Slay the Spire 2 Boss Encounters

This Slay the Spire 2 boss encounters guide breaks down all 23 bosses you fight on the climb — their win rates, how hard they hit, and exactly which cards and relics give each class the best shot at beating them. Bosses are grouped by act, from the Act I gatekeepers to the brutal Act III finales. For every boss you can see its clear rate, how many turns the fight usually lasts, the average damage it deals and the HP you are left with, plus the floor it appears on. Kakarotmod-frieza Boss Encounter is currently the toughest boss in the game at just 0.0% cleared, while Pika Mod Encounter Rayquaza Encounter is the most forgiving. Each entry lists the best and worst cards to bring as every class — Ironclad, Silent, Defect, Necrobinder and Regent — along with the top relics that swing the fight in your favour. Use it to prep your deck, dodge the traps, and stop losing runs to the same boss fight.

Act I

Soul Fysh

Soul Fysh

Act I
Win rate: 82.7%Times faced: 2667Avg turns: 9.9Avg damage taken: 30Avg HP left: 25Avg floor: 16.7

Best & Worst Cards Against Soul Fysh by Class

The IroncladThe Ironclad
Best
PyrePyre+16.1%BreakBreak+15.0%Pact's EndPact's End+14.7%One-Two PunchOne-Two Punch+14.4%Mad ScienceMad Science+14.2%Ultimate DefendUltimate Defend+14.1%
Worst
Spoils MapSpoils Map-28.6%InjuryInjury-11.5%CaltropsCaltrops-11.2%Dual WieldDual Wield-9.1%ShameShame-9.1%Hand of GreedHand of Greed-5.3%
The SilentThe Silent
Best
EnvenomEnvenom+15.6%Knife TrapKnife Trap+15.6%Storm of SteelStorm of Steel+15.1%Tools of the TradeTools of the Trade+14.3%Mad ScienceMad Science+13.7%BurstBurst+13.6%
Worst
Spoils MapSpoils Map-29.3%Dual WieldDual Wield-14.1%Rip and TearRip and Tear-9.2%InjuryInjury-7.4%Dramatic EntranceDramatic Entrance-6.2%ExpertiseExpertise-5.5%
The DefectThe Defect
Best
BufferBuffer+11.7%NullNull+11.5%Mad ScienceMad Science+10.8%Ice LanceIce Lance+10.8%Lightning RodLightning Rod+10.8%Flak CannonFlak Cannon+10.7%
Worst
Spoils MapSpoils Map-24.4%InjuryInjury-14.1%Neow's FuryNeow's Fury-13.5%Believe in YouBelieve in You-6.0%RegretRegret-4.5%StratagemStratagem-4.5%
The NecrobinderThe Necrobinder
Best
Sentry ModeSentry Mode+12.4%HangHang+12.3%SqueezeSqueeze+12.2%High FiveHigh Five+12.1%Sleight of FleshSleight of Flesh+12.1%No EscapeNo Escape+11.9%
Worst
Spoils MapSpoils Map-23.2%Neow's FuryNeow's Fury-15.3%AutomationAutomation-9.7%ClumsyClumsy-8.8%SpeedsterSpeedster-5.7%AngerAnger-5.7%
The RegentThe Regent
Best
CometComet+17.7%Seeking EdgeSeeking Edge+17.1%GenesisGenesis+16.9%Meteor ShowerMeteor Shower+16.5%Void FormVoid Form+16.3%ConquerorConqueror+15.8%
Worst
Spoils MapSpoils Map-26.4%InjuryInjury-15.8%OmnisliceOmnislice-14.7%CatastropheCatastrophe-10.4%

Top Relics for Beating Soul Fysh

Touch of OrobasTouch of Orobas+16.3%Yummy CookieYummy Cookie+16.3%Archaic ToothArchaic Tooth+16.2%Fragrant MushroomFragrant Mushroom+16.1%Very Hot CocoaVery Hot Cocoa+16.1%Nutritious SoupNutritious Soup+16.0%Pael's WingPael's Wing+15.9%Pael's FleshPael's Flesh+15.9%Pael's BloodPael's Blood+15.7%Pael's TearsPael's Tears+15.7%
Vantom

Vantom

Act I
Win rate: 80.8%Times faced: 2707Avg turns: 8.6Avg damage taken: 32Avg HP left: 24Avg floor: 16.7

Best & Worst Cards Against Vantom by Class

The IroncladThe Ironclad
Best
BreakBreak+17.9%Mad ScienceMad Science+17.4%ImperviousImpervious+17.3%AggressionAggression+17.0%CascadeCascade+16.9%Tear AsunderTear Asunder+16.7%
Worst
Spoils MapSpoils Map-42.1%GuiltyGuilty-33.4%InjuryInjury-14.9%Byrdonis EggByrdonis Egg-13.0%ReaveReave-13.0%Poor SleepPoor Sleep-10.4%
The SilentThe Silent
Best
Blade of InkBlade of Ink+15.1%AbrasiveAbrasive+15.1%AfterimageAfterimage+14.7%Knife TrapKnife Trap+14.6%SuppressSuppress+14.2%SquashSquash+14.1%
Worst
Spoils MapSpoils Map-30.2%GuiltyGuilty-27.9%Byrdonis EggByrdonis Egg-11.3%Poor SleepPoor Sleep-10.3%Follow ThroughFollow Through-9.7%StratagemStratagem-7.4%
The DefectThe Defect
Best
Genetic AlgorithmGenetic Algorithm+11.5%ModdedModded+10.8%Machine LearningMachine Learning+10.8%Energy SurgeEnergy Surge+10.7%MetamorphosisMetamorphosis+10.6%NullNull+10.6%
Worst
Spoils MapSpoils Map-29.0%GuiltyGuilty-17.9%InjuryInjury-10.9%AlchemizeAlchemize-6.1%DismantleDismantle-6.0%StompStomp-6.0%
The NecrobinderThe Necrobinder
Best
UndeathUndeath+15.8%HangHang+14.9%Time's UpTime's Up+14.4%Call of the VoidCall of the Void+14.2%Reaper FormReaper Form+13.4%TransfigureTransfigure+13.2%
Worst
Spoils MapSpoils Map-20.4%GuiltyGuilty-19.5%Believe in YouBelieve in You-11.1%InjuryInjury-8.1%Dramatic EntranceDramatic Entrance-7.2%CatastropheCatastrophe-7.2%
The RegentThe Regent
Best
CometComet+19.9%Beat into ShapeBeat into Shape+18.2%Meteor ShowerMeteor Shower+18.1%Mad ScienceMad Science+18.1%Decisions, DecisionsDecisions, Decisions+17.1%MetamorphosisMetamorphosis+16.6%
Worst
GuiltyGuilty-25.3%Spoils MapSpoils Map-21.5%RestlessnessRestlessness-7.4%OmnisliceOmnislice-5.3%Neow's FuryNeow's Fury-5.3%

