
Zoevs Lissandra
Zoe vs Lissandra is a decisive matchup in LoL patch 26.7. Lissandra wins with a 64.0% win rate (+28.0%) over Zoe based on 25 games. Zoe wins the early laning phase while Lissandra scales better into the late game. Below you'll find the best Zoe build, runes, laning stats, and strategies for the Zoe vs Lissandra matchup.
Zoe Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Zoe performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Who Wins the Zoe vs Lissandra Matchup?

Zoe vs Lissandra Matchup Summary
The Zoe vs Lissandra matchup is a decisive matchup in League of Legends ranked play. Based on 25 recent matches analyzed, Lissandra wins with a 64.0% win rate compared to Zoe's 36.0%, giving Lissandra a 28.0 percentage point advantage. Game phase dynamics play a critical role here: Zoe controls the early laning stage, but Lissandra outscales as the game goes longer. The matchup shifts dramatically depending on game length — Zoe needs to press advantages before Lissandra reaches their power spikes, while Lissandra should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Lissandra leads by 153 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Lissandra has a strong advantage in this matchup. Zoe players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Lissandra overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Zoe vs Lissandra Laning Phase Breakdown
Lissandra is favored during the laning phase against Zoe, winning 4 out of 5 key stat categories. Lissandra holds advantages in farming, gold income, crowd control and sustain, making them the stronger laner in this matchup.
Best Zoe Build Against Lissandra
Crimson Lucidity is the optimal boots choice against Lissandra, providing the mobility and stats Zoe needs most in this matchup. The top-performing core items for Zoe against Lissandra are Luden's Echo, Shadowflame and Rabadon's Deathcap. This combination gives Zoe an effective balance of damage, survivability, and utility for the matchup. This build has a 25.0% win rate across 4 games. While the overall matchup may be difficult, this item path gives Zoe the best chance to compete against Lissandra. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Zoe vs Lissandra matchup.
Early Game vs Late Game
The early game (first 15 minutes) is a toss-up between Zoe and Lissandra, with Zoe holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.
Lissandra is far superior in the late game (25+ minutes), boasting a 73.3% win rate — 46.7 points above Zoe. Extended games heavily favor Lissandra, whose kit and scaling make them a dominant force in team fights and objective control.
The power dynamics shift as the game progresses — Zoe has the edge early, but Lissandra gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.
Best Zoe Runes Against Lissandra
The Domination and Sorcery rune setup gives Zoe the best tools to compete against Lissandra in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.
Zoe matchup data for League of Legends patch 26.7. The table below shows Zoe's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Zoe build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 44.76% | 105 | 6.0 | 883 | 11,863 | 38.0% | 50.9% | |
