Slay the Spire 2 Potion Tier List

62 potions ranked by pick lift: the win rate of runs that took a potion from a reward minus runs that skipped it. Foul Potion leads at +10.1 points, with Potion of Doom, Fairy in a Bottle, Orobic Acid close behind in S tier.

31.7%

Use your potions

31.7% of runs that died were still holding at least one unused potion, and the average death left 0.4 potions unused. A potion saved for later does nothing once the run is over.

Tiers rank pick lift, not raw win rate. A potion that mostly appears late, in runs that are already strong, would look great on raw win rate for reasons that have nothing to do with the potion. Pick lift compares runs that were offered the same potion, across 228,505 recorded offers: S is the top 15% of the 62 potions with enough data, then A (20%), B (30%), C (20%) and D (15%). 1 potions with too few offers are listed separately. Like every number here it is observational: it shows what went with winning runs, not a guarantee.

S

S Tier

Runs that took these did far better than runs that skipped them.
Foul Potion

Foul Potion+10.1 pts

Event

Deal damage to ALL players and enemies. Can be thrown at the Merchant for X Gold instead.

Win rate if taken: 41.5%If skipped: 31.3%Taken when offered: 80.4%Offered: 2346
Potion of Doom

Potion of Doom+9.7 pts

Common

Apply Doom.

Win rate if taken: 32.3%If skipped: 22.4%Taken when offered: 49.9%Offered: 1327
Fairy in a Bottle

Fairy in a Bottle+8.5 pts

Rare

When your HP would be reduced to 0, instead this potion is discarded and you heal to 30% of your Max HP.

Win rate if taken: 34.1%If skipped: 25.5%Taken when offered: 59.1%Offered: 1463
Orobic Acid

Orobic Acid+7.4 pts

Rare

Add a random Attack, Skill, and Power into your Hand. They're free to play this turn.

Win rate if taken: 33.0%If skipped: 25.5%Taken when offered: 53.4%Offered: 1454
Energy Potion

Energy Potion+5.1 pts

Common

Gain Energy.

Win rate if taken: 28.0%If skipped: 22.9%Taken when offered: 51.9%Offered: 9156
Fruit Juice

Fruit Juice+5.1 pts

Rare

Gain Max HP.

Win rate if taken: 32.2%If skipped: 27.1%Taken when offered: 58.7%Offered: 1433
Star Potion

Star Potion+4.4 pts

Common

Gain Stars.

Win rate if taken: 34.9%If skipped: 30.4%Taken when offered: 51.9%Offered: 1236
Touch of Insanity

Touch of Insanity+4.4 pts

Uncommon

Choose a card in your Hand. It is free to play this combat.

Win rate if taken: 31.6%If skipped: 27.2%Taken when offered: 52.3%Offered: 3267
Blood Potion

Blood Potion+4.3 pts

Common

Heal for X% of your Max HP.

Win rate if taken: 26.7%If skipped: 22.4%Taken when offered: 58.6%Offered: 1752
A

A Tier

A clear edge over skipping in most runs.
Power Potion

Power Potion+3.8 pts

Common

Choose 1 of 3 random Power cards to add into your Hand. It's free to play this turn.

Win rate if taken: 28.3%If skipped: 24.5%Taken when offered: 55.6%Offered: 8955
Focus Potion

Focus Potion+3.7 pts

Common

Gain Focus.

Win rate if taken: 21.0%If skipped: 17.2%Taken when offered: 51.7%Offered: 1409
King's Courage

King's Courage+3.6 pts

Uncommon

Forge X.

Win rate if taken: 36.3%If skipped: 32.5%Taken when offered: 51.6%Offered: 512
Block Potion

Block Potion+3.5 pts

Common

Gain Block.

Win rate if taken: 27.7%If skipped: 24.2%Taken when offered: 53.1%Offered: 9181
Skill Potion

Skill Potion+3.5 pts

Common

Choose 1 of 3 random Skill cards to add into your Hand. It's free to play this turn.

Win rate if taken: 27.8%If skipped: 24.3%Taken when offered: 52.2%Offered: 8900
Mazaleth's Gift

Mazaleth's Gift+3.3 pts

Rare

Gain Ritual.

