Slay the Spire 2 Card Tier List
This Slay the Spire 2 cards tier list places 547 cards for August 2026, from S-tier down to F-tier. Placement combines win rate, pick rate and how much match data sits behind each result, so it is not a straight win-rate sort — an entry with a high win rate over few games ranks below a steadier one. The S-tier — the 82 strongest cards right now — features Knockdown (81.8%), Anointed (73.3%), Apotheosis (67.6%), Salvo (64.7%), and Rend (64.3%). Knockdown posts the single highest win rate at 81.8%. For players hunting an edge, Knockdown is the most underrated pick this patch — S-tier results at only a 0.1% pick rate — while Ascender's Bane looks overrated, popular at 53.7% but landing in F-tier. Rankings update daily from real ranked matches, so every placement reflects current performance rather than a one-off result. Use the tiers below to pick the best cards for your games.
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S
S Tier - Meta Defining
(82)S-tier is led by Knockdown, which dominates the current data with a 81.8% win rate on a 0.1% pick rate. They are followed by Anointed (73.3%), Apotheosis (67.6%), Salvo (64.7%), Rend (64.3%), Tank (64.3%), Mimic (62.5%), and Beat Down (60.0%). The remaining 74 cards in this tier average a 41.4% win rate. These cards define the current meta and are the safest, highest-impact picks. Popularity within S-tier is uneven: Mad Science is picked in 3.9% of games against 0.1% for Knockdown, despite both landing in the same tier.