| 45.83% | 72 | 5.7 | 862 | 11,529 | 46.0% | 45.7% | |
| 45.31% | 64 | 6.2 | 792 | 11,330 | 34.4% | 56.3% | |
| 53.97% | 63 | 5.5 | 848 | 10,585 | 50.0% | 57.6% | |
| 63.46% | 52 | 5.8 | 922 | 12,143 | 60.0% | 65.6% | |
| 56.00% | 50 | 6.3 | 887 | 11,562 | 59.1% | 53.6% | |
| 40.00% | 50 | 5.2 | 814 | 11,562 | 37.5% | 41.2% | |
| 55.10% | 49 | 5.9 | 945 | 11,503 | 59.1% | 51.9% | |
| 42.55% | 47 | 4.3 | 794 | 10,863 | 18.8% | 54.8% | |
| 44.44% | 45 | 6.0 | 965 | 11,850 | 37.5% | 48.3% | |
| 60.00% | 40 | 5.9 | 923 | 11,972 | 71.4% | 53.9% | |
| 50.00% | 38 | 5.7 | 833 | 11,630 | 56.3% | 45.5% | |
| 51.35% | 37 | 6.2 | 902 | 10,968 | 42.1% | 61.1% | |
| 43.24% | 37 | 5.8 | 936 | 11,492 | 43.8% | 42.9% | |
| 50.00% | 34 | 5.8 | 986 | 12,865 | 45.5% | 52.2% | |
| 48.48% | 33 | 6.3 | 874 | 10,323 | 38.1% | 66.7% | |
| 51.52% | 33 | 5.8 | 894 | 11,688 | 61.1% | 40.0% | |
| 46.88% | 32 | 5.7 | 898 | 11,124 | 47.1% | 46.7% | |
| 50.00% | 32 | 5.9 | 890 | 10,476 | 52.6% | 46.1% | |
| 62.07% | 29 | 6.5 | 918 | 11,990 | 58.3% | 64.7% | |
| 62.07% | 29 | 6.2 | 945 | 13,004 | 63.6% | 61.1% | |
| 44.83% | 29 | 3.8 | 813 | 10,727 | 44.4% | 45.0% | |
| 30.77% | 26 | 5.4 | 866 | 10,530 | 55.6% | 17.6% | |
| 44.00% | 25 | 5.8 | 820 | 10,451 | 23.1% | 66.7% | |
| 36.00% | 25 | 6.2 | 956 | 10,910 | 50.0% | 26.7% | |
| 54.17% | 24 | 3.7 | 953 | 10,324 | 58.3% | 50.0% | |
| 45.83% | 24 | 5.5 | 887 | 11,933 | 50.0% | 43.8% | |
| 54.55% | 22 | 6.3 | 945 | 12,258 | 62.5% | 50.0% | |
| 54.55% | 22 | 6.1 | 871 | 10,694 | 55.6% | 53.9% | |
| 50.00% | 22 | 5.6 | 927 | 11,851 | 75.0% | 35.7% | |
| 42.86% | 21 | 5.6 | 917 | 12,059 | 50.0% | 40.0% | |
| 52.38% | 21 | 4.1 | 873 | 11,830 | 50.0% | 53.9% | |
| 52.38% | 21 | 6.2 | 977 | 12,872 | 66.7% | 46.7% | |
| 47.37% | 19 | 6.5 | 898 | 12,104 | 33.3% | 60.0% | |
| 31.58% | 19 | 1.3 | 700 | 8,787 | 30.0% | 33.3% | |
| 52.63% | 19 | 5.7 | 916 | 11,866 | 87.5% | 27.3% | |
| 50.00% | 18 | 2.1 | 818 | 10,088 | 55.6% | 44.4% | |
| 47.06% | 17 | 1.5 | 714 | 9,352 | 33.3% | 62.5% | |
| 41.18% | 17 | 1.4 | 805 | 9,541 | 57.1% | 30.0% | |
| 46.67% | 15 | 3.7 | 894 | 12,482 | 75.0% | 36.4% | |
| 57.14% | 14 | 6.7 | 871 | 11,044 | 54.5% | 66.7% | |
| 35.71% | 14 | 5.5 | 817 | 10,957 | 33.3% | 37.5% | |
| 69.23% | 13 | 7.0 | 1,083 | 13,220 | 75.0% | 60.0% | |
| 53.85% | 13 | 1.7 | 753 | 10,608 | 75.0% | 44.4% | |
| 61.54% | 13 | 1.6 | 708 | 9,683 | 83.3% | 42.9% | |
| 66.67% | 12 | 1.6 | 871 | 11,224 | 66.7% | 66.7% | |
| 75.00% | 12 | 4.8 | 904 | 12,416 | 75.0% | 75.0% | |
| 50.00% | 12 | 6.0 | 943 | 11,926 | 66.7% | 44.4% | |
| 41.67% | 12 | 6.2 | 875 | 9,655 | 25.0% | 75.0% | |
| 41.67% | 12 | 2.0 | 719 | 9,627 | 60.0% | 28.6% | |
| 63.64% | 11 | 1.6 | 777 | 9,797 | 83.3% | 40.0% | |
| 80.00% | 10 | 2.1 | 819 | 11,386 | 100.0% | 60.0% | |
| 60.00% | 10 | 5.7 | 865 | 10,115 | 50.0% | 75.0% | |
| 80.00% | 10 | 5.5 | 1,072 | 11,159 | 100.0% | 71.4% | |
| 55.56% | 9 | 2.7 | 849 | 11,947 | 50.0% | 57.1% | |
| 66.67% | 9 | 5.8 | 996 | 12,035 | 100.0% | 50.0% | |
| 55.56% | 9 | 1.3 | 751 | 9,438 | 60.0% | 50.0% | |
