Slay the Spire 2 Card Tier List

This Slay the Spire 2 card tier list ranks the 188 most-played cards by win rate, sorting them into S, B, C, D, and F tiers so you can see at a glance which cards are worth picking. Tiers use the same percentile method as our full card rankings: the top 15% of cards by win rate land in S, the next 15% in B, and so on down to F. Right now the S tier — the 28 meta-defining best cards in Slay the Spire 2 — is led by Mayhem, Mad Science, Big Bang, while Mayhem posts the single highest win rate at 70.0%. Only cards with enough recorded runs are included, so every placement reflects real performance rather than a one-off result. Use this tier list to prioritise your card rewards, build your deck around the strongest options for each class, and avoid the low-tier picks that drag a run down. Win rates update as more matches are tracked.