Vaynevs Miss Fortune
Vayne vs Miss Fortune is a decisive matchup in LoL patch 26.11. Miss Fortune wins with a 53.7% win rate (+7.5%) over Vayne based on 428 games. Miss Fortune holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Miss Fortune matchup.
Vayne Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Who Wins the Vayne vs Miss Fortune Matchup?
Vayne vs Miss Fortune Matchup Summary
The Vayne vs Miss Fortune matchup is a decisive matchup in League of Legends ranked play. Based on 428 recent matches analyzed, Miss Fortune wins with a 53.7% win rate compared to Vayne's 46.3%, giving Miss Fortune a 7.5 percentage point advantage. Miss Fortune dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Vayne players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Vayne leads by 0.1s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Miss Fortune has a strong advantage in this matchup. Vayne players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Miss Fortune overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Vayne vs Miss Fortune Laning Phase Breakdown
Miss Fortune is favored during the laning phase against Vayne, winning 3 out of 5 key stat categories. Miss Fortune holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.
Early Game vs Late Game
Vayne44.9%
Miss Fortune55.1%Vayne47.3%Miss Fortune52.7%Miss Fortune dominates the early game (first 15 minutes) with a commanding 55.1% win rate — a 10.2 percentage point lead over Vayne. This lopsided early game means Miss Fortune can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Miss Fortune is far superior in the late game (25+ minutes), boasting a 52.7% win rate — 5.4 points above Vayne. Extended games heavily favor Miss Fortune, whose kit and scaling make them a dominant force in team fights and objective control.
Miss Fortune holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Vayne players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.
Best Vayne Runes Against Miss Fortune
Precision
Resolve
The Precision and Resolve rune setup gives Vayne the best tools to compete against Miss Fortune in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.
Vayne matchup data for League of Legends patch 26.11. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 46.01% | 476 | 6.0 | 789 | 12,875 | 44.3% | 47.4% | |
| 47.20% | 447 | 6.0 | 791 | 12,725 | 45.4% | 48.6% | |
| 46.26% | 428 | 5.7 | 796 | 12,715 | 44.9% | 47.3% | |
| 53.92% | 395 | 6.0 | 857 | 12,968 | 53.2% | 54.6% | |
| 47.85% | 372 | 6.2 | 894 | 13,189 | 46.8% | 48.6% | |
| 52.99% | 351 | 6.2 | 843 | 13,142 | 52.5% | 53.4% | |
| 52.98% | 285 | 6.3 | 904 | 13,456 | 46.2% | 58.8% | |
| 53.90% | 269 | 6.3 | 877 | 13,737 | 48.2% | 58.0% | |
| 52.38% | 189 | 5.9 | 886 | 12,468 | 46.1% | 58.2% | |
| 51.92% | 156 | 6.5 | 913 | 11,989 | 50.0% | 53.4% | |
