Is Mad Science good in Slay the Spire 2?

In Slay the Spire 2, Mad Science is an event attack from the Event card pool. Its effect: Skill|Power):Deal 12 damage|Skill|Power): ???| ???|???} Right now it’s a premium pick that sits at S tier — one of the better cards you can add to a deck this run.

Over 330 tracked runs its win rate sits at 53.2%, 39.5% ahead of the 13.7% all-deck baseline. It sees niche play, included in only 3.8% of eligible runs. Within Silent runs it’s drafted 3.1% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.0 copies on average.

Its standout pairing so far is Adrenaline, which lifts its win rate by +17.3% when the two share a deck. On the relic side, Ice Cream is its standout companion, worth a +16.9% win-rate swing alongside it. It costs 1 energy, gets upgraded 31.1% of the time, and tends to be picked up near floor 39.

Of the runs that drafted it, 175 ended in victory against 154 deaths and 1 abandons. Its most common run-ender is Test Subject Boss, finishing 14.8% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Mad Science fits a Event deck.

When to Pick Up Mad Science

Of the 1 pickup windows recorded for Mad Science, Act 3 is the best: 53.2% across 330 runs.

Win rate of runs by the act Mad Science entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Mad Science

Mad Science’s strongest card pairings so far are Adrenaline (+17.3%), Knife Trap (+17.3%), and Crush Under (+16.1%), each shown with the win-rate lift it adds.

Adrenaline+17.3%16 runsKnife Trap+17.3%16 runsCrush Under+16.1%15 runsFinisher

Mad Science Win Rate by Class

Of the 5 classes that draft Mad Science, it performs best with Silent (63.4%), Regent (59.3%), and Necrobinder (56.4%).

The Silent63.4%71 runsThe Regent59.3%54 runsThe Necrobinder56.4%56 runsThe Ironclad46.9%81 runs

Best Relics for Mad Science

The relics that swing Mad Science’s win rate the most are Ice Cream (+16.9%), Pael's Blood (+16.1%), and Arcane Scroll (+16.1%), with each lift shown.

Ice Cream+16.9%19 runsPael's Blood+16.1%15 runsArcane Scroll+16.1%28 runsLizard Tail

Mad Science Card Details

A 1-energy event attack, Mad Science is upgraded 31.1% of the time and tends to enter the deck around floor 39.

Skill|Power):Deal 12 damage|Skill|Power): ???| ???|???}

What Ends Runs with Mad Science

Runs holding Mad Science end most often against Test Subject Boss (14.8%), Queen Boss (14.5%), and Aeonglass Boss (7.0%) — the share of its runs each accounts for is shown.

• Test Subject Boss14.8% of runs
• Queen Boss14.5% of runs
• Aeonglass Boss7.0% of runs
• Doormaker Boss2.4% of runs
• Knights Elite1.5% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.