Slay the Spire 2 Relic Tier List

This Slay the Spire 2 relic tier list ranks the 114 most-carried relics by win rate, grouping them into S, B, C, D, and F tiers so you know which relics are worth grabbing. Tiers use the same percentile method as our full relic rankings: the top 15% by win rate are S, the next 15% B, and so on down to F. The S tier — the 17 most powerful relics in Slay the Spire 2 — is led by Fragrant Mushroom, Jeweled Mask, Mango, with Fragrant Mushroom holding the highest win rate at 100.0%. Only relics with enough recorded runs are ranked, so each placement reflects real results rather than a lucky single run. Use this tier list to decide which relics to take from bosses, elites, shops and events, build around the strongest options for your class, and recognise the low-tier relics that rarely pay off. Win rates refresh as more runs are tracked.