Ambessa - League of Legends Champion
Win Rate
49.6%
Pick Rate
3.0%

Ambessavs Karthus

CFighterAssassin
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 21, 2026
MethodologyData Methodology

Ambessa vs Karthus is a decisive matchup in LoL patch 26.7. Ambessa wins with a 75.0% win rate (+50.0%) over Karthus based on 12 games. Ambessa wins the early laning phase while Karthus scales better into the late game. Below you'll find the best Ambessa build, runes, laning stats, and strategies for the Ambessa vs Karthus matchup.

Ambessa Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Ambessa performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Karthus - 75.0% win rateKarthus(75.0%)
Ambessa - 75.0% win rate in this matchup
Ambessa
75.0% WR
VS
Karthus vs Ambessa matchup - 25.0% win rate
Karthus
25.0% WR

Who Wins the Ambessa vs Karthus Matchup?

Ambessa wins the Ambessa vs Karthus matchup
Winner
Ambessa
Matches: 12
75.0%
Win Rate
25.0%
1.0
CS / min
1.2
966
DMG / min
1,076
15,176
Gold / game
13,887
500
Heal / min
287
1,265
DMG Mitigated / min
428
0.6
CC / min
0.6
100.0%
Early Game WR
0.0%
40.0%
Late Game WR
60.0%

Ambessa vs Karthus Matchup Summary

The Ambessa vs Karthus matchup is a decisive matchup in League of Legends ranked play. Based on 12 recent matches analyzed, Ambessa wins with a 75.0% win rate compared to Karthus's 25.0%, giving Ambessa a 50.0 percentage point advantage. Game phase dynamics play a critical role here: Ambessa controls the early laning stage, but Karthus outscales as the game goes longer. The matchup shifts dramatically depending on game length — Ambessa needs to press advantages before Karthus reaches their power spikes, while Karthus should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Ambessa leads by 1,050 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Ambessa players can confidently pick into Karthus and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Karthus away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Ambessa vs Karthus Laning Phase Breakdown

Karthus wins the laning phase against Ambessa in League of Legends

Karthus is favored during the laning phase against Ambessa, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and crowd control, making them the stronger laner in this matchup.

Farming
1.0Ambessa
1.2Karthus
Ambessa and Karthus farm at nearly identical rates in this matchup, with only a 0.2 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
966Ambessa
1,076Karthus
Karthus heavily out-damages Ambessa by 109 DMG/min, dominating both short trades and all-in fights. Ambessa should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
15,176Ambessa
13,887Karthus
Ambessa generates a commanding 1,289 more gold per game than Karthus. This substantial economic advantage means Ambessa consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Karthus should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.6Ambessa
0.6Karthus
Both Ambessa and Karthus provide similar amounts of crowd control (0.0s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
1,765Ambessa
715Karthus
Ambessa vastly out-sustains Karthus, healing and mitigating 1,050 more damage per minute. This massive durability gap means Ambessa can absorb significant punishment and remain in lane while Karthus is forced to recall. Building grievous wounds early is essential for Karthus, and focusing on burst trade patterns rather than sustained fights is critical.

Best Ambessa Build Against Karthus

Mercury's Treads is the optimal boots choice against Karthus, providing the mobility and stats Ambessa needs most in this matchup. The top-performing core items for Ambessa against Karthus are Profane Hydra, Axiom Arc and Death's Dance. This combination gives Ambessa an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 3 games — well above average and making it the top item path against Karthus. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Ambessa vs Karthus matchup.

Early Game vs Late Game

Early Game
Ambessa
100.0%
+100.0% advantage
Ambessa early game win rateAmbessa100.0%
Karthus early game win rateKarthus0.0%
Late Game
Karthus
60.0%
+20.0% advantage
Ambessa late game win rateAmbessa40.0%
Karthus late game win rateKarthus60.0%

Ambessa dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Karthus. This lopsided early game means Ambessa can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Karthus is far superior in the late game (25+ minutes), boasting a 60.0% win rate — 20.0 points above Ambessa. Extended games heavily favor Karthus, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Ambessa must aggressively press their early advantage and close out the game before Karthus reaches their scaling breakpoints. If Karthus survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Ambessa Runes Against Karthus

Precision rune tree - Ambessa primary runes vs KarthusPrecision
Conqueror - best Ambessa rune vs KarthusTriumph - best Ambessa rune vs KarthusLegend: Haste - best Ambessa rune vs KarthusLast Stand - best Ambessa rune vs Karthus
Domination rune tree - Ambessa secondary runes vs KarthusDomination
Sudden Impact - best Ambessa rune vs KarthusUltimate Hunter - best Ambessa rune vs Karthus
100.0% WR

Running Precision primary with Domination secondary allows Ambessa to press their advantage against Karthus, amplifying the strengths that make this a favorable matchup.


Ambessa matchup data for League of Legends patch 26.7. The table below shows Ambessa's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Ambessa build, runes, laning stats, and early vs late game analysis for that specific matchup.