Win rate if taken: 31.3%If skipped: 27.9%Taken when offered: 51.1%Offered: 1426
Weak Potion

Weak Potion+3.3 pts

Common

Apply Weak.

Win rate if taken: 28.4%If skipped: 25.1%Taken when offered: 49.0%Offered: 8944
Blessing of the Forge

Blessing of the Forge+2.9 pts

Uncommon

Upgrade all cards in your Hand for the rest of combat.

Win rate if taken: 30.1%If skipped: 27.2%Taken when offered: 50.0%Offered: 3603
Swift Potion

Swift Potion+2.8 pts

Common

Draw X cards.

Win rate if taken: 28.0%If skipped: 25.2%Taken when offered: 50.3%Offered: 8952
Duplicator

Duplicator+2.7 pts

Uncommon

This turn, your next card is played an extra time.

Win rate if taken: 29.3%If skipped: 26.6%Taken when offered: 54.1%Offered: 3620
Vulnerable Potion

Vulnerable Potion+2.7 pts

Common

Apply Vulnerable.

Win rate if taken: 27.4%If skipped: 24.7%Taken when offered: 49.6%Offered: 8860
Cunning Potion

Cunning Potion+1.9 pts

Uncommon

Add X Upgraded Shivs into your Hand.

Win rate if taken: 34.0%If skipped: 32.0%Taken when offered: 57.4%Offered: 685
B

B Tier

A modest edge; worth the slot if it is free.
Fortifier

Fortifier+1.8 pts

Uncommon

Triple your Block.

Win rate if taken: 28.9%If skipped: 27.1%Taken when offered: 48.9%Offered: 3501
Gigantification Potion

Gigantification Potion+1.8 pts

Rare

The next Attack you play deals triple damage.

Win rate if taken: 29.9%If skipped: 28.0%Taken when offered: 53.6%Offered: 1513
Radiant Tincture

Radiant Tincture+1.6 pts

Uncommon

Gain Energy. Gain an additional -cost at the start of your next turns.

Win rate if taken: 30.6%If skipped: 29.0%Taken when offered: 52.3%Offered: 3554
Fysh Oil

Fysh Oil+1.5 pts

Uncommon

Gain Strength and Dexterity.

Win rate if taken: 30.1%If skipped: 28.5%Taken when offered: 49.4%Offered: 3424
Powdered Demise

Powdered Demise+1.4 pts

Uncommon

Enemy loses X HP at the end of each of its turns.

Win rate if taken: 29.0%If skipped: 27.5%Taken when offered: 51.4%Offered: 3270
Pot of Ghouls

Pot of Ghouls+1.1 pts

Rare

Add X Souls into your Hand.

Win rate if taken: 30.6%If skipped: 29.4%Taken when offered: 52.6%Offered: 190
Regen Potion

Regen Potion+1.0 pts

Uncommon

Gain Regen.

Win rate if taken: 30.5%If skipped: 29.5%Taken when offered: 54.2%Offered: 3544
Colorless Potion

Colorless Potion+0.6 pts

Common

Choose 1 of 3 random Colorless cards to add into your Hand. It's free to play this turn.

Win rate if taken: 27.3%If skipped: 26.8%Taken when offered: 51.6%Offered: 8775
Liquid Memories

Liquid Memories+0.6 pts

Rare

Put a card from your Discard Pile into your Hand. It's free to play this turn.

Win rate if taken: 30.7%If skipped: 30.1%Taken when offered: 51.8%Offered: 1433
Attack Potion

Attack Potion+0.6 pts

Common

Choose 1 of 3 random Attack cards to add into your Hand. It's free to play this turn.

Win rate if taken: 26.8%If skipped: 26.2%Taken when offered: 51.8%Offered: 8897
Explosive Ampoule

Explosive Ampoule+0.5 pts

Common

Deal damage to ALL enemies.

Win rate if taken: 26.4%If skipped: 25.9%Taken when offered: 48.2%Offered: 9039
Cosmic Concoction

Cosmic Concoction+0.3 pts

Rare

Add X Upgraded Colorless cards into your Hand.