Top Relics for Beating Vantom

Very Hot CocoaVery Hot Cocoa+18.2%Archaic ToothArchaic Tooth+18.1%Yummy CookieYummy Cookie+18.1%Pael's FleshPael's Flesh+18.1%Touch of OrobasTouch of Orobas+18.0%Fragrant MushroomFragrant Mushroom+17.9%Nutritious SoupNutritious Soup+17.8%Pael's WingPael's Wing+17.5%Pael's BloodPael's Blood+17.3%Daughter of the WindDaughter of the Wind+17.2%
Ceremonial Beast

Ceremonial Beast

Act I
Win rate: 81.3%Times faced: 2624Avg turns: 9.1Avg damage taken: 31Avg HP left: 24Avg floor: 16.7

Best & Worst Cards Against Ceremonial Beast by Class

The IroncladThe Ironclad
Best
Demon FormDemon Form+13.7%ConflagrationConflagration+13.2%Mad ScienceMad Science+12.9%BreakBreak+12.5%Ultimate DefendUltimate Defend+12.1%Primal ForcePrimal Force+12.0%
Worst
Spoils MapSpoils Map-28.5%GuiltyGuilty-24.2%Poor SleepPoor Sleep-19.5%InjuryInjury-12.0%BlurBlur-5.7%
The SilentThe Silent
Best
Blade of InkBlade of Ink+18.9%Mad ScienceMad Science+18.8%BurstBurst+18.2%Bubble BubbleBubble Bubble+17.9%SuppressSuppress+17.4%Knife TrapKnife Trap+17.1%
Worst
Spoils MapSpoils Map-29.9%InjuryInjury-19.7%GuiltyGuilty-18.9%Byrdonis EggByrdonis Egg-14.8%Poor SleepPoor Sleep-12.3%GreedGreed-10.8%
The DefectThe Defect
Best
DefragmentDefragment+13.9%QuadcastQuadcast+13.6%Mad ScienceMad Science+13.4%MetamorphosisMetamorphosis+13.1%ShatterShatter+12.8%SupercriticalSupercritical+12.7%
Worst
GuiltyGuilty-39.2%Spoils MapSpoils Map-32.1%Poor SleepPoor Sleep-12.3%GreedGreed-8.7%ShockwaveShockwave-6.0%
The NecrobinderThe Necrobinder
Best
Sentry ModeSentry Mode+18.0%ReanimateReanimate+17.8%UndeathUndeath+16.7%Call of the VoidCall of the Void+16.5%Reaper FormReaper Form+15.9%HangHang+15.8%
Worst
Spoils MapSpoils Map-32.4%GuiltyGuilty-29.4%InjuryInjury-24.0%LiftLift-10.5%NormalityNormality-4.8%StrikeStrike-4.4%
The RegentThe Regent
Best
Meteor ShowerMeteor Shower+12.7%Decisions, DecisionsDecisions, Decisions+12.1%Big BangBig Bang+12.0%GenesisGenesis+11.9%Bundle of JoyBundle of Joy+11.6%BombardmentBombardment+11.4%
Worst
Spoils MapSpoils Map-18.2%InjuryInjury-14.0%Thrumming HatchetThrumming Hatchet-9.7%PanachePanache-9.6%GuiltyGuilty-9.6%

Top Relics for Beating Ceremonial Beast

Archaic ToothArchaic Tooth+17.6%Yummy CookieYummy Cookie+17.6%Very Hot CocoaVery Hot Cocoa+17.6%Touch of OrobasTouch of Orobas+17.5%Pael's FleshPael's Flesh+17.3%Fragrant MushroomFragrant Mushroom+17.2%Pael's WingPael's Wing+17.1%Nutritious SoupNutritious Soup+17.0%Daughter of the WindDaughter of the Wind+16.8%Pael's TearsPael's Tears+16.7%
Waterfall Giant

Waterfall Giant

Act I
Win rate: 80.3%Times faced: 2622Avg turns: 10.3Avg damage taken: 33Avg HP left: 23Avg floor: 16.7

