Annie - League of Legends Champion
Win Rate
50.1%
Pick Rate
1.5%

Annievs Cassiopeia

CMageSupport
Patch26.5
Matches469,660
LaneAll Lanes
TierAll Tiers
Last UpdatedMar 12, 2026
MethodologyData Methodology

Annie vs Cassiopeia is a decisive matchup in LoL patch 26.5. Cassiopeia wins with a 83.3% win rate (+66.7%) over Annie based on 6 games. Cassiopeia holds the advantage in both the early and late game. Below you'll find the best Annie build, runes, laning stats, and strategies for the Annie vs Cassiopeia matchup.

Annie Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Annie performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Cassiopeia - 16.7% win rateCassiopeia(16.7%)
Annie - 16.7% win rate in this matchup
Annie
16.7% WR
VS
Cassiopeia vs Annie matchup - 83.3% win rate
Cassiopeia
83.3% WR

Who Wins the Annie vs Cassiopeia Matchup?

Cassiopeia wins the Annie vs Cassiopeia matchup
Winner
Cassiopeia
Matches: 6
16.7%
Win Rate
83.3%
5.9
CS / min
6.7
940
DMG / min
644
11,632
Gold / game
12,117
80
Heal / min
310
492
DMG Mitigated / min
572
1.2
CC / min
1.1
0.0%
Early Game WR
100.0%
25.0%
Late Game WR
75.0%

Annie vs Cassiopeia Matchup Summary

The Annie vs Cassiopeia matchup is a decisive matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Cassiopeia wins with a 83.3% win rate compared to Annie's 16.7%, giving Cassiopeia a 66.7 percentage point advantage. Cassiopeia dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Annie players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Cassiopeia leads by 310 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Cassiopeia has a strong advantage in this matchup. Annie players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Cassiopeia overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Annie vs Cassiopeia Laning Phase Breakdown

Cassiopeia wins the laning phase against Annie in League of Legends

Cassiopeia is favored during the laning phase against Annie, winning 3 out of 5 key stat categories. Cassiopeia holds advantages in farming, gold income and sustain, making them the stronger laner in this matchup.

Farming
5.9Annie
6.7Cassiopeia
Cassiopeia edges out Annie by 0.8 CS per minute — a moderate farming advantage that adds up to roughly 12 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Cassiopeia.
Damage
940Annie
644Cassiopeia
Annie heavily out-damages Cassiopeia by 296 DMG/min, dominating both short trades and all-in fights. Cassiopeia should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Annie's sustained damage advantage take over.
Economy
11,632Annie
12,117Cassiopeia
Cassiopeia earns 485 more gold per game than Annie, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Cassiopeia slightly faster item completions.
Utility
1.2Annie
1.1Cassiopeia
Both Annie and Cassiopeia provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
572Annie
882Cassiopeia
Cassiopeia vastly out-sustains Annie, healing and mitigating 310 more damage per minute. This massive durability gap means Cassiopeia can absorb significant punishment and remain in lane while Annie is forced to recall. Building grievous wounds early is essential for Annie, and focusing on burst trade patterns rather than sustained fights is critical.

Best Annie Build Against Cassiopeia

Spellslinger's Shoes is the optimal boots choice against Cassiopeia, providing the mobility and stats Annie needs most in this matchup. The top-performing core items for Annie against Cassiopeia are Luden's Echo, Stormsurge and Zhonya's Hourglass. This combination gives Annie an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Cassiopeia. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Annie vs Cassiopeia matchup.

Early Game vs Late Game

Early Game
Cassiopeia
100.0%
+100.0% advantage
Annie early game win rateAnnie0.0%
Cassiopeia early game win rateCassiopeia100.0%
Late Game
Cassiopeia
75.0%
+50.0% advantage
Annie late game win rateAnnie25.0%
Cassiopeia late game win rateCassiopeia75.0%

Cassiopeia dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Annie. This lopsided early game means Cassiopeia can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Cassiopeia is far superior in the late game (25+ minutes), boasting a 75.0% win rate — 50.0 points above Annie. Extended games heavily favor Cassiopeia, whose kit and scaling make them a dominant force in team fights and objective control.

Cassiopeia holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Annie players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Annie Runes Against Cassiopeia

Domination rune tree - Annie primary runes vs CassiopeiaDomination
Electrocute - best Annie rune vs CassiopeiaSudden Impact - best Annie rune vs CassiopeiaGrisly Mementos - best Annie rune vs CassiopeiaTreasure Hunter - best Annie rune vs Cassiopeia
Precision rune tree - Annie secondary runes vs CassiopeiaPrecision
Coup de Grace - best Annie rune vs CassiopeiaLegend: Alacrity - best Annie rune vs Cassiopeia
100.0% WR

The Domination and Precision rune setup gives Annie the best tools to compete against Cassiopeia in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Annie matchup data for League of Legends patch 26.5. The table below shows Annie's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Annie build, runes, laning stats, and early vs late game analysis for that specific matchup.

