Cosmic Indifference•Skill

Is Cosmic Indifference good in Slay the Spire 2?

In Slay the Spire 2, Cosmic Indifference is a common skill from the Regent card pool. Its effect: Gain 6 Block. Put a card from your Discard Pile on top of your Draw Pile. Right now it’s a premium pick that sits at B tier — one of the better cards you can add to a deck this run.

Over 98 tracked runs its win rate sits at 38.9%, 19.9% ahead of the 18.9% all-deck baseline. It sees niche play, included in only 2.6% of eligible runs. Within Ironclad runs it’s drafted 0.1% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.2 copies on average.

Its standout pairing so far is Mad Science, which lifts its win rate by +27.3% when the two share a deck. On the relic side, Venerable Tea Set is its standout companion, worth a +28.6% win-rate swing alongside it. It costs 1 energy, gets upgraded 26.1% of the time, and tends to be picked up near floor 15.

Upgrading the card adds +3 Block to its stat line. Of the runs that drafted it, 35 ended in victory against 55 deaths and 8 abandons. Its most common run-ender is Decimillipede Elite, finishing 5.1% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Cosmic Indifference fits a Regent deck.

Best Cards to Pair with Cosmic Indifference

Cosmic Indifference’s strongest card pairings so far are Mad Science (+27.3%), Bulwark (+25.8%), and Photon Cut (+18.4%), each shown with the win-rate lift it adds.

Mad Science+27.3%11 runsBulwark+25.8%14 runsPhoton Cut+18.4%10 runsAlignment+18.4%17 runsMeteor Shower+17.5%4 runsRoyal Gamble+15.6%21 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Cosmic Indifference Win Rate by Class

Of the 4 classes that draft Cosmic Indifference, it performs best with Ironclad (100.0%), Silent (100.0%), and Regent (38.4%).

The Ironclad100.0%1 runsThe Silent100.0%1 runsThe Regent38.4%94 runsThe Defect0.0%2 runs

Best Relics for Cosmic Indifference

The relics that swing Cosmic Indifference’s win rate the most are Venerable Tea Set (+28.6%), Permafrost (+27.2%), and Bronze Scales (+23.1%), with each lift shown.

Venerable Tea Set+28.6%18 runsPermafrost+27.2%8 runsBronze Scales+23.1%14 runsLetter Opener+21.6%8 runsWar Paint+21.6%9 runsBag of Preparation+21.5%13 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Cosmic Indifference Card Details

A 1-energy common skill, Cosmic Indifference is upgraded 26.1% of the time and tends to enter the deck around floor 15.

Gain 6 Block. Put a card from your Discard Pile on top of your Draw Pile.

Upgrade: +3 Block

What Ends Runs with Cosmic Indifference

Runs holding Cosmic Indifference end most often against Decimillipede Elite (5.1%), Skulking Colony Elite (5.1%), and Soul Fysh Boss (4.1%) — the share of its runs each accounts for is shown.

• Decimillipede Elite5.1% of runs
• Skulking Colony Elite5.1% of runs
• Soul Fysh Boss4.1% of runs
• The Insatiable Boss4.1% of runs
• Knowledge Demon Boss4.1% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.