Best & Worst Cards Against Waterfall Giant by Class

The IroncladThe Ironclad
Best
PyrePyre+20.9%Crimson MantleCrimson Mantle+19.5%Mad ScienceMad Science+19.3%Tear AsunderTear Asunder+19.3%BreakBreak+18.4%BrandBrand+17.7%
Worst
Spoils MapSpoils Map-37.9%WritheWrithe-12.5%StackStack-12.5%Dual WieldDual Wield-9.4%InjuryInjury-7.9%
The SilentThe Silent
Best
Knife TrapKnife Trap+17.4%Serpent FormSerpent Form+16.6%SquashSquash+16.3%SuppressSuppress+16.2%AccuracyAccuracy+16.1%AdrenalineAdrenaline+15.8%
Worst
Spoils MapSpoils Map-48.7%InjuryInjury-16.9%Gold AxeGold Axe-6.4%MimicMimic-4.9%NostalgiaNostalgia-4.9%Crush UnderCrush Under-4.9%
The DefectThe Defect
Best
Echo FormEcho Form+19.3%HailstormHailstorm+18.1%ShatterShatter+16.0%ModdedModded+15.6%DefragmentDefragment+15.6%BufferBuffer+15.5%
Worst
Spoils MapSpoils Map-28.8%InjuryInjury-20.9%Thinking AheadThinking Ahead-13.1%Spoils of BattleSpoils of Battle-13.1%DistractionDistraction-8.1%Rip and TearRip and Tear-8.1%
The NecrobinderThe Necrobinder
Best
NeurosurgeNeurosurge+8.3%Danse MacabreDanse Macabre+8.0%UndeathUndeath+7.8%Sentry ModeSentry Mode+7.8%Soul StormSoul Storm+7.5%Spirit of AshSpirit of Ash+7.4%
Worst
Spoils MapSpoils Map-17.9%ReboundRebound-13.2%DiscoveryDiscovery-8.9%ClashClash-6.8%PurityPurity-6.8%Secret WeaponSecret Weapon-5.5%
The RegentThe Regent
Best
Pale Blue DotPale Blue Dot+17.5%The SmithThe Smith+16.8%GUARDS!!!GUARDS!!!+16.4%Meteor ShowerMeteor Shower+16.2%Mad ScienceMad Science+15.9%Heirloom HammerHeirloom Hammer+15.8%
Worst
Spoils MapSpoils Map-19.0%InjuryInjury-13.3%FisticuffsFisticuffs-7.1%Thrumming HatchetThrumming Hatchet-6.2%Jack of All TradesJack of All Trades-6.2%Dramatic EntranceDramatic Entrance-5.6%

Top Relics for Beating Waterfall Giant

Yummy CookieYummy Cookie+18.6%Touch of OrobasTouch of Orobas+18.4%Archaic ToothArchaic Tooth+18.4%Fragrant MushroomFragrant Mushroom+18.3%Very Hot CocoaVery Hot Cocoa+18.2%Nutritious SoupNutritious Soup+18.1%Pael's WingPael's Wing+18.1%Pael's FleshPael's Flesh+17.9%Pael's TearsPael's Tears+17.8%Mr. StrugglesMr. Struggles+17.5%
The Kin

The Kin

Act I
Win rate: 78.7%Times faced: 2652Avg turns: 9.2Avg damage taken: 33Avg HP left: 23Avg floor: 16.7

Best & Worst Cards Against The Kin by Class

The IroncladThe Ironclad
Best
BreakBreak+17.5%Mad ScienceMad Science+17.5%OfferingOffering+17.0%Tear AsunderTear Asunder+16.8%Demon FormDemon Form+16.8%Ultimate StrikeUltimate Strike+16.6%
Worst
Spoils MapSpoils Map-35.0%GuiltyGuilty-18.1%InjuryInjury-11.1%EntropyEntropy-4.7%Beam CellBeam Cell-4.7%AutomationAutomation-4.7%
The SilentThe Silent
Best
AbrasiveAbrasive+16.0%Noxious FumesNoxious Fumes+15.8%AfterimageAfterimage+15.4%Mad ScienceMad Science+15.3%SuppressSuppress+15.1%Fan of KnivesFan of Knives+14.9%
Worst
Spoils MapSpoils Map-34.4%GuiltyGuilty-30.1%StratagemStratagem-13.4%ShameShame-13.4%Poor SleepPoor Sleep-11.7%Byrdonis EggByrdonis Egg-10.8%
The DefectThe Defect
Best
Echo FormEcho Form+18.8%Mad ScienceMad Science+17.6%DefragmentDefragment+17.5%GlacierGlacier+16.8%Helix DrillHelix Drill+16.7%SpinnerSpinner+16.7%
Worst
GuiltyGuilty-34.2%Spoils MapSpoils Map-33.3%GreedGreed-15.8%InjuryInjury-8.1%Seeker StrikeSeeker Strike-7.7%Ascender's BaneAscender's Bane-6.0%
The NecrobinderThe Necrobinder
Best
DemesneDemesne+15.2%HangHang+15.1%Sentry ModeSentry Mode+13.3%Mad ScienceMad Science+13.1%MiseryMisery+12.9%ProtectorProtector+12.8%
Worst
Spoils MapSpoils Map-25.1%InjuryInjury-21.7%GuiltyGuilty-18.8%SalvoSalvo-13.6%PeckPeck-5.8%Secret TechniqueSecret Technique-5.2%
The RegentThe Regent
Best
BombardmentBombardment+18.2%Void FormVoid Form+17.6%Foregone ConclusionForegone Conclusion+17.4%SquashSquash+17.2%CometComet+17.0%Mad ScienceMad Science+16.8%
Worst
Spoils MapSpoils Map-45.6%GuiltyGuilty-25.6%InjuryInjury-16.8%Spore MindSpore Mind-16.1%Poor SleepPoor Sleep-9.8%Toric ToughnessToric Toughness-5.0%

Top Relics for Beating The Kin

Yummy CookieYummy Cookie+20.1%Touch of OrobasTouch of Orobas+20.1%Very Hot CocoaVery Hot Cocoa+19.9%Archaic ToothArchaic Tooth+19.8%Daughter of the WindDaughter of the Wind+19.2%Pael's WingPael's Wing+19.2%Pael's FleshPael's Flesh+19.2%Nutritious SoupNutritious Soup+19.2%Fragrant MushroomFragrant Mushroom+19.1%Forgotten SoulForgotten Soul+18.9%
Lagavulin Matriarch

Lagavulin Matriarch

Act I
Win rate: 76.9%Times faced: 2501Avg turns: 9.2Avg damage taken: 30Avg HP left: 25Avg floor: 16.7

