Nautilus - League of Legends Champion
Win Rate
48.8%
Pick Rate
4.6%

Nautilusvs Vayne

DTankSupport
Patch26.10
Matches1,009,027
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 18, 2026
MethodologyData Methodology

Nautilus vs Vayne is a decisive matchup in LoL patch 26.10. Vayne wins with a 60.0% win rate (+20.0%) over Nautilus based on 5 games. Nautilus wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Nautilus build, runes, laning stats, and strategies for the Nautilus vs Vayne matchup.

Nautilus Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Nautilus performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 40.0% win rateVayne(40.0%)
Nautilus - 40.0% win rate in this matchup
Nautilus
40.0% WR
VS
Vayne vs Nautilus matchup - 60.0% win rate
Vayne
60.0% WR

Who Wins the Nautilus vs Vayne Matchup?

Vayne wins the Nautilus vs Vayne matchup
Winner
Vayne
Matches: 5
40.0%
Win Rate
60.0%
2.7
CS / min
3.8
432
DMG / min
850
9,214
Gold / game
11,660
113
Heal / min
228
1,539
DMG Mitigated / min
437
2.0
CC / min
0.4
50.0%
Early Game WR
50.0%
33.3%
Late Game WR
66.7%

Nautilus vs Vayne Matchup Summary

The Nautilus vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Vayne wins with a 60.0% win rate compared to Nautilus's 40.0%, giving Vayne a 20.0 percentage point advantage. Game phase dynamics play a critical role here: Nautilus controls the early laning stage, but Vayne outscales as the game goes longer. The matchup shifts dramatically depending on game length — Nautilus needs to press advantages before Vayne reaches their power spikes, while Vayne should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Nautilus leads by 1.6s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne has a strong advantage in this matchup. Nautilus players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Vayne overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Nautilus vs Vayne Laning Phase Breakdown

Vayne wins the laning phase against Nautilus in League of Legends

Vayne is favored during the laning phase against Nautilus, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
2.7Nautilus
3.8Vayne
Vayne significantly out-farms Nautilus by 1.0 CS per minute, accumulating an estimated 15 CS lead by mid game. This substantial farming gap gives Vayne a major gold advantage and earlier item completions. Nautilus players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
432Nautilus
850Vayne
Vayne heavily out-damages Nautilus by 418 DMG/min, dominating both short trades and all-in fights. Nautilus should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Vayne's sustained damage advantage take over.
Economy
9,214Nautilus
11,660Vayne
Vayne generates a commanding 2,446 more gold per game than Nautilus. This substantial economic advantage means Vayne consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Nautilus should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
2.0Nautilus
0.4Vayne
Nautilus brings significantly more crowd control than Vayne, with 1.6 more seconds of CC per minute. This large utility gap makes Nautilus far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Vayne should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
1,653Nautilus
665Vayne
Nautilus vastly out-sustains Vayne, healing and mitigating 988 more damage per minute. This massive durability gap means Nautilus can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Best Nautilus Build Against Vayne

Plated Steelcaps is the optimal boots choice against Vayne, providing the mobility and stats Nautilus needs most in this matchup. The top-performing core items for Nautilus against Vayne are Locket of the Iron Solari, Thornmail and Protoplasm Harness. This combination gives Nautilus an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Vayne. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Nautilus vs Vayne matchup.

Early Game vs Late Game

Early Game
Nautilus
50.0%
+0.0% advantage
Nautilus early game win rateNautilus50.0%
Vayne early game win rateVayne50.0%
Late Game
Vayne
66.7%
+33.3% advantage
Nautilus late game win rateNautilus33.3%
Vayne late game win rateVayne66.7%

The early game (first 15 minutes) is a toss-up between Nautilus and Vayne, with Nautilus holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Vayne is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Nautilus. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.

The power dynamics shift as the game progresses — Nautilus has the edge early, but Vayne gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.

