Lissandra - League of Legends Champion
Win Rate
49.8%
Pick Rate
1.9%

Lissandravs Zilean

CMage
Patch26.10
Matches1,120,787
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 19, 2026
MethodologyData Methodology

Lissandra vs Zilean is a decisive matchup in LoL patch 26.10. Lissandra wins with a 60.0% win rate (+20.0%) over Zilean based on 5 games. Lissandra holds the advantage in both the early and late game. Below you'll find the best Lissandra build, runes, laning stats, and strategies for the Lissandra vs Zilean matchup.

Lissandra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Lissandra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Zilean - 60.0% win rateZilean(60.0%)
Lissandra - 60.0% win rate in this matchup
Lissandra
60.0% WR
VS
Zilean vs Lissandra matchup - 40.0% win rate
Zilean
40.0% WR

Who Wins the Lissandra vs Zilean Matchup?

Lissandra wins the Lissandra vs Zilean matchup
Winner
Lissandra
Matches: 5
60.0%
Win Rate
40.0%
3.5
CS / min
3.0
755
DMG / min
636
11,004
Gold / game
10,086
206
Heal / min
417
452
DMG Mitigated / min
503
1.9
CC / min
1.2
66.7%
Early Game WR
33.3%
50.0%
Late Game WR
50.0%

Lissandra vs Zilean Matchup Summary

The Lissandra vs Zilean matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Lissandra wins with a 60.0% win rate compared to Zilean's 40.0%, giving Lissandra a 20.0 percentage point advantage. Lissandra dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Zilean players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Lissandra leads by 0.7s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Lissandra players can confidently pick into Zilean and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Zilean away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Lissandra vs Zilean Laning Phase Breakdown

Lissandra wins the laning phase against Zilean in League of Legends

Lissandra is favored during the laning phase against Zilean, winning 4 out of 5 key stat categories. Lissandra holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
3.5Lissandra
3.0Zilean
Lissandra edges out Zilean by 0.5 CS per minute — a moderate farming advantage that adds up to roughly 8 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Lissandra.
Damage
755Lissandra
636Zilean
Lissandra heavily out-damages Zilean by 119 DMG/min, dominating both short trades and all-in fights. Zilean should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Lissandra's sustained damage advantage take over.
Economy
11,004Lissandra
10,086Zilean
Lissandra generates a commanding 918 more gold per game than Zilean. This substantial economic advantage means Lissandra consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Zilean should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.9Lissandra
1.2Zilean
Lissandra provides 0.7 seconds more crowd control per minute than Zilean, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Lissandra coordinate with their jungler and control the pace of skirmishes.
Sustain
658Lissandra
920Zilean
Zilean vastly out-sustains Lissandra, healing and mitigating 263 more damage per minute. This massive durability gap means Zilean can absorb significant punishment and remain in lane while Lissandra is forced to recall. Building grievous wounds early is essential for Lissandra, and focusing on burst trade patterns rather than sustained fights is critical.

Best Lissandra Build Against Zilean

Crimson Lucidity is the optimal boots choice against Zilean, providing the mobility and stats Lissandra needs most in this matchup. The top-performing core items for Lissandra against Zilean are Cosmic Drive, Hextech Rocketbelt and Malignance. This combination gives Lissandra an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Zilean. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Lissandra vs Zilean matchup.

Early Game vs Late Game

Early Game
Lissandra
66.7%
+33.3% advantage
Lissandra early game win rateLissandra66.7%
Zilean early game win rateZilean33.3%
Late Game
Lissandra
50.0%
+0.0% advantage
Lissandra late game win rateLissandra50.0%
Zilean late game win rateZilean50.0%

Lissandra dominates the early game (first 15 minutes) with a commanding 66.7% win rate — a 33.3 percentage point lead over Zilean. This lopsided early game means Lissandra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Lissandra at 50.0% win rate — only 0.0 points ahead of Zilean. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

Lissandra holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Zilean players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Lissandra Runes Against Zilean

Domination rune tree - Lissandra primary runes vs ZileanDomination
Electrocute - best Lissandra rune vs ZileanCheap Shot - best Lissandra rune vs ZileanGrisly Mementos - best Lissandra rune vs ZileanUltimate Hunter - best Lissandra rune vs Zilean
Sorcery rune tree - Lissandra secondary runes vs ZileanSorcery
Manaflow Band - best Lissandra rune vs ZileanTranscendence - best Lissandra rune vs Zilean
100.0% WR

Running Domination primary with Sorcery secondary allows Lissandra to press their advantage against Zilean, amplifying the strengths that make this a favorable matchup.


