Cosmic Indifference Skill

Is Cosmic Indifference good in Slay the Spire 2?

In Slay the Spire 2, Cosmic Indifference is a common skill from the Regent card pool. Its effect: Gain 6 Block. Put a card from your Discard Pile on top of your Draw Pile. Performance-wise it’s a solid if unspectacular include, rated C tier overall.

Over 689 tracked runs its win rate sits at 31.1%, 17.2% ahead of the 13.8% all-deck baseline. It sees niche play, included in only 3.3% of eligible runs. When it is actually offered players take it 18.5% of the time, and that looks correct: those runs win 31.0% against 22.1% for runs that passed, a +8.8% pick lift over 577 decided runs. Within Regent runs it’s drafted 20.1% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.2 copies on average.

Its standout pairing so far is Mad Science, which lifts its win rate by +30.2% when the two share a deck. On the relic side, Jeweled Mask is its standout companion, worth a +30.9% win-rate swing alongside it. It costs 1 energy, gets upgraded 23.9% of the time, and tends to be picked up near floor 14.

Upgrading the card adds +3 Block to its stat line. Of the runs that drafted it, 213 ended in victory against 473 deaths and 3 abandons. Its most common run-ender is Aeonglass Boss, finishing 4.4% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Cosmic Indifference fits a Regent deck.

Pick or Skip: Cosmic Indifference

Players take Cosmic Indifference in 18.5% of the 3532 offers it appears in; those runs win 31.0% against 22.1% for runs that passed, a pick lift of +8.8% over 577 decided runs.

Taken 655 times out of 3532 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up Cosmic Indifference

Of the 4 pickup windows recorded for Cosmic Indifference, Act 3 is the best: 60.9% across 69 runs.

Win rate of runs by the act Cosmic Indifference entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Cosmic Indifference

Cosmic Indifference’s strongest card pairings so far are Mad Science (+30.2%), Sword Sage (+21.3%), and Hammer Time (+19.3%), each shown with the win-rate lift it adds.

Mad Science+30.2%62 runsSword Sage+21.3%80 runsHammer Time+19.3%24 runsLunar Blast+19.2%28 runsBundle of Joy+19.2%40 runsDying Star+18.6%89 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Cosmic Indifference Win Rate by Class

Exclusive to the Regent, Cosmic Indifference posts a 31.2% win rate over 661 tracked runs.

The Regentappears in 20.1% of its runs (661 tracked)

Best Relics for Cosmic Indifference

The relics that swing Cosmic Indifference’s win rate the most are Jeweled Mask (+30.9%), Tri-Boomerang (+29.4%), and Precise Scissors (+28.6%), with each lift shown.

Jeweled Mask+30.9%16 runsTri-Boomerang+29.4%15 runsPrecise Scissors+28.6%17 runsThe Courier+27.9%19 runsCaptain's Wheel+27.1%29 runsDolly's Mirror+26.8%23 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Cosmic Indifference Card Details

A 1-energy common skill, Cosmic Indifference is upgraded 23.9% of the time and tends to enter the deck around floor 14.

Gain 6 Block. Put a card from your Discard Pile on top of your Draw Pile.

Upgrade: +3 Block

What Ends Runs with Cosmic Indifference

Runs holding Cosmic Indifference end most often against Aeonglass Boss (4.4%), Decimillipede Elite (4.2%), and Infested Prisms Elite (4.1%) — the share of its runs each accounts for is shown.

• Aeonglass Boss4.4% of runs
• Decimillipede Elite4.2% of runs
• Infested Prisms Elite4.1% of runs
• The Insatiable Boss4.1% of runs
• Test Subject Boss3.9% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.