Ambessa matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
46.08%1026.488511,62642.5%49.1%
52.22%902.276313,05356.8%47.8%
49.35%771.379613,67142.1%56.4%
53.42%735.885011,53244.4%62.2%
51.39%721.173613,22657.6%46.1%
43.06%721.383713,45048.6%37.1%
52.94%684.184912,64945.2%59.5%
43.86%571.778213,74437.5%48.5%
61.40%571.374612,85246.4%75.9%
47.37%576.477010,91140.7%53.3%
68.42%571.484813,22068.6%68.2%
44.64%564.372411,08745.2%44.0%
48.21%565.578311,78029.2%62.5%
54.55%553.31,13513,53166.7%45.2%
57.69%525.296712,20550.0%64.3%
42.86%495.177111,61242.3%43.5%
44.68%476.596712,25045.0%44.4%
41.30%461.186813,58147.6%36.0%
63.04%461.181413,96957.1%68.0%
39.13%464.897312,78050.0%33.3%
52.27%445.395611,69952.2%52.4%
42.86%425.784011,60031.8%55.0%
51.22%411.276213,95042.9%55.6%
35.00%404.868710,79039.1%29.4%
55.00%403.775412,10557.1%52.6%
45.00%402.384813,15738.9%50.0%
43.59%396.069810,31840.9%47.1%
47.37%385.51,10713,06431.3%59.1%
44.74%381.577313,79129.4%57.1%
40.54%376.981911,40833.3%53.9%
57.14%356.987811,54444.4%70.6%
57.14%351.980613,20861.1%52.9%
47.06%341.781413,78638.9%56.3%
52.94%342.688913,79950.0%55.6%
51.52%331.585213,70864.7%37.5%
51.52%331.271713,71954.5%50.0%
72.73%331.992814,50961.5%80.0%
72.73%332.092515,14484.6%65.0%
56.25%321.977213,65436.4%66.7%
50.00%322.673012,55169.2%36.8%
56.25%326.986311,18357.9%53.9%
41.94%316.082411,25936.4%45.0%
56.67%302.382114,36157.1%56.3%
63.33%305.71,03211,42564.3%62.5%
40.00%304.463110,80652.4%11.1%
43.33%306.797411,96650.0%38.9%
37.93%291.291713,54830.8%43.8%
44.83%295.583411,29043.8%46.1%
51.85%276.879712,36466.7%40.0%
44.44%276.579511,09837.5%54.5%
40.74%275.577110,95133.3%44.4%
62.96%272.11,01914,74850.0%73.3%
60.00%256.478612,13950.0%66.7%
50.00%245.081213,66757.1%47.1%
47.83%232.486913,18933.3%63.6%
52.17%231.176313,54260.0%46.1%
54.55%224.581012,64666.7%40.0%
59.09%226.284411,40258.3%60.0%
42.86%211.177913,32133.3%50.0%
61.90%215.498512,23314.3%85.7%
57.14%215.977711,34262.5%53.9%
42.86%216.470811,21550.0%33.3%
23.81%211.069812,59915.4%37.5%
47.62%215.991610,42245.5%50.0%
45.00%206.779211,92860.0%30.0%
50.00%201.172113,30854.5%44.4%
26.32%192.181812,6410.0%45.5%
36.84%191.581413,31530.0%44.4%
26.32%192.978712,97128.6%25.0%
50.00%185.686012,42571.4%36.4%
52.94%175.885312,11166.7%37.5%
47.06%177.291912,34460.0%28.6%
64.71%171.294213,46450.0%72.7%
50.00%163.465111,09840.0%66.7%
43.75%161.165111,62644.4%42.9%
60.00%156.297711,25342.9%75.0%
66.67%156.273010,96454.5%100.0%
50.00%147.087111,69314.3%85.7%
35.71%144.780111,07733.3%40.0%
69.23%130.769811,18560.0%100.0%
75.00%121.096615,176100.0%40.0%
41.67%121.164814,21225.0%50.0%
63.64%116.266110,26957.1%75.0%
36.36%116.371310,79640.0%33.3%
72.73%116.295811,32283.3%60.0%
80.00%106.092013,35883.3%75.0%
50.00%102.477712,74960.0%40.0%
50.00%102.881612,40350.0%50.0%
50.00%101.775512,88233.3%75.0%
77.78%96.39129,33675.0%80.0%
62.50%83.986212,64350.0%75.0%
12.50%86.260010,0560.0%25.0%
57.14%75.784411,16960.0%50.0%
28.57%71.658410,87350.0%0.0%
85.71%76.778412,78366.7%100.0%
60.00%54.71,10215,680100.0%50.0%
40.00%56.277710,20166.7%0.0%
20.00%56.676110,6070.0%100.0%
80.00%56.71,01612,35866.7%100.0%
0.00%56.05556,9890.0%0.0%
20.00%55.77139,7720.0%33.3%
40.00%57.091212,370100.0%0.0%

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Ambessa vs Karthus - Frequently Asked Questions

How does Ambessa do against Karthus in League of Legends?

Ambessa wins the Ambessa vs Karthus matchup with a 75.0% win rate compared to Karthus's 25.0%, a 50.0 percentage point difference. This data is based on 12 recent ranked games in patch 26.7.

How does Ambessa do against Karthus in the early game?

In the early game, Ambessa has the advantage against Karthus with a 100.0% win rate versus 0.0%. Ambessa players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Ambessa do against Karthus in the late game?

In the late game, Karthus takes over the Ambessa vs Karthus matchup with a 60.0% win rate compared to 40.0%. Karthus scales better into team fights and objective contests after 25 minutes.

Who wins the Ambessa vs Karthus matchup?

Ambessa wins the matchup against Karthus with a 75.0% win rate in League of Legends patch 26.7. The 50.0 percentage point advantage means Ambessa is significantly favored in this lane matchup based on 12 games analyzed.

What is the best Ambessa build against Karthus?

The best Ambessa build against Karthus includes Profane Hydra, Axiom Arc, Death's Dance with Mercury's Treads. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Ambessa runes against Karthus?

The best Ambessa runes against Karthus use the Precision primary tree with Domination secondary. This rune setup achieves a 100.0% win rate in the Ambessa vs Karthus matchup. See the full rune breakdown in the matchup comparison above.

Does Ambessa counter Karthus?

Yes, Ambessa has a favorable matchup against Karthus with a 75.0% win rate. Ambessa strongly counters Karthus in lane based on current patch 26.7 data.

How do I play Ambessa against Karthus?

When playing Ambessa against Karthus, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.