Vayne - League of Legends Champion
Win Rate
50.0%
Pick Rate
5.2%

Vaynevs Nautilus

BMarksmanAssassin
Patch26.10
Matches1,009,027
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 18, 2026
MethodologyData Methodology

Vayne vs Nautilus is a decisive matchup in LoL patch 26.10. Vayne wins with a 60.0% win rate (+20.0%) over Nautilus based on 5 games. Vayne holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Nautilus matchup.

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Nautilus - 60.0% win rateNautilus(60.0%)
Vayne - 60.0% win rate in this matchup
Vayne
60.0% WR
VS
Nautilus vs Vayne matchup - 40.0% win rate
Nautilus
40.0% WR

Who Wins the Vayne vs Nautilus Matchup?

Vayne wins the Vayne vs Nautilus matchup
Winner
Vayne
Matches: 5
60.0%
Win Rate
40.0%
3.8
CS / min
2.7
850
DMG / min
432
11,660
Gold / game
9,214
228
Heal / min
113
437
DMG Mitigated / min
1,539
0.4
CC / min
2.0
50.0%
Early Game WR
50.0%
66.7%
Late Game WR
33.3%

Vayne vs Nautilus Matchup Summary

The Vayne vs Nautilus matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Vayne wins with a 60.0% win rate compared to Nautilus's 40.0%, giving Vayne a 20.0 percentage point advantage. Vayne dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Nautilus players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Nautilus leads by 1.6s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne players can confidently pick into Nautilus and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Nautilus away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Nautilus Laning Phase Breakdown

Vayne wins the laning phase against Nautilus in League of Legends

Vayne is favored during the laning phase against Nautilus, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
3.8Vayne
2.7Nautilus
Vayne significantly out-farms Nautilus by 1.0 CS per minute, accumulating an estimated 15 CS lead by mid game. This substantial farming gap gives Vayne a major gold advantage and earlier item completions. Nautilus players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
850Vayne
432Nautilus
Vayne heavily out-damages Nautilus by 418 DMG/min, dominating both short trades and all-in fights. Nautilus should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Vayne's sustained damage advantage take over.
Economy
11,660Vayne
9,214Nautilus
Vayne generates a commanding 2,446 more gold per game than Nautilus. This substantial economic advantage means Vayne consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Nautilus should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.4Vayne
2.0Nautilus
Nautilus brings significantly more crowd control than Vayne, with 1.6 more seconds of CC per minute. This large utility gap makes Nautilus far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Vayne should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
665Vayne
1,653Nautilus
Nautilus vastly out-sustains Vayne, healing and mitigating 988 more damage per minute. This massive durability gap means Nautilus can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against Nautilus

Gluttonous Greaves is the optimal boots choice against Nautilus, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Nautilus are Experimental Hexplate, Lord Dominik's Regards and Fiendhunter Bolts. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Nautilus. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Nautilus matchup.

Early Game vs Late Game

Early Game
Vayne
50.0%
+0.0% advantage
Vayne early game win rateVayne50.0%
Nautilus early game win rateNautilus50.0%
Late Game
Vayne
66.7%
+33.3% advantage
Vayne late game win rateVayne66.7%
Nautilus late game win rateNautilus33.3%

The early game (first 15 minutes) is a toss-up between Vayne and Nautilus, with Vayne holding a razor-thin 50.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Vayne is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Nautilus. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.

Vayne holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Nautilus players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Vayne Runes Against Nautilus

Domination rune tree - Vayne primary runes vs NautilusDomination
Electrocute - best Vayne rune vs NautilusSudden Impact - best Vayne rune vs NautilusSixth Sense - best Vayne rune vs NautilusRelentless Hunter - best Vayne rune vs Nautilus
Precision rune tree - Vayne secondary runes vs NautilusPrecision
Cut Down - best Vayne rune vs NautilusLegend: Haste - best Vayne rune vs Nautilus
100.0% WR

Running Domination primary with Precision secondary allows Vayne to press their advantage against Nautilus, amplifying the strengths that make this a favorable matchup.


