Mad Science Attack

Is Mad Science good in Slay the Spire 2?

In Slay the Spire 2, Mad Science is an event attack from the Event card pool. Its effect: Skill|Power):Deal 12 damage|Skill|Power): ???| ???|???} Right now it’s a premium pick that sits at B tier — one of the better cards you can add to a deck this run.

Over 632 tracked runs its win rate sits at 54.7%, 41.2% ahead of the 13.5% all-deck baseline. It sees niche play, included in only 3.8% of eligible runs. Within Regent runs it’s drafted 4.2% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.1 copies on average.

Its standout pairing so far is Quasar, which lifts its win rate by +24.3% when the two share a deck. On the relic side, Astrolabe is its standout companion, worth a +21.1% win-rate swing alongside it. It costs 1 energy, gets upgraded 30.1% of the time, and tends to be picked up near floor 39.

Of the runs that drafted it, 345 ended in victory against 286 deaths and 1 abandons. Its most common run-ender is Test Subject Boss, finishing 13.1% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Mad Science fits a Event deck.

When to Pick Up Mad Science

Of the 1 pickup windows recorded for Mad Science, Act 3 is the best: 54.7% across 632 runs.

Win rate of runs by the act Mad Science entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Mad Science

Mad Science’s strongest card pairings so far are Quasar (+24.3%), Stoke (+20.2%), and Reflex (+17.3%), each shown with the win-rate lift it adds.

Quasar+24.3%21 runsStoke+20.2%16 runsReflex+17.3%24 runsKnife Trap+16.9%27 runsBlur+16.4%23 runsArsenal+16.4%16 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Mad Science Win Rate by Class

Of the 5 classes that draft Mad Science, it performs best with Regent (61.0%), Silent (59.4%), and Necrobinder (57.3%).

The Regent61.0%105 runsThe Silent59.4%155 runsThe Necrobinder57.3%104 runsThe Ironclad52.0%146 runsThe Defect42.5%113 runs

Best Relics for Mad Science

The relics that swing Mad Science’s win rate the most are Astrolabe (+21.1%), Ice Cream (+20.3%), and Kunai (+18.8%), with each lift shown.

Astrolabe+21.1%17 runsIce Cream+20.3%36 runsKunai+18.8%26 runsShovel+18.1%25 runsMummified Hand+18.1%36 runsToxic Egg+17.6%28 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Mad Science Card Details

A 1-energy event attack, Mad Science is upgraded 30.1% of the time and tends to enter the deck around floor 39.

Skill|Power):Deal 12 damage|Skill|Power): ???| ???|???}

What Ends Runs with Mad Science

Runs holding Mad Science end most often against Test Subject Boss (13.1%), Queen Boss (13.0%), and Aeonglass Boss (10.0%) — the share of its runs each accounts for is shown.

• Test Subject Boss13.1% of runs
• Queen Boss13.0% of runs
• Aeonglass Boss10.0% of runs
• Knights Elite1.4% of runs
• Fabricator Normal1.4% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.