Centennial Puzzle Relic

Is Centennial Puzzle good in Slay the Spire 2?

Centennial Puzzle is a common relic in Slay the Spire 2. While carried, it does the following: The first time you lose HP each combat, draw cards. It currently underperforms most relics, sitting at D tier in our Slay the Spire 2 relic rankings.

Across 2010 recorded runs, decks carrying it win 35.9% of the time, comfortably clear of the 13.8% average, by 22.0%. It’s a more situational relic, showing up in just 9.6% of runs. The class that gets the most out of it is the Regent, at a 39.5% win rate. Regent players hold onto it in 9.1% of their runs.

It combos especially well with Anointed, worth a +50.8% win-rate swing together. Another strong card to run with it is Stoke, worth +44.5% to its win rate. On average it’s acquired around floor 21 of a run. Its common rarity shapes how frequently you’ll run into it.

It has 714 run wins against 1276 losses in our tracked data. When runs carrying it end, the most frequent culprit is Test Subject Boss, which closes out 6.8% of them. Read on for Centennial Puzzle’s complete card, class, and threat breakdown before you decide to pick it up.

Pick or Skip: Centennial Puzzle

Out of 3364 recorded offers Centennial Puzzle is taken 60.9% of the time, and taking it is worth +5.7% in pick lift — 36.3% for runs that picked it against 30.5% for runs that skipped, across 2025 decided runs.

Taken 2049 times out of 3364 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

Best Cards with Centennial Puzzle

Ranked by win-rate lift, the best cards to run with Centennial Puzzle are Anointed (+50.8%), Stoke (+44.5%), and Thinking Ahead (+44.1%).

Anointed+50.8%16 runsStoke+44.5%51 runsThinking Ahead+44.1%16 runsEntropy+40.3%22 runsSecret Technique+37.8%20 runsMonarch's Gaze+37.2%26 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Centennial Puzzle Win Rate by Class

Centennial Puzzle shows up across 5 classes, led by Regent (39.5%), Silent (38.6%), and Ironclad (38.4%) by win rate.

The Regent39.5%298 runsThe Silent38.6%460 runsThe Ironclad38.4%507 runsThe Necrobinder36.0%372 runsThe Defect25.1%362 runs

Centennial Puzzle Details

Centennial Puzzle is a common relic carried in 9.6% of runs and usually picked up around floor 21.

The first time you lose HP each combat, draw cards.

What Ends Runs with Centennial Puzzle

Centennial Puzzle’s most common run-enders are Test Subject Boss (6.8%), Queen Boss (6.0%), and Aeonglass Boss (5.3%).

• Test Subject Boss6.8% of runs
• Queen Boss6.0% of runs
• Aeonglass Boss5.3% of runs
• Knowledge Demon Boss4.5% of runs
• Kaiser Crab Boss4.4% of runs

See Also

Compare Centennial Puzzle with the rest of the best Slay the Spire 2 relics, cards, and classes below.