| 54.30% | 151 | 6.1 | 859 | 13,227 | 58.5% | 51.2% | |
| 50.33% | 151 | 6.1 | 804 | 13,007 | 43.8% | 55.2% | |
| 45.95% | 148 | 5.9 | 780 | 13,603 | 45.3% | 46.3% | |
| 45.38% | 130 | 6.1 | 776 | 13,081 | 38.2% | 50.7% | |
| 47.83% | 115 | 6.4 | 812 | 13,765 | 38.5% | 52.6% | |
| 42.61% | 115 | 6.1 | 781 | 12,082 | 34.0% | 49.2% | |
| 50.88% | 114 | 5.8 | 866 | 12,989 | 41.2% | 58.7% | |
| 45.19% | 104 | 6.4 | 899 | 13,175 | 48.7% | 43.1% | |
| 59.80% | 102 | 6.5 | 854 | 13,189 | 63.5% | 56.0% | |
| 31.00% | 100 | 5.5 | 635 | 10,360 | 11.1% | 47.3% | |
| 45.83% | 96 | 5.8 | 857 | 13,164 | 44.4% | 46.7% | |
| 50.53% | 95 | 6.3 | 1,120 | 12,737 | 51.6% | 50.0% | |
| 58.06% | 93 | 6.3 | 796 | 13,008 | 54.8% | 60.8% | |
| 44.09% | 93 | 5.8 | 625 | 11,330 | 42.4% | 45.0% | |
| 45.56% | 90 | 5.8 | 830 | 11,355 | 43.6% | 47.1% | |
| 45.98% | 87 | 6.3 | 851 | 13,572 | 37.9% | 50.0% | |
| 55.81% | 86 | 6.1 | 899 | 10,748 | 43.2% | 65.3% | |
| 55.95% | 84 | 6.2 | 1,292 | 11,546 | 51.4% | 59.2% | |
| 56.41% | 78 | 6.3 | 883 | 13,435 | 57.1% | 55.8% | |
| 54.84% | 62 | 5.9 | 814 | 12,061 | 58.3% | 52.6% | |
| 45.76% | 59 | 6.2 | 877 | 12,775 | 48.0% | 44.1% | |
| 51.92% | 52 | 6.0 | 913 | 11,592 | 48.1% | 56.0% | |
| 45.10% | 51 | 6.5 | 921 | 12,144 | 40.9% | 48.3% | |
| 52.00% | 50 | 6.0 | 875 | 13,621 | 47.8% | 55.6% | |
| 35.42% | 48 | 6.2 | 721 | 10,982 | 28.0% | 43.5% | |
| 58.33% | 48 | 6.1 | 989 | 11,810 | 64.0% | 52.2% | |
| 45.83% | 48 | 6.2 | 1,005 | 10,838 | 51.9% | 38.1% | |
| 50.00% | 46 | 6.2 | 970 | 13,364 | 47.4% | 51.9% | |
| 58.70% | 46 | 6.2 | 914 | 13,671 | 62.5% | 54.5% | |
| 54.55% | 44 | 6.2 | 874 | 14,063 | 57.1% | 53.3% | |
| 44.19% | 43 | 6.6 | 839 | 13,744 | 55.0% | 34.8% | |
| 26.19% | 42 | 5.9 | 874 | 11,678 | 23.5% | 28.0% | |
| 48.78% | 41 | 5.9 | 836 | 11,644 | 43.5% | 55.6% | |
| 52.50% | 40 | 5.6 | 838 | 13,607 | 37.5% | 56.3% | |
| 38.46% | 39 | 6.7 | 854 | 10,961 | 50.0% | 28.6% | |
| 41.03% | 39 | 6.0 | 743 | 9,571 | 28.6% | 55.6% | |
| 67.57% | 37 | 6.5 | 898 | 11,526 | 62.5% | 76.9% | |
| 45.95% | 37 | 5.6 | 832 | 11,998 | 40.0% | 50.0% | |
| 52.94% | 34 | 6.4 | 759 | 12,245 | 50.0% | 54.5% | |
| 52.94% | 34 | 6.4 | 1,051 | 11,474 | 52.6% | 53.3% | |
| 66.67% | 33 | 6.3 | 938 | 13,524 | 61.5% | 70.0% | |
| 48.48% | 33 | 6.4 | 784 | 11,269 | 50.0% | 46.1% | |
| 48.48% | 33 | 6.5 | 979 | 13,305 | 62.5% | 44.0% | |
| 40.63% | 32 | 5.3 | 820 | 11,344 | 42.1% | 38.5% | |
| 62.50% | 32 | 5.7 | 796 | 13,163 | 41.7% | 75.0% | |
| 40.63% | 32 | 6.2 | 676 | 10,369 | 31.6% | 53.9% | |
| 58.06% | 31 | 6.4 | 849 | 12,138 | 64.3% | 52.9% | |
| 53.33% | 30 | 5.6 | 855 | 12,152 | 55.6% | 52.4% | |
| 60.00% | 30 | 6.0 | 953 | 12,308 | 76.9% | 47.1% | |
| 43.33% | 30 | 6.6 | 646 | 11,441 | 37.5% | 50.0% | |
| 55.56% | 27 | 5.3 | 792 | 11,006 | 50.0% | 60.0% | |