Win rate if taken: 34.0%If skipped: 33.7%Taken when offered: 50.3%Offered: 197
Cure All

Cure All+0.2 pts

Uncommon

Gain Energy. Draw X cards.

Win rate if taken: 28.4%If skipped: 28.2%Taken when offered: 52.6%Offered: 3538
Beetle Juice

Beetle Juice+0.2 pts

Rare

Enemy's attacks deal X% less damage for the next.

Win rate if taken: 30.2%If skipped: 30.0%Taken when offered: 53.3%Offered: 1373
Strength Potion

Strength Potion+0.1 pts

Common

Gain Strength.

Win rate if taken: 26.6%If skipped: 26.5%Taken when offered: 49.4%Offered: 9139
Gambler's Brew

Gambler's Brew0.0 pts

Uncommon

Discard any number of cards, then draw that many.

Win rate if taken: 28.2%If skipped: 28.2%Taken when offered: 47.5%Offered: 3453
Bone Brew

Bone Brew0.0 pts

Uncommon

Summon.

Win rate if taken: 33.9%If skipped: 33.8%Taken when offered: 54.6%Offered: 549
Bottled Potential

Bottled Potential-0.1 pts

Rare

Shuffle ALL your cards into your Draw Pile. Draw X cards.

Win rate if taken: 28.2%If skipped: 28.3%Taken when offered: 47.0%Offered: 1411
Flex Potion

Flex Potion-0.1 pts

Common

Gain Strength. At the end of your turn, lose Strength.

Win rate if taken: 26.1%If skipped: 26.2%Taken when offered: 47.2%Offered: 9050
C

C Tier

Little difference between taking and skipping.
Heart of Iron

Heart of Iron-0.1 pts

Uncommon

Gain Plating.

Win rate if taken: 28.0%If skipped: 28.1%Taken when offered: 52.7%Offered: 3635
Dexterity Potion

Dexterity Potion-0.2 pts

Common

Gain Dexterity.

Win rate if taken: 25.5%If skipped: 25.7%Taken when offered: 47.5%Offered: 9008
Potion of Binding

Potion of Binding-0.2 pts

Uncommon

Apply 1 Weak and 1 Vulnerable to ALL enemies.

Win rate if taken: 28.3%If skipped: 28.5%Taken when offered: 47.7%Offered: 3469
Glowwater Potion

Glowwater Potion-0.4 pts

Event

Exhaust your Hand. Draw X cards.

Win rate if taken: 15.1%If skipped: 15.5%Taken when offered: 82.5%Offered: 674
Droplet of Precognition

Droplet of Precognition-0.7 pts

Rare

Choose a card in your Draw Pile and add it into your Hand.

Win rate if taken: 30.2%If skipped: 30.9%Taken when offered: 49.1%Offered: 1341
Fire Potion

Fire Potion-0.7 pts

Common

Deal damage.

Win rate if taken: 25.8%If skipped: 26.5%Taken when offered: 49.0%Offered: 8920
Ghost in a Jar

Ghost in a Jar-0.7 pts

Rare

Gain 1 Intangible.

Win rate if taken: 36.7%If skipped: 37.5%Taken when offered: 57.7%Offered: 291
Ship in a Bottle

Ship in a Bottle-1.1 pts

Rare

Gain 10 Block. Next turn, gain 10 Block.

Win rate if taken: 27.9%If skipped: 29.0%Taken when offered: 51.8%Offered: 1307
Potion of Capacity

Potion of Capacity-1.2 pts

Uncommon

Gain X Orb Slots.

Win rate if taken: 23.0%If skipped: 24.2%Taken when offered: 50.6%Offered: 542
Speed Potion

Speed Potion-1.2 pts

Common

Gain Dexterity. At the end of your turn, lose Dexterity.

Win rate if taken: 25.5%If skipped: 26.7%Taken when offered: 46.2%Offered: 8840
Essence of Darkness

Essence of Darkness-1.3 pts

Rare

Channel a Dark for each of your Orb Slots.

Win rate if taken: 20.4%If skipped: 21.7%Taken when offered: 53.6%Offered: 220
Clarity Extract

Clarity Extract-2.0 pts

Uncommon

Draw X cards. At the start of your next, draw 1 additional card.