Best & Worst Cards Against Lagavulin Matriarch by Class

The IroncladThe Ironclad
Best
BreakBreak+16.0%PyrePyre+15.6%Demon FormDemon Form+15.4%CrueltyCruelty+15.4%JuggernautJuggernaut+15.3%HellraiserHellraiser+15.1%
Worst
Spoils MapSpoils Map-36.4%Neow's FuryNeow's Fury-20.4%InjuryInjury-11.9%Hello WorldHello World-8.8%ShameShame-6.9%FisticuffsFisticuffs-6.5%
The SilentThe Silent
Best
Mad ScienceMad Science+27.9%Serpent FormSerpent Form+27.6%TrackingTracking+27.2%EnvenomEnvenom+25.2%Blade of InkBlade of Ink+23.9%AbrasiveAbrasive+23.8%
Worst
Spoils MapSpoils Map-30.1%InjuryInjury-11.9%CoordinateCoordinate-11.7%FisticuffsFisticuffs-7.9%ThunderclapThunderclap-7.5%
The DefectThe Defect
Best
SupercriticalSupercritical+21.4%Energy SurgeEnergy Surge+20.9%Machine LearningMachine Learning+20.8%Mad ScienceMad Science+20.2%DefragmentDefragment+19.5%ShatterShatter+19.5%
Worst
Spoils MapSpoils Map-36.8%InjuryInjury-32.0%ReboundRebound-12.0%Feeding FrenzyFeeding Frenzy-11.0%GreedGreed-10.4%ClashClash-8.9%
The NecrobinderThe Necrobinder
Best
NeurosurgeNeurosurge+13.5%HangHang+12.8%Sentry ModeSentry Mode+12.7%SeanceSeance+12.3%FriendshipFriendship+12.2%Shared FateShared Fate+12.1%
Worst
Spoils MapSpoils Map-21.3%InjuryInjury-14.6%EntrenchEntrench-11.8%ClashClash-8.1%DistractionDistraction-5.7%CoolheadedCoolheaded-5.7%
The RegentThe Regent
Best
The SmithThe Smith+13.4%Sword SageSword Sage+12.8%Mad ScienceMad Science+12.8%I Am InvincibleI Am Invincible+12.5%Beat into ShapeBeat into Shape+12.5%Meteor ShowerMeteor Shower+12.3%
Worst
Spoils MapSpoils Map-33.1%InjuryInjury-8.7%DismantleDismantle-5.7%RestlessnessRestlessness-5.7%ScourgeScourge-5.7%HeadbuttHeadbutt-5.7%

Top Relics for Beating Lagavulin Matriarch

Very Hot CocoaVery Hot Cocoa+21.5%Touch of OrobasTouch of Orobas+21.5%Archaic ToothArchaic Tooth+21.5%Yummy CookieYummy Cookie+21.2%Nutritious SoupNutritious Soup+21.1%Pael's FleshPael's Flesh+20.9%Pael's WingPael's Wing+20.9%Fragrant MushroomFragrant Mushroom+20.9%Daughter of the WindDaughter of the Wind+20.6%Pael's TearsPael's Tears+20.5%

Act II

Knowledge Demon

Knowledge Demon

Act II
Win rate: 70.3%Times faced: 2873Avg turns: 8.3Avg damage taken: 38Avg HP left: 25Avg floor: 32.4

Best & Worst Cards Against Knowledge Demon by Class

The IroncladThe Ironclad
Best
Mad ScienceMad Science+24.4%ApotheosisApotheosis+17.0%RegretRegret+16.6%MaulMaul+16.1%CrueltyCruelty+15.6%Bad LuckBad Luck+15.1%
Worst
Lantern KeyLantern Key-27.1%NormalityNormality-20.9%MiseryMisery-17.4%AssassinateAssassinate-13.5%Monarch's GazeMonarch's Gaze-12.1%TransfigureTransfigure-12.1%
The SilentThe Silent
Best
Mad ScienceMad Science+26.3%FollyFolly+21.0%ApotheosisApotheosis+18.3%EnthralledEnthralled+17.3%Bad LuckBad Luck+16.2%EnvenomEnvenom+16.0%
Worst
Lantern KeyLantern Key-23.4%ProlongProlong-20.2%Second WindSecond Wind-16.2%Precise CutPrecise Cut-15.4%Memento MoriMemento Mori-13.7%OutmaneuverOutmaneuver-12.9%
The DefectThe Defect
Best
Mad ScienceMad Science+27.6%FollyFolly+21.3%ApotheosisApotheosis+19.5%Bulk UpBulk Up+18.5%EnthralledEnthralled+17.7%DefragmentDefragment+17.5%
Worst
Lantern KeyLantern Key-30.0%AdrenalineAdrenaline-19.3%NormalityNormality-19.1%InjuryInjury-14.1%PreparedPrepared-12.2%Poor SleepPoor Sleep-11.3%
The NecrobinderThe Necrobinder
Best
Mad ScienceMad Science+25.4%EnthralledEnthralled+18.1%Legion of BoneLegion of Bone+17.0%Call of the VoidCall of the Void+16.6%Shared FateShared Fate+14.9%RelaxRelax+14.7%
Worst
Believe in YouBelieve in You-17.3%Lantern KeyLantern Key-16.9%Feeding FrenzyFeeding Frenzy-11.8%Well-Laid PlansWell-Laid Plans-11.8%ExterminateExterminate-11.6%PurityPurity-10.2%
The RegentThe Regent
Best
Mad ScienceMad Science+25.9%FinesseFinesse+19.2%Pale Blue DotPale Blue Dot+17.6%DoubtDoubt+17.3%Bundle of JoyBundle of Joy+17.0%ApotheosisApotheosis+16.7%
Worst
Lantern KeyLantern Key-26.0%RebootReboot-16.0%EnlightenmentEnlightenment-14.7%NormalityNormality-14.2%Kingly PunchKingly Punch-12.2%SubroutineSubroutine-11.6%