| 48.15% | 27 | 6.2 | 834 | 11,465 | 43.8% | 54.5% | |
| 50.00% | 26 | 5.9 | 693 | 11,801 | 41.7% | 57.1% | |
| 50.00% | 26 | 6.1 | 710 | 11,421 | 46.1% | 53.9% | |
| 30.77% | 26 | 5.3 | 700 | 11,001 | 27.3% | 33.3% | |
| 50.00% | 26 | 5.8 | 834 | 12,301 | 54.5% | 46.7% | |
| 48.00% | 25 | 6.0 | 816 | 12,910 | 20.0% | 66.7% | |
| 44.00% | 25 | 6.4 | 758 | 11,844 | 50.0% | 38.5% | |
| 54.17% | 24 | 6.3 | 991 | 12,325 | 64.3% | 40.0% | |
| 45.83% | 24 | 6.0 | 850 | 11,125 | 57.1% | 30.0% | |
| 56.52% | 23 | 5.7 | 610 | 10,299 | 45.5% | 66.7% | |
| 45.45% | 22 | 6.5 | 734 | 12,184 | 38.5% | 55.6% | |
| 40.91% | 22 | 6.0 | 806 | 12,815 | 44.4% | 38.5% | |
| 42.11% | 19 | 6.2 | 920 | 10,372 | 45.5% | 37.5% | |
| 63.16% | 19 | 6.3 | 870 | 12,589 | 50.0% | 72.7% | |
| 42.11% | 19 | 5.8 | 817 | 12,142 | 57.1% | 33.3% | |
| 61.11% | 18 | 5.6 | 1,008 | 13,433 | 66.7% | 58.3% | |
| 62.50% | 16 | 6.1 | 885 | 11,547 | 62.5% | 62.5% | |
| 80.00% | 15 | 2.2 | 885 | 17,368 | 50.0% | 84.6% | |
| 53.33% | 15 | 6.4 | 985 | 13,301 | 50.0% | 54.5% | |
| 60.00% | 15 | 6.5 | 833 | 11,244 | 37.5% | 85.7% | |
| 46.67% | 15 | 6.6 | 876 | 11,530 | 50.0% | 42.9% | |
| 46.67% | 15 | 5.4 | 916 | 13,992 | 25.0% | 54.5% | |
| 42.86% | 14 | 6.4 | 824 | 13,966 | 75.0% | 30.0% | |
| 42.86% | 14 | 6.0 | 841 | 13,447 | 0.0% | 66.7% | |
| 53.85% | 13 | 6.5 | 849 | 13,506 | 100.0% | 33.3% | |
| 46.15% | 13 | 5.2 | 750 | 11,579 | 50.0% | 42.9% | |
| 66.67% | 12 | 5.6 | 1,025 | 12,928 | 80.0% | 57.1% | |
| 33.33% | 12 | 6.0 | 927 | 11,900 | 33.3% | 33.3% | |
| 54.55% | 11 | 5.6 | 1,002 | 13,298 | 50.0% | 57.1% | |
| 63.64% | 11 | 6.1 | 642 | 10,204 | 50.0% | 80.0% | |
| 54.55% | 11 | 2.9 | 820 | 14,068 | 66.7% | 40.0% | |
| 81.82% | 11 | 6.2 | 775 | 12,783 | 100.0% | 71.4% | |
| 54.55% | 11 | 3.4 | 846 | 13,743 | 33.3% | 62.5% | |
| 54.55% | 11 | 5.5 | 761 | 11,649 | 71.4% | 25.0% | |
| 45.45% | 11 | 5.6 | 915 | 9,808 | 75.0% | 28.6% | |
| 40.00% | 10 | 4.6 | 708 | 11,732 | 50.0% | 25.0% | |
| 60.00% | 10 | 5.7 | 820 | 12,597 | 50.0% | 62.5% | |
| 50.00% | 10 | 3.8 | 771 | 13,237 | 33.3% | 57.1% | |
| 40.00% | 10 | 5.5 | 926 | 11,893 | 40.0% | 40.0% | |
| 66.67% | 9 | 3.8 | 1,039 | 13,798 | 66.7% | 66.7% | |
| 33.33% | 9 | 6.1 | 1,076 | 13,273 | 0.0% | 50.0% | |
| 55.56% | 9 | 6.7 | 930 | 13,145 | 100.0% | 20.0% | |
| 33.33% | 9 | 6.0 | 855 | 13,018 | 33.3% | 33.3% | |
| 55.56% | 9 | 3.9 | 860 | 12,860 | 33.3% | 66.7% | |
| 50.00% | 8 | 5.8 | 870 | 14,565 | 50.0% | 50.0% | |
| 62.50% | 8 | 7.3 | 684 | 11,847 | 66.7% | 50.0% | |
| 50.00% | 8 | 3.2 | 883 | 13,479 | 75.0% | 25.0% | |
| 25.00% | 8 | 5.2 | 690 | 9,102 | 16.7% | 50.0% | |
| 37.50% | 8 | 5.8 | 526 | 9,894 | 50.0% | 25.0% | |
| 57.14% | 7 | 4.0 | 760 | 10,750 | 33.3% | 75.0% | |
| 71.43% | 7 | 3.6 | 743 | 11,425 | 80.0% | 50.0% | |