Vayne matchup data for League of Legends patch 26.10. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
42.79%8886.187313,42543.8%42.2%
45.78%6516.183212,92942.2%49.0%
48.13%6426.079912,92043.9%51.2%
53.42%5266.184213,10753.0%53.8%
51.10%5016.080012,97847.5%53.5%
50.31%4855.876912,32347.6%52.7%
49.35%3836.384512,93348.2%50.2%
53.27%3066.391613,43450.7%55.4%
53.62%2356.086412,64049.6%57.4%
54.59%2076.183412,66748.9%59.3%
47.29%2035.980413,16448.8%46.2%
48.15%1896.185513,55151.4%46.2%
49.11%1696.084412,90648.1%50.0%
45.51%1676.081812,76943.1%47.4%
46.99%1666.277612,77449.4%44.9%
48.77%1626.595411,99745.2%51.7%
39.75%1615.862010,95728.8%48.9%
50.63%1606.589913,74644.8%54.8%
59.73%1496.489911,99949.2%67.4%
59.12%1376.091811,82360.3%58.2%
46.67%1356.080513,26436.4%53.8%
31.34%1345.556510,41421.4%38.5%
45.08%1226.281212,58444.4%45.8%
42.02%1196.084812,89935.3%47.1%
40.71%1136.384313,35245.5%37.7%
49.54%1096.387912,55455.8%43.9%
57.14%1056.183812,22757.1%57.1%
47.52%1015.992311,20553.1%42.3%
58.62%876.172810,51751.2%65.2%
54.02%876.51,11012,89542.1%63.3%
46.34%825.688511,27345.0%47.6%
48.72%786.11,30512,21745.5%51.1%
51.35%746.079811,63060.0%45.5%
54.29%705.71,11912,77750.0%56.5%
43.48%696.193512,09237.5%46.7%
50.00%686.496012,25767.7%35.1%
58.82%686.985811,92157.6%60.0%
52.31%656.691911,61948.4%55.9%
51.72%586.31,00412,69160.9%45.7%
47.17%536.482911,66048.4%45.5%
48.08%526.277812,96940.9%53.3%
65.38%526.190112,18565.2%65.5%
50.00%526.299612,61152.9%48.6%
49.02%516.089111,77545.5%51.7%
52.94%515.878913,08645.0%58.1%
52.00%506.11,03113,73050.0%53.6%
58.33%485.975411,85658.8%58.1%
52.08%486.21,07512,35247.4%55.2%
58.70%466.492212,82560.9%56.5%
45.65%466.187812,27036.0%57.1%
59.09%445.988513,40042.1%72.0%
65.91%446.588712,62471.4%60.9%
41.86%435.976712,17650.0%37.9%
50.00%425.681411,71250.0%50.0%
65.85%414.788011,77569.6%61.1%
60.00%406.297511,57856.3%62.5%
48.72%395.582212,49557.1%44.0%
55.26%386.385312,78562.5%50.0%
50.00%386.586012,42650.0%50.0%
50.00%366.085410,98050.0%50.0%
62.86%356.395612,63158.3%65.2%
45.71%355.678510,66629.4%61.1%
68.57%355.971011,76068.8%68.4%
45.45%334.982512,05018.2%59.1%
51.61%316.384413,16546.1%55.6%
54.84%316.479312,36658.3%52.6%
56.67%306.492610,44042.1%81.8%
60.00%306.082813,52050.0%63.6%
37.93%296.297813,97050.0%33.3%
53.57%285.185912,05146.1%60.0%
50.00%286.387512,48542.9%57.1%
35.71%286.173810,27726.7%46.1%
51.85%275.985614,50250.0%52.6%
37.04%276.591710,35928.6%46.1%
48.15%275.676812,78136.4%56.3%
50.00%264.770511,60150.0%50.0%
34.62%265.986911,15830.8%38.5%
46.15%266.188412,59760.0%42.9%
44.00%255.46408,87031.3%66.7%
68.00%256.588012,13066.7%68.8%
45.83%245.873110,71650.0%41.7%
52.17%236.184913,28733.3%64.3%
39.13%236.090710,46630.8%50.0%
30.43%235.872811,24718.2%41.7%
57.14%216.287513,99137.5%69.2%
57.14%213.496513,01458.3%55.6%
60.00%206.31,04112,75760.0%60.0%
35.29%175.973211,73928.6%40.0%
56.25%166.081713,55725.0%66.7%
62.50%164.81,11613,76050.0%75.0%