Top Relics for Beating Knowledge Demon

Fragrant MushroomFragrant Mushroom+28.6%Forgotten SoulForgotten Soul+27.7%Jeweled MaskJeweled Mask+27.4%SaiSai+27.1%Tri-BoomerangTri-Boomerang+26.9%Throwing AxeThrowing Axe+26.6%Signet RingSignet Ring+26.6%Whispering EarringWhispering Earring+26.4%Choices ParadoxChoices Paradox+26.4%Big MushroomBig Mushroom+26.4%
The Insatiable

The Insatiable

Act II
Win rate: 77.9%Times faced: 2824Avg turns: 7.7Avg damage taken: 31Avg HP left: 29Avg floor: 32.4

Best & Worst Cards Against The Insatiable by Class

The IroncladThe Ironclad
Best
Mad ScienceMad Science+20.8%DoubtDoubt+15.9%FollyFolly+15.2%RegretRegret+15.2%MaulMaul+14.3%ApparitionApparition+14.3%
Worst
Lantern KeyLantern Key-28.8%Mind BlastMind Blast-15.3%NormalityNormality-14.0%ImpatienceImpatience-12.3%SalvoSalvo-8.4%
The SilentThe Silent
Best
Mad ScienceMad Science+15.3%ApotheosisApotheosis+12.5%FollyFolly+11.8%Tools of the TradeTools of the Trade+11.3%Blade of InkBlade of Ink+11.2%FastenFasten+11.2%
Worst
FearFear-19.0%Lantern KeyLantern Key-19.0%MetamorphosisMetamorphosis-15.9%BludgeonBludgeon-13.7%Enfeebling TouchEnfeebling Touch-13.7%Curse of the BellCurse of the Bell-11.7%
The DefectThe Defect
Best
Mad ScienceMad Science+22.5%FollyFolly+16.4%ApotheosisApotheosis+15.7%Machine LearningMachine Learning+15.7%EnthralledEnthralled+13.3%Multi-CastMulti-Cast+13.2%
Worst
EnlightenmentEnlightenment-15.2%InjuryInjury-14.3%HellraiserHellraiser-12.4%Rip and TearRip and Tear-12.4%Meteor StrikeMeteor Strike-11.4%Dramatic EntranceDramatic Entrance-7.4%
The NecrobinderThe Necrobinder
Best
Mad ScienceMad Science+17.9%DemesneDemesne+14.2%EnthralledEnthralled+13.8%Banshee's CryBanshee's Cry+13.0%FollyFolly+12.9%Time's UpTime's Up+11.9%
Worst
NormalityNormality-22.4%Lantern KeyLantern Key-15.3%RageRage-13.1%ThrashThrash-13.1%RestlessnessRestlessness-12.8%Neow's FuryNeow's Fury-10.7%
The RegentThe Regent
Best
Mad ScienceMad Science+20.5%Decisions, DecisionsDecisions, Decisions+17.3%ArsenalArsenal+16.9%Sword SageSword Sage+14.7%FollyFolly+13.9%BombardmentBombardment+13.6%
Worst
InjuryInjury-17.2%NormalityNormality-12.7%Calculated GambleCalculated Gamble-9.9%Thinking AheadThinking Ahead-9.8%GlitterstreamGlitterstream-9.6%Dramatic EntranceDramatic Entrance-7.8%

Top Relics for Beating The Insatiable

Fragrant MushroomFragrant Mushroom+21.2%Forgotten SoulForgotten Soul+20.9%Jeweled MaskJeweled Mask+20.4%GlitterGlitter+20.3%Tri-BoomerangTri-Boomerang+20.2%Signet RingSignet Ring+20.1%Big MushroomBig Mushroom+19.9%Looming FruitLooming Fruit+19.8%Throwing AxeThrowing Axe+19.8%Preserved FogPreserved Fog+19.8%
Kaiser Crab

Kaiser Crab

Act II
Win rate: 71.0%Times faced: 2790Avg turns: 8.1Avg damage taken: 40Avg HP left: 24Avg floor: 32.4

Best & Worst Cards Against Kaiser Crab by Class

The IroncladThe Ironclad
Best
Mad ScienceMad Science+30.5%RegretRegret+23.1%DebtDebt+22.7%Hidden GemHidden Gem+22.7%DoubtDoubt+21.7%ApotheosisApotheosis+21.2%
Worst
Lantern KeyLantern Key-29.1%MetamorphosisMetamorphosis-21.3%Gold AxeGold Axe-14.8%SquashSquash-12.6%Toric ToughnessToric Toughness-12.6%Dodge and RollDodge and Roll-11.8%
The SilentThe Silent
Best
Mad ScienceMad Science+22.5%DoubtDoubt+18.3%Bad LuckBad Luck+16.6%SneakySneaky+16.0%ApotheosisApotheosis+15.2%ProwessProwess+15.2%
Worst
Lantern KeyLantern Key-27.6%PeckPeck-27.1%MetamorphosisMetamorphosis-17.5%BarricadeBarricade-12.4%InjuryInjury-12.4%HeadbuttHeadbutt-9.6%
The DefectThe Defect
Best
Mad ScienceMad Science+29.3%DiscoveryDiscovery+19.3%JackpotJackpot+19.3%ApotheosisApotheosis+19.3%Bulk UpBulk Up+19.1%FollyFolly+18.5%
Worst
EnlightenmentEnlightenment-24.3%Lantern KeyLantern Key-24.2%InjuryInjury-12.3%ProwessProwess-11.7%Feeding FrenzyFeeding Frenzy-11.7%EquilibriumEquilibrium-10.8%
The NecrobinderThe Necrobinder
Best
Mad ScienceMad Science+18.0%EnthralledEnthralled+14.2%RegretRegret+13.9%Glimpse BeyondGlimpse Beyond+12.9%Hidden GemHidden Gem+12.5%OblivionOblivion+12.4%
Worst
Seeker StrikeSeeker Strike-16.7%ExterminateExterminate-13.6%FinesseFinesse-12.1%GreedGreed-10.5%TrembleTremble-10.3%VeilpiercerVeilpiercer-9.1%
The RegentThe Regent
Best
Mad ScienceMad Science+21.3%ApotheosisApotheosis+14.9%ProductionProduction+14.5%TyrannyTyranny+14.1%Crash LandingCrash Landing+13.4%Monarch's GazeMonarch's Gaze+13.3%
Worst
Lantern KeyLantern Key-28.2%Poor SleepPoor Sleep-12.5%One-Two PunchOne-Two Punch-12.5%Mind BlastMind Blast-11.7%RelaxRelax-9.6%FearFear-9.6%

