Nautilus - League of Legends Champion
Win Rate
48.9%
Pick Rate
4.9%

Nautilusvs Lissandra

DTankSupport
Patch26.4
Matches1,089,240
LaneAll Lanes
TierAll Tiers
Last UpdatedMar 5, 2026
MethodologyData Methodology

Nautilus vs Lissandra is a decisive matchup in LoL patch 26.4. Nautilus wins with a 75.0% win rate (+50.0%) over Lissandra based on 5 games. Nautilus holds the advantage in both the early and late game. Below you'll find the best Nautilus build, runes, laning stats, and strategies for the Nautilus vs Lissandra matchup.

Nautilus Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Nautilus performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 75.0% win rateLissandra(75.0%)
Nautilus - 75.0% win rate in this matchup
Nautilus
75.0% WR
VS
Lissandra vs Nautilus matchup - 25.0% win rate
Lissandra
25.0% WR

Who Wins the Nautilus vs Lissandra Matchup?

Nautilus wins the Nautilus vs Lissandra matchup
Winner
Nautilus
Matches: 5
75.0%
Win Rate
25.0%
0.9
CS / min
1.9
452
DMG / min
631
12,086
Gold / game
11,367
207
Heal / min
85
1,816
DMG Mitigated / min
543
2.5
CC / min
2.0
0.0%
Early Game WR
0.0%
75.0%
Late Game WR
25.0%

Nautilus vs Lissandra Matchup Summary

The Nautilus vs Lissandra matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Nautilus wins with a 75.0% win rate compared to Lissandra's 25.0%, giving Nautilus a 50.0 percentage point advantage. Nautilus dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Lissandra players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Nautilus leads by 1,395 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Nautilus players can confidently pick into Lissandra and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Lissandra away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Nautilus vs Lissandra Laning Phase Breakdown

Nautilus wins the laning phase against Lissandra in League of Legends

Nautilus is favored during the laning phase against Lissandra, winning 3 out of 5 key stat categories. Nautilus holds advantages in gold income, crowd control and sustain, making them the stronger laner in this matchup.

Farming
0.9Nautilus
1.9Lissandra
Lissandra significantly out-farms Nautilus by 1.0 CS per minute, accumulating an estimated 15 CS lead by mid game. This substantial farming gap gives Lissandra a major gold advantage and earlier item completions. Nautilus players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
452Nautilus
631Lissandra
Lissandra heavily out-damages Nautilus by 180 DMG/min, dominating both short trades and all-in fights. Nautilus should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Lissandra's sustained damage advantage take over.
Economy
12,086Nautilus
11,367Lissandra
Nautilus earns 719 more gold per game than Lissandra, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Nautilus slightly faster item completions.
Utility
2.5Nautilus
2.0Lissandra
Nautilus provides 0.5 seconds more crowd control per minute than Lissandra, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Nautilus coordinate with their jungler and control the pace of skirmishes.
Sustain
2,023Nautilus
628Lissandra
Nautilus vastly out-sustains Lissandra, healing and mitigating 1,395 more damage per minute. This massive durability gap means Nautilus can absorb significant punishment and remain in lane while Lissandra is forced to recall. Building grievous wounds early is essential for Lissandra, and focusing on burst trade patterns rather than sustained fights is critical.

Best Nautilus Build Against Lissandra

Plated Steelcaps is the optimal boots choice against Lissandra, providing the mobility and stats Nautilus needs most in this matchup. The top-performing core items for Nautilus against Lissandra are Locket of the Iron Solari, Randuin's Omen and Bandlepipes. This combination gives Nautilus an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Nautilus vs Lissandra matchup.

Early Game vs Late Game

Early Game
Nautilus
0.0%
+0.0% advantage
Nautilus early game win rateNautilus0.0%
Lissandra early game win rateLissandra0.0%
Late Game
Nautilus
75.0%
+50.0% advantage
Nautilus late game win rateNautilus75.0%
Lissandra late game win rateLissandra25.0%

The early game (first 15 minutes) is a toss-up between Nautilus and Lissandra, with Nautilus holding a razor-thin 0.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Nautilus is far superior in the late game (25+ minutes), boasting a 75.0% win rate — 50.0 points above Lissandra. Extended games heavily favor Nautilus, whose kit and scaling make them a dominant force in team fights and objective control.