| 42.86% | 7 | 4.5 | 723 | 11,697 | 33.3% | 50.0% | |
| 28.57% | 7 | 4.5 | 676 | 12,046 | 0.0% | 40.0% | |
| 50.00% | 6 | 3.5 | 781 | 15,022 | 0.0% | 60.0% | |
| 33.33% | 6 | 6.8 | 823 | 13,779 | 0.0% | 50.0% | |
| 33.33% | 6 | 2.9 | 989 | 12,898 | 33.3% | 33.3% | |
| 66.67% | 6 | 5.9 | 1,006 | 14,143 | 50.0% | 75.0% | |
| 20.00% | 5 | 4.7 | 577 | 8,999 | 33.3% | 0.0% | |
| 40.00% | 5 | 2.1 | 611 | 12,290 | 50.0% | 0.0% | |
| 40.00% | 5 | 6.4 | 1,176 | 14,594 | 0.0% | 50.0% | |
| 80.00% | 5 | 6.2 | 1,024 | 13,762 | 100.0% | 66.7% | |
| 40.00% | 5 | 5.9 | 962 | 13,248 | 0.0% | 50.0% | |
| 40.00% | 5 | 6.0 | 673 | 9,218 | 50.0% | 0.0% | |
| 40.00% | 5 | 6.4 | 726 | 9,892 | 40.0% | 0.0% | |
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Vayne vs Miss Fortune - Frequently Asked Questions
How does Vayne do against Miss Fortune in League of Legends?
Miss Fortune wins the Vayne vs Miss Fortune matchup with a 53.7% win rate compared to Vayne's 46.3%, a 7.5 percentage point difference. This data is based on 428 recent ranked games in patch 26.11.
How does Vayne do against Miss Fortune in the early game?
In the early game, Miss Fortune has the advantage against Vayne with a 55.1% win rate versus 44.9%. Miss Fortune players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Vayne do against Miss Fortune in the late game?
In the late game, Miss Fortune takes over the Vayne vs Miss Fortune matchup with a 52.7% win rate compared to 47.3%. Miss Fortune scales better into team fights and objective contests after 25 minutes.
Who wins the Vayne vs Miss Fortune matchup?
Miss Fortune wins the matchup against Vayne with a 53.7% win rate in League of Legends patch 26.11. The 7.5 percentage point advantage means Miss Fortune is significantly favored in this lane matchup based on 428 games analyzed.
What is the best Vayne build against Miss Fortune?
The best Vayne build against Miss Fortune includes optimized core items. Check the matchup breakdown above for the full item path and build order.
What are the best Vayne runes against Miss Fortune?
The best Vayne runes against Miss Fortune use the Precision primary tree with Resolve secondary. This rune setup achieves a 54.8% win rate in the Vayne vs Miss Fortune matchup. See the full rune breakdown in the matchup comparison above.
Does Vayne counter Miss Fortune?
No, Vayne struggles against Miss Fortune with only a 46.3% win rate. Miss Fortune has the advantage in this matchup. Vayne players should focus on safe farming and avoiding extended trades to minimize Miss Fortune's lead.
How do I play Vayne against Miss Fortune?
When playing Vayne against Miss Fortune, play cautiously and avoid Miss Fortune's power spikes. Look for jungle assistance and team-dependent plays since Miss Fortune has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.