Top Relics for Beating Kaiser Crab

Fragrant MushroomFragrant Mushroom+27.8%Forgotten SoulForgotten Soul+27.3%Jeweled MaskJeweled Mask+26.8%Signet RingSignet Ring+26.5%Throwing AxeThrowing Axe+26.1%Meat CleaverMeat Cleaver+25.9%Big MushroomBig Mushroom+25.8%SaiSai+25.8%Lord's ParasolLord's Parasol+25.7%Looming FruitLooming Fruit+25.6%

Act III

Kakarotmod-frieza Boss Encounter

Kakarotmod-frieza Boss Encounter

Act III
Win rate: 0.0%Times faced: 1Avg turns: 17.0Avg damage taken: 170Avg HP left: 0Avg floor: 45.0

Best & Worst Cards Against Kakarotmod-frieza Boss Encounter by Class

Not enough class-level data for Kakarotmod-frieza Boss Encounter yet — check back as more runs are recorded.

Pika Mod Encounter Rayquaza Encounter

Pika Mod Encounter Rayquaza Encounter

Act III
Win rate: 100.0%Times faced: 2Avg turns: 8.0Avg damage taken: 9Avg HP left: 46Avg floor: 46.5

Best & Worst Cards Against Pika Mod Encounter Rayquaza Encounter by Class

Not enough class-level data for Pika Mod Encounter Rayquaza Encounter yet — check back as more runs are recorded.

Aeonglass

Aeonglass

Act III
Win rate: 67.9%Times faced: 1779Avg turns: 7.0Avg damage taken: 43Avg HP left: 34Avg floor: 46.9

Best & Worst Cards Against Aeonglass by Class

The IroncladThe Ironclad
Best
Ultimate DefendUltimate Defend+15.3%Demonic ShieldDemonic Shield+14.5%Dark EmbraceDark Embrace+14.1%Eternal ArmorEternal Armor+11.9%Master of StrategyMaster of Strategy+11.2%Ultimate StrikeUltimate Strike+11.0%
Worst
EnthralledEnthralled-20.5%PeckPeck-20.5%EnlightenmentEnlightenment-18.2%StompStomp-16.4%PredatorPredator-11.9%Poisoned StabPoisoned Stab-11.9%
The SilentThe Silent
Best
Bad LuckBad Luck+16.1%FisticuffsFisticuffs+15.7%ApotheosisApotheosis+13.1%MayhemMayhem+13.0%JackpotJackpot+11.7%ExterminateExterminate+11.7%
Worst
Toric ToughnessToric Toughness-16.7%MetamorphosisMetamorphosis-13.1%PurityPurity-12.4%UproarUproar-12.4%CHARGE!!CHARGE!!-11.4%
The DefectThe Defect
Best
HyperbeamHyperbeam+20.7%ProlongProlong+14.9%GreedGreed+14.5%FisticuffsFisticuffs+14.2%ApotheosisApotheosis+12.3%ProductionProduction+12.3%
Worst
Flash of SteelFlash of Steel-15.8%Biased CognitionBiased Cognition-15.3%ChaosChaos-14.5%DoubtDoubt-14.4%PeckPeck-14.4%QuadcastQuadcast-13.9%
The NecrobinderThe Necrobinder
Best
FastenFasten+12.8%Ultimate DefendUltimate Defend+12.1%The ScytheThe Scythe+11.6%
Worst
ApparitionApparition-15.5%WishWish-15.5%StratagemStratagem-15.3%FisticuffsFisticuffs-15.3%InterceptIntercept-15.3%Sentry ModeSentry Mode-15.1%
The RegentThe Regent
Best
Dramatic EntranceDramatic Entrance+13.3%FollyFolly+13.3%Bundle of JoyBundle of Joy+11.8%AlchemizeAlchemize+11.8%Neutron AegisNeutron Aegis+11.2%Summon ForthSummon Forth+11.0%
Worst
Byrd SwoopByrd Swoop-13.8%RegretRegret-11.2%Kingly KickKingly Kick-10.7%Ultimate DefendUltimate Defend-9.5%Huddle UpHuddle Up-9.3%

Top Relics for Beating Aeonglass

History CourseHistory Course+19.6%Sword of JadeSword of Jade+17.1%
Queen

Queen

Act III
Win rate: 71.2%Times faced: 1941Avg turns: 8.3Avg damage taken: 39Avg HP left: 37Avg floor: 47.0