Best Nautilus Runes Against Vayne

Resolve rune tree - Nautilus primary runes vs VayneResolve
Aftershock - best Nautilus rune vs VayneShield Bash - best Nautilus rune vs VayneBone Plating - best Nautilus rune vs VayneUnflinching - best Nautilus rune vs Vayne
Inspiration rune tree - Nautilus secondary runes vs VayneInspiration
Biscuit Delivery - best Nautilus rune vs VayneCosmic Insight - best Nautilus rune vs Vayne
100.0% WR

The Resolve and Inspiration rune setup gives Nautilus the best tools to compete against Vayne in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Nautilus matchup data for League of Legends patch 26.10. The table below shows Nautilus's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Nautilus build, runes, laning stats, and early vs late game analysis for that specific matchup.

Nautilus matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
40.49%5681.13598,30137.6%43.1%
48.26%5181.13618,50649.8%46.8%
50.82%4861.13488,69048.2%52.6%
45.19%4781.13658,34542.0%48.0%
47.90%4051.13718,61549.2%46.8%
46.10%3971.13878,48145.7%46.5%
47.49%3791.13358,63344.0%50.5%
44.19%3011.13608,29141.6%46.7%
50.94%2671.13958,97745.9%55.2%
48.48%2641.13919,48441.2%52.0%
45.22%2311.13888,81147.3%43.9%
45.65%2301.13348,33548.0%43.8%
50.93%2161.14308,18049.1%53.1%
54.72%2121.13468,48650.5%58.1%
48.80%2091.13638,46447.7%50.0%
53.17%2051.13958,47051.0%55.3%
57.71%2021.13348,35657.5%57.9%
53.81%1971.13438,56152.0%55.8%
45.95%1851.14308,52846.7%45.2%
49.44%1801.13708,90943.3%53.1%
46.11%1671.13518,69143.5%48.0%
43.98%1661.13568,73445.6%42.5%
50.92%1631.24199,16048.0%53.4%
53.55%1551.14278,95348.6%57.8%
52.63%1521.13968,57247.3%57.7%
54.68%1391.23738,95452.9%56.3%
44.17%1201.13458,15150.0%38.7%
58.72%1091.14058,88659.3%58.0%
45.26%951.03919,07144.1%45.9%
47.87%941.14138,97850.0%46.3%
43.68%871.03758,16543.8%43.6%
39.53%861.13378,12738.1%40.9%
51.19%841.14038,59942.5%59.1%
46.67%751.13828,79450.0%44.4%
46.58%731.13598,01040.0%52.6%
46.43%561.54579,20262.5%34.4%
55.81%431.44409,32052.4%59.1%
48.78%411.03638,93847.1%50.0%
46.15%391.13657,68947.6%44.4%
54.29%351.54308,84850.0%57.1%
47.06%341.54239,21040.0%52.6%
24.24%331.33569,00342.9%10.5%
60.61%331.13979,31069.2%55.0%
51.72%291.04139,28450.0%53.3%
60.71%281.03488,69366.7%56.3%
40.00%251.64649,54833.3%43.8%
58.33%240.93709,08275.0%50.0%
39.13%231.03868,63141.7%36.4%
66.67%211.64598,67258.3%77.8%
52.38%211.34398,56350.0%55.6%
52.38%211.138210,00516.7%66.7%
55.00%202.253410,28842.9%61.5%
50.00%201.44059,19075.0%33.3%
36.84%191.13598,57336.4%37.5%
44.44%181.94198,67460.0%25.0%
72.22%181.14049,12875.0%66.7%
27.78%181.43578,56814.3%36.4%
41.18%174.65849,25433.3%50.0%
64.71%171.34399,08755.6%75.0%
26.67%150.94016,72225.0%28.6%
35.71%141.24109,57414.3%57.1%
64.29%141.34179,10957.1%71.4%
64.29%141.147710,58342.9%85.7%
50.00%141.042410,34633.3%54.5%
61.54%131.14319,96933.3%70.0%
45.45%111.14999,68933.3%50.0%
81.82%111.853311,13980.0%83.3%
72.73%110.74849,22971.4%75.0%
27.27%113.555010,65425.0%28.6%
60.00%102.24739,29450.0%66.7%
70.00%101.65069,89750.0%83.3%
55.56%92.150810,26433.3%66.7%
55.56%90.64999,07260.0%50.0%
77.78%90.851911,867100.0%75.0%
55.56%90.954710,41025.0%80.0%
77.78%91.154710,77260.0%100.0%
22.22%91.158710,74433.3%16.7%
44.44%92.159610,0120.0%57.1%
55.56%91.73439,983100.0%42.9%
11.11%93.75608,64725.0%0.0%
37.50%84.359911,2590.0%50.0%
62.50%82.36248,94260.0%66.7%
75.00%81.95869,988100.0%60.0%
75.00%81.34389,97350.0%100.0%
37.50%83.360110,76850.0%25.0%
25.00%82.55399,68033.3%20.0%
37.50%81.25299,51250.0%25.0%
50.00%81.14589,23180.0%0.0%
71.43%75.272410,591100.0%50.0%
57.14%73.049210,998100.0%50.0%
100.00%74.65309,990100.0%100.0%
57.14%71.049810,574100.0%0.0%
42.86%72.563811,19350.0%40.0%
71.43%72.14319,87066.7%75.0%
57.14%72.36199,89325.0%100.0%
42.86%73.07689,66250.0%40.0%
42.86%71.94299,06833.3%50.0%
42.86%73.054111,538100.0%20.0%
85.71%72.13539,409100.0%80.0%
57.14%73.95158,13440.0%100.0%
33.33%61.856211,0150.0%50.0%
50.00%60.953911,462100.0%0.0%
50.00%60.955910,30750.0%50.0%
50.00%64.84839,16340.0%100.0%
60.00%52.25049,87566.7%50.0%
40.00%52.74329,21450.0%33.3%
80.00%50.94598,84966.7%100.0%
100.00%52.14118,577100.0%100.0%
60.00%50.93999,964100.0%50.0%
60.00%52.152511,0680.0%75.0%
60.00%52.063010,03666.7%50.0%
40.00%51.03358,817100.0%25.0%
100.00%52.44929,844100.0%100.0%
40.00%51.240310,1990.0%50.0%
60.00%51.12887,30560.0%0.0%
40.00%50.36198,24266.7%0.0%
60.00%52.469910,7840.0%75.0%
60.00%50.73486,98166.7%50.0%

