Mad Science•Attack

Is Mad Science good in Slay the Spire 2?

In Slay the Spire 2, Mad Science is an event attack from the Event card pool. Its effect: Skill|Power):Deal 12 damage|Skill|Power): ???| ???|???} Right now it’s a premium pick that sits at S tier — one of the better cards you can add to a deck this run.

Over 14 tracked runs its win rate sits at 64.3%, 51.7% ahead of the 12.6% all-deck baseline. It sees niche play, included in only 2.7% of eligible runs. Within Regent runs it’s drafted 3.6% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.1 copies on average.

Its standout pairing so far is Child of the Stars, which lifts its win rate by +35.7% when the two share a deck. On the relic side, Mercury Hourglass is its standout companion, worth a +35.7% win-rate swing alongside it. It costs 1 energy, gets upgraded 33.3% of the time, and tends to be picked up near floor 40.

Of the runs that drafted it, 9 ended in victory against 5 deaths and 0 abandons. Its most common run-ender is Queen Boss, finishing 14.3% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Mad Science fits a Event deck.

Best Cards to Pair with Mad Science

Mad Science’s strongest card pairings so far are Child of the Stars (+35.7%), Devastate (+35.7%), and Cosmic Indifference (+35.7%), each shown with the win-rate lift it adds.

Child of the Stars+35.7%4 runsDevastate+35.7%3 runsCosmic Indifference+35.7%3 runsCrescent Spear+35.7%3 runsDefend+35.7%6 runsFalling Star+35.7%5 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Mad Science Win Rate by Class

Of the 5 classes that draft Mad Science, it performs best with Regent (100.0%), Ironclad (100.0%), and Silent (100.0%).

The Regent100.0%6 runsThe Ironclad100.0%1 runsThe Silent100.0%1 runsThe Necrobinder50.0%2 runsThe Defect0.0%4 runs

Best Relics for Mad Science

The relics that swing Mad Science’s win rate the most are Mercury Hourglass (+35.7%), Pendulum (+35.7%), and Divine Right (+35.7%), with each lift shown.

Mercury Hourglass+35.7%3 runsPendulum+35.7%5 runsDivine Right+35.7%5 runsIce Cream+35.7%3 runsHappy Flower+19.0%6 runsRegal Pillow+15.7%5 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Mad Science Card Details

A 1-energy event attack, Mad Science is upgraded 33.3% of the time and tends to enter the deck around floor 40.

Skill|Power):Deal 12 damage|Skill|Power): ???| ???|???}

What Ends Runs with Mad Science

Runs holding Mad Science end most often against Queen Boss (14.3%) — the share of its runs each accounts for is shown.

• Queen Boss14.3% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.