Nautilus holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Lissandra players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Nautilus Runes Against Lissandra

Resolve rune tree - Nautilus primary runes vs LissandraResolve
Aftershock - best Nautilus rune vs LissandraShield Bash - best Nautilus rune vs LissandraConditioning - best Nautilus rune vs LissandraRevitalize - best Nautilus rune vs Lissandra
Precision rune tree - Nautilus secondary runes vs LissandraPrecision
Legend: Haste - best Nautilus rune vs LissandraTriumph - best Nautilus rune vs Lissandra
100.0% WR

Running Resolve primary with Precision secondary allows Nautilus to press their advantage against Lissandra, amplifying the strengths that make this a favorable matchup.


Nautilus matchup data for League of Legends patch 26.4. The table below shows Nautilus's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Nautilus build, runes, laning stats, and early vs late game analysis for that specific matchup.

Nautilus matchup win rates and stats in League of Legends patch 26.4
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
49.24%6591.03578,40249.6%48.9%
48.66%6361.13618,74745.3%51.9%
47.77%5171.13728,70543.2%52.3%
49.61%5111.13528,96441.3%56.2%
45.78%4521.13498,85844.7%46.5%
43.01%3891.13518,40041.8%44.4%
45.12%3811.13558,67643.9%46.1%
48.08%3691.13638,49450.3%46.0%
56.06%3311.03858,85854.9%57.1%
55.56%2891.13568,34752.8%58.9%
57.54%2871.13228,59360.3%54.7%
45.25%2631.13788,22442.3%48.8%
50.19%2631.13388,49348.5%51.9%
50.97%2611.13849,08950.4%51.5%
46.67%2581.13919,06344.5%48.0%
51.57%2541.13398,59550.7%52.5%
52.63%2511.13948,91452.5%52.7%
52.50%2421.03918,74853.7%51.3%
52.04%2231.13889,03049.1%54.8%
47.93%2171.14178,75944.3%51.4%
51.21%2091.14339,02847.4%54.5%
48.08%2081.13538,93944.1%51.3%
50.97%2071.13958,65047.3%55.2%
49.21%1911.13448,46352.1%46.4%
42.11%1721.13668,37345.6%38.3%
50.60%1671.14228,94654.0%47.8%
58.23%1591.24049,45756.1%59.8%
50.39%1271.23838,37453.7%46.7%
46.03%1261.13488,77439.6%50.7%
42.86%1191.13938,58041.3%44.6%
40.17%1181.13548,30142.4%37.9%
54.95%1111.14179,61752.4%56.5%
45.05%1111.03888,62851.7%37.7%
55.10%981.13759,12746.5%61.8%
53.49%871.03608,74347.2%58.0%
45.59%681.44339,39944.8%46.1%
40.00%651.23899,62832.1%46.0%
52.46%611.64238,67343.3%61.3%
60.00%511.03939,83358.8%60.6%
54.55%441.64109,65957.9%52.0%
51.28%401.13418,79733.3%66.7%
56.41%391.23719,17669.2%50.0%
55.26%381.23929,74266.7%50.0%
58.33%371.14339,21370.6%47.4%
48.48%331.13768,83164.7%31.3%
44.83%301.44519,47738.5%50.0%
36.67%301.13809,03230.8%41.2%
64.00%251.13468,39666.7%61.5%
37.50%241.54348,75527.3%46.1%
43.48%231.74638,83536.4%50.0%
45.45%222.34809,41014.3%60.0%
42.86%211.33459,08933.3%50.0%
57.89%191.64609,71360.0%57.1%
66.67%181.34399,54050.0%80.0%
50.00%181.14889,63436.4%71.4%
35.29%171.14728,89333.3%37.5%
35.29%171.84309,43733.3%37.5%
47.06%172.86429,89555.6%37.5%
52.94%172.24469,67750.0%54.5%
50.00%160.93888,58644.4%57.1%
62.50%161.84719,33183.3%50.0%
33.33%154.575310,55340.0%30.0%
46.67%154.354910,16240.0%60.0%
23.08%132.86078,98425.0%20.0%
46.15%131.34499,30975.0%0.0%
53.85%131.24199,84875.0%44.4%
38.46%130.94217,75737.5%40.0%
38.46%131.14629,57828.6%50.0%
50.00%121.853110,16825.0%62.5%
41.67%122.86279,23628.6%60.0%
25.00%124.35238,72522.2%33.3%
58.33%121.14377,75450.0%75.0%
50.00%121.447210,18728.6%80.0%
54.55%111.13939,16680.0%33.3%
63.64%111.24488,40660.0%66.7%
45.45%113.358310,0160.0%71.4%
36.36%111.34049,0900.0%66.7%
30.00%101.652210,68660.0%0.0%
70.00%101.44307,71971.4%66.7%
50.00%100.963711,61220.0%80.0%
60.00%101.43748,561100.0%42.9%
50.00%101.162711,92875.0%33.3%
20.00%101.159110,99425.0%16.7%
22.22%91.751110,97950.0%14.3%
66.67%91.457011,92966.7%66.7%
37.50%82.54938,76333.3%50.0%
37.50%82.258611,5320.0%60.0%
50.00%81.93978,41350.0%50.0%
50.00%83.651811,95150.0%50.0%
25.00%82.550910,2550.0%28.6%
42.86%72.453511,16133.3%50.0%
85.71%71.264711,099100.0%83.3%
57.14%74.552010,10425.0%100.0%
42.86%73.54829,61733.3%50.0%
57.14%73.04248,43140.0%100.0%
42.86%71.14257,39025.0%66.7%
42.86%71.14228,66725.0%66.7%
85.71%71.445910,403100.0%80.0%
50.00%71.93968,92250.0%50.0%
28.57%73.04348,35620.0%50.0%
42.86%72.24319,81433.3%50.0%
50.00%62.63907,55160.0%0.0%
66.67%63.448810,935100.0%50.0%
66.67%61.95209,15050.0%100.0%
33.33%62.33887,96025.0%50.0%
33.33%61.858912,221100.0%20.0%
50.00%60.83049,91350.0%50.0%
66.67%61.452110,91350.0%75.0%
83.33%61.56139,47666.7%100.0%
50.00%62.35367,12450.0%50.0%
33.33%62.25259,64733.3%33.3%
75.00%50.945212,0860.0%75.0%
60.00%56.972311,91475.0%0.0%
0.00%51.93888,8850.0%0.0%
60.00%51.051811,63566.7%50.0%
20.00%55.076110,24950.0%0.0%
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Nautilus vs Lissandra - Frequently Asked Questions

