Cosmic Indifference•Skill

Is Cosmic Indifference good in Slay the Spire 2?

In Slay the Spire 2, Cosmic Indifference is a common skill from the Regent card pool. Its effect: Gain 6 Block. Put a card from your Discard Pile on top of your Draw Pile. Right now it’s a premium pick that sits at B tier — one of the better cards you can add to a deck this run.

Over 12 tracked runs its win rate sits at 25.0%, 12.4% ahead of the 12.6% all-deck baseline. It sees niche play, included in only 2.3% of eligible runs. Within Regent runs it’s drafted 7.2% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.3 copies on average.

Its standout pairing so far is Mad Science, which lifts its win rate by +75.0% when the two share a deck. On the relic side, Red Mask is its standout companion, worth a +41.7% win-rate swing alongside it. It costs 1 energy, gets upgraded 40.0% of the time, and tends to be picked up near floor 14.

Upgrading the card adds +3 Block to its stat line. Of the runs that drafted it, 3 ended in victory against 9 deaths and 0 abandons. Its most common run-ender is Skulking Colony Elite, finishing 16.7% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Cosmic Indifference fits a Regent deck.

Best Cards to Pair with Cosmic Indifference

Cosmic Indifference’s strongest card pairings so far are Mad Science (+75.0%), Glow (+75.0%), and Refine Blade (+41.7%), each shown with the win-rate lift it adds.

Mad Science+75.0%3 runsGlow+75.0%3 runsRefine Blade+41.7%3 runsParticle Wall+41.7%3 runsOrbit+41.7%3 runsRoyal Gamble+41.7%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Cosmic Indifference Win Rate by Class

Exclusive to the Regent, Cosmic Indifference posts a 25.0% win rate over 12 tracked runs.

The Regentappears in 7.2% of its runs (12 tracked)

Best Relics for Cosmic Indifference

The relics that swing Cosmic Indifference’s win rate the most are Red Mask (+41.7%), Happy Flower (+41.7%), and Horn Cleat (+8.3%), with each lift shown.

Red Mask+41.7%3 runsHappy Flower+41.7%3 runsHorn Cleat+8.3%3 runsAmethyst Aubergine+8.3%3 runsLantern+8.3%3 runsDivine Right-6.8%11 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Cosmic Indifference Card Details

A 1-energy common skill, Cosmic Indifference is upgraded 40.0% of the time and tends to enter the deck around floor 14.

Gain 6 Block. Put a card from your Discard Pile on top of your Draw Pile.

Upgrade: +3 Block

What Ends Runs with Cosmic Indifference

Runs holding Cosmic Indifference end most often against Skulking Colony Elite (16.7%) — the share of its runs each accounts for is shown.

• Skulking Colony Elite16.7% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.