Best & Worst Cards Against Queen by Class

The IroncladThe Ironclad
Best
Seeker StrikeSeeker Strike+19.1%CascadeCascade+13.5%StokeStoke+13.2%WhistleWhistle+12.9%The GambitThe Gambit+12.7%Demonic ShieldDemonic Shield+12.3%
Worst
Byrd SwoopByrd Swoop-25.2%Prep TimePrep Time-15.6%OmnisliceOmnislice-15.5%RegretRegret-13.8%RampageRampage-13.6%DismantleDismantle-13.0%
The SilentThe Silent
Best
AlchemizeAlchemize+13.1%Well-Laid PlansWell-Laid Plans+12.7%Grand FinaleGrand Finale+12.5%FlankingFlanking+9.8%Mind BlastMind Blast+9.4%
Worst
The HuntThe Hunt-17.4%Ultimate StrikeUltimate Strike-16.1%AnticipateAnticipate-13.2%DoubtDoubt-13.2%ExpertiseExpertise-13.0%EquilibriumEquilibrium-12.5%
The DefectThe Defect
Best
SubroutineSubroutine+14.8%Creative AICreative AI+13.8%ScavengeScavenge+12.6%Echo FormEcho Form+12.6%Curse of the BellCurse of the Bell+12.0%
Worst
Mind BlastMind Blast-20.2%PeckPeck-17.4%RainbowRainbow-16.5%OmnisliceOmnislice-15.8%Ball LightningBall Lightning-14.0%BolasBolas-14.0%
The NecrobinderThe Necrobinder
Best
FastenFasten+10.8%PagestormPagestorm+9.7%ShockwaveShockwave+9.6%Curse of the BellCurse of the Bell+9.6%DiscoveryDiscovery+9.6%MayhemMayhem+8.1%
Worst
Byrd SwoopByrd Swoop-20.5%EnlightenmentEnlightenment-19.4%Prep TimePrep Time-15.2%MaulMaul-14.6%The ScytheThe Scythe-11.2%Piercing WailPiercing Wail-10.6%
The RegentThe Regent
Best
AutomationAutomation+13.2%TyrannyTyranny+12.7%ArsenalArsenal+11.4%CatastropheCatastrophe+11.2%The Sealed ThroneThe Sealed Throne+10.1%Decisions, DecisionsDecisions, Decisions+9.4%
Worst
WhistleWhistle-14.4%EnthralledEnthralled-14.4%Ultimate StrikeUltimate Strike-13.4%Toric ToughnessToric Toughness-13.2%CometComet-12.3%Crash LandingCrash Landing-12.3%

Top Relics for Beating Queen

History CourseHistory Course+21.1%Mummified HandMummified Hand+16.2%
Test Subject

Test Subject

Act III
Win rate: 66.2%Times faced: 1942Avg turns: 9.3Avg damage taken: 44Avg HP left: 32Avg floor: 47.0

Best & Worst Cards Against Test Subject by Class

The IroncladThe Ironclad
Best
ProlongProlong+25.0%FisticuffsFisticuffs+15.2%StokeStoke+15.1%Huddle UpHuddle Up+12.8%ApotheosisApotheosis+11.9%
Worst
Curse of the BellCurse of the Bell-22.9%EnlightenmentEnlightenment-20.9%ExterminateExterminate-16.4%BludgeonBludgeon-15.1%ProductionProduction-15.0%Twin StrikeTwin Strike-13.8%
The SilentThe Silent
Best
OmnisliceOmnislice+15.6%SplashSplash+15.0%Jack of All TradesJack of All Trades+14.1%BolasBolas+12.7%FlankingFlanking+12.6%PanachePanache+12.4%
Worst
Neow's FuryNeow's Fury-24.2%Dramatic EntranceDramatic Entrance-16.8%Bouncing FlaskBouncing Flask-16.3%Gang UpGang Up-15.8%
The DefectThe Defect
Best
ApparitionApparition+20.3%Flash of SteelFlash of Steel+18.5%Master of StrategyMaster of Strategy+17.2%Bulk UpBulk Up+15.3%Creative AICreative AI+13.6%
Worst
ChaosChaos-24.3%RelaxRelax-22.9%HyperbeamHyperbeam-19.8%PanachePanache-16.7%DarknessDarkness-14.3%ExposeExpose-14.1%
The NecrobinderThe Necrobinder
Best
EidolonEidolon+13.5%DemesneDemesne+12.8%Capture SpiritCapture Spirit+11.6%Dark ShacklesDark Shackles+11.4%
Worst
DoubtDoubt-14.4%Necro MasteryNecro Mastery-13.3%ShockwaveShockwave-12.0%RelaxRelax-11.9%Sic 'EmSic 'Em-11.8%SqueezeSqueeze-11.7%
The RegentThe Regent
Best
Pale Blue DotPale Blue Dot+14.7%MayhemMayhem+13.0%Heirloom HammerHeirloom Hammer+12.3%Pillar of CreationPillar of Creation+11.5%SplashSplash+11.1%
Worst
Heavenly DrillHeavenly Drill-17.8%FisticuffsFisticuffs-17.5%Crescent SpearCrescent Spear-15.5%Knockout BlowKnockout Blow-14.8%ResonanceResonance-14.8%MetamorphosisMetamorphosis-12.4%

Top Relics for Beating Test Subject

History CourseHistory Course+20.5%Iron ClubIron Club+19.2%Runic PyramidRunic Pyramid+19.1%Snecko EyeSnecko Eye+17.7%
Doormaker

Doormaker

Act III
Win rate: 78.2%Times faced: 330Avg turns: 8.4Avg damage taken: 40Avg HP left: 32Avg floor: 47.1

