Slay the Spire 2 Card Tier List

S-tier is led by Anointed, which dominates the current data with a 74.2% win rate on a 0.2% pick rate. They are followed by Mimic (71.4%), Knockdown (66.7%), Rend (63.6%), Beat Down (60.4%), Apotheosis (58.1%), Beacon of Hope (54.9%), and Mad Science (54.7%). The remaining 74 cards in this tier average a 40.7% win rate. These cards define the current meta and are the safest, highest-impact picks. Popularity within S-tier is uneven: Mad Science is picked in 3.8% of games against 0.1% for Knockdown, despite both landing in the same tier.

B-tier is led by Jackpot, which posts competitive results with a 34.0% win rate on a 1.2% pick rate. They are followed by Assassinate (34.0%), Demesne (34.0%), GUARDS!!! (33.6%), The Smith (33.5%), Genesis (33.5%), Energy Surge (33.3%), and Largesse (33.3%). The remaining 75 cards in this tier average a 31.3% win rate. These cards are balanced and fully viable with solid execution. Popularity within B-tier is uneven: Accuracy is picked in 4.7% of games against 0.1% for Biased Cognition, despite both landing in the same tier.

C-tier is led by Bulwark, which shows mixed results with a 29.5% win rate on a 2.5% pick rate. They are followed by Dredge (29.4%), Bury (29.4%), Finisher (29.4%), Call of the Void (29.3%), Reanimate (29.3%), Up My Sleeve (29.2%), and Ice Lance (29.2%). The remaining 102 cards in this tier average a 27.3% win rate. These cards are situational and need favourable matchups or team comps to shine. Prepared stays widely picked at 8.8% despite its C-tier results, while Eidolon sees 0.3%.

D-tier is led by Rupture, which trails stronger options with a 25.4% win rate on a 3.0% pick rate. They are followed by Necro Mastery (25.3%), Protector (25.3%), Drum of Battle (25.3%), Snakebite (25.3%), Cloak of Stars (25.2%), Creative AI (25.1%), and Deathbringer (25.1%). The remaining 130 cards in this tier average a 22.5% win rate. These cards underperform against the current meta and take extra effort to win with. Shrug It Off stays widely picked at 8.1% despite its D-tier results, while Rebound sees 0.1%.

F-tier is led by Resonance, which currently underperforms with a 19.9% win rate on a 1.0% pick rate. They are followed by Wrought in War (19.8%), Pounce (19.8%), Anger (19.7%), Chill (19.7%), Genetic Algorithm (19.7%), Helix Drill (19.6%), and Refract (19.6%). The remaining 130 cards in this tier average a 15.0% win rate. These cards are the weakest options this patch and are best avoided in ranked. Ascender's Bane stays widely picked at 54.5% despite its F-tier results, while Hello World sees 0.1%.