superior in the late game (25+ minutes), boasting a 54.5% win rate — 9.1 points above Zoe. Extended games heavily favor Lissandra, whose kit and scaling make them a dominant force in team fights and objective control.

Lissandra holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Zoe players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Zoe Runes Against Lissandra

Domination rune tree - Zoe primary runes vs LissandraDomination
Electrocute - best Zoe rune vs LissandraSudden Impact - best Zoe rune vs LissandraGrisly Mementos - best Zoe rune vs LissandraRelentless Hunter - best Zoe rune vs Lissandra
Sorcery rune tree - Zoe secondary runes vs LissandraSorcery
Nimbus Cloak - best Zoe rune vs LissandraTranscendence - best Zoe rune vs Lissandra
42.9% WR

The Domination and Sorcery rune setup gives Zoe the best tools to compete against Lissandra in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Zoe matchup data for League of Legends patch 26.14. The table below shows Zoe's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Zoe build, runes, laning stats, and early vs late game analysis for that specific matchup.

Zoe matchup win rates and stats in League of Legends patch 26.14
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
50.57%874.180611,04150.0%50.9%
46.75%775.793210,37243.2%50.0%
45.90%615.293411,56070.6%36.4%
56.67%605.692010,97561.9%53.9%
50.00%545.51,00610,33257.7%42.9%
52.83%535.886311,16155.0%51.5%
50.00%505.58199,88755.0%46.7%
56.41%395.090111,41144.4%60.0%
56.41%395.585111,17515.4%76.9%
35.90%395.884411,21158.3%25.9%
50.00%384.992810,53081.8%37.0%
51.35%375.58579,77773.3%36.4%
61.76%345.697711,25950.0%68.2%
58.82%345.687211,36690.9%43.5%
63.64%331.675310,09153.9%70.0%
54.55%335.382811,62366.7%50.0%
45.16%315.269810,37040.0%47.6%
46.43%285.596010,96546.1%46.7%
52.17%235.291311,19345.5%58.3%
47.83%235.286810,05655.6%42.9%
59.09%226.291411,22537.5%71.4%
40.91%225.897610,85236.4%45.5%
40.00%206.184610,07437.5%41.7%
42.11%195.695011,18957.1%33.3%
57.89%196.17628,12961.5%50.0%
42.11%194.81,02110,75425.0%54.5%
42.11%195.785211,44250.0%40.0%
55.56%185.91,13512,42266.7%50.0%
61.11%185.986711,09885.7%45.5%
37.50%163.678710,04416.7%50.0%
62.50%161.46929,44566.7%57.1%
56.25%163.58439,97985.7%33.3%
40.00%155.686411,28550.0%33.3%
60.00%156.31,03810,10457.1%62.5%
78.57%145.793410,92985.7%71.4%
57.14%145.68589,97842.9%71.4%
42.86%145.381311,33633.3%45.5%
69.23%135.11,02010,44866.7%71.4%
61.54%135.21,03410,00540.0%75.0%
41.67%121.66989,56350.0%37.5%
58.33%121.77079,67050.0%62.5%
66.67%125.37579,70866.7%66.7%
72.73%114.777411,106100.0%62.5%
18.18%115.58278,73028.6%0.0%
27.27%111.67199,27416.7%40.0%
36.36%112.671310,90325.0%42.9%
54.55%113.878310,71575.0%42.9%
30.00%102.782110,819100.0%22.2%
30.00%102.695111,65650.0%16.7%
30.00%101.65227,42333.3%25.0%
44.44%95.81,05514,9030.0%44.4%
22.22%92.071910,61525.0%20.0%
44.44%91.876410,81775.0%20.0%
50.00%85.01,07410,63333.3%60.0%
37.50%81.55457,41333.3%50.0%
75.00%81.978210,18533.3%100.0%
50.00%81.880411,166100.0%33.3%
57.14%72.49369,88450.0%66.7%
42.86%71.77189,491100.0%20.0%
71.43%76.387210,36775.0%66.7%
42.86%71.281411,53050.0%40.0%
57.14%71.66849,60433.3%75.0%
66.67%67.194311,014100.0%33.3%
50.00%63.477912,856100.0%40.0%
50.00%62.570010,747100.0%25.0%
80.00%52.777510,96850.0%100.0%
40.00%52.46699,81733.3%50.0%
40.00%51.374710,50850.0%33.3%
60.00%55.26809,12850.0%66.7%
60.00%55.79059,72033.3%100.0%
60.00%52.05309,40166.7%50.0%
60.00%56.48558,85266.7%50.0%
40.00%54.01,02514,0430.0%50.0%
20.00%55.376812,1080.0%25.0%
40.00%55.592710,44450.0%33.3%
60.00%55.691713,371100.0%50.0%
60.00%55.898611,795100.0%50.0%
80.00%53.991513,836100.0%75.0%
60.00%55.31,05212,462100.0%50.0%
40.00%51.665412,3300.0%40.0%
80.00%54.21,14614,134100.0%66.7%

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Zoe vs Lissandra - Frequently Asked Questions

How does Zoe do against Lissandra in League of Legends?

Lissandra wins the Zoe vs Lissandra matchup with a 57.1% win rate compared to Zoe's 42.9%, a 14.3 percentage point difference. This data is based on 14 recent ranked games in patch 26.14.

How does Zoe do against Lissandra in the early game?

In the early game, Lissandra has the advantage against Zoe with a 66.7% win rate versus 33.3%. Lissandra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Zoe do against Lissandra in the late game?

In the late game, Lissandra takes over the Zoe vs Lissandra matchup with a 54.5% win rate compared to 45.5%. Lissandra scales better into team fights and objective contests after 25 minutes.

Who wins the Zoe vs Lissandra matchup?

Lissandra wins the matchup against Zoe with a 57.1% win rate in League of Legends patch 26.14. The 14.3 percentage point advantage means Lissandra is significantly favored in this lane matchup based on 14 games analyzed.

What is the best Zoe build against Lissandra?

The best Zoe build against Lissandra includes Luden's Echo, Shadowflame, Lich Bane with Crimson Lucidity. This build achieves a 50.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Zoe runes against Lissandra?

The best Zoe runes against Lissandra use the Domination primary tree with Sorcery secondary. This rune setup achieves a 42.9% win rate in the Zoe vs Lissandra matchup. See the full rune breakdown in the matchup comparison above.

Does Zoe counter Lissandra?

No, Zoe struggles against Lissandra with only a 42.9% win rate. Lissandra has the advantage in this matchup. Zoe players should focus on safe farming and avoiding extended trades to minimize Lissandra's lead.

How do I play Zoe against Lissandra?

When playing Zoe against Lissandra, play cautiously and avoid Lissandra's power spikes. Look for jungle assistance and team-dependent plays since Lissandra has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.