Knockout Blow•Attack

Is Knockout Blow good in Slay the Spire 2?

In Slay the Spire 2, Knockout Blow is an uncommon attack from the Regent card pool. Its effect: Deal 30 damage. If this kills an enemy, gain Stars. Performance-wise it’s a solid if unspectacular include, rated C tier overall.

Over 5 tracked runs its win rate sits at 20.0%, 7.4% ahead of the 12.6% all-deck baseline. It sees niche play, included in only 1.0% of eligible runs. Within Regent runs it’s drafted 3.0% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.0 copies on average.

Its standout pairing so far is Child of the Stars, which lifts its win rate by +13.3% when the two share a deck. On the relic side, Divine Right is its standout companion, worth a 0.0% win-rate swing alongside it. It costs 3 energy, gets upgraded 40.0% of the time, and tends to be picked up near floor 13.

Upgrading the card adds +8 Damage to its stat line. Of the runs that drafted it, 1 ended in victory against 4 deaths and 0 abandons. See the synergies, class split, and threats below for the full picture of where Knockout Blow fits a Regent deck.

Best Cards to Pair with Knockout Blow

Knockout Blow’s strongest card pairings so far are Child of the Stars (+13.3%), Comet (+13.3%), and Furnace (+13.3%), each shown with the win-rate lift it adds.

Child of the Stars+13.3%3 runsComet+13.3%3 runsFurnace+13.3%3 runsGamma Blast+13.3%3 runsGather Light+13.3%3 runsHidden Cache+13.3%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Knockout Blow Win Rate by Class

Exclusive to the Regent, Knockout Blow posts a 20.0% win rate over 5 tracked runs.

The Regentappears in 3.0% of its runs (5 tracked)

Best Relics for Knockout Blow

The relics that swing Knockout Blow’s win rate the most are Divine Right (0.0%), with each lift shown.

Divine Right0.0%5 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Knockout Blow Card Details

A 3-energy uncommon attack, Knockout Blow is upgraded 40.0% of the time and tends to enter the deck around floor 13.

Deal 30 damage. If this kills an enemy, gain Stars.

Upgrade: +8 Damage

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.