Zoe - League of Legends Champion
Win Rate
47.8%
Pick Rate
1.9%

Zoevs Lissandra

FMage
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 7, 2026
MethodologyData Methodology

Zoe vs Lissandra is a decisive matchup in LoL patch 26.11. Zoe wins with a 62.5% win rate (+25.0%) over Lissandra based on 24 games. Zoe holds the advantage in both the early and late game. Below you'll find the best Zoe build, runes, laning stats, and strategies for the Zoe vs Lissandra matchup.

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Zoe Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Zoe performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Zoe - 62.5% win rate in this matchup
Zoe
62.5% WR
VS
Lissandra vs Zoe matchup - 37.5% win rate
Lissandra
37.5% WR

Who Wins the Zoe vs Lissandra Matchup?

Zoe wins the Zoe vs Lissandra matchup
Winner
Zoe
Matches: 24
62.5%
Win Rate
37.5%
6.0
CS / min
6.4
1,013
DMG / min
701
13,003
Gold / game
11,947
95
Heal / min
154
308
DMG Mitigated / min
439
1.3
CC / min
1.4
55.6%
Early Game WR
44.4%
66.7%
Late Game WR
33.3%

Zoe vs Lissandra Matchup Summary

The Zoe vs Lissandra matchup is a decisive matchup in League of Legends ranked play. Based on 24 recent matches analyzed, Zoe wins with a 62.5% win rate compared to Lissandra's 37.5%, giving Zoe a 25.0 percentage point advantage. Zoe dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Lissandra players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Lissandra leads by 190 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Zoe players can confidently pick into Lissandra and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Lissandra away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Zoe vs Lissandra Laning Phase Breakdown

Lissandra wins the laning phase against Zoe in League of Legends

Lissandra is favored during the laning phase against Zoe, winning 3 out of 5 key stat categories. Lissandra holds advantages in farming, crowd control and sustain, making them the stronger laner in this matchup.

Farming
6.0Zoe
6.4Lissandra
Lissandra edges out Zoe by 0.4 CS per minute — a moderate farming advantage that adds up to roughly 5 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Lissandra.
Damage
1,013Zoe
701Lissandra
Zoe heavily out-damages Lissandra by 312 DMG/min, dominating both short trades and all-in fights. Lissandra should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Zoe's sustained damage advantage take over.
Economy
13,003Zoe
11,947Lissandra
Zoe generates a commanding 1,056 more gold per game than Lissandra. This substantial economic advantage means Zoe consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Lissandra should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.3Zoe
1.4Lissandra
Both Zoe and Lissandra provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
403Zoe
593Lissandra
Lissandra vastly out-sustains Zoe, healing and mitigating 190 more damage per minute. This massive durability gap means Lissandra can absorb significant punishment and remain in lane while Zoe is forced to recall. Building grievous wounds early is essential for Zoe, and focusing on burst trade patterns rather than sustained fights is critical.

Best Zoe Build Against Lissandra

Spellslinger's Shoes is the optimal boots choice against Lissandra, providing the mobility and stats Zoe needs most in this matchup. The top-performing core items for Zoe against Lissandra are Luden's Echo, Shadowflame and Lich Bane. This combination gives Zoe an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 66.7% win rate across 3 games — well above average and making it the top item path against Lissandra. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Zoe vs Lissandra matchup.

Early Game vs Late Game

Early Game
Zoe
55.6%
+11.1% advantage
Zoe early game win rateZoe55.6%
Lissandra early game win rateLissandra44.4%
Late Game
Zoe
66.7%
+33.3% advantage
Zoe late game win rateZoe66.7%
Lissandra late game win rateLissandra33.3%

Zoe dominates the early game (first 15 minutes) with a commanding 55.6% win rate — a 11.1 percentage point lead over Lissandra. This lopsided early game means Zoe can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Zoe is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Lissandra. Extended games heavily favor Zoe, whose kit and scaling make them a dominant force in team fights and objective control.

Zoe holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Lissandra players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Zoe Runes Against Lissandra

Domination rune tree - Zoe primary runes vs LissandraDomination
Dark Harvest - best Zoe rune vs LissandraSudden Impact - best Zoe rune vs LissandraGrisly Mementos - best Zoe rune vs LissandraRelentless Hunter - best Zoe rune vs Lissandra
Sorcery rune tree - Zoe secondary runes vs LissandraSorcery
Nimbus Cloak - best Zoe rune vs LissandraTranscendence - best Zoe rune vs Lissandra
60.0% WR

Running Domination primary with Sorcery secondary allows Zoe to press their advantage against Lissandra, amplifying the strengths that make this a favorable matchup.


Zoe matchup data for League of Legends patch 26.11. The table below shows Zoe's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Zoe build, runes, laning stats, and early vs late game analysis for that specific matchup.

