Resonance•Skill

Is Resonance good in Slay the Spire 2?

Resonance is an uncommon Regent skill in Slay the Spire 2. In combat it resolves as: Gain 1 Strength. ALL enemies lose 1 Strength. It currently underperforms most alternatives, sitting at F tier in our Slay the Spire 2 card rankings.

Across 48 recorded runs, decks running it win 16.7% of the time, trailing the 19.0% average by 2.3%. It’s a more selective pick, turning up in just 1.3% of decks that could run it. Regent players keep it in 7.0% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.0 times in the decks that take it.

It performs best next to Alignment — together they post a +18.8% swing in win rate. It also has strong chemistry with the relic Regal Pillow, which moves its win rate by +21.1%. At 1 energy, it’s upgraded in 16.3% of runs and usually joins the deck around floor 12.

That’s 7 wins, 35 deaths, and 6 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is The Kin Boss, which closes out 12.5% of its appearances. Read on for Resonance’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Regent run.

Best Cards to Pair with Resonance

Ranked by win-rate lift, Resonance performs best alongside Alignment (+18.8%), Child of the Stars (+18.2%), and Knockout Blow (+16.7%).

Alignment+18.8%7 runsChild of the Stars+18.2%13 runsKnockout Blow+16.7%7 runsTyranny+14.4%5 runsComet+14.4%5 runsBlack Hole+13.2%10 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Resonance Win Rate by Class

Resonance is drafted only by the Regent, where it holds a 16.7% win rate across 48 runs.

The Regentappears in 7.0% of its runs (48 tracked)

Best Relics for Resonance

Resonance pairs best with the relics Regal Pillow (+21.1%), Centennial Puzzle (+19.2%), and Bag of Marbles (+18.8%), ranked by win-rate lift.

Regal Pillow+21.1%6 runsCentennial Puzzle+19.2%3 runsBag of Marbles+18.8%6 runsVajra+16.7%4 runsFencing Manual+16.7%4 runsNunchaku+16.7%4 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Resonance Card Details

Resonance is an uncommon skill costing 1 energy; it’s upgraded in 16.3% of runs and usually picked up by floor 12.

Gain 1 Strength. ALL enemies lose 1 Strength.

What Ends Runs with Resonance

Resonance’s most common run-enders are The Kin Boss (12.5%), The Insatiable Boss (8.3%), and Infested Prisms Elite (8.3%).

• The Kin Boss12.5% of runs
• The Insatiable Boss8.3% of runs
• Infested Prisms Elite8.3% of runs
• Knowledge Demon Boss6.3% of runs
• Phrog Parasite Elite4.2% of runs

See Also

Compare Resonance with the rest of the best Slay the Spire 2 cards, relics, and classes below.