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Nautilus vs Vayne - Frequently Asked Questions

How does Nautilus do against Vayne in League of Legends?

Vayne wins the Nautilus vs Vayne matchup with a 60.0% win rate compared to Nautilus's 40.0%, a 20.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.10.

How does Nautilus do against Vayne in the early game?

In the early game, Nautilus has the advantage against Vayne with a 50.0% win rate versus 50.0%. Nautilus players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Nautilus do against Vayne in the late game?

In the late game, Vayne takes over the Nautilus vs Vayne matchup with a 66.7% win rate compared to 33.3%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Nautilus vs Vayne matchup?

Vayne wins the matchup against Nautilus with a 60.0% win rate in League of Legends patch 26.10. The 20.0 percentage point advantage means Vayne is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Nautilus build against Vayne?

The best Nautilus build against Vayne includes Locket of the Iron Solari, Thornmail, Protoplasm Harness with Plated Steelcaps. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Nautilus runes against Vayne?

The best Nautilus runes against Vayne use the Resolve primary tree with Inspiration secondary. This rune setup achieves a 100.0% win rate in the Nautilus vs Vayne matchup. See the full rune breakdown in the matchup comparison above.

Does Nautilus counter Vayne?

No, Nautilus struggles against Vayne with only a 40.0% win rate. Vayne has the advantage in this matchup. Nautilus players should focus on safe farming and avoiding extended trades to minimize Vayne's lead.

How do I play Nautilus against Vayne?

When playing Nautilus against Vayne, play cautiously and avoid Vayne's power spikes. Look for jungle assistance and team-dependent plays since Vayne has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.