Alignment•Skill

Is Alignment good in Slay the Spire 2?

In Slay the Spire 2, Alignment is an uncommon skill from the Regent card pool. Its effect: Gain Energy. Right now it’s a premium pick that sits at B tier — one of the better cards you can add to a deck this run.

Over 21 tracked runs its win rate sits at 28.6%, 15.9% ahead of the 12.6% all-deck baseline. It sees niche play, included in only 4.0% of eligible runs. Within Regent runs it’s drafted 12.7% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.1 copies on average.

Its standout pairing so far is Glow, which lifts its win rate by +51.4% when the two share a deck. On the relic side, Red Mask is its standout companion, worth a +71.4% win-rate swing alongside it. It costs 0 energy, gets upgraded 27.3% of the time, and tends to be picked up near floor 13.

Upgrading the card adds +1 Energy to its stat line. Of the runs that drafted it, 6 ended in victory against 15 deaths and 0 abandons. Its most common run-ender is Vantom Boss, finishing 9.5% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Alignment fits a Regent deck.

Best Cards to Pair with Alignment

Alignment’s strongest card pairings so far are Glow (+51.4%), Stardust (+51.4%), and Gamma Blast (+38.1%), each shown with the win-rate lift it adds.

Glow+51.4%5 runsStardust+51.4%5 runsGamma Blast+38.1%3 runsChild of the Stars+38.1%6 runsClumsy+38.1%3 runsReflect+38.1%6 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Alignment Win Rate by Class

Exclusive to the Regent, Alignment posts a 28.6% win rate over 21 tracked runs.

The Regentappears in 12.7% of its runs (21 tracked)

Best Relics for Alignment

The relics that swing Alignment’s win rate the most are Red Mask (+71.4%), Anchor (+71.4%), and War Paint (+51.4%), with each lift shown.

Red Mask+71.4%3 runsAnchor+71.4%3 runsWar Paint+51.4%5 runsPendulum+46.4%4 runsBag of Marbles+46.4%4 runsChandelier+38.1%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Alignment Card Details

A 0-energy uncommon skill, Alignment is upgraded 27.3% of the time and tends to enter the deck around floor 13.

Gain Energy.

Upgrade: +1 Energy

What Ends Runs with Alignment

Runs holding Alignment end most often against Vantom Boss (9.5%) and Entomancer Elite (9.5%) — the share of its runs each accounts for is shown.

• Vantom Boss9.5% of runs
• Entomancer Elite9.5% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.