Annie matchup win rates and stats in League of Legends patch 26.5
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
35.24%1056.093711,01226.2%41.3%
55.07%696.087610,88342.1%71.0%
34.69%496.282311,10220.0%44.8%
42.22%456.185811,20042.1%42.3%
50.00%425.796612,34135.7%57.1%
63.41%415.697512,33071.4%59.3%
66.67%396.099411,59371.4%61.1%
55.56%364.782011,28672.7%48.0%
46.67%305.385411,23818.8%78.6%
46.43%285.680710,97725.0%75.0%
57.14%286.278211,11163.6%52.9%
61.54%264.674611,56166.7%58.8%
73.08%265.997812,77270.0%75.0%
57.69%265.491911,02546.1%69.2%
44.00%255.992311,25238.5%50.0%
41.67%246.279810,80327.3%53.9%
45.83%245.484611,26633.3%53.3%
47.62%216.21,07412,19040.0%50.0%
61.90%215.798212,57850.0%69.2%
61.90%215.891212,28666.7%58.3%
57.14%216.191810,33158.3%55.6%
40.00%205.595712,25428.6%46.1%
42.11%195.88389,97933.3%57.1%
44.44%184.284410,25950.0%37.5%
50.00%186.284410,29446.1%60.0%
58.82%175.71,05411,63571.4%50.0%
58.82%175.51,10012,37083.3%45.5%
43.75%161.45218,41740.0%50.0%
62.50%162.964511,39957.1%66.7%
37.50%161.468010,62016.7%50.0%
73.33%155.385711,46085.7%62.5%
73.33%153.473710,31683.3%66.7%
50.00%145.71,06213,12333.3%62.5%
64.29%145.877911,47966.7%60.0%
35.71%141.46119,18416.7%50.0%
71.43%145.295811,62062.5%83.3%
57.14%145.498711,70666.7%50.0%
50.00%121.682811,66860.0%42.9%
63.64%116.095413,649100.0%60.0%
27.27%116.187411,88225.0%28.6%
60.00%106.77859,86162.5%50.0%
44.44%94.179210,9770.0%66.7%
33.33%92.074210,59625.0%40.0%
44.44%93.37868,85150.0%40.0%
33.33%95.61,11811,36125.0%40.0%
55.56%95.81,17312,07450.0%57.1%
37.50%83.161710,63033.3%40.0%
62.50%86.41,20313,20050.0%75.0%
62.50%84.81,18012,62366.7%60.0%
37.50%85.694111,90850.0%25.0%
50.00%85.096511,26733.3%60.0%
37.50%81.65718,50550.0%25.0%
42.86%74.09299,86066.7%25.0%
42.86%76.41,12213,59750.0%40.0%
14.29%71.04549,0480.0%25.0%
28.57%72.15918,39425.0%33.3%
28.57%76.77268,63920.0%50.0%
71.43%75.51,02814,528100.0%66.7%
66.67%61.366010,473100.0%50.0%
33.33%64.790612,674100.0%20.0%
33.33%65.990211,24225.0%50.0%
16.67%65.994011,6320.0%25.0%
83.33%66.11,00012,399100.0%50.0%
50.00%61.66729,59233.3%66.7%
33.33%62.38238,54725.0%50.0%
33.33%65.793812,197100.0%0.0%
33.33%62.56899,13640.0%0.0%
40.00%52.570112,3710.0%40.0%
40.00%51.259110,90950.0%33.3%
40.00%53.878510,43433.3%50.0%
60.00%53.81,02014,301100.0%50.0%
40.00%51.664810,4520.0%40.0%
60.00%51.25379,948100.0%50.0%

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Annie vs Cassiopeia - Frequently Asked Questions

How does Annie do against Cassiopeia in League of Legends?

Cassiopeia wins the Annie vs Cassiopeia matchup with a 83.3% win rate compared to Annie's 16.7%, a 66.7 percentage point difference. This data is based on 6 recent ranked games in patch 26.5.

How does Annie do against Cassiopeia in the early game?

In the early game, Cassiopeia has the advantage against Annie with a 100.0% win rate versus 0.0%. Cassiopeia players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Annie do against Cassiopeia in the late game?

In the late game, Cassiopeia takes over the Annie vs Cassiopeia matchup with a 75.0% win rate compared to 25.0%. Cassiopeia scales better into team fights and objective contests after 25 minutes.

Who wins the Annie vs Cassiopeia matchup?

Cassiopeia wins the matchup against Annie with a 83.3% win rate in League of Legends patch 26.5. The 66.7 percentage point advantage means Cassiopeia is significantly favored in this lane matchup based on 6 games analyzed.

What is the best Annie build against Cassiopeia?

The best Annie build against Cassiopeia includes Luden's Echo, Stormsurge, Zhonya's Hourglass with Spellslinger's Shoes. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Annie runes against Cassiopeia?

The best Annie runes against Cassiopeia use the Domination primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Annie vs Cassiopeia matchup. See the full rune breakdown in the matchup comparison above.

Does Annie counter Cassiopeia?

No, Annie struggles against Cassiopeia with only a 16.7% win rate. Cassiopeia has the advantage in this matchup. Annie players should focus on safe farming and avoiding extended trades to minimize Cassiopeia's lead.

How do I play Annie against Cassiopeia?

When playing Annie against Cassiopeia, play cautiously and avoid Cassiopeia's power spikes. Look for jungle assistance and team-dependent plays since Cassiopeia has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.