Knockout Blow•Attack

Is Knockout Blow good in Slay the Spire 2?

In Slay the Spire 2, Knockout Blow is an uncommon attack from the Regent card pool. Its effect: Deal 30 damage. If this kills an enemy, gain Stars. The data flags it as a weaker pick, settling at F tier — usually one to pass on unless your deck specifically wants it.

Over 60 tracked runs its win rate sits at 17.4%, 1.6% short of the 18.9% all-deck baseline. It sees niche play, included in only 1.6% of eligible runs. Within Regent runs it’s drafted 8.8% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.2 copies on average.

Its standout pairing so far is Dying Star, which lifts its win rate by +18.5% when the two share a deck. On the relic side, Candelabra is its standout companion, worth a +20.9% win-rate swing alongside it. It costs 3 energy, gets upgraded 28.6% of the time, and tends to be picked up near floor 12.

Upgrading the card adds +8 Damage to its stat line. Of the runs that drafted it, 8 ended in victory against 38 deaths and 14 abandons. Its most common run-ender is Bowlbugs Normal, finishing 6.7% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Knockout Blow fits a Regent deck.

Best Cards to Pair with Knockout Blow

Knockout Blow’s strongest card pairings so far are Dying Star (+18.5%), Resonance (+16.5%), and Stardust (+13.2%), each shown with the win-rate lift it adds.

Dying Star+18.5%6 runsResonance+16.5%7 runsStardust+13.2%12 runsBig Bang+12.2%6 runsDebt+11.4%4 runsNeutron Aegis+11.4%4 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Knockout Blow Win Rate by Class

Exclusive to the Regent, Knockout Blow posts a 17.4% win rate over 60 tracked runs.

The Regentappears in 8.8% of its runs (60 tracked)

Best Relics for Knockout Blow

The relics that swing Knockout Blow’s win rate the most are Candelabra (+20.9%), Oddly Smooth Stone (+16.4%), and Lantern (+14.2%), with each lift shown.

Candelabra+20.9%6 runsOddly Smooth Stone+16.4%7 runsLantern+14.2%5 runsLeafy Poultice+13.8%6 runsPocketwatch+11.4%3 runsBeating Remnant+11.4%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Knockout Blow Card Details

A 3-energy uncommon attack, Knockout Blow is upgraded 28.6% of the time and tends to enter the deck around floor 12.

Deal 30 damage. If this kills an enemy, gain Stars.

Upgrade: +8 Damage

What Ends Runs with Knockout Blow

Runs holding Knockout Blow end most often against Bowlbugs Normal (6.7%), Infested Prisms Elite (6.7%), and Test Subject Boss (5.0%) — the share of its runs each accounts for is shown.

• Bowlbugs Normal6.7% of runs
• Infested Prisms Elite6.7% of runs
• Test Subject Boss5.0% of runs
• The Kin Boss5.0% of runs
• Decimillipede Elite5.0% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.