Centennial Puzzle•Relic

Is Centennial Puzzle good in Slay the Spire 2?

Centennial Puzzle is a common relic in Slay the Spire 2. While carried, it does the following: The first time you lose HP each combat, draw cards. It’s a reliable mid-tier relic, landing at C tier in our rankings.

Across 378 recorded runs, decks carrying it win 40.4% of the time, comfortably clear of the 18.9% average, by 21.5%. It’s a more situational relic, showing up in just 10.0% of runs. The class that gets the most out of it is the Silent, at a 48.3% win rate. Silent players hold onto it in 9.9% of their runs.

It combos especially well with Bury, worth a +59.6% win-rate swing together. Another strong card to run with it is Secret Technique, worth +59.6% to its win rate. On average it’s acquired around floor 22 of a run. Its common rarity shapes how frequently you’ll run into it.

It has 139 run wins against 205 losses in our tracked data. When runs carrying it end, the most frequent culprit is Test Subject Boss, which closes out 7.9% of them. Read on for Centennial Puzzle’s complete card, class, and threat breakdown before you decide to pick it up.

Best Cards with Centennial Puzzle

Ranked by win-rate lift, the best cards to run with Centennial Puzzle are Bury (+59.6%), Secret Technique (+59.6%), and Spoils of Battle (+59.6%).

Bury+59.6%3 runsSecret Technique+59.6%4 runsSpoils of Battle+59.6%6 runsResonance+59.6%3 runsBeat Down+59.6%5 runsPact's End+59.6%4 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Centennial Puzzle Win Rate by Class

Centennial Puzzle shows up across 5 classes, led by Silent (48.3%), Regent (42.9%), and Ironclad (40.0%) by win rate.

The Silent48.3%97 runsThe Regent42.9%51 runsThe Ironclad40.0%77 runsThe Necrobinder37.8%87 runsThe Defect30.6%66 runs

Centennial Puzzle Details

Centennial Puzzle is a common relic carried in 10.0% of runs and usually picked up around floor 22.

The first time you lose HP each combat, draw cards.

What Ends Runs with Centennial Puzzle

Centennial Puzzle’s most common run-enders are Test Subject Boss (7.9%), Queen Boss (6.1%), and Kaiser Crab Boss (4.2%).

• Test Subject Boss7.9% of runs
• Queen Boss6.1% of runs
• Kaiser Crab Boss4.2% of runs
• Knowledge Demon Boss3.7% of runs
• Aeonglass Boss3.2% of runs

See Also

Compare Centennial Puzzle with the rest of the best Slay the Spire 2 relics, cards, and classes below.