Resonance•Skill

Is Resonance good in Slay the Spire 2?

Resonance is an uncommon Regent skill in Slay the Spire 2. In combat it resolves as: Gain 1 Strength. ALL enemies lose 1 Strength. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 17 recorded runs, decks running it win 17.6% of the time, comfortably clear of the 12.6% average, by 5.0%. It’s a more selective pick, turning up in just 3.3% of decks that could run it. Regent players keep it in 10.2% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.0 times in the decks that take it.

It performs best next to Alignment — together they post a +49.0% swing in win rate. It also has strong chemistry with the relic Bag of Marbles, which moves its win rate by +57.4%. At 1 energy, it’s upgraded in 35.3% of runs and usually joins the deck around floor 13.

That’s 3 wins, 14 deaths, and 0 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is The Insatiable Boss, which closes out 17.6% of its appearances. Read on for Resonance’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Regent run.

Best Cards to Pair with Resonance

Ranked by win-rate lift, Resonance performs best alongside Alignment (+49.0%), Black Hole (+42.4%), and Hidden Cache (+42.4%).

Alignment+49.0%3 runsBlack Hole+42.4%5 runsHidden Cache+42.4%5 runsGamma Blast+32.4%4 runsGlow+32.4%4 runsChild of the Stars+25.2%7 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Resonance Win Rate by Class

Resonance is drafted only by the Regent, where it holds a 17.6% win rate across 17 runs.

The Regentappears in 10.2% of its runs (17 tracked)

Best Relics for Resonance

Resonance pairs best with the relics Bag of Marbles (+57.4%), Leafy Poultice (+15.7%), and Tiny Mailbox (+15.7%), ranked by win-rate lift.

Bag of Marbles+57.4%4 runsLeafy Poultice+15.7%3 runsTiny Mailbox+15.7%3 runsNeow's Bones+15.7%3 runsDivine Right0.0%17 runsScroll Boxes-17.6%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Resonance Card Details

Resonance is an uncommon skill costing 1 energy; it’s upgraded in 35.3% of runs and usually picked up by floor 13.

Gain 1 Strength. ALL enemies lose 1 Strength.

What Ends Runs with Resonance

Resonance’s most common run-enders are The Insatiable Boss (17.6%), Vantom Boss (11.8%), and Terror Eel Elite (11.8%).

• The Insatiable Boss17.6% of runs
• Vantom Boss11.8% of runs
• Terror Eel Elite11.8% of runs

See Also

Compare Resonance with the rest of the best Slay the Spire 2 cards, relics, and classes below.