Best & Worst Cards Against Doormaker by Class

The IroncladThe Ironclad
Best
Fight Me!Fight Me!+13.0%CrueltyCruelty+12.7%AggressionAggression+12.3%UnrelentingUnrelenting+12.2%UnmovableUnmovable+11.6%Ultimate StrikeUltimate Strike+11.6%
Worst
Bad LuckBad Luck-17.1%WishWish-17.1%Dramatic EntranceDramatic Entrance-15.3%Infernal BladeInfernal Blade-14.7%DebtDebt-14.0%RampageRampage-13.1%
The SilentThe Silent
Best
Fan of KnivesFan of Knives+9.7%Hand TrickHand Trick+9.2%Dagger SprayDagger Spray+9.2%SkewerSkewer+8.6%FinisherFinisher+8.1%Dark ShacklesDark Shackles+8.0%
Worst
PinpointPinpoint-13.6%MetamorphosisMetamorphosis-13.4%UntouchableUntouchable-12.8%Follow ThroughFollow Through-9.6%ClumsyClumsy-9.6%Up My SleeveUp My Sleeve-9.5%
The DefectThe Defect
Best
DarknessDarkness+14.4%SubroutineSubroutine+14.4%HailstormHailstorm+10.8%White NoiseWhite Noise+10.8%SynchronizeSynchronize+10.8%VoltaicVoltaic+10.1%
Worst
Ascender's BaneAscender's Bane-23.2%GreedGreed-16.1%Momentum StrikeMomentum Strike-14.1%Boot SequenceBoot Sequence-13.8%All for OneAll for One-12.8%HologramHologram-11.3%
The NecrobinderThe Necrobinder
Best
Drain PowerDrain Power+9.2%HangHang+8.8%DredgeDredge+8.3%PagestormPagestorm+8.3%RattleRattle+7.8%Capture SpiritCapture Spirit+7.2%
Worst
Bone ShardsBone Shards-20.0%EradicateEradicate-13.7%DecayDecay-11.3%MelancholyMelancholy-11.3%EnthralledEnthralled-9.3%Blight StrikeBlight Strike-8.6%
The RegentThe Regent
Best
QuasarQuasar+9.6%ParryParry+8.2%The SmithThe Smith+8.2%ArsenalArsenal+8.2%GlitterstreamGlitterstream+7.4%Child of the StarsChild of the Stars+7.4%
Worst
Pale Blue DotPale Blue Dot-15.3%DebtDebt-14.1%TyrannyTyranny-12.9%Photon CutPhoton Cut-12.9%Collision CourseCollision Course-12.2%RegretRegret-11.8%

Top Relics for Beating Doormaker

PantographPantograph+15.5%KunaiKunai+14.0%Fur CoatFur Coat+11.9%Bone FluteBone Flute+11.4%OrichalcumOrichalcum+11.2%Ice CreamIce Cream+10.8%History CourseHistory Course+10.3%Mystic LighterMystic Lighter+9.7%Divine DestinyDivine Destiny+9.0%Pael's TearsPael's Tears+9.0%
Pikamod-giratina Encounter

Pikamod-giratina Encounter

Act III
Win rate: 100.0%Times faced: 1Avg turns: 1.0Avg damage taken: 1Avg HP left: 80Avg floor: 48.0

Best & Worst Cards Against Pikamod-giratina Encounter by Class

Not enough class-level data for Pikamod-giratina Encounter yet — check back as more runs are recorded.

Slugcat The Spire Ii Encounter Mushroom

Slugcat The Spire Ii Encounter Mushroom

Act III
Win rate: 100.0%Times faced: 1Avg turns: 7.0Avg damage taken: 10Avg HP left: 70Avg floor: 48.0

Best & Worst Cards Against Slugcat The Spire Ii Encounter Mushroom by Class

Not enough class-level data for Slugcat The Spire Ii Encounter Mushroom yet — check back as more runs are recorded.

Corrupt Heart

Corrupt Heart

Act III
Win rate: 50.0%Times faced: 6Avg turns: 6.7Avg damage taken: 48Avg HP left: 19Avg floor: 50.5

Best & Worst Cards Against Corrupt Heart by Class

Not enough class-level data for Corrupt Heart yet — check back as more runs are recorded.

Top Relics for Beating Corrupt Heart

WhetstoneWhetstone+8.3%Touch of OrobasTouch of Orobas+8.3%Festive PopperFestive Popper+8.3%BreadBread+8.3%Big MushroomBig Mushroom+8.3%Blood VialBlood Vial+7.1%Red MaskRed Mask+3.9%AnchorAnchor+3.9%PearPear+3.9%Regal PillowRegal Pillow+3.9%
Act4placeholder-act4 Architect Boss Encounter

Act4placeholder-act4 Architect Boss Encounter

Act III
Win rate: 100.0%Times faced: 1Avg turns: 13.0Avg damage taken: 87Avg HP left: 112Avg floor: 58.0

Best & Worst Cards Against Act4placeholder-act4 Architect Boss Encounter by Class

Not enough class-level data for Act4placeholder-act4 Architect Boss Encounter yet — check back as more runs are recorded.

Heathcliffwildhunt Encounter.act4 Demon King Boss Encounter

Heathcliffwildhunt Encounter.act4 Demon King Boss Encounter

Act III
Win rate: 100.0%Times faced: 3Avg turns: 2.3Avg damage taken: 8Avg HP left: 772Avg floor: 59.0

Best & Worst Cards Against Heathcliffwildhunt Encounter.act4 Demon King Boss Encounter by Class

Not enough class-level data for Heathcliffwildhunt Encounter.act4 Demon King Boss Encounter yet — check back as more runs are recorded.

Heathcliffwildhunt Encounter.nelly Boss Encounter

Heathcliffwildhunt Encounter.nelly Boss Encounter

Act III
Win rate: 100.0%Times faced: 3Avg turns: 1.7Avg damage taken: 1Avg HP left: 896Avg floor: 60.0

Best & Worst Cards Against Heathcliffwildhunt Encounter.nelly Boss Encounter by Class

Not enough class-level data for Heathcliffwildhunt Encounter.nelly Boss Encounter yet — check back as more runs are recorded.

Rien Boss Encounter

Rien Boss Encounter

Act III
Win rate: 100.0%Times faced: 1Avg turns: 1.0Avg damage taken: 0Avg HP left: 94Avg floor: 62.0

Best & Worst Cards Against Rien Boss Encounter by Class

Not enough class-level data for Rien Boss Encounter yet — check back as more runs are recorded.

Heathcliffwildhunt Encounter.discordant Heart Boss Encounter

Heathcliffwildhunt Encounter.discordant Heart Boss Encounter

Act III
Win rate: 100.0%Times faced: 2Avg turns: 10.5Avg damage taken: 7Avg HP left: 366Avg floor: 68.0

Best & Worst Cards Against Heathcliffwildhunt Encounter.discordant Heart Boss Encounter by Class

Not enough class-level data for Heathcliffwildhunt Encounter.discordant Heart Boss Encounter yet — check back as more runs are recorded.

See Also

Slay the Spire 2 Event GuidePotion Tier ListCard Reward AdvisorCard Tier ListRelic Tier List