Lissandra matchup data for League of Legends patch 26.10. The table below shows Lissandra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lissandra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Lissandra matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
49.52%2106.780611,49247.1%51.9%
56.59%1826.783911,99159.5%54.6%
52.87%1746.782212,05054.9%51.5%
56.55%1686.587411,71648.7%63.0%
58.60%1576.689811,29963.4%54.6%
48.30%1476.777011,69251.6%45.9%
55.47%1287.093111,79762.9%48.5%
46.73%1076.885911,57343.8%49.1%
52.43%1036.390712,50166.7%44.8%
42.27%976.571211,06638.5%44.8%
45.83%966.071610,74441.7%50.0%
39.33%896.576911,25340.0%38.8%
41.86%866.782311,93752.8%34.0%
44.59%746.491510,86541.5%48.5%
36.76%686.790311,35542.9%32.5%
50.85%596.376511,07056.3%44.4%
54.24%596.780110,88448.4%60.7%
50.00%586.574811,52952.0%48.5%
57.14%566.787211,31845.5%64.7%
48.15%546.975010,13247.1%50.0%
49.06%537.095810,85655.2%41.7%
52.00%506.381311,56564.7%45.5%
57.14%496.694711,72651.9%63.6%
51.02%496.683811,64055.6%48.4%
54.17%486.989211,22356.0%52.2%
53.33%456.480410,81659.1%47.8%
50.00%426.579410,00152.6%47.8%
50.00%426.474711,88246.7%51.9%
40.00%406.387811,64643.8%37.5%
58.97%396.684212,09046.1%65.4%
52.63%386.876610,73557.9%47.4%
47.37%386.681812,14053.9%44.0%
55.56%366.583311,62466.7%47.6%
54.29%357.082112,00366.7%47.8%
36.36%336.789211,02138.5%35.0%
48.39%316.885511,51653.3%43.8%
54.84%317.082211,03757.1%52.9%
35.48%317.184111,97745.5%30.0%
50.00%306.684711,44250.0%50.0%
55.17%295.486810,53453.3%57.1%
58.62%296.781310,92262.5%53.9%
58.33%245.875610,88580.0%42.9%
45.45%223.963711,05250.0%44.4%
36.36%226.568011,21444.4%30.8%
40.91%226.087212,16033.3%43.8%
52.38%216.782910,15853.9%50.0%
65.00%206.687311,63357.1%69.2%
60.00%206.282412,77960.0%60.0%
42.11%195.975512,91940.0%42.9%
68.42%197.690311,91980.0%55.6%
44.44%187.081311,16866.7%22.2%
52.94%176.387511,75557.1%50.0%
47.06%176.782512,20333.3%54.5%
70.59%176.889213,507100.0%58.3%
66.67%156.593712,18950.0%72.7%
53.33%153.581412,57475.0%45.5%
42.86%146.11,02912,75233.3%50.0%
28.57%146.667811,34757.1%0.0%
33.33%127.397613,34550.0%25.0%
50.00%127.598812,49566.7%33.3%
81.82%117.294010,32471.4%100.0%
27.27%111.65108,41225.0%28.6%
27.27%116.178211,74950.0%22.2%
50.00%106.471310,616100.0%0.0%
40.00%102.462511,4840.0%57.1%
60.00%107.093411,69733.3%71.4%
40.00%102.25587,75942.9%33.3%
20.00%106.885212,5610.0%25.0%
20.00%106.983411,49825.0%16.7%
33.33%97.29009,61816.7%66.7%
77.78%97.089312,872100.0%66.7%
77.78%96.68969,42683.3%66.7%
22.22%95.485611,921100.0%12.5%
55.56%96.47397,59860.0%50.0%
37.50%87.077010,29050.0%25.0%
50.00%82.04379,623100.0%42.9%
50.00%85.784111,21275.0%25.0%
50.00%82.563810,00375.0%25.0%
75.00%83.67597,86675.0%75.0%
62.50%86.293212,90475.0%50.0%
25.00%86.71,12614,691100.0%14.3%
12.50%85.81,04512,37850.0%0.0%
28.57%74.760010,21133.3%25.0%
57.14%77.11,07711,75233.3%75.0%
71.43%76.384711,98966.7%75.0%
57.14%73.95649,98533.3%75.0%
66.67%67.989710,42475.0%50.0%
83.33%67.096111,53366.7%100.0%
33.33%62.173812,593100.0%20.0%
40.00%56.57919,62650.0%0.0%
40.00%52.380711,49866.7%0.0%
60.00%56.28127,81460.0%0.0%
60.00%53.575511,00466.7%50.0%
80.00%57.996712,333100.0%50.0%
40.00%54.34254,93850.0%0.0%
60.00%52.14718,59966.7%50.0%
40.00%57.195412,15750.0%33.3%
60.00%56.880513,071100.0%33.3%
40.00%56.379412,840100.0%25.0%

Get the MetaBot Desktop App

Level up your gameplay with real-time overlays, automatic game detection, and instant stats — all on your desktop.

In-game overlaysAuto game detectionMulti-game supportPersonal dashboard
Download NowFree download
🔍

Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.

Report an Issue

Lissandra vs Zilean - Frequently Asked Questions

How does Lissandra do against Zilean in League of Legends?

Lissandra wins the Lissandra vs Zilean matchup with a 60.0% win rate compared to Zilean's 40.0%, a 20.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.10.

How does Lissandra do against Zilean in the early game?

In the early game, Lissandra has the advantage against Zilean with a 66.7% win rate versus 33.3%. Lissandra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Lissandra do against Zilean in the late game?

In the late game, Lissandra takes over the Lissandra vs Zilean matchup with a 50.0% win rate compared to 50.0%. Lissandra scales better into team fights and objective contests after 25 minutes.

Who wins the Lissandra vs Zilean matchup?

Lissandra wins the matchup against Zilean with a 60.0% win rate in League of Legends patch 26.10. The 20.0 percentage point advantage means Lissandra is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Lissandra build against Zilean?

The best Lissandra build against Zilean includes Cosmic Drive, Hextech Rocketbelt, Malignance with Crimson Lucidity. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Lissandra runes against Zilean?

The best Lissandra runes against Zilean use the Domination primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Lissandra vs Zilean matchup. See the full rune breakdown in the matchup comparison above.

Does Lissandra counter Zilean?

Yes, Lissandra has a favorable matchup against Zilean with a 60.0% win rate. Lissandra strongly counters Zilean in lane based on current patch 26.10 data.

How do I play Lissandra against Zilean?

When playing Lissandra against Zilean, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.