How does Nautilus do against Lissandra in League of Legends?

Nautilus wins the Nautilus vs Lissandra matchup with a 75.0% win rate compared to Lissandra's 25.0%, a 50.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.4.

How does Nautilus do against Lissandra in the early game?

In the early game, Nautilus has the advantage against Lissandra with a 0.0% win rate versus 0.0%. Nautilus players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Nautilus do against Lissandra in the late game?

In the late game, Nautilus takes over the Nautilus vs Lissandra matchup with a 75.0% win rate compared to 25.0%. Nautilus scales better into team fights and objective contests after 25 minutes.

Who wins the Nautilus vs Lissandra matchup?

Nautilus wins the matchup against Lissandra with a 75.0% win rate in League of Legends patch 26.4. The 50.0 percentage point advantage means Nautilus is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Nautilus build against Lissandra?

The best Nautilus build against Lissandra includes Locket of the Iron Solari, Randuin's Omen, Bandlepipes with Plated Steelcaps. Check the matchup breakdown above for the full item path and build order.

What are the best Nautilus runes against Lissandra?

The best Nautilus runes against Lissandra use the Resolve primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Nautilus vs Lissandra matchup. See the full rune breakdown in the matchup comparison above.

Does Nautilus counter Lissandra?

Yes, Nautilus has a favorable matchup against Lissandra with a 75.0% win rate. Nautilus strongly counters Lissandra in lane based on current patch 26.4 data.

How do I play Nautilus against Lissandra?

When playing Nautilus against Lissandra, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.