53.33%156.099014,4700.0%72.7%
60.00%156.098911,79762.5%57.1%
33.33%156.483412,17566.7%11.1%
42.86%146.166210,38250.0%33.3%
57.14%146.895614,50483.3%37.5%
42.86%144.975114,0450.0%46.1%
50.00%146.51,11113,81366.7%37.5%
50.00%145.81,02411,71466.7%45.5%
38.46%134.063411,63550.0%33.3%
53.85%136.085511,23837.5%80.0%
50.00%126.470210,98140.0%57.1%
33.33%126.386213,28920.0%42.9%
66.67%122.484313,17450.0%75.0%
41.67%123.980212,00340.0%42.9%
54.55%112.083310,53842.9%75.0%
45.45%114.874010,87828.6%75.0%
54.55%115.097314,27966.7%50.0%
36.36%116.693310,38360.0%16.7%
54.55%115.51,10012,54325.0%71.4%
70.00%105.690313,78850.0%83.3%
50.00%102.874712,54320.0%80.0%
77.78%97.01,05114,103100.0%60.0%
55.56%94.31,00013,94133.3%66.7%
44.44%92.988115,885100.0%37.5%
55.56%93.585112,68933.3%66.7%
62.50%81.777112,33966.7%60.0%
50.00%85.477711,605100.0%20.0%
37.50%82.073912,73325.0%50.0%
57.14%72.25918,26750.0%66.7%
28.57%75.769712,250100.0%16.7%
57.14%71.065913,56650.0%66.7%
57.14%72.41,29615,60766.7%50.0%
50.00%64.399614,68650.0%50.0%
16.67%66.87488,36520.0%0.0%
50.00%63.21,12817,178100.0%40.0%
33.33%66.28279,58025.0%50.0%
60.00%56.163311,23366.7%50.0%
80.00%55.11,03613,35450.0%100.0%
20.00%57.179310,59033.3%0.0%
80.00%54.783512,087100.0%66.7%
60.00%53.885011,66050.0%66.7%
80.00%52.41,03614,100100.0%75.0%

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Vayne vs Nautilus - Frequently Asked Questions

How does Vayne do against Nautilus in League of Legends?

Vayne wins the Vayne vs Nautilus matchup with a 60.0% win rate compared to Nautilus's 40.0%, a 20.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.10.

How does Vayne do against Nautilus in the early game?

In the early game, Vayne has the advantage against Nautilus with a 50.0% win rate versus 50.0%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Nautilus in the late game?

In the late game, Vayne takes over the Vayne vs Nautilus matchup with a 66.7% win rate compared to 33.3%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Nautilus matchup?

Vayne wins the matchup against Nautilus with a 60.0% win rate in League of Legends patch 26.10. The 20.0 percentage point advantage means Vayne is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Vayne build against Nautilus?

The best Vayne build against Nautilus includes Experimental Hexplate, Lord Dominik's Regards, Fiendhunter Bolts with Gluttonous Greaves. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Nautilus?

The best Vayne runes against Nautilus use the Domination primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Nautilus matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Nautilus?

Yes, Vayne has a favorable matchup against Nautilus with a 60.0% win rate. Vayne strongly counters Nautilus in lane based on current patch 26.10 data.

How do I play Vayne against Nautilus?

When playing Vayne against Nautilus, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.