Win rate if taken: 27.1%If skipped: 29.1%Taken when offered: 48.3%Offered: 3546
D

D Tier

Runs that took these did no better, or worse, than runs that skipped them.
Entropic Brew

Entropic Brew-2.2 pts

Rare

Fill all your empty potion slots with random potions.

Win rate if taken: 29.5%If skipped: 31.8%Taken when offered: 55.4%Offered: 1458
Distilled Chaos

Distilled Chaos-2.5 pts

Rare

Play the top X cards of your Draw Pile.

Win rate if taken: 27.5%If skipped: 30.1%Taken when offered: 56.9%Offered: 1373
Poison Potion

Poison Potion-2.8 pts

Common

Apply Poison.

Win rate if taken: 30.4%If skipped: 33.3%Taken when offered: 47.6%Offered: 1678
Liquid Bronze

Liquid Bronze-3.0 pts

Uncommon

Gain Thorns.

Win rate if taken: 27.0%If skipped: 30.0%Taken when offered: 49.4%Offered: 3603
Soldier's Stew

Soldier's Stew-3.2 pts

Rare

All cards containing Strike gain 1 Replay this combat.

Win rate if taken: 22.5%If skipped: 25.9%Taken when offered: 52.6%Offered: 270
Shackling Potion

Shackling Potion-3.4 pts

Rare

ALL enemies lose Strength this turn.

Win rate if taken: 27.2%If skipped: 30.6%Taken when offered: 51.7%Offered: 1454
Stable Serum

Stable Serum-3.7 pts

Uncommon

Retain your Hand for X turns.

Win rate if taken: 26.8%If skipped: 30.5%Taken when offered: 45.9%Offered: 3514
Snecko Oil

Snecko Oil-4.3 pts

Rare

Draw X cards. Randomize the cost of cards in your Hand this turn.

Win rate if taken: 28.1%If skipped: 32.5%Taken when offered: 48.9%Offered: 1331
Lucky Tonic

Lucky Tonic-4.5 pts

Rare

Gain Buffer.

Win rate if taken: 28.0%If skipped: 32.6%Taken when offered: 53.8%Offered: 1399
Ashwater

Ashwater-5.2 pts

Uncommon

Exhaust any number of cards in your Hand.

Win rate if taken: 23.0%If skipped: 28.4%Taken when offered: 48.1%Offered: 701
?

Not enough data yet

Potion-Shaped Rock

Potion-Shaped Rock0.0 pts

Token

Deal damage.

Win rate if taken: 31.4%If skipped: —%Taken when offered: 100.0%Offered: 5600
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Slay the Spire 2 Potion FAQ - October 2026

What is the best potion in Slay the Spire 2?

Foul Potion has the biggest pick lift: runs that took it from a reward won 41.5%, against 31.3% for runs that skipped it (+10.1 points). Potion of Doom and Fairy in a Bottle are next.

Is Block Potion good in Slay the Spire 2?

Block Potion is A tier. Runs that took it won 27.7% against 24.2% when it was skipped, a +3.5-point gap, and players took it 53.1% of the times it was offered.

Is Energy Potion good in Slay the Spire 2?

Energy Potion is S tier. Runs that took it won 28.0% against 22.9% when it was skipped, a +5.1-point gap, and players took it 51.9% of the times it was offered.

Which potions are the worst in Slay the Spire 2?

Ashwater has the lowest pick lift (-5.2 points): runs that took it won 23.0% against 28.4% for runs that skipped it. Lucky Tonic and Snecko Oil are next from the bottom.

Should I save my potions in Slay the Spire 2?

Not for too long. 31.7% of runs that died were still holding at least one potion. Use them in the elite and boss fights where they keep you alive, and free the slot for the next one.

How is the potion tier list calculated?

From 228,505 potion offers recorded by MetaBot users. For each potion we compare the win rate of runs that took it with runs that skipped it, and that gap (pick lift) sets the tier for the 62 potions with enough data. It is observational: it shows what went with winning runs, not a guarantee.

See Also

Slay the Spire 2 Event GuideCard Reward AdvisorBoss EncountersCard Tier ListRelic Tier List