Zoe matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
52.32%1515.891411,00053.4%51.3%
55.88%1024.380810,65257.8%54.4%
46.88%965.881211,27634.3%54.1%
45.98%875.488611,53237.5%50.9%
55.70%794.687511,43953.9%56.6%
48.72%785.585611,76346.9%50.0%
45.95%745.794411,28055.6%40.4%
56.34%715.790811,07457.1%55.6%
52.17%695.886611,22158.1%47.4%
43.48%695.684011,39631.0%52.5%
48.39%625.390310,34648.3%48.5%
45.00%605.385211,27933.3%52.8%
49.12%575.987610,85555.6%43.3%
47.37%575.485610,84740.6%56.0%
48.94%471.96839,59352.4%46.1%
44.68%473.480011,20035.7%48.5%
66.67%455.691311,25472.2%63.0%
51.16%435.094810,58866.7%40.0%
57.50%405.592811,93047.1%65.2%
35.90%391.869110,06052.6%20.0%
53.85%395.991611,36935.0%73.7%
41.03%393.772310,01129.4%50.0%
57.89%381.47639,41957.9%57.9%
43.24%375.896012,15446.7%40.9%
48.65%375.688112,10554.5%46.1%
66.67%366.096110,57375.0%56.3%
38.89%365.890412,57333.3%40.7%
62.86%352.07189,58870.6%55.6%
35.29%343.97449,78733.3%36.4%
44.12%345.884711,13746.1%42.9%
61.76%345.387110,95560.0%63.2%
51.52%335.886410,53457.9%42.9%
29.03%316.089511,40440.0%23.8%
53.33%306.390810,53550.0%57.1%
60.00%301.780810,67462.5%59.1%
55.17%295.590011,08563.6%50.0%
42.86%286.21,00011,15957.1%28.6%
57.14%285.898012,65066.7%50.0%
53.85%265.589310,89545.5%60.0%
23.08%266.08959,49617.6%33.3%
38.46%261.66209,90145.5%33.3%
50.00%241.76708,51060.0%33.3%
45.83%242.173310,97444.4%46.7%
62.50%246.01,01313,00355.6%66.7%
54.17%245.689411,31666.7%46.7%
30.43%235.288810,73020.0%38.5%
57.14%212.56698,22863.6%50.0%
47.62%215.696412,12445.5%50.0%
47.62%213.784710,74466.7%40.0%
20.00%203.381311,4550.0%30.8%
60.00%205.074010,26077.8%45.5%
55.00%205.491712,31937.5%66.7%
42.11%191.64678,45044.4%40.0%
57.89%191.771210,20150.0%66.7%
27.78%181.67189,76511.1%44.4%
58.82%176.195311,08975.0%44.4%
35.29%172.170110,09475.0%23.1%
43.75%162.65998,13330.0%66.7%
43.75%164.174311,53550.0%41.7%
33.33%151.47709,89440.0%30.0%
73.33%155.01,06412,03180.0%70.0%
35.71%141.36689,31437.5%33.3%
46.15%135.99269,92162.5%20.0%
69.23%135.492612,54150.0%77.8%
61.54%131.56399,849100.0%37.5%
46.15%132.986310,72133.3%57.1%
46.15%131.556410,05633.3%57.1%
53.85%132.17409,89740.0%62.5%
41.67%121.57399,09175.0%25.0%
81.82%113.072110,662100.0%75.0%
40.00%104.786310,3290.0%57.1%
30.00%104.889711,26350.0%25.0%
50.00%105.51,05613,0630.0%55.6%
22.22%95.071710,66033.3%16.7%
50.00%86.087312,3190.0%66.7%
62.50%81.659510,27380.0%33.3%
57.14%75.974412,40766.7%50.0%
42.86%75.81,18413,4260.0%60.0%
57.14%74.872311,31166.7%50.0%
57.14%71.37828,951100.0%40.0%
57.14%71.36169,11050.0%66.7%
28.57%76.11,07412,8530.0%40.0%
33.33%65.77319,43266.7%0.0%
16.67%61.25806,6560.0%33.3%
16.67%64.59118,72233.3%0.0%
66.67%65.16879,18566.7%66.7%
50.00%65.78559,61633.3%66.7%
0.00%65.27179,7150.0%0.0%
60.00%54.79968,75866.7%50.0%
80.00%55.394711,156100.0%50.0%
20.00%55.781011,5700.0%33.3%
20.00%56.077210,15850.0%0.0%
40.00%55.287012,0140.0%66.7%

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Zoe vs Lissandra - Frequently Asked Questions

How does Zoe do against Lissandra in League of Legends?

Zoe wins the Zoe vs Lissandra matchup with a 62.5% win rate compared to Lissandra's 37.5%, a 25.0 percentage point difference. This data is based on 24 recent ranked games in patch 26.11.

How does Zoe do against Lissandra in the early game?

In the early game, Zoe has the advantage against Lissandra with a 55.6% win rate versus 44.4%. Zoe players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Zoe do against Lissandra in the late game?

In the late game, Zoe takes over the Zoe vs Lissandra matchup with a 66.7% win rate compared to 33.3%. Zoe scales better into team fights and objective contests after 25 minutes.

Who wins the Zoe vs Lissandra matchup?

Zoe wins the matchup against Lissandra with a 62.5% win rate in League of Legends patch 26.11. The 25.0 percentage point advantage means Zoe is significantly favored in this lane matchup based on 24 games analyzed.

What is the best Zoe build against Lissandra?

The best Zoe build against Lissandra includes Luden's Echo, Shadowflame, Lich Bane with Spellslinger's Shoes. This build achieves a 66.7% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Zoe runes against Lissandra?

The best Zoe runes against Lissandra use the Domination primary tree with Sorcery secondary. This rune setup achieves a 60.0% win rate in the Zoe vs Lissandra matchup. See the full rune breakdown in the matchup comparison above.

Does Zoe counter Lissandra?

Yes, Zoe has a favorable matchup against Lissandra with a 62.5% win rate. Zoe strongly counters Lissandra in lane based on current patch 26.11 data.

How do I play Zoe against Lissandra?

When playing Zoe against Lissandra, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.