| 33.33% | 9 | 5.0 | 795 | 12,251 | 50.0% | 28.6% | |
| 66.67% | 9 | 1.6 | 806 | 9,510 | 80.0% | 50.0% | |
| 11.11% | 9 | 6.0 | 889 | 10,038 | 16.7% | 0.0% | |
| 62.50% | 8 | 1.5 | 754 | 9,551 | 50.0% | 100.0% | |
| 75.00% | 8 | 5.9 | 1,325 | 13,267 | 100.0% | 66.7% | |
| 37.50% | 8 | 1.7 | 771 | 11,599 | 33.3% | 40.0% | |
| 25.00% | 8 | 1.8 | 886 | 10,682 | 33.3% | 20.0% | |
| 50.00% | 8 | 1.4 | 755 | 10,710 | 25.0% | 75.0% | |
| 42.86% | 7 | 1.4 | 626 | 6,355 | 33.3% | 100.0% | |
| 42.86% | 7 | 5.1 | 910 | 12,663 | 75.0% | 0.0% | |
| 16.67% | 6 | 6.7 | 719 | 9,851 | 25.0% | 0.0% | |
| 50.00% | 6 | 5.8 | 1,008 | 11,710 | 0.0% | 100.0% | |
| 50.00% | 6 | 2.2 | 723 | 9,856 | 50.0% | 50.0% | |
| 100.00% | 6 | 6.8 | 798 | 13,448 | 100.0% | 100.0% | |
| 66.67% | 6 | 4.8 | 853 | 10,365 | 80.0% | 0.0% | |
| 100.00% | 5 | 1.6 | 634 | 10,257 | 100.0% | 100.0% | |
| 60.00% | 5 | 5.7 | 1,014 | 12,481 | 50.0% | 66.7% | |
| 20.00% | 5 | 6.2 | 610 | 8,044 | 20.0% | 0.0% | |
| 80.00% | 5 | 6.3 | 1,211 | 11,720 | 100.0% | 66.7% | |
| 60.00% | 5 | 5.6 | 893 | 12,472 | 66.7% | 50.0% | |
| 60.00% | 5 | 6.5 | 1,070 | 13,251 | 100.0% | 33.3% | |
Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.
Zoe vs Lissandra - Frequently Asked Questions
How does Zoe do against Lissandra in League of Legends?
Lissandra wins the Zoe vs Lissandra matchup with a 64.0% win rate compared to Zoe's 36.0%, a 28.0 percentage point difference. This data is based on 25 recent ranked games in patch 26.7.
How does Zoe do against Lissandra in the early game?
In the early game, Zoe has the advantage against Lissandra with a 50.0% win rate versus 50.0%. Zoe players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Zoe do against Lissandra in the late game?
In the late game, Lissandra takes over the Zoe vs Lissandra matchup with a 73.3% win rate compared to 26.7%. Lissandra scales better into team fights and objective contests after 25 minutes.
Who wins the Zoe vs Lissandra matchup?
Lissandra wins the matchup against Zoe with a 64.0% win rate in League of Legends patch 26.7. The 28.0 percentage point advantage means Lissandra is significantly favored in this lane matchup based on 25 games analyzed.
What is the best Zoe build against Lissandra?
The best Zoe build against Lissandra includes Luden's Echo, Shadowflame, Rabadon's Deathcap with Crimson Lucidity. This build achieves a 25.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.
What are the best Zoe runes against Lissandra?
The best Zoe runes against Lissandra use the Domination primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Zoe vs Lissandra matchup. See the full rune breakdown in the matchup comparison above.
Does Zoe counter Lissandra?
No, Zoe struggles against Lissandra with only a 36.0% win rate. Lissandra has the advantage in this matchup. Zoe players should focus on safe farming and avoiding extended trades to minimize Lissandra's lead.
How do I play Zoe against Lissandra?
When playing Zoe against Lissandra, play cautiously and avoid Lissandra's power spikes. Look for jungle assistance and team-dependent plays since Lissandra has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.